One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: (S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 184346-45-0, Name is (S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one, molecular formula is C18H19NO2
Applications of the chiral auxiliaries DIOZ and TRIOZ for conjugate additions and comparison with other auxiliaries
A number of N-acryloyl-, N-crotonoyl-, N-(3,3,3-trifluorocrotonoyl)-, N-cinnamoyl-, and N-(3-nitroacryloyl)-4-isopropyl- or -4-phenyl-oxazolidin-2- ones with geminal diphenyl substitution, i.e., 7-15, have been prepared and used for conjugate additions of organocuprate reagents (Me, iPr, Ph, 4-MeOPh) in the beta-carbonyl (Table 2) and in the alpha-carbonyl position (NO2-derivative 11 in Scheme 3). The yields and diastereoselectivities are compared with previously tested enoyl-oxazolidinones (Table 2). Highest diastereoselectivities (>90%) are always observed with the 4-Ph derivatives (Hruby effect). Nitroacryloyl-oxazolidinones and a corresponding phenylmenthol ester undergo less diastereoselective additions (Scheme 3). A 3-(1-methylethyl)-5,5-diphenyloxazolidin-2-one (DIOZ)-derived Li2-enolatenitronate was also tested for alpha-carbonyl alkylation (Scheme 4). The X-ray crystal structures of three acryloyl-oxazolidinones and of four adducts are described (Tables 1 and 3), and they serve for configurational assignments and description of the stereochemical courses of the additions and alkylation. Possible applications of the nitro compounds for the preparation of beta2-amino acids are discussed (Scheme 2).
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Recommanded Product: (S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 184346-45-0, in my other articles.
Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H2652NO – PubChem