Month: November 2022

Vechorkin, Oleg published the artcileThe Nickel/Copper-Catalyzed Direct Alkylation of Heterocyclic C-H Bonds, Category: oxazolidine, the publication is Angewandte Chemie, International Edition (2010), 49(17), 3061-3064, S3061/1-S3061/94, database is CAplus and MEDLINE.

A combination of the Ni complex I and CuI gave efficient coupling of aromatic heterocycles with nonactivated alkyl halides containing a β-hydrogen atom. The chemo- and regioselectivities were excellent. E.g., alkylation of benzoxazole by octyl bromide gave 72% 2-octylbenzoxazole.

Angewandte Chemie, International Edition published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C4Br2N2O4S, Category: oxazolidine.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Foti, Claudia published the artcileOxazolidinone Antibiotics: Chemical, Biological and Analytical Aspects, Recommanded Product: (R)-3-(3-Fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one, the publication is Molecules (2021), 26(14), 4280, database is CAplus and MEDLINE.

A review. This review covers the main aspects concerning the chem., the biol. activity and the anal. determination of oxazolidinones, the only new class of synthetic antibiotics advanced in clin. use over the past 50 years. They are characterized by a chem. structure including the oxazolidone ring with the S configuration of substituent at C5, the acylaminomethyl group linked to C5 and the N-aryl substituent. The synthesis of oxazolidinones has gained increasing interest due to their unique mechanism of action that assures high antibiotic efficiency and low susceptibility to resistance mechanisms. Here, the main features of oxazolidinone antibiotics licensed or under development, such as Linezolid, Sutezolid, Eperezolid, Radezolid, Contezolid, Posizolid, Tedizolid, Delpazolid and TBI-223, are discussed. As they are protein synthesis inhibitors active against a wide spectrum of multidrug-resistant Gram-pos. bacteria, their biol. activity is carefully analyzed, together with the drug delivery systems recently developed to overcome the poor oxazolidinone water solubility Finally, the most employed anal. techniques for oxazolidinone determination in different matrixes, such as biol. fluids, tissues, drugs and natural waters, are reviewed. Most are based on HPLC (High Performance Liquid Chromatog.) coupled with UV-Vis or mass spectrometer detectors, but, to a lesser extent are also based on spectrofluorimetry or voltammetry.

Molecules published new progress about 1219707-39-7. 1219707-39-7 belongs to oxazolidine, auxiliary class Other Aliphatic Heterocyclic,Oxazolidine,Chiral,Fluoride,Benzene,Amide,Alcohol,Anti-infection, name is (R)-3-(3-Fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one, and the molecular formula is C14H17FN4O3, Recommanded Product: (R)-3-(3-Fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Hsu, Chen Ming published the artcileCharacterization of new volatile compounds in the neutral fraction of roasted beef flavor, Quality Control of 20662-83-3, the publication is Journal of Food Science (1982), 47(6), 2068-9, 2071, database is CAplus.

Volatile flavor compounds were isolated from 190 lb of roasted eye round beef. The neutral fraction of the flavor isolate was subjected to extensive gas-chromatog. (GC) fractionation and the pure fractions obtained were identified by GC-mass spectrometry. A total of 67 compounds were reported to be new constituents in beef flavor.

Journal of Food Science published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Quality Control of 20662-83-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Mortensen, Deborah S. published the artcileDiscovery and SAR exploration of a novel series of imidazo[4,5-b]pyrazin-2-ones as potent and selective mTOR kinase inhibitors, Recommanded Product: 5-(4-Bromophenyl)oxazole, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(22), 6793-6799, database is CAplus and MEDLINE.

We report here the discovery of a novel series of selective mTOR kinase inhibitors. A series of imidazo[4,5-b]pyrazin-2-ones, represented by screening hit 1, was developed into lead compounds with excellent mTOR potency and exquisite kinase selectivity. Potent compounds from this series show >1000-fold selectivity over the related PI3Kα lipid kinase. Further, compounds such as 2 achieve mTOR pathway inhibition, blocking both mTORC1 and mTORC2 signaling, in PC3 cancer cells as measured by inhibition of pS6 and pAkt (S473).

Bioorganic & Medicinal Chemistry Letters published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Recommanded Product: 5-(4-Bromophenyl)oxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Lu, Chih-Ying published the artcileMaillard volatile generation from reaction of glucose with dipeptides, Gly-Ser, and Ser-Gly, Name: 4,5-Dimethyloxazole, the publication is ACS Symposium Series (2008), 147-157, database is CAplus.

Peptides abundant in food and protein hydrolyzates are known to be important to both unprocessed and processed flavors. The effect of peptide bond hydrolysis on the formation of Maillard volatile compounds was studied. The Gly-Ser dipeptide bond was the most labile among all the Gly-X dipeptides (X = Ala, Cys, Gln, Glu, Gly, His, Leu, Lys, Phe, Pro, Ser, Thr, Tyr and Val). However, Ser-Gly was 2 to 3 times more stable than Gly-Ser. Volatiles formation was investigated using Gly-Ser and Ser-Gly as precursors in the reaction with glucose. Gly-Ser generated more volatiles than Ser-Gly which confirmed the pos. correlation between peptide bond susceptibility and volatiles generation.

ACS Symposium Series published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Name: 4,5-Dimethyloxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Trifonov, R. E. published the artcileBasicity of phenyl-substituted 1,3-oxazoles, Category: oxazolidine, the publication is Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) (2001), 37(3), 416-420, database is CAplus.

Ph substituents in positions 2, 4, and 5 of the oxazole ring exert different effects on the electronic structure of the hetero ring, which are reflected in the basicity constants of isomeric phenyl-substituted oxazoles and in changes of the spectral patterns on protonation. The calculated (AM1) gas-phase proton affinities and energies of ionization of isomeric methyl-, phenyl-, and methylphenyloxazoles were correlated with the exptl. pK_BH⁺ values. In acid medium specific solvation of phenyloxazoles is possible with participation of the heterocyclic fragment.

Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C8H19NO, Category: oxazolidine.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Dart, S. K. published the artcileThe changes in the volatile components of instant coffee with storage, Related Products of oxazolidine, the publication is Developments in Food Science (1985), 239-52, database is CAplus.

The headspace volatiles of fresh instant coffee were identified by capillary gas chromatog.-mass spectrometry, after enrichment on activated charcoal. The changes occurring to the volatiles during storage for â‰?2 mo at -18° and at ambient temperature were followed by direct headspace anal. Several components were highly susceptible to change, even at -18°. Overall, changes (increases as well as decreases) took place in about half the peaks, and these were interpreted in terms of the identifications made.

Developments in Food Science published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Related Products of oxazolidine.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Nakamura, Shuichi published the artcileIdentification of volatile flavor components of the oil from roasted sesame seeds, Synthetic Route of 20662-83-3, the publication is Agricultural and Biological Chemistry (1989), 53(7), 1891-9, database is CAplus.

The volatile extract obtained by steam distillation of the oil from roasted sesame seeds was separated into its neutral, weakly acidic, acidic, and basic fractions. The neutral fraction was further separated by preparative TLC. All fractions were analyzed by a gas chromatograph (GC) equipped with FID and FPD, and by gas chromatog./mass spectrometry (GC/MS) and/or gas chromatog./Fourier transform-IR (GC/FT-IR) spectrometry. Two-hundred-and-twenty-one constituents were identified. One-hundred-and-forty-six of these compounds are being reported for the 1st time in the aroma of roasted sesame seeds, 7 of which were newly identified as naturally occurring flavor components. Two dithioketones, 1-methyldithio-2-propanone, and 1-methyldithio-2-butanone, are new compounds

Agricultural and Biological Chemistry published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Synthetic Route of 20662-83-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Jouquand, Celine published the artcileEffect of added nitrogen fertilizer on pyrazines of roasted chicory, Recommanded Product: 4,5-Dimethyloxazole, the publication is Journal of the Science of Food and Agriculture (2017), 97(4), 1172-1177, database is CAplus and MEDLINE.

BACKGROUND : Coffee substitutes made of roasted chicory are affected by the formation of acrylamide whose main precursor is asparagine. One strategy for limiting the formation of acrylamide is to reduce free asparagine in the chicory roots by lessening the supply of nitrogen in the field. However, decreasing nitrogen fertilizer could affect the formation of the volatile compounds and, consequently, the sensory characteristics of the roasted chicory. The present study aimed to investigate the impact of the nitrogen supply in five com. varieties on their aroma profile. RESULTS : The addition of 120 kg ha^-1 of nitrogen fertilizer in the field resulted in a greater amount of pyrazines in the roasted chicory. Triangle tests were performed to determine the effect of the nitrogen level on the sensory quality of the five varieties. The results revealed that the chicory aroma was modified in two out of five varieties. CONCLUSION : The results of the present study suggest that a strategy aiming to limit the amount of acrylamide could affect the sensory quality of some varieties of chicory. Further acceptance tests need to be conducted to assess the effect (whether favorable or otherwise) on the sensory quality of the coffee substitutes. © 2016 Society of Chem. Industry.

Journal of the Science of Food and Agriculture published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Recommanded Product: 4,5-Dimethyloxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Li, Minyong published the artcileStructure-based discovery and experimental verification of novel Al-2 quorum sensing inhibitors against Vibrio harveyi, Product Details of C9H6BrNO, the publication is ChemMedChem (2008), 3(8), 1242-1249, database is CAplus and MEDLINE.

Quorum sensing has been implicated in the control of pathol. relevant bacterial behavior such as secretion of virulence factors, biofilm formation, sporulation, and swarming motility. The Al-2 quorum sensing pathway is found in both Gram-pos. and Gram-neg. bacteria. Therefore, antagonizing Al-2 quorum sensing is a possible approach to modifying bacterial behavior. However, efforts in developing inhibitors of Al-2-mediated quorum sensing are especially lacking. High-throughput virtual screening using the V. harveyi LuxP crystal structure identified two compounds that were found to antagonize Al-2-mediated quorum sensing in V. harveyi without cytotoxicity. The sulfone functionality of these inhibitors was identified as critical to their ability to mimic the natural ligand in their interactions with Arg215 and Arg310 of the active site.

ChemMedChem published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Product Details of C9H6BrNO.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem