Day: February 22, 2023

Hypoxia-responsive nanocarriers for chemotherapy sensitization via dual-mode inhibition of hypoxia-inducible factor-1 alpha was written by Wang, Zheng;Mu, Xuewen;Yang, Qian;Luo, Jiajia;Zhao, Yanjun. And the article was included in Journal of Colloid and Interface Science in 2022.Name: (S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate This article mentions the following:

The overexpression of hypoxia-inducible factor-1 alpha (HIF-1α) in solid tumor compromises the potency of chemotherapy under hypoxia. The high level of HIF-1α arises from the stabilization effect of reduced NAD (phosphate) NAD(P)H: quinone oxidoreductase 1 (NQO1). It was postulated that the inhibition of NQO1 could degrade HIF-1α and sensitize hypoxic cancer cells to antineoplastic agents. In the current work, we report hypoxia-responsive polymer micelles, i.e. methoxyl poly(ethylene glycol)-co-poly(aspartate-nitroimidazole) orchestrate with a NQO1 inhibitor (dicoumarol) to sensitize the ovarian cancer cell line (SKOV3) to a model anticancer agent (sorafenib) at low oxygen conditions. Both cargos were phys. encapsulated in the nanoscale micelles. The placebo micelles transiently induced the depletion of reduced NADP (NADPH) as well as glutathione and thioredoxin under hypoxia, which further inactivated NQO1 because NADPH was the cofactor of NQO1. As a consequence, the expression of HIF-1α was repressed due to the dual action of dicoumarol and polymer. The degradation of HIF-1α significantly increased the vulnerability of SKOV3 cells to sorafenib-induced apoptosis, as indicated by the enhancement of cytotoxicity, and increase of caspase 3 and cytochrome C. The current work opens new avenues of addressing hypoxia-induced drug resistance in chemotherapy. In the experiment, the researchers used many compounds, for example, (S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate (cas: 13590-42-6Name: (S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate).

(S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate (cas: 13590-42-6) belongs to oxazolidine derivatives. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries. Some reports highlighted again the effectiveness of oxazolidine-based compounds in driving the stereo- or diastereotopic outcome of chemical reactions.Name: (S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Comparson of fermented soybean paste (Doenjang) prepared by different methods based on profiling of volatile compounds was written by Jo, Ye-Jin;Cho, In Hee;Song, Chi Kwang;Shin, Hye Won;Kim, Young-Suk. And the article was included in Journal of Food Science in 2011.Recommanded Product: 2,4,5-Trimethyloxazole This article mentions the following:

In this study, 2 different extraction methods, namely solvent-assisted flavor evaporation (SAFE) and solid-phase microextraction (SPME), were employed to investigate the comprehensive volatile profile of Doenjang (one of Korean fermented soybean pastes) efficiently. Quant., major volatiles of Doenjang isolated by SAFE were 3-methylbutanoic acid, butanoic acid, 3-hydroxy-2-methyl-4H-pyran-4-one (maltol), Et 2-methylbutanoate, 2-methylpropanoic acid, tetramethylpyrazine, and 4-ethyl-2-methoxyphenol, while ethanol, ethenylbenzene, Et benzoate, Et linoleate, Et acetate, Et butanoate, tetramethylpyrazine, and Et 2-methylpropanoate extracted by SPME. In addition, volatile profiling that applied principal component anal. to gas chromatog.-mass spectrometry datasets allowed Doenjang samples that had been prepared using different traditional and com. methods to be discriminated, and the volatile compounds that contributed to their discrimination were assigned. The major volatiles that were related to differentiation of traditional and com. Doenjang samples were 2-pentylfuran, 4-ethylphenol, dihydro-5-methyl-2(3H)-furanone, butanoic acid, pyrazines (for example, 2-ethyl-5-methylpyrazine and 2,3-dimethylpyrazine), esters (for example, Et 4-methylpentanoate and di-Et succinate), maltol, di-Me disulfide, 2- and 3-methylbutanal, hexanal, 4-vinylphenol, and ethanol. In the experiment, the researchers used many compounds, for example, 2,4,5-Trimethyloxazole (cas: 20662-84-4Recommanded Product: 2,4,5-Trimethyloxazole).

2,4,5-Trimethyloxazole (cas: 20662-84-4) belongs to oxazolidine derivatives. A common way to produce multisubstituted oxazolidines is by means of cycloaddition reactions. Oxazolidines are commonly used as metal ligands in asymmetric catalysis, synthetic intermediates in organic synthesis, and also used as the protecting groups.Recommanded Product: 2,4,5-Trimethyloxazole

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Structural dependence on the property of chiral stationary phases derived from chitosan bis(arylcarbamate)-(amide)s was written by Feng, Zi-Wei;Qiu, Guo-Song;Mei, Xiao-Meng;Liang, Shuang;Yang, Fei;Huang, Shao-Hua;Chen, Wei;Bai, Zheng-Wu. And the article was included in Carbohydrate Polymers in 2017.Reference of 99395-88-7 This article mentions the following:

The goal of present study was to study the structural dependence of chitosan derivatives on enantioseparation and mobile phase tolerance of the corresponding chiral packing materials for liquid chromatog. Hence, a series of chitosan bis(arylcarbamate)-(n-pentyl amide)s and the related chiral stationary phases (CSPs) were prepared from chitosans with different mol. weights Because of the H-bond formed via CH₃-π interaction, the CSP bearing Me substituent exhibited higher tolerance than the ones bearing dichloro substituents. The CSP derived from the chitosan bis(3,5-dichlorophenylcarbamate)-(n-pentyl amide) with a higher mol. weight possessed high tolerance to mobile phases, whereas the enantioseparation capability of this CSP was not as good as that of the one prepared from the chitosan derivative with a lower mol. weight Therefore, enantioseparation capability and mobile phase tolerance have to be counterbalanced in designing chiral selectors for the CSPs derived from chitosan bis(arylcarbamate)-(amide)s. In the experiment, the researchers used many compounds, for example, (S)-4-Phenyloxazolidin-2-one (cas: 99395-88-7Reference of 99395-88-7).

(S)-4-Phenyloxazolidin-2-one (cas: 99395-88-7) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.Reference of 99395-88-7

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Cp*Co(III)-Catalyzed oxidative [5+2] annulation: regioselective synthesis of 2-aminobenzoxepines via C-H/O-H functionalization of 2-vinylphenols with ynamides was written by Han, Xiang-Lei;Liu, Xu-Ge;Lin, E.;Chen, Yunyun;Chen, Zhuangzhong;Wang, Honggen;Li, Qingjiang. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2018.Computed Properties of C11H9NO2 This article mentions the following:

A Cp*Co(III)-catalyzed [5+2] C-H annulation reaction of 2-vinylphenols with ynamides was developed. The reaction led to the efficient synthesis of valuable 2-aminobenzoxepines in high regioselectivity. Mild reaction conditions, good functional group tolerance, and moderate to good yields were observed The synthetic utility was demonstrated by a gram-scale synthesis and further transformations of the products. Preliminary mechanistic studies were conducted, and a possible catalytic cycle was proposed. In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2Computed Properties of C11H9NO2).

3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.Computed Properties of C11H9NO2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Switching Diastereoselectivity in Catalytic Enantioselective (3+2) Cycloadditions of Azomethine Ylides Promoted by Metal Salts and Privileged Segphos-Derived Ligands was written by Caleffi, Guilherme S.;Larranaga, Olatz;Ferrandiz-Saperas, Marcos;Costa, Paulo R. R.;Najera, Carmen;de Cozar, Abel;Cossio, Fernando P.;Sansano, Jose M.. And the article was included in Journal of Organic Chemistry in 2019.Name: 3-Acryloyloxazolidin-2-one This article mentions the following:

Catalytic enantioselective 1,3-dipolar cycloaddition between imino esters and electrophilic alkenes, employing chiral metal complexes derived from copper(I) and silver(I) salts and (S)-DM- or (S)-DTBM-Segphos as ligands produces diastereodivergently exo- or endo-cycloadducts, resp. The effect of the functional group of the dipolarophile and the fine tuning of the catalyst plays an important role in promoting reverse diastereoselectivities. The origins of exptl. observed enantioselectivity and diastereoselectivity data, as well as the origin of the observed switched endo/exo ratios, are also explained by means of d. functional theory calculations In the experiment, the researchers used many compounds, for example, 3-Acryloyloxazolidin-2-one (cas: 2043-21-2Name: 3-Acryloyloxazolidin-2-one).

3-Acryloyloxazolidin-2-one (cas: 2043-21-2) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Oxazolidines are commonly used as metal ligands in asymmetric catalysis, synthetic intermediates in organic synthesis, and also used as the protecting groups.Name: 3-Acryloyloxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

A Unified Stereodivergent Strategy for Prostaglandin and Isoprostanoid Synthesis was written by Valli, Matteo;Chiesa, Francesco;Gandini, Andrea;Porta, Alessio;Vidari, Giovanni;Zanoni, Giuseppe. And the article was included in Journal of Organic Chemistry in 2014.Computed Properties of C6H7NO3 This article mentions the following:

Acetoxyfulvene I surrendered to asym. Diels-Alder cycloaddition, paving the way to the development of a unified strategy for the stereodivergent synthesis of both prostaglandins and isoprostanoids. In fact, the cycloadduct II was subsequently converted to a common intermediate, which through two different stereoselective pathways afforded the two lactones III and IV, which are key building blocks in the synthesis of prostaglandins and isoprostanoids, resp. In the experiment, the researchers used many compounds, for example, 3-Acryloyloxazolidin-2-one (cas: 2043-21-2Computed Properties of C6H7NO3).

3-Acryloyloxazolidin-2-one (cas: 2043-21-2) belongs to oxazolidine derivatives. Oxazolidines are commonly obtained by reaction of strained heterocycles, mainly aziridines. Oxazolidines are commonly used as metal ligands in asymmetric catalysis, synthetic intermediates in organic synthesis, and also used as the protecting groups.Computed Properties of C6H7NO3

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Nutritional value and volatile compounds of black cherry (Prunus serotina) seeds was written by Garcia-Aguilar, Leticia;Rojas-Molina, Alejandra;Ibarra-Alvarado, Cesar;Rojas-Molina, Juana I.;Vazquez-Landaverde, Pedro A.;Luna-Vazquez, Francisco J.;Zavala-Sanchez, Miguel A.. And the article was included in Molecules in 2015.Recommanded Product: 20662-84-4 This article mentions the following:

Prunus serotina (black cherry), commonly known in Mexico as capulin, is used in Mexican traditional medicine for the treatment of cardiovascular, respiratory, and gastrointestinal diseases. Particularly, P. serotina seeds, consumed in Mexico as snacks, are used for treating cough. In the present study, nutritional and volatile analyses of black cherry seeds were carried out to determine their nutraceutical potential. Proximate anal. indicated that P. serotina raw and toasted seeds contain mostly fat, followed by protein, fiber, carbohydrates, and ash. The potassium content in black cherry raw and toasted seeds is high, and their protein digestibility-corrected amino acid scores suggest that they might represent a complementary source of proteins. Solid phase microextraction and gas chromatog./flame ionization detection/mass spectrometry anal. allowed identification of 59 and 99 volatile compounds in the raw and toasted seeds, resp. The major volatile compounds identified in raw and toasted seeds were 2,3-butanediol and benzaldehyde, which contribute to the flavor and odor of the toasted seeds. Moreover, it has been previously demonstrated that benzaldehyde possesses a significant vasodilator effect, therefore, the presence of this compound along with oleic, linoleic, and α-eleostearic fatty acids indicate that black cherry seeds consumption might have beneficial effects on the cardiovascular system. In the experiment, the researchers used many compounds, for example, 2,4,5-Trimethyloxazole (cas: 20662-84-4Recommanded Product: 20662-84-4).

2,4,5-Trimethyloxazole (cas: 20662-84-4) belongs to oxazolidine derivatives.Oxazolidines are readily available also from propargyl amines. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries.Recommanded Product: 20662-84-4

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Asymmetric nitrone cycloadditions and their application to the synthesis of enantiopure pyrrolidine and pyrrolizidine derivatives was written by Argyropoulos, Nikolaos G.;Panagiotidis, Theodoros;Coutouli-Argyropoulou, Evdoxia;Raptopoulou, Catherine. And the article was included in Tetrahedron in 2007.HPLC of Formula: 2043-21-2 This article mentions the following:

The cycloaddition reactions of a pair of chiral pyrroline-N-oxides derived from D-ribose, e.g. I, with some typical mono- and disubstituted alkenes are reported. In all these reactions with monosubstituted alkenes as well as with di-Me maleate the preferred stereochem. outcome of the cycloaddition step comes from a 5-exo-anti transition state whereas stereoisomers from the 5-exo-syn transition state are also present as minor adducts. In the reaction with di-Me fumarate the major adduct comes from a 4-exo-5-endo-syn transition state. The further behavior of the obtained isoxazolidines, e.g. II [R = EtO, MeO₂C, (2-oxooxazolidin-3-yl)carbonyl], upon reductive ring opening conditions depends on the kind and the geometry of the preexisting substituents and they are transformed to enantiomerically pure pyrrolidine or pyrrolizidinone derivatives In the experiment, the researchers used many compounds, for example, 3-Acryloyloxazolidin-2-one (cas: 2043-21-2HPLC of Formula: 2043-21-2).

3-Acryloyloxazolidin-2-one (cas: 2043-21-2) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Some reports highlighted again the effectiveness of oxazolidine-based compounds in driving the stereo- or diastereotopic outcome of chemical reactions.HPLC of Formula: 2043-21-2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Yb(III)-catalysed syn-thioallylation of ynamides was written by Gogoi, Manash Protim;Vanjari, Rajeshwer;Prabagar, B.;Yang, Shengwen;Dutta, Shubham;Mallick, Rajendra K.;Gandon, Vincent;Sahoo, Akhila K.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2021.Computed Properties of C11H9NO2 This article mentions the following:

The syn-thioallylation of ynamides I (R = Ph, 4-methylphenyl, 3-cyanophenyl, etc.) to give products incorporating a sulfide moiety at the α-position and an allyl group at the β-position of the ynamide was reported. The transformation is successful under ytterbium(III)-catalysis, providing access to highly substituted thioamino-skipped-dienes II (R¹ = 2-propenyl, Ph, 2-fluorophenyl, naphthalen-2-yl, etc.) with broad substrate scope. Thus, tetrasubstituted olefins II (with four different functional groups: amide, Ph, thioaryl/alkyl, and allyl on the carbon centers) are made in a single step from readily accessible ynamides I preserving complete atom economy. The reaction can be extended to the synthesis of selenoamino diene III by ynamide I (Ar = Ph) syn-selenoallylation. DFT studies and control experiments provide insight into the reaction mechanism. In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2Computed Properties of C11H9NO2).

3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives. Oxazolidines are commonly obtained by reaction of strained heterocycles, mainly aziridines. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol. Oxazolidines are weaker bases (pKa 6–7) than parent β-amino alcohols and found to be more lipophilic than the parent compound at physiological pH.Computed Properties of C11H9NO2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem