Month: November 2022

2-[(4R)-4,5-dihydro-4-R-2-oxazolyl]phenyl diphenylphosphonate, and synthesis method and application thereof was written by Luo, Mei. And the patent was published on July 20,2011.Recommanded Product: 150699-08-4 The following contents are mentioned in the patent:

Title compound as shown formula I is synthesized by allowing to react 2-cyanophenol with d-amino alc. in O2-free anhydrous chlorobenzene in the presence of ZnCl2 under refluxing for 24 h to obtain 2-[(4R)-4,5-dihydro-4-R-2-oxazolyl]phenol, and then allowing to react with diphenylphosphonyl chloride in O2-free anhydrous toluene-triethylamine under refluxing for 24 h, wherein R = -CH2CH(CH3)2, -CH(CH3)2, Ph, or -CH2Ph. The compound can be used as chiral catalyst and shows good catalytic activity and high enantioselectivity during asym. synthesis of 2-methylbenzaldehyde. This study involved multiple reactions and reactants, such as (R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-08-4Recommanded Product: 150699-08-4).

(R)-2-(4-Phenyl-4,5-dihydrooxazol-2-yl)phenol (cas: 150699-08-4) belongs to oxazolidine derivatives. Oxazolidines are commonly obtained by reaction of strained heterocycles, mainly aziridines. Oxazolidines are commonly used as metal ligands in asymmetric catalysis, synthetic intermediates in organic synthesis, and also used as the protecting groups.Recommanded Product: 150699-08-4

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Preparation of 2-substituted oxazoline derivative was written by Lu, Zhan; Xi, Tuo; Mei, Yuncai. And the patent was published on May 25,2016.Related Products of 163165-92-2 The following contents are mentioned in the patent:

The invention discloses a method for preparing 2-substituted oxazoline derivative of formula I via reaction of II and III in the presence of palladium catalysts, ligand and a base, wherein R1 is C1-6 alkyl, OH, CN, etc.; R2, R3, and R4 are aryl, C1-6 alkyl, or cycloalkyl; Y is N or C; X halo or halo-like group. The invention provides a route for efficiently and rapidly synthesizing the 2-substituted oxazoline compound, which uses the catalytic amount of palladium and ligand, so that the reaction can be carried out at a high yield and high adaptability, has stereochem. specificity, and can prepare the enantiomer-purity 2-substituted oxazoline compound This study involved multiple reactions and reactants, such as (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2Related Products of 163165-92-2).

(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2) belongs to oxazolidine derivatives. Oxazolidines are commonly obtained by reaction of strained heterocycles, mainly aziridines. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries.Related Products of 163165-92-2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Chiral phosphoramidate compound used as chiral catalyst was written by Luo, Mei. And the patent was published on May 25,2011.Application In Synthesis of (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol The following contents are mentioned in the patent:

The invention relates to chiral phosphoramidate compound as shown in formula I, wherein R is -CH2CH(CH3)2 or -CH(CH3)2 or -CH2Ph. Title chiral phosphoramidate compound is prepared by allowing to react 2-cyanophenol with L-amino alc. in chlorobenzene solvent for 24 h under water-free and oxygen-free conditions and refluxing in the presence of anhydrous ZnCl2 as catalyst to obtain 2-[(4S)-4,5-dihydro-4-R-2-oxazolinyl]phenol intermediate, then reacting with phenylphosphonyl dichloride in toluene-triethylamine solvent under refluxing for 24 h. The inventive product can be used as chiral catalyst, showing fine catalytic activity and high enantioselectivity in asym. cyanosilylation of 2-methylbenzaldehyde. This study involved multiple reactions and reactants, such as (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2Application In Synthesis of (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol).

(S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol (cas: 163165-92-2) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. Some reports highlighted again the effectiveness of oxazolidine-based compounds in driving the stereo- or diastereotopic outcome of chemical reactions.Application In Synthesis of (S)-2-(4-Benzyl-4,5-dihydrooxazol-2-yl)phenol

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

2-[(4R)-4,5-dihydro-4-R-2-oxazolyl]phenyl diphenylphosphonate, and synthesis method and application thereof was written by Luo, Mei. And the patent was published on July 20,2011.SDS of cas: 1045894-43-6 The following contents are mentioned in the patent:

Title compound as shown formula I is synthesized by allowing to react 2-cyanophenol with d-amino alc. in O2-free anhydrous chlorobenzene in the presence of ZnCl2 under refluxing for 24 h to obtain 2-[(4R)-4,5-dihydro-4-R-2-oxazolyl]phenol, and then allowing to react with diphenylphosphonyl chloride in O2-free anhydrous toluene-triethylamine under refluxing for 24 h, wherein R = -CH2CH(CH3)2, -CH(CH3)2, Ph, or -CH2Ph. The compound can be used as chiral catalyst and shows good catalytic activity and high enantioselectivity during asym. synthesis of 2-methylbenzaldehyde. This study involved multiple reactions and reactants, such as (R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6SDS of cas: 1045894-43-6).

(R)-2-(4-Isopropyl-4,5-dihydrooxazol-2-yl)phenol (cas: 1045894-43-6) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. Chiral oxazolidines are widely used as chiral auxiliaries, chiral ligands, protecting and/or directing groups in a variety of asymmetric transformations, thanks also to their easy cleavage or their further elaboration possibilities.SDS of cas: 1045894-43-6

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On May 31, 1985, Hamaguchi, Shigeki; Yamamura, Hiroshi; Hasegawa, Junzo; Watanabe, Kiyoshi published an article.Product Details of 97859-49-9 The title of the article was Biological resolution of racemic 2-oxazolidinones. Part IV. Enzymic resolution of 2-oxazolidinone esters. And the article contained the following:

The asym. hydrolysis was investigated of (R,S)-5-butanoyloxymethyl-3-phenyl-2-oxazolidinone (I) and (R,S)-5-hexanoyloxymethyl-2-oxazolidinone (II) by lipoprotein lipase from Pseudomonas aeruginosa. Lipoprotein lipase had the ability to hydrolyze racemates of I and II enantioselectively, but had no enantioselectivity on the hydrolysis of (R,S)-5-hexanoyloxymethyl-3-tert-butyloxazolidine and (R,S)-4-hexanoyloxymethyl-1,3-dioxolane-2-one. The experimental process involved the reaction of (R)-5-(Hydroxymethyl)oxazolidin-2-one(cas: 97859-49-9).Product Details of 97859-49-9

The Article related to oxazolidinone ester hydrolysis lipoprotein lipase, enzyme resolution oxazolidinone ester racemate, Biochemical Methods: Biological and other aspects.Product Details of 97859-49-9

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On May 3, 2018, Huang, Hui; Lanter, James C.; Meegalla, Sanath K.; Player, Mark R. published a patent.Recommanded Product: 168297-86-7 The title of the patent was Preparation of cyclohexyl derivatives as GPR40 agonists for the treatment of type II diabetes. And the patent contained the following:

Disclosed are compounds of formula I, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Compounds of formula I wherein G is 5-C1-3 alkoxy-2-fluorophenyl, 2-C1-3 alkoxy-5-fluoropyridin-4-yl, 6-methoxypyrazin-2-yl-4-methoxypyrimidin-2-yl, 2-ethyl-5-fluorophenyl and 2-ethyl-5-fluoropyridin-4-yl; R1 is H, OH, MeO and F; Ra is H and C1-4 alkyl; L is OCH2, NHCH2, CH2CH2 and CH:CH; ring W is Ph and pyridinyl; R2 is C3-5 cycloalkyl, methoxyacetylenyl, and EtO; R3 is H, Me, CF3 and F; A is carboxy and 1H-tetrazol-5-yl; and enantiomers, diastereoisomers and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The example compounds were evaluated for their GPR40 agonistic activity. From the assay, it was determined that compound II exhibited IC50 values in the range of 0.0005 μM tp 0.0028 μM. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Recommanded Product: 168297-86-7

The Article related to cyclohexyl derivative preparation gpr40 agonist treatment diabetes type ii, Alicyclic Compounds: Cyclohexanes and other aspects.Recommanded Product: 168297-86-7

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On October 5, 2012, Ivashkin, Pavel; Couve-Bonnaire, Samuel; Jubault, Philippe; Pannecoucke, Xavier published an article.COA of Formula: C8H15NO2 The title of the article was Asymmetric synthesis of cyclopropanes with a monofluorinated quaternary stereocenter. And the article contained the following:

New chiral fluorinated reagents (N-(dibromofluoroacetyl)oxazolidinones) were easily synthesized and used in an asym. cyclopropanation process. The Michael initiated ring closure reaction provided chiral cyclopropanes bearing a fluorinated quaternary stereocenter. Various electron-deficient alkenes can be used to efficiently obtain chiral polysubtituted fluorinated cyclopropanes in good yields. Moderate to very good cis/trans ratios were obtained with a high level of diastereoselectivity for each isomer. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).COA of Formula: C8H15NO2

The Article related to fluorocyclopropane enantioselective preparation, dibromofluoroacetyl oxazolidinone preparation acrylate asym cyclopropanation, Alicyclic Compounds: Cyclopropanes and other aspects.COA of Formula: C8H15NO2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On January 31, 2007, Gourlay, Matthew D.; Kendrick, John; Leusen, Frank J. J. published an article.Synthetic Route of 97859-49-9 The title of the article was Rationalization of racemate resolution: predicting spontaneous resolution through crystal structure prediction. And the article contained the following:

Crystal structure prediction simulations are reported on 5-hydroxymethyl-2-oxazolidinone and 4-hydroxymethyl-2-oxazolidinone to establish the feasibility of predicting the spontaneous resolution of racemates of small organic mols. It is assumed that spontaneous resolution occurs when the enantiomorph is more stable than the racemic solid. The starting point is a gas phase conformational search to locate all low-energy conformations. These conformations were used to predict the possible crystal structures of 5- and 4-hydroxymethyl-2-oxazolidinone. In both cases, the racemic crystal structure is predicted to have the lowest energy. The energy differences between the lowest-energy racemic solids and the lowest-energy enantiomorphs are 0.2 kcal mol-1 for 5-hydroxymethyl-2-oxazolidinone and 0.9 kcal mol-1 for 4-hydroxymethyl-2-oxazolidinone. In the case of 4-hydroxymethyl-2-oxazolidinone, where the racemic crystal is known to be more stable and the exptl. crystal structures of both the racemate and the enantiomorph are available, the simulation results match the observed data. For 5-hydroxymethyl-2-oxazolidinone, where only enantiopure crystals are observed exptl., the known exptl. structure is found 1.6 kcal mol-1 above the lowest-energy predicted structure. It is possible to predict whether the racemate of a small chiral mol. can be resolved spontaneously, although further advances in the accuracy of lattice energy calculations are required. The experimental process involved the reaction of (R)-5-(Hydroxymethyl)oxazolidin-2-one(cas: 97859-49-9).Synthetic Route of 97859-49-9

The Article related to spontaneous organic racemate resolution crystal structure prediction, Organic Analytical Chemistry: Separations and other aspects.Synthetic Route of 97859-49-9

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On October 3, 2019, Qiu, Yao-Ling; Kass, Jorden; Suh, Byung-Chul; Cao, Hui; Li, Wei; Peng, Xiaowen; Gao, Xuri; Or, Yat Sun published a patent.Application In Synthesis of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one The title of the patent was Hepatitis B antiviral agents. And the patent contained the following:

The present invention discloses compounds of Formula (I; W and Y are each N and Z is CR10; or W is C, one of Y and Z is N and the other is NR11; R10 is hydrogen, halo, or optionally substituted C1-C6 alkyl; R11 is hydrogen, etc.), and pharmaceutically acceptable salts, esters, or prodrugs thereof which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Application In Synthesis of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

The Article related to hepatitis b virus antiviral, Pharmaceuticals: Formulation and Compounding and other aspects.Application In Synthesis of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On January 17, 2014, Mabe, Phillip J.; Zakarian, Armen published an article.Category: oxazolidine The title of the article was Asymmetric Radical Addition of TEMPO to Titanium Enolates. And the article contained the following:

A mild method for α-hydroxylation of N-acyl oxazolidinones by asym. radical addition of the 2,2,6,6-tetramethylpiperidine N-oxy (TEMPO) radical to titanium enolates was developed. The high diastereoselectivity and broad scope of the reaction show synthetic utility for the α-hydroxylation of substrates that are not tolerant to strongly basic conditions. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Category: oxazolidine

The Article related to asym radical addition tempo titanium enolate alpha hydroxylation, General Organic Chemistry: Synthetic Methods and other aspects.Category: oxazolidine

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem