99395-88-7, (S)-4-Phenyloxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
In a reaction flask, tetrahydrofuran (50 mL) was added, (S)-4-phenyloxazol-2-one (5.0 g, 30.6 mmol) was added, and the temperature was cooled to -70 C.; under nitrogen gas protection, the internal temperature was maintained at -65-75 C., 2.5 M n-butyllithium (12.9 mL, 32.2 mmol, 1.05 eq) solution was added dropwise, after the addition, the reaction was conducted for half an hour at a maintained temperature; then the internal temperature was maintained at -65-75 C., valeryl chloride (4.1 g, 34.0 mmol, 1.11 eq) was added dropwise and reacted for 1 hour, and TLC was used to detect the disappearance of (S)-4-phenyloxazol-2-one, and treatment was performed; then the temperature was raised to 0 C., 20 mL saturated aqueous ammonium chloride solution was added and quenched by butyl lithium to separate the phase. The organic phase was concentrated under a reduced pressure. The concentrate was dissolved in 50 mL methylene dichloride, washed with water twice (25 mL¡Á2). The organic phase was dried over 10.0 g anhydrous sodium sulfate for 2 hours; filtered and concentrated under a reduced pressure to give the target product as a white solid (7.4 g, yield 97.6%). (0085) 1H NMR (600 MHz, CDCl3) delta 7.38 (dd, J=8.2, 6.6 Hz, 2H), 7.35-7.31 (m, 1H), 7.31-7.27 (m, 2H), 5.42 (dd, J=8.7, 3.7 Hz, 1H), 4.68 (t, J=8.8 Hz, 1H), 4.27 (dd, J=8.9, 3.7 Hz, 1H), 2.93 (td, J=7.4, 2.6 Hz, 2H), 1.63-1.53 (m, 3H), 1.33 (dtd, J=15.1, 7.6, 5.5 Hz, 2H), 0.89 (t, J=7.4 Hz, 3H). MS (ESI): m/z 248.1 [M+H]+. [alpha]D19 +60.0 (c=1.0 g/100 mL, CHCl3)., 99395-88-7
The synthetic route of 99395-88-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BEIJING ABLEPHARMTECH CO., LTD.; MA, Liang; (14 pag.)US2019/359583; (2019); A1;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem