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102029-44-7, Name is (R)-4-Benzyl-2-oxazolidinone, belongs to oxazolidine compound, is a common compound. Formula: C10H11NO2In an article, once mentioned the new application about 102029-44-7.

A copper-catalyzed new C-N bond formation involving a sp-hybridized carbon is described here leading to a facile entry for syntheses of chiral ynamides. This direct N-alkynylation of amides should have a significant impact on the future development of synthetic methodologies employing ynamides. Copyright

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1822NO – PubChem

 

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A method of treating atherosclerosis in a mammal, including a human, comprising administering to said mammal an amount of the compound of the formula an enantiomer, or the pharmaceutically acceptable salt thereof; effective to treat atherosclerosis, wherein R1, R2 and R3 are as defined herein.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1536NO – PubChem

 

Brief introduction of 102029-44-7

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Provided are compounds of Formula (I) and/or Formula (II) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections mediated by a member of the Flaviviridae family of viruses such as hepatitis C virus (HCV).

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1551NO – PubChem

 

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Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 102029-44-7. In my other articles, you can also check out more blogs about 102029-44-7

Synthetic Route of 102029-44-7, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 102029-44-7, (R)-4-Benzyl-2-oxazolidinone, introducing its new discovery.

Total synthesis of (-)-(2R,9S)- and (+)-(2S,9S)-stereoisomers of laingolide B has been accomplished by using sequential ring-closing metathesis (RCM) and alkene isomerization to construct the macrocyclic trans-N-methyl enamide moiety. The Myers alkylation was used to secure the C2 stereochemistry of the two RCM precursors from a common (9S)-C3-C9 alkyl iodide. The absolute configuration of laingolide B has been assigned as (2S,9R) by comparison of the optical rotation data.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1779NO – PubChem

 

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The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 102029-44-7 is helpful to your research. Electric Literature of 102029-44-7

Electric Literature of 102029-44-7, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 102029-44-7, molcular formula is C10H11NO2, introducing its new discovery.

The first efficient asymmetric total syntheses of xestodecalactones B and C have been accomplished in 10 steps with an overall yield of 22 and 20.2%, respectively. The key steps involve the utility of Evans oxazolidinone-mediated syn-aldol condensations to establish the C-9 configuration and the macrolide ring formation by intramolecular acylation. The absolute configurations of xestodecalactones B and C have been determined via these syntheses.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1907NO – PubChem

 

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A general method was developed to construct monocyclic alpha-methylene- gamma-butyrolactone moiety. The key step is to introduce the alpha-methylene group by the ozonolysis of mono-substituted alkenes followed by reacting with a preheated mixture of CH2Br2-Et2NH. Application of this key step in the total synthesis of the (±)- and (-)-methylenolactocin was described.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1853NO – PubChem

 

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The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 102029-44-7 is helpful to your research. Synthetic Route of 102029-44-7

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“Stapled” peptides are typically designed to replace two non-interacting residues with a constraining, olefinic staple. To mimic interacting leucine and isoleucine residues, we have created new amino acids that incorporate a methyl group in the gamma-position of the stapling amino acid S5. We have incorporated them into a sequence derived from steroid receptor coactivator2, which interacts with estrogen receptoralpha. The best peptide (IC50=89nm) replaces isoleucine689 with an S-gamma-methyl stapled amino acid, and has significantly higher affinity than unsubstituted peptides (390 and 760nm). Through X-ray crystallography and molecular dynamics studies, we show that the conformation taken up by the S-gamma-methyl peptide minimizes the syn-pentane interactions between the alpha- and gamma-methyl groups.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H2027NO – PubChem

 

Final Thoughts on Chemistry for (R)-4-Benzyl-2-oxazolidinone

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Application of 102029-44-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.102029-44-7, Name is (R)-4-Benzyl-2-oxazolidinone, molecular formula is C10H11NO2. In a Patent,once mentioned of 102029-44-7

The present invention relates to compounds of formula (I) wherein c, X, Y, R2, R3, R4 and R6 are as defined herein, compositions and uses thereof for treating human immunodeficiency virus (HIV) infection. In particular, the present invention provides novel inhibitors of HIV integrase, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HIV infection

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1567NO – PubChem

 

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The bicyclo[4.3.0]nonane (C11-C21) fragment of stawamycin has been prepared by a sequence involving 11 steps (10% overall yield) from methyl (R)-(-)-3-hydroxy-2-methylpropionate. Key steps are a Pd-catalysed Stille coupling reaction between a vinyl iodide and a vinyl stannane followed by an intramolecular Diels-Alder cycloaddition reaction to give the desired adduct as the major isomer in 21% overall yield.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1797NO – PubChem

 

Brief introduction of (R)-4-Benzyl-2-oxazolidinone

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(Equation presented) A new strategy to access the fumagillin/fumagillol skeleton is proposed. An Evans aldolization and a RCM involving an enone are used for the preparation of a key cyclohexanone intermediate, which was readily converted to fumagillol. The synthesis also features an efficient preparation of isogeraniol and isogeranic acid.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1737NO – PubChem