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A new approach to the synthesis of the C7-26 fragment of amphidinolides G and H was developed. In the sequence, the C7-18 portion of this fragment was synthesized using an acetylide coupling protocol, while an Evans alkylation and Sharpless asymmetric dihydroxylation were employed as key steps in construction of the C19-26 subfragment. Finally, both of these units were joined by utilizing an aldol coupling reaction to produce the target C7-26 fragment in good yield.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1847NO – PubChem

 

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According to our retrosynthesis, the main chain of the target molecule could be constructed using a C5 + C7 + C5 strategy. The key induction reaction afforded chiral methyl group moieties using different Evans templates with different configurations. Li2CuCl4 was effectively employed in the Csp3[sbnd]Csp3 coupling protocol. The target molecular was obtained in a 12.6% overall yield with nine steps in the longest linear route.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H2040NO – PubChem

 

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The thermal reaction of 3-[(1S)-2-alkoxy-1-apocamphanecarbonyl]-2-oxazolones with dialkyl azodicarboxylates results in exclusive formation of [4 + 2] type cycloadducts with moderate levels of diastereofacial selection, which serve as versatile chiral synthons for a wide variety of 4-alkyl and 4-alkyl-2-oxazolidinones as well as alpha-amino acids.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1928NO – PubChem

 

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The first direct catalytic asymmetric alpha-amination of aldehydes is described herein. alpha-Unbranched aldehydes react in this novel proline-catalyzed reaction with dialkyl azodicarboxylates to give alpha-amino aldehydes in excellent yields and enantioselectivities. Copyright

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Reference:
Oxazolidine – Wikipedia,
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An iodine-catalyzed direct allylation of chiral oxazolidinones with aldehydes and alkenes has been developed. The reaction proceeds, without use of any bases or metals, directly converted the 3-chiral oxazolidinones into N-allylated oxazolidinones. Additionally, the 3-chiral allylamine skeleton was constructed and the diastereomers were isolated by simple column chromatography.

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Reference:
Oxazolidine – Wikipedia,
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Chemical equations presented. Synthesis of the proposed structure of lytophilippine A was accomplished employing SmI2-mediated 5-exo cyclization of an aldehydo beta-alkoxyvinyl sulfoxide and ring-closing metathesis reaction.

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Oxazolidine – Wikipedia,
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The present invention provides compounds of Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are Factor VIIa inhibitors which may be used as medicaments.

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Formula: C10H11NO2, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.102029-44-7, Name is (R)-4-Benzyl-2-oxazolidinone, molecular formula is C10H11NO2. In a article,once mentioned of 102029-44-7

An enantioselective route for oxazoline 4, a key fragment toward the asymmetric synthesis of leiodelide A, is described. We synthesized northern subunit 6 through a Julia-Lythgoe olefination and subsequent Sharpless asymmetric dihydroxylation. Moreover, a highly diastereoselective method using well-established Evans’ asymmetric aldol condensation was developed for preparation of southern fragment 5. The additional feature of this synthetic route is the formation of oxazoline 4 through DAST-promoted cyclization of the amidation product from subunits 5 and 6.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1996NO – PubChem

 

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Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.Read on for other articles about 102029-44-7

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The conformation of cyclic peptides is closely related to their physicochemical and biological properties, but their rational design to obtain a conformation with the desired properties is difficult. Herein, we present a new strategy by using conformationally restricted cyclopropane tethers (CPTs) to control the conformation and improve the cell permeability of cyclic peptides regardless of the amino acid sequence. Newly designed cis- or trans-CPTs with three-dimensional structural diversity were introduced into a model cyclic peptide, and the relationship between the conformation of the cyclic peptides and their cell permeability was analyzed. Peptides containing a CPT exhibited conformational diversity due to the characteristic steric feature of cyclopropane, among which peptides containing a CPT, cis-NfCf had remarkably higher cell permeability than peptides containing other CPTs?even superior to that of cyclosporine A, a known permeable cyclic peptide.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1926NO – PubChem

 

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The present invention relates to an improved process for the preparation of renin inhibitor Aliskiren intermediates of Formula-II and further conversion into Aliskiren and its pharmaceutically acceptable salts.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1663NO – PubChem