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We explore the adaptability at a protein-DNA interface using phage display to re-engineer a homeodomain to specifically recognize a chemically synthesized, unnatural nucleotide. The engineered homeodomain preferentially binds to the modified DNA with affinity and specificity similar to those of natural homeodomains. Copyright
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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1004NO – PubChem