In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 497-25-6, name is Oxazolidin-2-one, introducing its new discovery. Recommanded Product: Oxazolidin-2-one
Direct Metal-Free Entry to Aminocyclobutenes or Aminocyclobutenols from Ynamides: Synthetic Applications
The [2+2] cycloaddition of ynamides with the highly polarized reagent Tf2C=CH2has been developed to regioselectively afford bis(triflyl)aminocyclobutenes in the absence of catalyst under mild conditions. Incidentally, with the ynamides bearing electron-rich aromatic rings at the C-terminal, an interesting reactivity switch was observed; a cyclization/hydroxylation sequence yielded 2-amino-3-(triflyl)cyclobut-2-enols. Aminocyclobutene construction with addition of alcohols resulted in the formation of aminocyclobutenyl ethers through a cyclization/hydroalkoxylation process. Moreover, the utility of functionalized aminocyclobutenes as precursors for further elaboration was demonstrated with the preparation of alpha-amino-beta,gamma-unsaturated ketones and 3-(triflyl)buta-1,3-dien-2-amines through 4 pi-electrocyclic ring opening.
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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H284NO – PubChem