Month: November 2022

On July 24, 2014, Basarab, Gregory Steven; Gowravaram, Madhusudhan Reddy; Hauck, Sheila Irene; Zhou, Fei published a patent.Recommanded Product: (R)-5-(Hydroxymethyl)oxazolidin-2-one The title of the patent was Preparation of spiro[oxazino[4,3-a]isoxazolo[4,5-g]quinoline-pyrimidine]trione compounds and methods for treating bacterial infections. And the patent contained the following:

Compounds of formula I, pharmaceutically acceptable salts thereof, and uses of the compounds of formula I for treating bacterial infections are disclosed. Compounds of formula I wherein X is F and Cl; R1 is H, (un)substituted Ph, CN, tetrahydropyranyl, etc.; R2 is H, CN, pyridinyl and (un)substituted C1-3 alkyl; R3 is H and C1-3 alkyl; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by spirocyclization of (2R)-1-[[5-(1,3-Dioxolan-2-yl)-6,7-difluoro-1,2-benzoxazol-3-yl]amino]propan-2-ol with barbituric acid. The invention compounds were evaluated for their DNA gyrase inhibitory activity (data given). The experimental process involved the reaction of (R)-5-(Hydroxymethyl)oxazolidin-2-one(cas: 97859-49-9).Recommanded Product: (R)-5-(Hydroxymethyl)oxazolidin-2-one

The Article related to spirooxazinoisoxazoloquinoline pyrimidinetrione preparation treatment bacterial infection, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Recommanded Product: (R)-5-(Hydroxymethyl)oxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Cardillo, Giuliana; Orena, Mario; Sandri, Sergio; Tomasini, Claudia published an article in 1987, the title of the article was An efficient synthesis of (R)-(+)- and (S)-(-)-propranolol from resolved 5-(iodomethyl)oxazolidin-2-ones.Product Details of 97859-49-9 And the article contains the following content:

Oxazolidinones I and II were prepared by cyclization of (S)-PhCHMeNHCH2CH:CH2.HBr with iodine and Amberlyst A 26 in the CO3- form. I and II were converted in 8 steps to (S)-(-)- and (R)-(+)-propranolol, resp. The experimental process involved the reaction of (R)-5-(Hydroxymethyl)oxazolidin-2-one(cas: 97859-49-9).Product Details of 97859-49-9

The Article related to propranolol diastereomer, oxazolidinone iodomethyl preparation resolution, iodomethyloxazolidinone diastereomer preparation conversion propranolol, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Alcohols and Thiols and other aspects.Product Details of 97859-49-9

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On January 6, 2017, Sagawa, Naoya; Moriya, Hiroki; Hosokawa, Seijiro published an article.Application In Synthesis of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one The title of the article was Syn Selective Vinylogous Mukaiyama Aldol Reaction Using Z,E-Vinylketene N,O-Acetal with Acetals. And the article contained the following:

Stereoselective vinylogous Mukaiyama aldol reactions using the Z,E-vinylketene silyl N,O-acetal possessing a chiral auxiliary, derived from (E)-3-pentenoic acid and L-valine, have been achieved. The reaction proceeded smoothly to give a syn adduct in high stereoselectivity. Since the products possess structures including δ-alkoxy-γ-methyl-α,β-unsaturated imide, this reaction would be applicable to synthesize polyketides in a short procedure. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Application In Synthesis of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

The Article related to stereoselective vinylogous mukaiyama aldol vinylketene silyl acetal chiral auxiliary, alkoxy methyl unsaturated imide synthesis, polyketide synthesis, Biomolecules and Their Synthetic Analogs: Other Bacterial and Fungal Metabolites and other aspects.Application In Synthesis of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On October 17, 2005, Kinoshita, Hironori; Takahashi, Natsuko; Iwamura, Tatsunori; Watanabe, Shin-ichi; Kataoka, Tadashi; Muraoka, Osamu; Tanabe, Genzoh published an article.Electric Literature of 168297-86-7 The title of the article was Synthesis of 3-sulfanylpropanols containing three consecutive stereocenters via tandem Michael-aldol reaction of enoyl thioamides with acetals as key reaction. And the article contained the following:

(2S,3S,1’R)-2-(α-Methoxybenzyl)-3-phenyl-3-sulfanylpropionamides were diastereoselectively prepared by the reaction of N-cinnamoyl-4S-isopropyl-5,5-dimethyloxazolidinethione with acetals in the presence of SnCl4. The absolute configuration of the three newly created contiguous stereocenters was determined by the x-ray anal. of the disulfide [orthorhombic, space group P212121, a 20.404(4), b 23.153(3), c 11.679(3) Å, V 5517(1) Å3, Z 4]. The amides were transformed into propanols by the reductive removal of the oxazolidinone moiety. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Electric Literature of 168297-86-7

The Article related to sulfanylpropanol asym synthesis, enoyl thioamide acetal tandem stereoselective michael aldol, oxazolidinyloxopropyl disulfide preparation mol crystal structure, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Alcohols and Thiols and other aspects.Electric Literature of 168297-86-7

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On May 31, 1998, Bull, Steven D.; Davies, Stephen G.; Jones, Simon; Polywka, Mario E. C.; Prasad, R. Shyam; Sanganee, Hitesh J. published an article.Recommanded Product: 168297-86-7 The title of the article was A practical procedure for the multigram synthesis of the SuperQuat chiral auxiliaries. And the article contained the following:

An efficient and simple synthesis of oxazolidin-2-one SuperQuat chiral auxiliaries is described which provides rapid access to multigram quantities of the auxiliaries. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Recommanded Product: 168297-86-7

The Article related to oxazolidinone superquat chiral auxiliary preparation, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines (Including Morpholine) and other aspects.Recommanded Product: 168297-86-7

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On March 12, 2014, Lv, Binhua; Li, Chengwei published a patent.Application of 97859-49-9 The title of the patent was Preparation of substituted oxazolidinone compounds as factor Xα inhibitors. And the patent contained the following:

The present invention relates to substituted oxazolidinone compounds I [wherein R1 = 5-(un)substituted 2-thienyl or 4-(un)substituted Ph; R2 = 3-oxo-4-morpholinyl, 2-oxo-1-piperidinyl, etc.; R3 and R4 = independently H, D, F, Cl, OH, CN, etc.; R5 and R6 = independently H, D, F, Cl, OH, etc.; with proviso], pharmaceutically acceptable salts, crystal forms, hydrates, or solvates thereof as factor Xα inhibitors for treating and/or preventing thromboembolic diseases. For example, II was prepared in a multi-step synthesis. The title compounds showed inhibitory activity with IC50 < 50 nM against human blood-coagulation factor Xα. The experimental process involved the reaction of (R)-5-(Hydroxymethyl)oxazolidin-2-one(cas: 97859-49-9).Application of 97859-49-9

The Article related to preparation oxazolidinone factor xa inhibitor treatment thromboembolic disease human, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines (Including Morpholine) and other aspects.Application of 97859-49-9

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On February 27, 2014, Lv, Binhua; Li, Chengwei; Cao, Benwen published a patent.Electric Literature of 97859-49-9 The title of the patent was Preparation of substituted oxazolidinone compounds as factor Xα inhibitors. And the patent contained the following:

The present invention relates to substituted oxazolidinone compounds I [wherein R1 = 5-(un)substituted 2-thienyl or 4-(un)substituted Ph; R2 = 3-oxo-4-morpholinyl, 2-oxo-1-piperidinyl, etc.; R3 and R4 = independently H, D, F, Cl, OH, CN, etc.; R5 and R6 = independently H, D, F, Cl, OH, etc.; with proviso], pharmaceutically acceptable salts, crystal forms, hydrates, or solvates thereof as factor Xα inhibitors for treating and/or preventing thromboembolic diseases. For example, II was prepared in a multi-step synthesis, which showed inhibitory activity with IC50 of 0.002 nM against human blood-coagulation factor Xα. The experimental process involved the reaction of (R)-5-(Hydroxymethyl)oxazolidin-2-one(cas: 97859-49-9).Electric Literature of 97859-49-9

The Article related to preparation oxazolidinone factor xa inhibitor treatment thromboembolic disease human, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines (Including Morpholine) and other aspects.Electric Literature of 97859-49-9

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On December 13, 2018, Peer Mohamed, Shahul Hameed; Bharatham, Nagakumar; Katagihallimath, Nainesh; Sharma, Sreevalli; Nandishaiah, Radha; Ramachandran, Vasanthi; Venkataraman, Balasubramanian published a patent.Product Details of 97859-49-9 The title of the patent was Preparation of heterocyclic derivatives for use as antibacterial agents. And the patent contained the following:

Title compounds I [R1 = (un)substituted alkyl, alkenyl, cycloalkyl, etc.; R2 and R3 independently = H, F, OH, alkyl, etc.; R8 = H, F, or alkyl; R9 = H, F, CN, OH, or alkyl; L = N, CH, CCN, C-halo, etc.; M = CH or alkyl; each X and Y independently = N, CH, CCN, etc.; Z = O, S, or CH2; m = 0 or 1; n = 0 to 2; with provisions], and their stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivatives thereof, are prepared and disclosed as antibacterial agents. Thus, e.g., II was prepared by a multistep procedure (preparation given). I were evaluated in S. aureus (ATCC 29213) antibacterial activity assays, e.g., II demonstrated a <4 μg/mL min. inhibitory concentration in LB media. The experimental process involved the reaction of (R)-5-(Hydroxymethyl)oxazolidin-2-one(cas: 97859-49-9).Product Details of 97859-49-9

The Article related to heterocyclic preparation antibacterial agent, pyridooxazinone preparation antibacterial agent, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines (Including Morpholine) and other aspects.Product Details of 97859-49-9

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On June 15, 2018, Peer Mohamed, Shahul Hameed; Bharatham, Nagakumar; Katagihallimath, Nainesh; Sharma, Sreevalli; Nandishaiah, Radha; Ramachandran, Vasanthi published a patent.COA of Formula: C4H7NO3 The title of the patent was Preparation of heterocyclic derivatives for use as antibacterial agents. And the patent contained the following:

Title compounds I [R1 = (un)substituted alkyl, alkenyl, cycloalkyl, etc.; R2 and R3 independently = H, F, OH, alkyl, etc.; R8 = H, F, or alkyl; R9 = H, F, CN, OH, or alkyl; L = N, CH, CCN, C-halo, etc.; M = CH or alkyl; each X and Y independently = N, CH, CCN, etc.; Z = O, S, or CH2; m = 0 or 1; n = 0 to 2; with provisions], and their stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivatives thereof, are prepared and disclosed as antibacterial agents. Thus, e.g., II was prepared by a multistep procedure (preparation given). I were evaluated in S. aureus (ATCC 29213) antibacterial activity assays, e.g., II demonstrated a <4 μg/mL min. inhibitory concentration in LB media. The experimental process involved the reaction of (R)-5-(Hydroxymethyl)oxazolidin-2-one(cas: 97859-49-9).COA of Formula: C4H7NO3

The Article related to heterocyclic preparation antibacterial agent, pyridooxazinone preparation antibacterial agent, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines (Including Morpholine) and other aspects.COA of Formula: C4H7NO3

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On May 19, 2017, Abas, Hossay; Linsdall, Sean M.; Mamboury, Mathias; Rzepa, Henry S.; Spivey, Alan C. published an article.SDS of cas: 168297-86-7 The title of the article was Total Synthesis of (+)-Lophirone H and Its Pentamethyl Ether Utilizing an Oxonium-Prins Cyclization. And the article contained the following:

The first total synthesis of (+)-lophirone H (I) and its pentamethyl ether, featuring an oxonium-Prins cyclization/benzylic cation trapping reaction, is described. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).SDS of cas: 168297-86-7

The Article related to lophirone h stereoselective synthesis oxonium prins cyclization, Biomolecules and Their Synthetic Analogs: Flavonoids and Natural and Fused Coumarins and other aspects.SDS of cas: 168297-86-7

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem