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Militarinone C and fumosorinone A, 3-oligoenoyltetramic acids produced by insect pathogenic fungi, were synthesized for the first time. The pyrrolidine-2,4-dione ring was closed through a late-stage Dieckmann condensation of N-(beta-ketoacyl) derivatives of tyrosine, obtained by its acylation with either thioesters or Meldrum’s acid derivatives bearing the all-trans-polyene side chain. The latter was built up from (S)-citronellol via an Evans methylation and Wittig or HWE olefinations.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1747NO – PubChem

 

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The present invention provides compounds of Formula (Ia): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1625NO – PubChem

 

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An approach to a macrocyclic lactam designed to bind to a carboxylate anion is described.The diaryl ether 8 was synthesised by Ullmann coupling of the protected 3-hydroxyphenylglycine derivative 7 and (E)-4-bromocinnamic acid methyl ester.Elaboration of an optically pure (R)-tyrosine synthon was achieved by transfer of electrophilic azide to the N-acyl oxazolidinone 12.The synthesis of a model system is also described.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H2033NO – PubChem

 

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The present invention is directed to guanidine derivatives as inhibitors of transient receptor potential canonical channels (TRPC channels), in particular TRPC3 and/or TRPC6 and/or TRPC7 activity, more particularly TRPC6 activity. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders mediated by TRPC channels (Formula (I))

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1631NO – PubChem

 

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Cortisol homeostasis has been linked to the pathogenesis of metabolic syndrome (MetS), since it stimulates hepatic gluconeogenesis and adipogenesis. MetS is classified as a constellation of health conditions that increase the risk of type 2 diabetes and cardiovascular disease. Intracellular cortisol levels are regulated by 11beta-hydroxysteroid dehydrogenase (type 1 and type 2) in a tissue dependent manner. The type 1 enzyme (11beta-HSD1) is widely expressed in glucocorticoid targeted tissues and is responsible for the conversion of cortisone to the active cortisol. Local reduction of cortisol regeneration presents a potential strategy for MetS treatment. Recently we disclosed the total synthesis of (+)-colletoic acid as a potent 11beta-HSD1 inhibitor. Herein, we describe our improved processing chemistry for the synthesis of the colletoic acid core to access a diverse number of derivatives for evaluation against 11beta-HSD1. The Evan’s chiral auxiliary was utilized to construct the acyclic precursor 12 to afford the acorane core 9 using a modified Heck reaction in excellent chemical yields. The colletoic acid core derivatives showed modest activity against 11beta-HSD1 and will serve for further biological evaluation.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1909NO – PubChem

 

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The present invention provides a compound of formula I a method for manufacturing the compounds o f the invention, and its therapeutic uses as inhibitor of the complement alternative pathway and particularly as inhibitor of Factor B for the treatment of e.g. age-related macular degeneration and diabetic retinopathy. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1583NO – PubChem

 

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Synthesis and evaluation of difluorophenylglycinols as new modulators of proteolytic processing of the amyloid-beta precursor proteins for Alzheimer’s therapies were described. A range of N-substituted (R)- and (S)- difluorophenylglycinols, structured on the amino alcohol framework, were explored by incorporating the arylsulfonyl moieties and various N-substituents. Evans’ chiral auxiliary strategy was employed for the asymmetric synthesis of these enantiomeric difluorophenylglycinols. Compounds with effects on the gamma-secretase inhibition and ERK-mediated signaling pathways were evaluated on cell-based assays. Among them, N-cyclopropylmethyl derivatives R-12c and R-13c showed modest gamma-secretase inhibition as well as ERK-dependent activation. A range of N-substituted (R)- and (S)-difluorophenylglycinols, structured on the amino alcohol framework, were explored by incorporating the arylsulfonyl moieties and various N-substituents. Compounds with effects on gamma-secretase inhibition and ERK-mediated signaling pathways were evaluated on cell-based assays. The N-cyclopropylmethyl derivatives R-12c and R-13c showed modest gamma-secretase inhibition and ERK-dependent activation.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1758NO – PubChem

 

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The present invention relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof, where Ri, R2, R3, R4, R5, R6, R7, Rs and m are as defined herein, pharmaceutical compositions comprising these compounds and methods of use of these compounds for treating a TGR5 mediated disease or condition.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 102029-44-7, and how the biochemistry of the body works.name: (R)-4-Benzyl-2-oxazolidinone

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1653NO – PubChem

 

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The asymmetric synthesis of the enantiomerically pure bipiperidine core fragment of a potent dual NK1/NK2 antagonist is described. The utilization of a diastereoselective Michael addition employing Evans’ auxiliary as the key step allowed for the preparation of the fragment on a multi-kilogram scale.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1994NO – PubChem

 

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One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: (R)-4-Benzyl-2-oxazolidinone, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 102029-44-7, Name is (R)-4-Benzyl-2-oxazolidinone, molecular formula is C10H11NO2

The disclosure provides proteasome inhibitors that can be used to halt cell division of rapidly dividing cells by preventing the degradation of cell cycle-regulating proteins, such as cyclins, cyclin-dependent kinase inhibitors, and p53. The proteasome inhibitor compounds can be used to inhibit the proliferation of cancer cells.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1682NO – PubChem