Month: February 2023

Structural dependence on the property of chiral stationary phases derived from chitosan bis(arylcarbamate)-(amide)s was written by Feng, Zi-Wei;Qiu, Guo-Song;Mei, Xiao-Meng;Liang, Shuang;Yang, Fei;Huang, Shao-Hua;Chen, Wei;Bai, Zheng-Wu. And the article was included in Carbohydrate Polymers in 2017.Reference of 99395-88-7 This article mentions the following:

The goal of present study was to study the structural dependence of chitosan derivatives on enantioseparation and mobile phase tolerance of the corresponding chiral packing materials for liquid chromatog. Hence, a series of chitosan bis(arylcarbamate)-(n-pentyl amide)s and the related chiral stationary phases (CSPs) were prepared from chitosans with different mol. weights Because of the H-bond formed via CH₃-π interaction, the CSP bearing Me substituent exhibited higher tolerance than the ones bearing dichloro substituents. The CSP derived from the chitosan bis(3,5-dichlorophenylcarbamate)-(n-pentyl amide) with a higher mol. weight possessed high tolerance to mobile phases, whereas the enantioseparation capability of this CSP was not as good as that of the one prepared from the chitosan derivative with a lower mol. weight Therefore, enantioseparation capability and mobile phase tolerance have to be counterbalanced in designing chiral selectors for the CSPs derived from chitosan bis(arylcarbamate)-(amide)s. In the experiment, the researchers used many compounds, for example, (S)-4-Phenyloxazolidin-2-one (cas: 99395-88-7Reference of 99395-88-7).

(S)-4-Phenyloxazolidin-2-one (cas: 99395-88-7) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.Reference of 99395-88-7

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Cp*Co(III)-Catalyzed oxidative [5+2] annulation: regioselective synthesis of 2-aminobenzoxepines via C-H/O-H functionalization of 2-vinylphenols with ynamides was written by Han, Xiang-Lei;Liu, Xu-Ge;Lin, E.;Chen, Yunyun;Chen, Zhuangzhong;Wang, Honggen;Li, Qingjiang. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2018.Computed Properties of C11H9NO2 This article mentions the following:

A Cp*Co(III)-catalyzed [5+2] C-H annulation reaction of 2-vinylphenols with ynamides was developed. The reaction led to the efficient synthesis of valuable 2-aminobenzoxepines in high regioselectivity. Mild reaction conditions, good functional group tolerance, and moderate to good yields were observed The synthetic utility was demonstrated by a gram-scale synthesis and further transformations of the products. Preliminary mechanistic studies were conducted, and a possible catalytic cycle was proposed. In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2Computed Properties of C11H9NO2).

3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. As well as other multifunctional heterocyclic compounds, oxazolidine rings play an essential role in organic and medicinal chemistry, behaving, in some cases as powerful antitumor agents.Computed Properties of C11H9NO2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Switching Diastereoselectivity in Catalytic Enantioselective (3+2) Cycloadditions of Azomethine Ylides Promoted by Metal Salts and Privileged Segphos-Derived Ligands was written by Caleffi, Guilherme S.;Larranaga, Olatz;Ferrandiz-Saperas, Marcos;Costa, Paulo R. R.;Najera, Carmen;de Cozar, Abel;Cossio, Fernando P.;Sansano, Jose M.. And the article was included in Journal of Organic Chemistry in 2019.Name: 3-Acryloyloxazolidin-2-one This article mentions the following:

Catalytic enantioselective 1,3-dipolar cycloaddition between imino esters and electrophilic alkenes, employing chiral metal complexes derived from copper(I) and silver(I) salts and (S)-DM- or (S)-DTBM-Segphos as ligands produces diastereodivergently exo- or endo-cycloadducts, resp. The effect of the functional group of the dipolarophile and the fine tuning of the catalyst plays an important role in promoting reverse diastereoselectivities. The origins of exptl. observed enantioselectivity and diastereoselectivity data, as well as the origin of the observed switched endo/exo ratios, are also explained by means of d. functional theory calculations In the experiment, the researchers used many compounds, for example, 3-Acryloyloxazolidin-2-one (cas: 2043-21-2Name: 3-Acryloyloxazolidin-2-one).

3-Acryloyloxazolidin-2-one (cas: 2043-21-2) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Oxazolidines are commonly used as metal ligands in asymmetric catalysis, synthetic intermediates in organic synthesis, and also used as the protecting groups.Name: 3-Acryloyloxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

A Unified Stereodivergent Strategy for Prostaglandin and Isoprostanoid Synthesis was written by Valli, Matteo;Chiesa, Francesco;Gandini, Andrea;Porta, Alessio;Vidari, Giovanni;Zanoni, Giuseppe. And the article was included in Journal of Organic Chemistry in 2014.Computed Properties of C6H7NO3 This article mentions the following:

Acetoxyfulvene I surrendered to asym. Diels-Alder cycloaddition, paving the way to the development of a unified strategy for the stereodivergent synthesis of both prostaglandins and isoprostanoids. In fact, the cycloadduct II was subsequently converted to a common intermediate, which through two different stereoselective pathways afforded the two lactones III and IV, which are key building blocks in the synthesis of prostaglandins and isoprostanoids, resp. In the experiment, the researchers used many compounds, for example, 3-Acryloyloxazolidin-2-one (cas: 2043-21-2Computed Properties of C6H7NO3).

3-Acryloyloxazolidin-2-one (cas: 2043-21-2) belongs to oxazolidine derivatives. Oxazolidines are commonly obtained by reaction of strained heterocycles, mainly aziridines. Oxazolidines are commonly used as metal ligands in asymmetric catalysis, synthetic intermediates in organic synthesis, and also used as the protecting groups.Computed Properties of C6H7NO3

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Nutritional value and volatile compounds of black cherry (Prunus serotina) seeds was written by Garcia-Aguilar, Leticia;Rojas-Molina, Alejandra;Ibarra-Alvarado, Cesar;Rojas-Molina, Juana I.;Vazquez-Landaverde, Pedro A.;Luna-Vazquez, Francisco J.;Zavala-Sanchez, Miguel A.. And the article was included in Molecules in 2015.Recommanded Product: 20662-84-4 This article mentions the following:

Prunus serotina (black cherry), commonly known in Mexico as capulin, is used in Mexican traditional medicine for the treatment of cardiovascular, respiratory, and gastrointestinal diseases. Particularly, P. serotina seeds, consumed in Mexico as snacks, are used for treating cough. In the present study, nutritional and volatile analyses of black cherry seeds were carried out to determine their nutraceutical potential. Proximate anal. indicated that P. serotina raw and toasted seeds contain mostly fat, followed by protein, fiber, carbohydrates, and ash. The potassium content in black cherry raw and toasted seeds is high, and their protein digestibility-corrected amino acid scores suggest that they might represent a complementary source of proteins. Solid phase microextraction and gas chromatog./flame ionization detection/mass spectrometry anal. allowed identification of 59 and 99 volatile compounds in the raw and toasted seeds, resp. The major volatile compounds identified in raw and toasted seeds were 2,3-butanediol and benzaldehyde, which contribute to the flavor and odor of the toasted seeds. Moreover, it has been previously demonstrated that benzaldehyde possesses a significant vasodilator effect, therefore, the presence of this compound along with oleic, linoleic, and α-eleostearic fatty acids indicate that black cherry seeds consumption might have beneficial effects on the cardiovascular system. In the experiment, the researchers used many compounds, for example, 2,4,5-Trimethyloxazole (cas: 20662-84-4Recommanded Product: 20662-84-4).

2,4,5-Trimethyloxazole (cas: 20662-84-4) belongs to oxazolidine derivatives.Oxazolidines are readily available also from propargyl amines. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries.Recommanded Product: 20662-84-4

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Asymmetric nitrone cycloadditions and their application to the synthesis of enantiopure pyrrolidine and pyrrolizidine derivatives was written by Argyropoulos, Nikolaos G.;Panagiotidis, Theodoros;Coutouli-Argyropoulou, Evdoxia;Raptopoulou, Catherine. And the article was included in Tetrahedron in 2007.HPLC of Formula: 2043-21-2 This article mentions the following:

The cycloaddition reactions of a pair of chiral pyrroline-N-oxides derived from D-ribose, e.g. I, with some typical mono- and disubstituted alkenes are reported. In all these reactions with monosubstituted alkenes as well as with di-Me maleate the preferred stereochem. outcome of the cycloaddition step comes from a 5-exo-anti transition state whereas stereoisomers from the 5-exo-syn transition state are also present as minor adducts. In the reaction with di-Me fumarate the major adduct comes from a 4-exo-5-endo-syn transition state. The further behavior of the obtained isoxazolidines, e.g. II [R = EtO, MeO₂C, (2-oxooxazolidin-3-yl)carbonyl], upon reductive ring opening conditions depends on the kind and the geometry of the preexisting substituents and they are transformed to enantiomerically pure pyrrolidine or pyrrolizidinone derivatives In the experiment, the researchers used many compounds, for example, 3-Acryloyloxazolidin-2-one (cas: 2043-21-2HPLC of Formula: 2043-21-2).

3-Acryloyloxazolidin-2-one (cas: 2043-21-2) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Some reports highlighted again the effectiveness of oxazolidine-based compounds in driving the stereo- or diastereotopic outcome of chemical reactions.HPLC of Formula: 2043-21-2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Yb(III)-catalysed syn-thioallylation of ynamides was written by Gogoi, Manash Protim;Vanjari, Rajeshwer;Prabagar, B.;Yang, Shengwen;Dutta, Shubham;Mallick, Rajendra K.;Gandon, Vincent;Sahoo, Akhila K.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2021.Computed Properties of C11H9NO2 This article mentions the following:

The syn-thioallylation of ynamides I (R = Ph, 4-methylphenyl, 3-cyanophenyl, etc.) to give products incorporating a sulfide moiety at the α-position and an allyl group at the β-position of the ynamide was reported. The transformation is successful under ytterbium(III)-catalysis, providing access to highly substituted thioamino-skipped-dienes II (R¹ = 2-propenyl, Ph, 2-fluorophenyl, naphthalen-2-yl, etc.) with broad substrate scope. Thus, tetrasubstituted olefins II (with four different functional groups: amide, Ph, thioaryl/alkyl, and allyl on the carbon centers) are made in a single step from readily accessible ynamides I preserving complete atom economy. The reaction can be extended to the synthesis of selenoamino diene III by ynamide I (Ar = Ph) syn-selenoallylation. DFT studies and control experiments provide insight into the reaction mechanism. In the experiment, the researchers used many compounds, for example, 3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2Computed Properties of C11H9NO2).

3-(Phenylethynyl)oxazolidin-2-one (cas: 888329-88-2) belongs to oxazolidine derivatives. Oxazolidines are commonly obtained by reaction of strained heterocycles, mainly aziridines. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol. Oxazolidines are weaker bases (pKa 6–7) than parent β-amino alcohols and found to be more lipophilic than the parent compound at physiological pH.Computed Properties of C11H9NO2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Rare earth metal triflates promoted Diels-Alder reactions in ionic liquids was written by Sarma, Diganta;Kumar, Anil. And the article was included in Applied Catalysis, A: General in 2008.HPLC of Formula: 2043-21-2 This article mentions the following:

Rare earth metal triflates, when used with ionic liquids can promote Diels-Alder reactions of dienes and dienophiles, where the catalytic activity of the triflates is enhanced by ionic liquids It is possible to recover and reuse the ionic liquid phase with triflates to give comparable yields and stereoselectivity even after six cycles. In the experiment, the researchers used many compounds, for example, 3-Acryloyloxazolidin-2-one (cas: 2043-21-2HPLC of Formula: 2043-21-2).

3-Acryloyloxazolidin-2-one (cas: 2043-21-2) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.HPLC of Formula: 2043-21-2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Reuse of chiral cationic Pd-phosphinooxazolidine catalysts in ionic liquids: highly efficient catalytic asymmetric Diels-Alder reactions was written by Takahashi, Kouichi;Nakano, Hiroto;Fujita, Reiko. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2007.Product Details of 2043-21-2 This article mentions the following:

Chiral cationic palladium-phosphinooxazolidine catalysts in ionic liquid afforded excellent enantioselectivity in Diels-Alder reactions of cyclic dienes with β-(un)substituted N-acryloyl 2-oxazolidinones, and the catalyst was easily recycled eight times without any significant decrease in chem. yields or enantioselectivity (89-99% yields, 88-99% ee). In the experiment, the researchers used many compounds, for example, 3-Acryloyloxazolidin-2-one (cas: 2043-21-2Product Details of 2043-21-2).

3-Acryloyloxazolidin-2-one (cas: 2043-21-2) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries.Product Details of 2043-21-2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

pH and redox dual-responsive multifunctional gene delivery with enhanced capability of transporting DNA into the nucleus was written by Yang, Zhe;Li, Yingqin;Gao, Jinbiao;Cao, Zhong;Jiang, Qing;Liu, Jie. And the article was included in Colloids and Surfaces, B: Biointerfaces in 2017.Category: oxazolidine This article mentions the following:

Stimuli-responsive gene delivery vectors based on physiol. triggered structure changing have been recently recognized as a new therapeutic agent for their excellent performance in vivo. Herein, we present an intelligent gene delivery system based on the octa-arginine peptides (R₈)-conjugated polyamino acid derivatives noted as PPCRC (PVIm-(PAsp-Cystamine-R₈)-Cholesteryl), which processed pH responsive, surface charge-switching, intracellular redox-responsive and enhanced nucleus import of gene together. Due to the imidazole group in the PPCRC backbone, the DNA/PPCRC polyplexes not only exhibited the enhanced buffering capacity in the endosome after endocytosis, but also displayed the reversible surface charge from neg. to pos. with decreasing the pH value form pH 7.4 to pH 6.5-6.8, which would promote the cell membrane binding and cellular uptake. The disulfide bond for R₈ peptides conjugation in the polymer side chain could be rapidly cleaved under reductive conditions, facilitating DNA release in the cytoplasm. Subsequently, the DNA would be still associated with the R₈ peptides, which would promote the intracellular nucleus import of DNA. The luciferase gene expression level of COS-7 cells transfected by DNA/PPCRC polyplexes was almost 2000 folds higher than cells transfected by DNA/PPCC polyplexes (without R₈ peptides modification) in growth-arrested cell model. Nearly 10 folds enhanced gene transfection efficiency was found on human bone mesenchymal stem cells (hBMSCs) using the same strategy, which revealed that this intelligent vector can be also utilized in transfection of non-dividing cells. I.v. injection of the DNA/PPCRC polyplexes also achieved the effective transfection in s.c. tumor model. Taken together, PPCRC vector has great potential for both dividing and non-dividing cells transfection and in vivo gene delivery application. In the experiment, the researchers used many compounds, for example, (S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate (cas: 13590-42-6Category: oxazolidine).

(S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate (cas: 13590-42-6) belongs to oxazolidine derivatives. Oxazolidine-based compounds are well-known chiral auxiliaries and strategic molecular moieties in chemistry since they can effectively mask or mimic amino acid units or amino alcohols. In another report, the incorporation of an additional substituted oxazolidine ring over a range of new biphenylazepinium salt organocatalysts for the asymmetric epoxidation of alkenes improved enantiocontrol over the parent structures.Category: oxazolidine

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem