Month: November 2022

Method for the Preparation of Nonracemic Bis-Cyclometalated Iridium(III) Complexes was written by Helms, Melanie; Lin, Zhijie; Gong, Lei; Harms, Klaus; Meggers, Eric. And the article was included in European Journal of Inorganic Chemistry in 2013.Recommanded Product: 135948-04-8 The following contents are mentioned in the article:

A practical strategy for the generation of virtually enantiomerically pure bis-cyclometalated iridium(III) complexes is reported. Accordingly, the reactions of [Ir(μ-Cl)(ppy)2]2 (ppy = cyclometalating 2-phenylpyridine) with (S)-4-tert-butyl-2-(2′-hydroxyphenyl)-2-oxazoline [(S)-1a], [Ir(μ-Cl)(pq)2]2 (pq = cyclometalating 2-phenylquinoline) with (S)-2-(2′-hydroxyphenyl)-4-isopropyl-2-oxazoline [(S)-1b], and [Ir(μ-Cl)(pbt)2]2 (pbt = cyclometalating 2-phenylbenzothiazole) with (S)-2-(2′-hydroxyphenyl)-4-isopropyl-2-thiazoline [(S)-1d] afforded diastereomeric mixtures of salicyloxazolinato or salicylthiazolinato complexes Λ/Δ-[Ir(ppy)2{(S)-1a-H}]PF6, Λ/Δ-[Ir(pq)2{(S)-1b-H}]PF6, and Λ/Δ-[Ir(pbt)2{(S)-1d-H}]PF6, resp., which could be resolved by silica gel flash chromatog. With the individual diastereomers in hand, an acid-induced substitution of the chiral auxiliaries by achiral bidentate ligands with retention of configuration afforded several iridium complexes Λ- or Δ-[Ir(C-N)2(N N)]PF6 (C-N = cyclometalating ppy, pq, or pbt; N N = 2,2′-bipyridine, 1,10-phenanthroline, or 2,2′-biquinoline) with enantiomeric ratio (er) values of 24:1 to 230:1. This study involved multiple reactions and reactants, such as (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8Recommanded Product: 135948-04-8).

(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8) belongs to oxazolidine derivatives.Oxazolidines are readily available also from propargyl amines. Some reports highlighted again the effectiveness of oxazolidine-based compounds in driving the stereo- or diastereotopic outcome of chemical reactions.Recommanded Product: 135948-04-8

135948-04-8;(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol;The future of 135948-04-8;New trend of C13H17NO2;function of 135948-04-8

Inhibition of the Ras/Raf interaction and repression of renal cancer xenografts in vivo by an enantiomeric iridium(III) metal-based compound was written by Liu, Li-Juan; Wang, Wanhe; Huang, Shi-Ying; Hong, Yanjun; Li, Guodong; Lin, Sheng; Tian, Jinglin; Cai, Zongwei; Wang, Hui-Min David; Ma, Dik-Lung; Leung, Chung-Hang. And the article was included in Chemical Science in 2017.Recommanded Product: (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol The following contents are mentioned in the article:

Targeting protein-protein interactions (PPIs) offers tantalizing opportunities for therapeutic intervention for the treatment of human diseases. Modulating PPI interfaces with organic small mols. has been found to be exceptionally challenging, and few candidates have been successfully developed into clin. drugs. Meanwhile, the striking array of distinctive properties exhibited by metal compounds renders them attractive scaffolds for the development of bioactive leads. Here, we report the identification of iridium(III) compounds as inhibitors of the H-Ras/Raf-1 PPI. The lead iridium(III) compound 1 exhibited potent inhibitory activity against the H-Ras/Raf-1 interaction and its signaling pathway in vitro and in vivo, and also directly engaged both H-Ras and Raf-1-RBD in cell lysates. Moreover, 1 repressed tumor growth in a mouse renal xenograft tumor model. Intriguingly, the Δ-enantiomer of 1 showed superior potency in the biol. assays compared to Λ-1 or racemic 1. These compounds could potentially be used as starting scaffolds for the development of more potent Ras/Raf PPI inhibitors for the treatment of kidney cancer or other proliferative diseases. This study involved multiple reactions and reactants, such as (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8Recommanded Product: (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol).

(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8) belongs to oxazolidine derivatives. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries. Oxazolidines are commonly used as metal ligands in asymmetric catalysis, synthetic intermediates in organic synthesis, and also used as the protecting groups.Recommanded Product: (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol

135948-04-8;(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol;The future of 135948-04-8;New trend of C13H17NO2;function of 135948-04-8

Stereoisomers and functional groups in oxidorhenium(V) complexes: effects on catalytic activity was written by Schachner, J. A.; Berner, B.; Belaj, F.; Moesch-Zanetti, N. C.. And the article was included in Dalton Transactions in 2019.Quality Control of 2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol The following contents are mentioned in the article:

The syntheses of oxidorhenium(V) complexes [ReOCl(L1a-c)2] (3a-c), equipped with the bidentate, mono-anionic phenol-dimethyloxazoline ligands HL1a-c are described. Ligands HL1b-c contain functional groups on the phenol ring, compared to parent ligand 2-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-phenol H1a; namely a methoxy group ortho to the hydroxyl position (2-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-6-methoxyphenol, H1b), or a nitro group para to the hydroxyl position (2-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-4-nitrophenol, H1c). Furthermore, oxidorhenate(V) complexes (NBu4)[ReOCl3(L1a-b)] (2a-b) were synthesized for solid state structural comparisons to 3a-b. All novel complexes are fully characterized including NMR, IR and UV-Vis spectroscopy, MS spectrometry, X-ray crystallog., elemental anal. as well as cyclic voltammetry. The influence of functional groups (R = -H, -OMe and -NO2) on the catalytic activity of 3a-c was investigated in two benchmark catalytic reactions, namely cyclooctene epoxidation and perchlorate reduction In addition, the previously described oxidorhenium(V) complex [ReOCl(oz)2] (4), employing the phenol-oxazoline ligand 2-(4,5-dihydro-2-oxazolyl)phenol Hoz, was included in these catalysis studies. Complex 4 is a rare case in oxidorhenium(V) chem. where two stereoisomers could be separated and fully characterized. With respect to the position of the oxazoline nitrogen atoms on the rhenium atom, these two stereoisomers are referred to as N,N-cis and N,N-trans isomer. A potential correlation between spectroscopic and structural data to catalytic activity was evaluated. This study involved multiple reactions and reactants, such as 2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-91-1Quality Control of 2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol).

2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-91-1) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. In another report, the incorporation of an additional substituted oxazolidine ring over a range of new biphenylazepinium salt organocatalysts for the asymmetric epoxidation of alkenes improved enantiocontrol over the parent structures.Quality Control of 2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol

163165-91-1;2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol;The future of 163165-91-1;New trend of C11H13NO2;function of 163165-91-1

Isomers in chlorido and alkoxido-substituted oxidorhenium(V) complexes: effects on catalytic epoxidation activity was written by Schachner, Joerg A.; Belaj, Ferdinand; Moesch-Zanetti, Nadia C.. And the article was included in Dalton Transactions in 2020.Reference of 163165-91-1 The following contents are mentioned in the article:

The syntheses and characterizations of oxidorhenium(V) complexes trans-dichlorido [ReOCl2(PPh3)(L1a)] (trans-2a), cis-dichlorido [ReOCl2(PPh3)(L1b)] (cis-2b) and ethoxido-complex [ReO(OEt)(L1b)2] (4b), ligated with the dimethyloxazoline-phenol ligands HL1a and HL1b are described. The bidentate ligand HL1a (2-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)phenol) is unsubstituted on the phenol ring; ligand HL1b (2-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)-4-nitrophenol) contains a nitro group in para-position to the hydroxy group. In the reaction of precursor complex [ReOCl3(PPh3)2] and HL1a the two stereoisomers cis/trans-2a, with respect to chlorido ligands, are formed. The solid state structures of both isomers cis- and trans-2a were determined by single crystal x-ray diffraction anal. In contrast, with ligand HL1b, only the cis-isomer cis-2b was obtained. Ethoxido-complex 4b is exclusively obtained when precursor [ReOCl3(OPPh3)(SMe2)] is reacted with 2 equiv of HL1b in ethanol in the presence of the base 2,6-dimethylpyridine (lutidine). If no lutidine was added, chlorido-complex [ReOCl(L1b)2] (3b) was obtained. Complexes [ReOCl2(PPh3)(L1a)] (cis/trans-2a), [ReOCl2(PPh3)(L1b)] (cis-2b), [ReO(OMe)(L1a)2] (4a) and [ReO(OEt)(L1b)2] (4b) were tested as homogeneous catalysts in the benchmark reaction of cyclooctene epoxidation The influence of isomerism and effects of ligand substitutions on catalytic activity was studied. Based on the time-conversion plots cis/trans-isomerism does not influence catalytic activity, but electron-withdrawing substituents, as in cis-2b, 3b and 4b, show a beneficial effect. This study involved multiple reactions and reactants, such as 2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-91-1Reference of 163165-91-1).

2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-91-1) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Some reports highlighted again the effectiveness of oxazolidine-based compounds in driving the stereo- or diastereotopic outcome of chemical reactions.Reference of 163165-91-1

163165-91-1;2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol;The future of 163165-91-1;New trend of C11H13NO2;function of 163165-91-1

Alternatives to Phosphinooxazoline (t-BuPHOX) Ligands in the Metal-Catalyzed Hydrogenation of Minimally Functionalized Olefins and Cyclic β-Enamides was written by Biosca, Maria; Magre, Marc; Coll, Merce; Pamies, Oscar; Dieguez, Montserrat. And the article was included in Advanced Synthesis & Catalysis in 2017.Recommanded Product: (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol The following contents are mentioned in the article:

A new series of readily accessible iridium- and rhodium-phosphite/oxazoline catalytic systems that can efficiently hydrogenate, for the first time, both minimally functionalized olefins and functionalized olefins, such as Et 3-phenylbut-2-enoate, Et (2Z)-3-cyclohexyl-3-phenylprop-2-enoate, [(1E)-1-methyl-1-propen-1-yl]benzene, etc. (62 examples in total), with high enantioselectivities (up to >99% ee) and conversions has been reported. The phosphite-oxazoline ligands, which are readily available in only two synthetic steps, are derived from previous privileged 4-alkyl-2-[2-(diphenylphosphino)phenyl]-2-oxazoline (PHOX) ligands by replacing the phosphine moiety by a biaryl phosphite group and/or the introduction of a methylene spacer between the oxazoline and the Ph ring. The modular design of the ligands has given the opportunity not only to overcome the limitations of the iridium-PHOX catalytic systems in the hydrogenation of minimally functionalized Z-olefins and 1,1-disubstituted olefins, but also to expand their use to unfunctionalized olefins containing other challenging scaffolds (e.g., exocyclic benzo-fused and triaryl-substituted olefins) and also to olefins with poorly coordinative groups (e.g., α,β-unsaturated lactams, lactones, alkenylboronic esters, etc.) with enantioselectivities typically >95% ee. Moreover, both enantiomers of the hydrogenation product could be obtained by simply changing the configuration of the biaryl phosphite moiety. Remarkably, the new catalytic systems also provided excellent enantioselectivities (up to 99% ee) in the asym. hydrogenation of another challenging class of olefins – the functionalized cyclic β-enamides, such as N-(6-bromo-3,4-dihydronaphthalen-2-yl)acetamide, N-(2H-chromen-3-yl)acetamide, N-(8-methoxy-3,4-dihydronaphthalen-2-yl)acetamide, etc. Again, both enantiomers of the reduced amides could be obtained by changing the metal from Ir to Rh. The environmentally friendly propylene carbonate which can be used with no loss of enantioselectivity was also demonstrated. Another advantage of the new ligands over the PHOX ligands is that the best ligands are derived from the affordable (S)-phenylglycinol rather than from the expensive (S)-tert-leucinol. This study involved multiple reactions and reactants, such as (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8Recommanded Product: (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol).

(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol (cas: 135948-04-8) belongs to oxazolidine derivatives. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.Recommanded Product: (S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol

135948-04-8;(S)-2-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)phenol;The future of 135948-04-8;New trend of C13H17NO2;function of 135948-04-8

Half-Sandwich Ruthenium Phenolate-Oxazoline Complexes: Experimental and Theoretical Studies in Catalytic Transfer Hydrogenation of Nitroarene was written by Jia, Wei-Guo; Ling, Shuo; Zhang, Hai-Ning; Sheng, En-Hong; Lee, Richmond. And the article was included in Organometallics on January 8,2018.Related Products of 163165-91-1 The following contents are mentioned in the article:

Five Ru complexes [Ru(p-cymene)LCl] containing phenolate-oxazoline ligands [LH = 2-(4,5-dihydrooxazol-2-yl)phenol (1), 2-(4-methyl-4,5-dihydrooxazol-2-yl)phenol (2); L = 2-(4-ethyl-4,5-dihydrooxazol-2-yl)phenol (3), 2-(4-phenyl-4,5-dihydrooxazol-2-yl)phenol (4), 2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)phenol (5)] were synthesized and characterized. The solid-state structures of all Ru complexes were determined by single-crystal x-ray diffraction. The catalytic activities of these complexes in the transfer hydrogenation reaction of nitroarenes to anilines were studied. Aniline and their derivatives were obtained in good to excellent yields with iso-PrOH as the hydride source. The present protocol provides an environmentally benign synthetic method for the reduction of nitroarenes to anilines without employing harsh reaction conditions. Theor. studies employing d. functional theory were carried with the aim to propose a feasible reaction mechanism and to draw insights into the reactivity of the half-sandwich Ru catalyst. This study involved multiple reactions and reactants, such as 2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-91-1Related Products of 163165-91-1).

2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-91-1) belongs to oxazolidine derivatives. Oxazolidines are commonly obtained by reaction of strained heterocycles, mainly aziridines. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.Related Products of 163165-91-1

163165-91-1;2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol;The future of 163165-91-1;New trend of C11H13NO2;function of 163165-91-1

The Role of the Achiral Template in Enantioselective Transformations. Radical Conjugate Additions to α-Methacrylates Followed by Hydrogen Atom Transfer was written by Sibi, Mukund P.; Sausker, Justin B.. And the article was included in Journal of the American Chemical Society on February 13,2002.Safety of (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol The following contents are mentioned in the article:

We have evaluated various achiral templates in conjunction with chiral Lewis acids in the conjugate addition of nucleophilic radicals to α-methacrylates followed by enantioselective H-atom transfer. Of these, a novel naphthosultam template I gave high enantioselectivity in the H-atom-transfer reactions with ee’s up to 90%. A chiral Lewis acid derived from MgBr2 and a bisoxazoline gave the highest selectivity in the enantioselective hydrogen-atom-transfer reactions. Non-C2 sym. oxazolines have also been examined as ligands, and of these, compound II gave optimal results (87% yield and 80% ee). Insights into rotamer control in α-substituted acrylates and the critical role of the tetrahedral sulfone moiety in realizing high selectivity are discussed. This study involved multiple reactions and reactants, such as (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-08-4Safety of (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol).

(R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-08-4) belongs to oxazolidine derivatives. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries. Chiral oxazolidines are widely used as chiral auxiliaries, chiral ligands, protecting and/or directing groups in a variety of asymmetric transformations, thanks also to their easy cleavage or their further elaboration possibilities.Safety of (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol

150699-08-4;(R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol;The future of 150699-08-4;New trend of C15H13NO2;function of 150699-08-4

Ligand Design for Isomer-Selective Oxorhenium(V) Complex Synthesis was written by Liu, Jinyong; Su, Xiaoge; Han, Mengwei; Wu, Dimao; Gray, Danielle L.; Shapley, John R.; Werth, Charles J.; Strathmann, Timothy J.. And the article was included in Inorganic Chemistry on February 6,2017.Synthetic Route of C16H15NO2 The following contents are mentioned in the article:

Recently, N,N-trans Re(O)(LN-O)2X (LN-O = monoanionic N-O chelates; X = Cl or Br prior to being replaced by solvents or alkoxides) complexes are superior to the corresponding N,N-cis isomers in the catalytic reduction of perchlorate via oxygen atom transfer. However, reported methods for Re(O)(LN-O)2X synthesis often yield only the N,N-cis complex or a mixture of trans and cis isomers. This study reports a geometry-inspired ligand design rationale that selectively yields N,N-trans Re(O)(LN-O)2Cl complexes. Anal. of the crystal structures revealed that the dihedral angles (DAs) between the two LN-O ligands of N,N-cis Re(O)(LN-O)2Cl complexes are <90°, whereas the DAs in most N,N-trans complexes are >90°. Variably sized alkyl groups (-Me, -CH2Ph, and -CH2Cy) were then introduced to the 2-(2′-hydroxyphenyl)-2-oxazoline (Hhoz) ligand to increase steric hindrance in the N,N-cis structure, and substituents as small as -Me completely eliminate the formation of N,N-cis isomers. The generality of the relation between N,N-trans/cis isomerism and DAs is further established from a literature survey of 56 crystal structures of Re(O)(LN-O)2X, Re(O)(LO-N-N-O)X, and Tc(O)(LN-O)2X congeners. D. functional theory calculations support the general strategy of introducing ligand steric hindrance to favor synthesis of N,N-trans Re(O)(LN-O)2X and Tc(O)(LN-O)2X complexes. This study demonstrates the promise of applying rational ligand design for isomeric control of metal complex structures, providing a path forward for innovations in a number of catalytic, environmental, and biomedical applications. This study involved multiple reactions and reactants, such as (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2Synthetic Route of C16H15NO2).

(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.Synthetic Route of C16H15NO2

163165-92-2;(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol;The future of 163165-92-2;New trend of C16H15NO2;function of 163165-92-2

Ligand Design for Isomer-Selective Oxorhenium(V) Complex Synthesis was written by Liu, Jinyong; Su, Xiaoge; Han, Mengwei; Wu, Dimao; Gray, Danielle L.; Shapley, John R.; Werth, Charles J.; Strathmann, Timothy J.. And the article was included in Inorganic Chemistry on February 6,2017.Category: oxazolidine The following contents are mentioned in the article:

Recently, N,N-trans Re(O)(LN-O)2X (LN-O = monoanionic N-O chelates; X = Cl or Br prior to being replaced by solvents or alkoxides) complexes are superior to the corresponding N,N-cis isomers in the catalytic reduction of perchlorate via oxygen atom transfer. However, reported methods for Re(O)(LN-O)2X synthesis often yield only the N,N-cis complex or a mixture of trans and cis isomers. This study reports a geometry-inspired ligand design rationale that selectively yields N,N-trans Re(O)(LN-O)2Cl complexes. Anal. of the crystal structures revealed that the dihedral angles (DAs) between the two LN-O ligands of N,N-cis Re(O)(LN-O)2Cl complexes are <90°, whereas the DAs in most N,N-trans complexes are >90°. Variably sized alkyl groups (-Me, -CH2Ph, and -CH2Cy) were then introduced to the 2-(2′-hydroxyphenyl)-2-oxazoline (Hhoz) ligand to increase steric hindrance in the N,N-cis structure, and substituents as small as -Me completely eliminate the formation of N,N-cis isomers. The generality of the relation between N,N-trans/cis isomerism and DAs is further established from a literature survey of 56 crystal structures of Re(O)(LN-O)2X, Re(O)(LO-N-N-O)X, and Tc(O)(LN-O)2X congeners. D. functional theory calculations support the general strategy of introducing ligand steric hindrance to favor synthesis of N,N-trans Re(O)(LN-O)2X and Tc(O)(LN-O)2X complexes. This study demonstrates the promise of applying rational ligand design for isomeric control of metal complex structures, providing a path forward for innovations in a number of catalytic, environmental, and biomedical applications. This study involved multiple reactions and reactants, such as 2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-91-1Category: oxazolidine).

2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-91-1) belongs to oxazolidine derivatives. Oxazolidines are commonly obtained by reaction of strained heterocycles, mainly aziridines. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.Category: oxazolidine

163165-91-1;2-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenol;The future of 163165-91-1;New trend of C11H13NO2;function of 163165-91-1

Octahedral Ruthenium Complex with Exclusive Metal-Centered Chirality for Highly Effective Asymmetric Catalysis was written by Zheng, Yu; Tan, Yuqi; Harms, Klaus; Marsch, Michael; Riedel, Radostan; Zhang, Lilu; Meggers, Eric. And the article was included in Journal of the American Chemical Society on March 29,2017.HPLC of Formula: 1045894-43-6 The following contents are mentioned in the article:

A novel Ru catalyst is introduced which contains solely achiral ligands and acquires its chirality entirely from octahedral centrochirality. The configurationally stable catalyst is demonstrated to catalyze the alkynylation of trifluoromethyl ketones with very high enantioselectivity (up to >99% ee) at low catalyst loadings (down to 0.2 mol%). This study involved multiple reactions and reactants, such as (R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6HPLC of Formula: 1045894-43-6).

(R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6) belongs to oxazolidine derivatives. A common way to produce multisubstituted oxazolidines is by means of cycloaddition reactions. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol. Oxazolidines are weaker bases (pKa 6–7) than parent β-amino alcohols and found to be more lipophilic than the parent compound at physiological pH.HPLC of Formula: 1045894-43-6

1045894-43-6;(R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol;The future of 1045894-43-6;New trend of C12H15NO2;function of 1045894-43-6