Month: April 2022

Soleimani-Amiri, Somayeh; Shafaei, Faezeh; Varasteh Moradi, Ali; Gholami-Orimi, Fathali; Rostami, Zohreh published the article 《A Novel Synthesis and Antioxidant Evaluation of Functionalized [1,3]-Oxazoles Using Fe3O4-Magnetic Nanoparticles》. Keywords: cyclopenta oxazole thione green preparation radical trapping ferric reduction; oxazole thione preparation bromo ketone isothiocyanate cyclization; magnetic iron oxide nanoparticle catalyst preparation.They researched the compound: Ethyl 3-bromo-2-oxopropanoate( cas:70-23-5 ).Synthetic Route of C5H7BrO3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:70-23-5) here.

In this research, green procedure was employed for biosynthesis of magnetic nanoparticles of iron oxide (Fe3O4-MNPs) by reduction of ferric chloride solution with Orange peel water extract Also, dihydro-2H-cyclopenta[d][1,3]oxazoles I (R = CO2Et, 4-MeOC6H4, 4-MeC6H4, 4-BrC6H4; R1 = t-Bu, 4-MeOC6H4, 4-O2NC6H4; R2 = Me, Et; R3 = CO2Et, 4-MeOC6H4, 4-MeC6H4) were generated through multi-component reaction of 1,3-oxazole-2(3H)-thione, dialkyl acetylenedicarboxylates, α-haloketones, and Fe3O4-MNPs as catalyst at ambient temperature in good yield. Initially, 1,3-oxazole-2(3H)-thione derivatives as one of the precursors are produced through the reaction of alkyl bromides, isothiocyanate, sodium hydride, and Fe3O4-MNPs as catalyst water at ambient temperature in 83-95% yields. Also, diphenyl-picrylhydrazine radical trapping and ferric reduction activity potential assays are used for evaluation of antioxidant activity of some synthesized compounds Among investigated compounds, I (R = CO2Et; R1 = 4-O2NC6H4; R2 = Me; R3 = 4-MeOC6H4) has good power for radical trapping activity and I (R = 4-MeOC6H4; R1 = t-Bu; R2 = Me; R3 = 4-MeC6H4) has good reduction power to butylated hydroxytoluene and 2-tert-butylhydroquinone.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 5451-40-1, is researched, Molecular C5H2Cl2N4, about Promising 2,6,9-trisubstituted purine derivatives for anticancer compounds: synthesis, 3D-QSAR, and preliminary biological assays, the main research direction is trisubstituted purine regioselective preparation SAR QSAR antitumor apoptosis human; 3D-QSAR; apoptosis; cancer; cell cycle; cytotoxicity; purine derivatives.Reference of 2,6-Dichloropurine.

Two series of 2,6,9-trisubstituted purine derivatives I [R1 = Et, n-Bu, n-hexyl, etc.; R2 = cyclopentyl, cyclohexyl, cycloheptanyl, etc.] and II [R3 = 4-CF3OC6H4, 4-phenyl-piperidin-1-yl, 4-phenyl-piperazin-1-yl, 4-(4-chlorophenyl)piperazin-1-yl, etc.; R4 = Cl, 5-(nitropyridin-2-yl)piperazin-1-yl, 4-(pyrazin-2-yl)piperazin-1-yl, etc.; R5 = n-pentyl, n-hexyl, cyclopentyl] were synthesized and evaluated for their prospective role as antitumor compounds Compounds I and II were tested for their in vitro cell toxicity on seven cancer cells lines and one non-neoplastic cell line. Structural requirements for antitumor activity on two different cancer cell lines were analyzed with SAR and 3D-QSAR. The 3D-QSAR models showed that steric properties could better explain the cytotoxicity of compounds than electronic properties (70% and 30% of contribution, resp.). From this anal., conclusion was that arylpiperazinyl system connected at position 6 of the purine ring was beneficial for cytotoxic activity, while the use of bulky systems at position C-2 of the purine was not favorable. Compound II [R3 = 4-(4-nitrophenyl)piperazin-1-yl; R4 = Cl; R5 = cyclopentyl] was found to be an effective potential agent when compared with a currently marketed drug, cisplatin, in four out of the seven cancer cell lines tested. Compound II [R3 = 4-(4-nitrophenyl)piperazin-1-yl; R4 = Cl; R5 = cyclopentyl] showed the highest potency, unprecedented selectivity and complied with all the Lipinski rules. Finally, it was demonstrated that compound II [R3 = 4-(4-nitrophenyl)piperazin-1-yl; R4 = Cl; R5 = cyclopentyl] induced apoptosis and caused cell cycle arrest at the S-phase on HL-60 cells.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Quality Control of Cupric bromide. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Cupric bromide, is researched, Molecular Br2Cu, CAS is 7789-45-9, about Regenerative magnetic nanoparticle-supported ATRP ligand for bottlebrush copolymer preparation. Author is Jing, Jingyun; Shi, Congling.

A facile method is proposed to prepare functionalized Fe3O4@Me6TREN nanoparticles (NPs) for atom transfer radical polymerization (ATRP). The Me6TREN moieties on NPs surface can bind copper, thus making them effective nano ligands for ATRP reactions to synthesize bottlebrush copolymers. After polymerization, purification of the polymer achieved only by a magnet, is much simpler than traditional ATRP process. No column chromatog. is required. Furthermore, Fe3O4@Me6TREN NPs can thus be regenerated via separating copper from NPs surface by ligand exchange with EDTA-Na2. Such a versatile nano ligand is of great worth to promote the industrial application of ATRP at a large scale and low cost.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Single-chain folding and self-assembling of amphiphilic polyethyleneglycol-modified fluorinated styrene homopolymers in water solution》. Authors are Guazzelli, Elisa; Masotti, Elena; Calosi, Matteo; Kriechbaum, Manfred; Uhlig, Frank; Galli, Giancarlo; Martinelli, Elisa.The article about the compound:Cupric bromidecas:7789-45-9,SMILESS:[Cu+2].[Br-].[Br-]).COA of Formula: Br2Cu. Through the article, more information about this compound (cas:7789-45-9) is conveyed.

Amphiphilic tetrafluorostyrene monomers (EFSn) carrying in the para position a polyethyleneglycol (PEG) chain with varied lengths (n = 3-13) were synthesized and polymerized by ARGET-ATRP to obtain the corresponding amphiphilic homopolymers pEFSn-x with controlled and tailored polymerization degrees (x = 8-135). All polymers presented a reversible thermoresponsive LCST-type behavior, in water/methanol mixture when n ≤ 4 or in pure water when n ≥ 8, with a cloud point (Cp) temperature in the range 30-40°C strictly dependent on the length of the PEG side chain. Combined small angle X-scattering (SAXS) and dynamic light scattering (DLS) measurements were used to study the self-assembly behavior in water of the water-soluble amphiphilic homopolymers. SAXS confirmed the formation of compact-sized and spherical single-chain self-folded nanostructures below Cp, that generally presented small hydrodynamic diameters (Dh ≤ 11 nm) as proven by DLS anal. Above Cp, much larger multi-chain aggregates were formed (Dh ≥ 800 nm), that reversibly turned back to collapsed nanostructures on cooling below the Cp temperature By contrast, the polymers were not able to self-assemble in THF or DMF solutions, in which they adopted conventional random coil conformations.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

HPLC of Formula: 67914-60-7. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, is researched, Molecular C12H16N2O2, CAS is 67914-60-7, about Preparation and in vitro photodynamic activities of novel axially substituted silicon (IV) phthalocyanines and their bovine serum albumin conjugates. Author is Jiang, Xiong-Jie; Huang, Jian-Dong; Zhu, Yu-Jiao; Tang, Fen-Xiang; Ng, Dennis K. P.; Sun, Jian-Cheng.

Two novel axially substituted phthalocyanines, namely bis(4-(4-acetylpiperazine)phenoxy)phthalocyaninatosilicon (IV) (1) and its N-methylated derivative 2, have been synthesized. The dicationic phthalocyanine 2 is non-aggregated in water and exhibits good photophys. properties. The non-covalent BSA conjugates of these compounds have also been prepared Compound 2 and the conjugate 2-BSA show extremely high photodynamic activities toward B16 melanoma cancer cell lines. The corresponding 50% growth-inhibitory (IC50) ratios are 33 and 38 nM, resp.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 151509-01-2, is researched, SMILESS is O=C(OC)C1=C(CN)N=CC=C1.[H]Cl, Molecular C8H11ClN2O2Journal, Journal of Heterocyclic Chemistry called Synthesis of a new 1,4-dihydropyridine containing the imidazo[1,5-a]pyridine nucleus, Author is Fos, Empar; Bosca, Francisco; Mauleon, David; Carganico, Germano, the main research direction is imidazopyridinyl dihydropyridine preparation calcium channel blocker; antithrombotic imidazopyridinyl dihydropyridine preparation; pyridine imidazopyridinyl preparation; nifedipine imidazopyridinyl analog preparation.Electric Literature of C8H11ClN2O2.

The preparation of the new dihydropyridine di-Et 1,4-dihydro-4-(imidazo[1,5-a]pyridin-8-yl)-2,6-dimethylpyridine-3,5-dicarboxylate (I) is described. After many attempts to prepare the key intermediate aldehyde II by different approaches, this compound was obtained in good yields from Me 2-cyano-3-pyridinecarboxylate. A 3-step procedure involving reduction to the amine, formylation with concomitant cyclization and reduction of the ester group was used. I had activity as calcium antagonist but it was devoid of activity as thromboxane inhibitor.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Crystal Growth & Design called Substituent-Controlled Tailoring of Chalcogen-Bonded Supramolecular Nanoribbons in the Solid State, Author is Biot, Nicolas; Romito, Deborah; Bonifazi, Davide, which mentions a compound: 288-42-6, SMILESS is O1C=NC=C1, Molecular C3H3NO, Application of 288-42-6.

In this work, we design and synthesize supramol. 2,5-substituted chalcogenazolo[5,4-β]pyridine (CGP) synthons arranging in supramol. ribbons at the solid state. A careful choice of the combination of substituents at the 2- and 5-positions on the CGP scaffold is outlined to accomplish supramol. materials by means of multiple hybrid interactions, comprising both chalcogen and hydrogen bonds. Depending on the steric and electronic properties of the substituents, different solid-state arrangements have been achieved. Among the different moieties on the 5-position, an oxazole unit has been incorporated on the Se- and Te-congeners by Pd-catalyzed cross-coupling reaction and a supramol. ribbon-like organization was consistently obtained at the solid state. In this work, we design 2,5-substituted chalcogenazolo[5,4-β]pyridine (CGP) synthons arranging in supramol. ribbons at the solid state. Depending on the substituents at the 2- and 5-positions on the CGP scaffold, different solid-state arrangements comprising multiple hybrid interactions, i.e., chalcogen and hydrogen bonds, could be achieved.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Name: 2,6-Dichloropurine. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2,6-Dichloropurine, is researched, Molecular C5H2Cl2N4, CAS is 5451-40-1, about Synthesis of 2-triazolylpurine Phosphonates. Author is Kapilinskis, Zigfrids; Novosjolova, Irina; Bizdena, Erika; Turks, Maris.

A series of novel compounds containing triazole and phosphonate moieties were obtained under mild conditions. Reactions of 2,6-bis-(triazolyl)purine acyclic nucleoside phosphonates, in which triazole ring at C-6 atom of purine was acting as a good leaving group, and N- or S-nucleophiles allowed to obtain the resp. 2-triazolylpurine phosphonates in 62-87% yields.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Related Products of 70-23-5. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Green synthesis and evaluation of antioxidant and antimicrobial activity of new dihydropyrroloazepines: Using bio-Ag/CdO/ZnO@MWCNTs nanocomposites as a reusable organometallic catalyst. Author is Noushin, Annataj; Varasteh-Moradi, Ali; Sayyed-Alangi, S. Zahra; Hossaini, Zinatossadat.

In this study a new, economical and green method was reported for the synthesis of Ag/CdO/ZnO@MWCNTs nanocomposites (Ag/CdO/ZnO@MWCNTs NCs) as a new heterogeneous catalyst. For confirming the structure of synthesized nanocatalyst, XRD, FESEM, EDX and TEM anal. were utilized. The Ag/CdO/ZnO@MWCNTs NCs as a high performance catalyst was employed for the preparation of a new family of substituted dihydropyrroloazepines I [R = CO2Et, Ph, 4-MeC6H4, 4-MeOC6H4, 4-O2NC6H4; R1 = CO2Et, 4-BrC6H4, 4-MeOC6H4, 4-O2NC6H4] using the one-pot condensation reactions of isatin, ammonium acetate, α-haloketones and activated acetylenic compounds in water at room temperature Another work in this research was investigation of antioxidant property of some synthesized compounds I by diphenyl-picrylhydrazine (DPPH) radical trapping experiment Addnl., for confirming the antibacterial activity of some dihydropyrroloazepines, disk diffusion test was used on two kinds of bacteria.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Computed Properties of Br2Cu. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Cupric bromide, is researched, Molecular Br2Cu, CAS is 7789-45-9, about Following principles of green chemistry: Low ppm photo-ATRP of DMAEMA in water/ethanol mixture. Author is Flejszar, Monika; Chmielarz, Pawel; Smenda, Joanna; Wolski, Karol.

Based on the 12 principles of green chem., the possibility of the synthesis of cationic PDMAEMA brushes in environmentally favorable aqueous medium, water-alc. mixture as well as com. available alc. beverages (three types of traditional Polish vodka and spirit) via dually-controlled photo-ATRP was presented. The addition of ethanol to the polymerization medium allowed to obtain a product with narrower mol. weight distribution (ETH = 1.17) than a fully aqueous medium (ETH = 1.29). Moreover, the application of alc. beverages of organic origin (e.g. pure grain vodka) increases the synthetic process rate while maintaining a controlled structure of the synthesized product. Furthermore, pH-responsive character of polymer brushes grafted from the silicon wafers (Si-g-PDMAEMA) was confirmed, indicating the application potential for controlled adhesion of proteins or drug release.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem