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A study was conducted to evaluate the mechanical properties of low density fiberboard produced with combinations of two fibers soybean straw (Glycine max), and wheat straw (Triticum aestivum) and two resins methylene diphenyl diisocyanate (MDI) and epoxidized sucrose soyate (ESS) resin as binders. ESS is a high performance, soybean oil based epoxy that has shown promise as a highly biobased adhesive. Six formulations of panels were produced using various combinations of straw and resin binder. Mechanical testing of sample boards was conducted using ASTM standard D1037-12. Test results showed that type of resin did not influence soy straw or wheat straw board’s stiffness and strength properties but had a major impact on water resistance, screw withdrawal strength and internal bond strength. The study demonstrated the potential of ESS as a novel binder for fiberboard system if a suitable crosslinker and catalyst is utilized. It also showed that increasing ESS content over 50% in a MDI blend lowered the performance characteristics of boards. However, analytical testing of the resin systems showed limited reactivity between ESS soyate and MDI, indicating other compatible resin chemistries should be explored for achieving superior board properties. Overall, a resin blend with 25?50% ESS in MDI appears favorable for low density fiberboards. ESS can be a promising bio-based resin as it has the potential to meet California Air and Resources Board (CARB) standards while providing acceptable properties as an adhesive.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1009NO – PubChem

 

Discovery of (R)-4-Benzyl-2-oxazolidinone

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The present invention concerns the identification of inhibitors of ubiquitin specific protease 7 (USP7), and methods of use thereof.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1650NO – PubChem

 

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Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Formula: C3H5NO2, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 497-25-6, in my other articles.

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A highly efficient copper(i)-catalyzed asymmetric 1,3-dipolar cycloaddition of azomethine ylides with benzo[b]thiophene 1,1-dioxides as the dipolarophiles was developed, providing elegant access to novel chiral tricyclic pyrrolidine-fused benzo[b]thiophene 1,1-dioxide derivatives in good to excellent yields (up to 99%) with excellent diastereo- and enantioselectivities (up to >25:1 dr, up to 99% ee). Furthermore, the cycloadducts could be conveniently converted to synthetically important tricyclic pyrrolidine-fused benzo[b]thiophene and tetracyclic oxazolidin-2-one derivatives via simple transformations.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H483NO – PubChem

 

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Pregnant rats treated with dimethadione (DMO), the N-demethylated metabolite of the anticonvulsant trimethadione, produce offspring having a 74% incidence of congenital heart defects (CHD); however, the incidence of CHD has high inter-litter variability (40-100%) that presents a challenge when studying the initiating events prior to the presentation of an abnormal phenotype. We hypothesized that the variability in CHD incidence was the result of differences in maternal systemic concentrations or embryonic tissue concentrations of DMO. To test this hypothesis, dams were administered 300. mg/kg DMO every 12. h from the evening of gestational day (GD) 8 until the morning of GD 11 (six total doses). Maternal serum levels of DMO were assessed on GD 11, 12, 13, 14, 15, 18 and 21. Embryonic tissue concentrations of DMO were assessed on GD 11, 12, 13 and 14. In a separate cohort of GD 12 embryos, DMO concentrations and parameters of growth and development were assessed to determine if tissue levels of DMO were correlated with these endpoints. Embryos were exposed directly to different concentrations of DMO with whole embryo culture (WEC) and their growth and development assessed. Key findings were that neither maternal systemic concentrations nor tissue concentrations of DMO identified embryos that were sensitive or resistant to DMO in vivo. Direct exposure of embryos to DMO via WEC also failed to show correlations between embryonic concentrations of DMO with developmental outcomes in vitro. We conclude that neither maternal serum nor embryonic tissue concentrations of DMO predict embryonic outcome.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1376NO – PubChem

 

Final Thoughts on Chemistry for (R)-4-Benzyl-2-oxazolidinone

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Reference of 102029-44-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.102029-44-7, Name is (R)-4-Benzyl-2-oxazolidinone, molecular formula is C10H11NO2. In a Patent,once mentioned of 102029-44-7

There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1548NO – PubChem

 

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Quantitative online NMR spectroscopy was used for studying the species distribution in solutions of carbon dioxide in aqueous monoethanolamine (MEA) and diethanolamine (DEA). The mass fraction of the amine in the unloaded solution was 0.2 and 0.3 g/g, respectively, the carbon dioxide loading was up to 1.1 mo lC O2 / mo lamine, temperatures were between 293 and 353 K. A special apparatus was designed that allows preparing the mixtures gravimetrically and applying pressures up to 25 bar to keep the carbon dioxide in solution. It was coupled to a 400 MHz NMR spectrometer by heated capillaries. By using both 1H and 13C NMR spectroscopy quantitative information on the concentrations of the following species were obtained: amine, carbamate, bicarbonate, and carbon dioxide. Due to the fast proton transfer between molecular and protonated amine, only the sum of their concentrations can be determined. Furthermore, a byproduct, 2-oxazolidone, was observed and quantified. The experimental data were used for developing a thermodynamic model of the studied electrolyte solutions based on the extended Pitzer GE-model. In the model development, also vapor-liquid equilibrium data from the literature were included. The model gives reliable results both for the species distribution and the vapor-liquid equilibrium of the studied mixtures.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H353NO – PubChem

 

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Disclosed is a process for preparing an aryloxyalkylene amine compound via an aminoethylation reaction comprising: a) reacting an aromatic hydroxyl compound in the presence of a basic catalyst with a 2-oxazolidinone compound of the formula II to form an intermediate reaction product; wherein R3 is selected from the group consisting of hydrogen or lower alkyl having 1 to 6 carbon atoms, R4 is selected from the group consisting of hydrogen, straight or branched chain alkyl having from one to six carbon atoms, phenyl, alkaryl, or arylalkyl; and b) reacting the intermediate product of step a) with a polyalkylene polyamine.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H167NO – PubChem

 

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This invention provides an improved process for producing azetidinones. More particularly, this invention provides the steps of producing an azetidinone represented by the formula I STR1 from a carboxylic acid R2 –D–CH2 COOH, an aldehyde R1 –A–CHO and an amine RNH2, by the steps of: (a) converting a carboxylic acid to the corresponding acid chloride; (b) deprotonating a chiral oxazolidinone and treating the resulting anion with the product of step (a); (c) enolizing the product of step (b) and condensing with an imine; and (d) cyclizing the product of step (c). Steps (c) and (d) of this process are as shown in the following reaction scheme. STR2

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1683NO – PubChem

 

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The first transition-metal-free carboarylation of alkynes with commercial and readily available alcohols as alkylating agents was realized in the presence of an environmentally benign calcium catalyst. Thereby, a novel protocol for the one-step synthesis of highly congested, all-carbon tetrasubstituted alkenes, as incorporated in potentially bioactive, complex dihydronaphthalene, chromene and dihydroquinoline structures, is provided. The reaction features an unprecedented, particularly wide substrate scope, good functional-group tolerance and simple experimental operation under mild reaction conditions. Finally free: The first transition-metal-free one-step synthesis of highly congested, all-carbon tetrasubstituted olefins has been realized by a calcium-catalyzed carboarylation reaction. Internal alkynes react with alcohols as alkylating reagent under mild reaction conditions, which provides access to a variety of useful structural scaffolds via highly reactive trisubstituted vinyl cations.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H530NO – PubChem

 

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A new method for the preparation of Xxx-Gly (E)-alkene dipeptide isosteres (EADIs), using LDA deprotonation followed by 1 N HCl quench, was explored. The method, named kinetic deconjugation, enabled the synthesis of Tyr-Gly, Gly-Gly, Ser-Gly, Pro-Gly, and Phe-Gly EADIs, as well as one Tyr-Gly trisubstituted alkene dipeptide isostere (TADI). Overall, this method, based on commercially available materials, leads to high yields, requires few synthetic steps and works on the gram scale in the synthesis of a wide variety of EADIs.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H2382NO – PubChem