695-53-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.695-53-4,5,5-Dimethyloxazolidine-2,4-dione,as a common compound, the synthetic route is as follows.
To 14 g of Exemplified compound (12B) in 150 ml of methylene chloride solution, 3.2 g of bromine in 20 ml of methylene chloride solution was added dropwise, while the mixture was cooled on ice. After stirring was continued at room temperature for 30 minutes, water was added to the resulting mixture. The aqueous phase was separated. The organic phase was dried with magnesium sulfate anhydride, and then condensed by vacuum distillation. 20 ml of N,N-dimethylacetoamide was added to the residue. The resulting liquid was added dropwise to 7.7 g of 5,5-dimethyloxazolidine-2,4-dione and 8.3 ml of triethylamine in 100 ml of N,N-dimethylacetoamide solution, while the mixture was cooled on ice. Then, the mixture was stirred at room temperature for 2 hours. Ethyl acetate and water were added to the reaction mixture. The aqueous phase was separated. The organic phase was washed with 1N-aqueous solution of potassium carbonate and 1N-aqueous hydrochloric acid solution and saturated brine. The organic phase was dried with magnesium sulfate anhydride, and then condensed by vacuum distillation. The residue was crystallized from a mixed solvent of ethyl acetate and hexane to obtain 14 g of Exemplified compound (16B).
The synthetic route of 695-53-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; FUJIFILM Corporation; US7365199; (2008); B2;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem