Month: November 2022

Lehmann, Johannes’s team published research in Organic Letters in 15 | CAS: 72571-06-3

Organic Letters published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Recommanded Product: 5-(4-Bromophenyl)oxazole.

Lehmann, Johannes published the artcileThe Kondrat’eva Reaction in Flow: Direct Access to Annulated Pyridines, Recommanded Product: 5-(4-Bromophenyl)oxazole, the publication is Organic Letters (2013), 15(14), 3550-3553, database is CAplus and MEDLINE.

A continuous flow inverse-electron-demand Kondrat’eva reaction has been developed that provides direct access to cycloalka[c]pyridines from unactivated oxazoles and cycloalkenes. The cycloadditions of both unactivated alkenes and deactivated oxazoles are promoted in continuous flow at elevated temperatures and pressures (230 °C, 750psi). E.g., reaction of 5-phenyloxazole and cyclopentene in presence of TFA gave 55% 4-phenyl-6,7-dihydro-5H-cyclopenta[c]pyridine (I). Annulated pyridines obtained by this one-step process are valuable scaffolds for medicinal chem.

Organic Letters published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Recommanded Product: 5-(4-Bromophenyl)oxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

 

Al-Duri, B.’s team published research in Journal of Supercritical Fluids in 116 | CAS: 20662-83-3

Journal of Supercritical Fluids published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Category: oxazolidine.

Al-Duri, B. published the artcileSupercritical water oxidation (SCWO) for the removal of N-containing heterocyclic hydrocarbon wastes. Part I: Process enhancement by addition of isopropyl alcohol, Category: oxazolidine, the publication is Journal of Supercritical Fluids (2016), 155-163, database is CAplus.

The present work investigates the destruction of nitrogen-containing heterocyclic hydrocarbons frequently encountered in hazardous wastes by supercritical water oxidation (SCWO), with focus on the process enhancement using iso-Pr alc. (IPA) as co-fuel. 1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) was selected for SCWO in a continuous plug flow reactor, under a range of temperatures (400-525°C), oxidant ratios nSR (0.8-2.0) and IPA/DBU ratios (0.5-3.5). Exptl. results were presented in terms of total organic carbon (TOC) removal %, and nitrogenous products yield %. Based on GC-MS anal., a free radical reaction mechanism for SCWO of DBU was proposed. Results showed that temperature was the predominant factor to influence the rate of DBU oxidation, while oxidant ratio (nSR) significantly affected the N speciation in the exit stream. IPA addition had a significant impact on shifting recalcitrant aqueous ammonia NH+4 in the liquid stream to gaseous nitrogen. It also increased TOC removal% (DBU + IPA) due to the increased free radicals produced by IPA oxidation

Journal of Supercritical Fluids published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Category: oxazolidine.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

 

Bogdanov, V. S.’s team published research in Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya in | CAS: 20662-83-3

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Application In Synthesis of 20662-83-3.

Bogdanov, V. S. published the artcileCarbon-13, nitrogen-14, and proton NMR spectra and effects of substituents in oxazoles, Application In Synthesis of 20662-83-3, the publication is Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya (1980), 305-16, database is CAplus.

13C NMR data were obtained for 40 oxazoles; 1H and 14N data were obtained for 6 and 11 of these, resp. The following linear correlations were made: chem. shift (δ) for C-2 with δ for C-4, δ for C-4 with δ for C-5, δ for C-2 with δ for H-2, δ for C-4 with δ for H-4, δ for C-5 with the electronegativity of the substituent at C-5, and 13C δ values for 4,5-disubstituted oxazole with those for 1,2-disubstituted benzenes. An additive method for calculating 13C δ values was tested successfully. The effect of substituents on various coupling constants was also determined

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Application In Synthesis of 20662-83-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

 

Hay, Duncan A.’s team published research in Tetrahedron Letters in 52 | CAS: 20662-83-3

Tetrahedron Letters published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Application In Synthesis of 20662-83-3.

Hay, Duncan A. published the artcileA flexible synthesis of C-6 and N-1 analogues of a 4-amino-1,3-dihydroimidazo[4,5-c]pyridin-2-one core, Application In Synthesis of 20662-83-3, the publication is Tetrahedron Letters (2011), 52(44), 5728-5732, database is CAplus.

A flexible route which enables access to derivatives of 4-amino-1,3-dihydroimidazo[4,5-c]pyridin-2-ones is described. Issues of selectivity, reaction safety, and low yields in original routes are overcome with the key improvements to the route, including a Negishi cross-coupling and use of a carbamate as a protecting group and intrinsic carbonyl source. The new route enables variation of C-6 and N-1 substituents.

Tetrahedron Letters published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Application In Synthesis of 20662-83-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

 

Ferreira, Jasmin’s team published research in Organic & Biomolecular Chemistry in 2016 | CAS: 4042-43-7

Organic & Biomolecular Chemistry published new progress about Alkylation. 4042-43-7 belongs to class oxazolidine, name is (R)-4-Methyloxazolidin-2-one, and the molecular formula is C4H7NO2, Recommanded Product: (R)-4-Methyloxazolidin-2-one.

Ferreira, Jasmin published the artcileChemoselective room temperature E1cB N-N cleavage of oxazolidinone hydrazides from enantioselective aldehyde α-hydrazination: synthesis of (+)-1,4-dideoxyallonojirimycin, Recommanded Product: (R)-4-Methyloxazolidin-2-one, the main research area is enantioselective aldehyde hydrazination oxazolidinone hydrazide cleavage deoxyallonojirimycin synthesis; E1cB elimination alkylation enantioselective synthesis deoxyallonojirimycin oxazolidinone hydrazide bromomalonate.

Room temperature E1cB N-N cleavage of oxazolidinone hydrazides via N-alkylation with di-Et bromomalonate and potassium or cesium carbonate as base in acetonitrile is presented. The new method has a much improved chemoselectivity, which is illustrated by a concise total synthesis of the piperidine iminosugar (+)-1,4-dideoxyallonojirimycin.

Organic & Biomolecular Chemistry published new progress about Alkylation. 4042-43-7 belongs to class oxazolidine, name is (R)-4-Methyloxazolidin-2-one, and the molecular formula is C4H7NO2, Recommanded Product: (R)-4-Methyloxazolidin-2-one.

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

 

Koivusalo, M.’s team published research in Biochemische Zeitschrift in 1965 | CAS: 4042-43-7

Biochemische Zeitschrift published new progress about Mitochondria. 4042-43-7 belongs to class oxazolidine, name is (R)-4-Methyloxazolidin-2-one, and the molecular formula is C4H7NO2, Related Products of oxazolidine.

Koivusalo, M. published the artcileOn the yield of respiratory-chain phosphorylation, Related Products of oxazolidine, the main research area is .

The P/O ratio of guinea-pig heart sarcosomes oxidizing glutamate was 2.42-2.87 (mean 2.63) when the incubation procedure of Smith and Hansen (CA 61, 2077h) was followed. The steady-state P/O ratio of rat-liver mitochondria oxidizing glutamate, under the conditions used by Gurban and Cristea (Rev. Roumaine Biochem. 1(1), 51-7(1964)), was 2.5. Preceding this steady-state value there was a burst of phosphorylation in the 1st few minutes, which was not accompanied by a corresponding increase in O uptake. The true yield of oxidative phosphorylation was given by the ratios of the rates of phosphorylation and oxidation when the steady state was achieved, and that the burst of phosphorylation was related to the previous history of the mitochondria. The cause of the burst was not known.

Biochemische Zeitschrift published new progress about Mitochondria. 4042-43-7 belongs to class oxazolidine, name is (R)-4-Methyloxazolidin-2-one, and the molecular formula is C4H7NO2, Related Products of oxazolidine.

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

 

Wang, Linqing’s team published research in Chinese Chemical Letters in 2022-09-30 | CAS: 4042-43-7

Chinese Chemical Letters published new progress about Dearomatization. 4042-43-7 belongs to class oxazolidine, name is (R)-4-Methyloxazolidin-2-one, and the molecular formula is C4H7NO2, Formula: C4H7NO2.

Wang, Linqing published the artcileA tandem asymmetric oxidation-oxa-Michael sequence for dearomatization of β-naphthols, Formula: C4H7NO2, the main research area is spiro furan naphthalene preparation enantioselective; naphthol phenyl benzooxazirenoisothiazole dioxide hydroxylative dearomatization tandem.

A catalytic asym. hydroxylative dearomatization reaction was disclosed, and the products could smoothly transform into spiroannulation adducts I [R = H, Me, Et, etc.; R1 = Me, Et, Bn] by simply treating with a base under mild conditions. Novel in-situ generated magnesium catalytic methods were developed by application of combinational ligands. Related concise transformations of the spiroannulation adducts were carried out.

Chinese Chemical Letters published new progress about Dearomatization. 4042-43-7 belongs to class oxazolidine, name is (R)-4-Methyloxazolidin-2-one, and the molecular formula is C4H7NO2, Formula: C4H7NO2.

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

 

Chouhan, Gagan’s team published research in Journal of Organic Chemistry in 2009-08-21 | CAS: 4042-43-7

Journal of Organic Chemistry published new progress about Aldol condensation. 4042-43-7 belongs to class oxazolidine, name is (R)-4-Methyloxazolidin-2-one, and the molecular formula is C4H7NO2, Name: (R)-4-Methyloxazolidin-2-one.

Chouhan, Gagan published the artcileSynthesis of Ring-Fused Oxazolo- and Pyrazoloisoquinolinones by a One-Pot Pd-Catalyzed Carboxamidation and Aldol-Type Condensation Cascade Process, Name: (R)-4-Methyloxazolidin-2-one, the main research area is aryl halide oxazolidinone pyrazolidinone carboxamidation palladium catalyst cyclization; oxazolo pyrazoloisoquinolinone preparation.

A three-component cascade process is described for the synthesis of ring-fused oxazolo- and pyrazoloisoquinolinones, i.e. I, by a one-pot carboxamidation/aldol-type condensation reaction. The cascade process involves Pd-catalyzed carboxamidation of an aryl halide/active methylene compound with oxazolidinone or pyrazolidinone, and subsequent intramol. base-catalyzed cyclization/dehydration through an aldol-type condensation process, to give ring-fused oxazolo- and pyrazoloisoquinolinones. This methodol. provides an easy one-step approach to these important classes of nitrogen-containing heterocycles and can tolerate a wide array of functional groups, including ester, nitrile, methoxy, and halide.

Journal of Organic Chemistry published new progress about Aldol condensation. 4042-43-7 belongs to class oxazolidine, name is (R)-4-Methyloxazolidin-2-one, and the molecular formula is C4H7NO2, Name: (R)-4-Methyloxazolidin-2-one.

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

 

Allali, Hocine’s team published research in Tetrahedron: Asymmetry in 2004-04-19 | CAS: 4042-43-7

Tetrahedron: Asymmetry published new progress about Hofmann degradation. 4042-43-7 belongs to class oxazolidine, name is (R)-4-Methyloxazolidin-2-one, and the molecular formula is C4H7NO2, SDS of cas: 4042-43-7.

Allali, Hocine published the artcileAn easy route to 4-substituted 2-oxazolidinones from prochiral 1,3-diols, SDS of cas: 4042-43-7, the main research area is acetoxy amide Hofmann rearrangement; oxazolidinone asym preparation.

A synthesis of 4-substituted 2-oxazolidinones I (R = Me, t-BuOCH2), starting from prochiral 1,3-diols, has been developed. After enzymic desymmetrization the resulting monoacetylated diols were transformed into amides. A Hofmann rearrangement of these amides gave I in good yields and enantiomeric excess.

Tetrahedron: Asymmetry published new progress about Hofmann degradation. 4042-43-7 belongs to class oxazolidine, name is (R)-4-Methyloxazolidin-2-one, and the molecular formula is C4H7NO2, SDS of cas: 4042-43-7.

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

 

Solomon, Marissa R.’s team published research in Letters in Organic Chemistry in 2009-07-31 | CAS: 4042-43-7

Letters in Organic Chemistry published new progress about Elimination reaction. 4042-43-7 belongs to class oxazolidine, name is (R)-4-Methyloxazolidin-2-one, and the molecular formula is C4H7NO2, SDS of cas: 4042-43-7.

Solomon, Marissa R. published the artcileIsolation and syn elimination of a Peterson adduct to obtain optically pure product in the diastereoselective synthesis of oxazolidinone-functionalized enecarbamates, SDS of cas: 4042-43-7, the main research area is Peterson adduct oxazole phenylpropiophenone preparation elimination diphenylbutenyloxazolidinone.

The Peterson reaction of (4R)-N-(trimethylsilyl)methyl-4-alkyloxazolidin-2-one gives (E/Z)-(4R)-N-(2′,3′-diphenylbut-1′-enyl)-4-alkyloxazolidin-2-ones (enecarbamates) with increasing (Z)-selectivity and moderate-to-high diastereoselectivity in the individual E isomer as a function of increasing temperature X-ray structure of the Peterson adduct, (4R,3’S)-N-(2′,3′-diphenyl-2′-hydroxy-but-1′-enyl)-4-isopropyloxazolidin-2-one reveals the rationale for the formation of a single isomer through syn elimination. The optically pure enecarbamates obtained with the Peterson adduct were further employed for photochem. and photophys. studies.

Letters in Organic Chemistry published new progress about Elimination reaction. 4042-43-7 belongs to class oxazolidine, name is (R)-4-Methyloxazolidin-2-one, and the molecular formula is C4H7NO2, SDS of cas: 4042-43-7.

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem