Month: February 2023

Rare earth metal triflates promoted Diels-Alder reactions in ionic liquids was written by Sarma, Diganta;Kumar, Anil. And the article was included in Applied Catalysis, A: General in 2008.HPLC of Formula: 2043-21-2 This article mentions the following:

Rare earth metal triflates, when used with ionic liquids can promote Diels-Alder reactions of dienes and dienophiles, where the catalytic activity of the triflates is enhanced by ionic liquids It is possible to recover and reuse the ionic liquid phase with triflates to give comparable yields and stereoselectivity even after six cycles. In the experiment, the researchers used many compounds, for example, 3-Acryloyloxazolidin-2-one (cas: 2043-21-2HPLC of Formula: 2043-21-2).

3-Acryloyloxazolidin-2-one (cas: 2043-21-2) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.HPLC of Formula: 2043-21-2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Reuse of chiral cationic Pd-phosphinooxazolidine catalysts in ionic liquids: highly efficient catalytic asymmetric Diels-Alder reactions was written by Takahashi, Kouichi;Nakano, Hiroto;Fujita, Reiko. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2007.Product Details of 2043-21-2 This article mentions the following:

Chiral cationic palladium-phosphinooxazolidine catalysts in ionic liquid afforded excellent enantioselectivity in Diels-Alder reactions of cyclic dienes with β-(un)substituted N-acryloyl 2-oxazolidinones, and the catalyst was easily recycled eight times without any significant decrease in chem. yields or enantioselectivity (89-99% yields, 88-99% ee). In the experiment, the researchers used many compounds, for example, 3-Acryloyloxazolidin-2-one (cas: 2043-21-2Product Details of 2043-21-2).

3-Acryloyloxazolidin-2-one (cas: 2043-21-2) belongs to oxazolidine derivatives. Oxazolidines that are the precursor to bisoxazolidines are in effect mono-oxazolidines. They are also used as moisture scavengers in polyurethane and other systems. Oxazolidines are well known as key portions of bioactive molecules or precursors of chiral molecules, as well as established chiral auxiliaries.Product Details of 2043-21-2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

pH and redox dual-responsive multifunctional gene delivery with enhanced capability of transporting DNA into the nucleus was written by Yang, Zhe;Li, Yingqin;Gao, Jinbiao;Cao, Zhong;Jiang, Qing;Liu, Jie. And the article was included in Colloids and Surfaces, B: Biointerfaces in 2017.Category: oxazolidine This article mentions the following:

Stimuli-responsive gene delivery vectors based on physiol. triggered structure changing have been recently recognized as a new therapeutic agent for their excellent performance in vivo. Herein, we present an intelligent gene delivery system based on the octa-arginine peptides (R₈)-conjugated polyamino acid derivatives noted as PPCRC (PVIm-(PAsp-Cystamine-R₈)-Cholesteryl), which processed pH responsive, surface charge-switching, intracellular redox-responsive and enhanced nucleus import of gene together. Due to the imidazole group in the PPCRC backbone, the DNA/PPCRC polyplexes not only exhibited the enhanced buffering capacity in the endosome after endocytosis, but also displayed the reversible surface charge from neg. to pos. with decreasing the pH value form pH 7.4 to pH 6.5-6.8, which would promote the cell membrane binding and cellular uptake. The disulfide bond for R₈ peptides conjugation in the polymer side chain could be rapidly cleaved under reductive conditions, facilitating DNA release in the cytoplasm. Subsequently, the DNA would be still associated with the R₈ peptides, which would promote the intracellular nucleus import of DNA. The luciferase gene expression level of COS-7 cells transfected by DNA/PPCRC polyplexes was almost 2000 folds higher than cells transfected by DNA/PPCC polyplexes (without R₈ peptides modification) in growth-arrested cell model. Nearly 10 folds enhanced gene transfection efficiency was found on human bone mesenchymal stem cells (hBMSCs) using the same strategy, which revealed that this intelligent vector can be also utilized in transfection of non-dividing cells. I.v. injection of the DNA/PPCRC polyplexes also achieved the effective transfection in s.c. tumor model. Taken together, PPCRC vector has great potential for both dividing and non-dividing cells transfection and in vivo gene delivery application. In the experiment, the researchers used many compounds, for example, (S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate (cas: 13590-42-6Category: oxazolidine).

(S)-Benzyl 2-(2,5-dioxooxazolidin-4-yl)acetate (cas: 13590-42-6) belongs to oxazolidine derivatives. Oxazolidine-based compounds are well-known chiral auxiliaries and strategic molecular moieties in chemistry since they can effectively mask or mimic amino acid units or amino alcohols. In another report, the incorporation of an additional substituted oxazolidine ring over a range of new biphenylazepinium salt organocatalysts for the asymmetric epoxidation of alkenes improved enantiocontrol over the parent structures.Category: oxazolidine

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem