Category: 1194-22-5

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Series of 2-methyl-5-alkyl-4,6-dihydroxypyrimidines》. Authors are Ferris, Livingston P. II; Ronzio, Anthony R..The article about the compound:6-Hydroxy-2-methylpyrimidin-4(3H)-onecas:1194-22-5,SMILESS:CC1=NC(=CC(N1)=O)O).SDS of cas: 1194-22-5. Through the article, more information about this compound (cas:1194-22-5) is conveyed.

Acetamidine-HCl (1/8 mol.), added to 150 cc. absolute EtOH and 3.3 g. Na, followed by 0.05 mol. of CH2(CO2Et)2 or its monoalkyl derivative, and allowed to stand 2-3 days, the solution exactly neutralized with concentrated HCl, H2O added to dissolve the NaCl, the undissolved pyrimidine filtered, decolorized in boiling AcOH and reprecipitated with Et2O, gives the following 2-methyl-5-alkyl-4,6-dihydroxypyrimidines, the group in position 5 being: H (I) (43%), Me (18%), Et (15%), Pr (22%), Bu (II) (33%) and Am (26%). These do not show definite m. ps. but sublime between 260-350°; in a sealed tube they decompose without melting. The absorption spectra curves are given for I in H2O, HCl and KOH and for II in EtOH.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1194-22-5, is researched, SMILESS is CC1=NC(=CC(N1)=O)O, Molecular C5H6N2O2Conference, New Trends in Research of Energetic Materials, Proceedings of the Seminar, 10th, Pardubice, Czech Republic, Apr. 25-27, 2007 called On the synthesis of 1,1-diamino-2,2-dinitroethene (FOX-7) by nitration of 4,6-dihydroxy-2-methylpyrimidine, Author is Johansson, Martin; Latypov, Nikolaj V.; Holmgren, Erik; Sizova, Ekaterina V.; Sizov, Vladimir; Bellamny, Anthony J., the main research direction is dihydroxy methylpyrimidine nitration diamino dinitroethene explosive.Category: oxazolidine.

The synthesis of 1,1-diamino-2,2-dinitroethene (FOX-7) by nitration of 4, 6-dihydroxy-2-methylpyrimidine and hydrolysis of the resulting intermediate 2-dinitromethylene-5,5-dinitropyrimidine-4, 6-dione has been studied. By varying the reactions parameters the optimal conditions for the synthesis of FOX-7 have been identified and gave a >90% yield of the pure product. The optimized process allowed the spent acid to be recycled without loss of yield, with almost stoichiometric consumption of nitric acid. The purity of the FOX-7 has been determined using a newly developed HPLC method.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called The effect of some derivatives of pyrimidine on metastasis of the transplantable rat sarcoma SSK, published in 1963, which mentions a compound: 1194-22-5, mainly applied to , Reference of 6-Hydroxy-2-methylpyrimidin-4(3H)-one.

Sarcoma SSK was transferred to normal rats by injection of a tumor cell suspension in physiol. saline containing penicillin into the middle third of the tail. Treatment by intraperitoneal injection of metacil (I), 2-methyl-4,6-dioxypyrimidine (II), thymine (III), dihydrothymine (IV), cytosine (V), isocytosine (VI), 4,6-dioxy-5-nitropyrimidine (VII), 2,6-mercapto-5-amino-4-methylpyrimidine (VIII), and pentoxyl (IX) in solution or suspension in physiol. saline in doses of 100 mg./kg./day was begun within 24 hrs., and continued for 19 days. Control animals received physiol. saline. In one group, the tails were amputated after 5 days; in the second, after 9 days. In the 1st group, animals which received VII all died in the postoperative period, while those which received I, II, V, VI, or IX developed fewer metastases than the controls. No such inhibitory effect of metastasis was observed in the 2nd group. In both groups, animals which received III, IV, or VIII developed more metastases than the controls.

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Related Products of 1194-22-5. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Reaction of sulfate radical anion (SO4•-) with hydroxy- and methyl-substituted pyrimidines: A pulse radiolysis study. Author is Luke, T. L.; Mohan, H.; Manoj, V. M.; Manoj, P.; Mittal, J. P.; Aravindakumar, C. T..

Reactions of sulfate radical anion with 4,6-dihydroxy-2-methylpyrimidine (DHMP), 2,4-dimethyl-6-hydroxypyrimidine (DMHP), 6-methyluracil (MU) and 5,6-dimethyluracil (DMU) have been studied by pulse radiolysis at pH 3 and at pH 10. The transient intermediate spectra were compared with those from the reaction of hydroxyl radical. It is proposed that sulfate radical anion produces radical cations of these pyrimidines in the initial stage. These radical cations are short-lived except in the case of DMHP where a relatively longer lived radical cation is proposed to be formed. When there is a hydrogen atom attached to the N(1) or N(3) position, a deprotonation from these sites is highly favored. When there is no hydrogen attached to these sites, deprotonation from a substituted Me group is favored. At acidic pH, deprotonation from nitrogen is observed for DHMP, MU and DMU. At basic pH, the radical cation reacts with OH- leading to the formation of OH adducts.

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Reference of 6-Hydroxy-2-methylpyrimidin-4(3H)-one. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Modeling & simulation of micro reactor with nitration of 2-methyl-4,6-dihydroxy-pyrimidine. Author is Mandal, Alok Kumar; Pandey, Raj Kishore; Asthana, Shri Nandan; Kulkarni, Amol; Kulkarni, Bhaskar Dattatraya.

Nitration of 2-methyl-4,6-dihydroxypyrimidine (MDP) using concentrated sulfuric acid and nitric acid as nitrating mixture is a highly exothermic and hazardous reaction. Conducting such reaction in a batch reactor follow an unsteady state and its trajectory depends on various important parameters such as initial reactor temperature, initial composition of reaction mass, temperature of circulating coolant, etc. However, over all productivity, process control, and safety of the batch process is highly restricted due to lower surface to volume ratio. In the present work, an effort was made to over come the limitations of batch reactor by using the novel micro reactor device. Micro reactor is having extremely high surface to volume ratio, which was explored to carry out nitration of MDP both numerically as well as exptl. and the results were compared with conventional batch reactor. The micro reaction system was modeled using two dimensional (2-D) heat flow and mass transfer equations. The kinetic rate equation for nitration of MDP has evaluated exptl. by differential method which is used in modeling of the micro reactor. The numerical results from the 2-D model for conversion and temperature profile along the length and radius of micro reactor were compared with corresponding results obtained from batch reactor. In order to validate the model, several experiments were conducted in micro reactor set-up with the variation of flow rate, residence time, concentration, temperature, etc. The exptl. results from micro reactor revealed that nitration of MDP takes place even at much lower concentration and lower residence time with better control of temperature profile. Also, the reaction takes place in laminar region compared to turbulent region in corresponding batch reactor setup.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1194-22-5, is researched, SMILESS is CC1=NC(=CC(N1)=O)O, Molecular C5H6N2O2Journal, Journal of Heterocyclic Chemistry called Ylides of heterocycles. VII. Iodonium-, nitrogen-, phosphonium-, and sulfonium-ylides of pyrimidones, Author is Habib, Nargues Samuel; Kappe, Samuel, the main research direction is pyrimidinone ylide; iodonium ylide pyrimidinone; phosphonium ylide pyrimidinone; sulfonium ylide pyrimidinone; pyridinium ylide pyrimidinone; isoquinolinium ylide pyrimidinone.Electric Literature of C5H6N2O2.

Reaction of pyrimidinone I (R = OH; R1 = H, Me, Ph, R2 = H; R1 = R2 = Ph; R3 = H) with PhIO prepared in situ gave iodonium ylides I (R = O-, R3 = PhI+; II) in good yield. Thermal rearrangement of II gave I (R = OPh; R3 = iodo), which were deiodinated to give I (R = OPh, R3 = H). Treatment of II with pyridine, nicotinamide, isoquinoline, Ph3P, or thiophene gave the corresponding N, P, or S ylides. The pyridinium ylides were also prepared from I (R = OH, R1 = Br, Cl) which were prepared from II by treatment with HBr or HCl, resp.

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COA of Formula: C5H6N2O2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about 1,1-Diamino-2,2-dinitroethylenes are always zwitterions. Author is Gilinsky-Sharon, Pessia; Gottlieb, Hugo E.; Rajsfus, David E.; Keinan-Adamsky, Keren; Marks, Vered; Aped, Pinchas; Frimer, Aryeh A..

The nitration of tetraiodoethylene (7) yields 1,1-diiodo-2,2-dinitroethylene (8). The latter reacts with alkylamines 9 or alkyldiamines 11 to give the corresponding acyclic 1,1-diamino-2,2-dinitroethylenes 10 or their cyclic analogs 12, resp. On the basis of liquid and solid-state 13C and 15N NMR data, x-ray anal. and ab initio calculations, we suggest that the title compounds are always zwitterionic and that the CA-CN bond is not a true double bond. Copyright © 2012 John Wiley & Sons, Ltd.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Reaction of 4,6-dihydroxypyrimidines with bisulfite ion. III. Reactions of 2- and 5-substituted 4,6-dihydroxypyrimidines with the participation of bisulfite ion.Quality Control of 6-Hydroxy-2-methylpyrimidin-4(3H)-one.

Bisulfite catalyzed the hydrolysis of I (R = H, R1 = MeS) to barbituric acid and the debromination of I (R = Br, R1 = H). The debromination occurred via the bisulfite adduct. UV and 13C NMR data were given.

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Bagli, Jehan; Bogri, T.; Palameta, B.; Rakhit, S.; Peseckis, S.; McQuillan, J.; Lee, D. K. H. published the article 《Chemistry and positive inotropic effect of pelrinone and related derivatives. A novel class of 2-methylpyrimidones as inotropic agents》. Keywords: inotropic activity aminomethylpyrimidinone preparation; chronotropic activity aminomethylpyridinone; cardiotonic activity aminomethylpyrimidinone; mol structure cardiotonic activity; crystal structure cyanomethylpyridylmethylaminopyrimidinone salt.They researched the compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one( cas:1194-22-5 ).Synthetic Route of C5H6N2O2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1194-22-5) here.

Novel pyrimidine derivatives (e.g., I; R = cyano, R1 = 3-pyridylmethyl) were synthesized and evaluated for pos. inotropic activity. Thus, (MeS)2C:C(CN)CO2Me cyclocondensed with MeC(:NH)NH2·HCl to give cyano methyl(methythio)dihydropyrimidinone II, which was treated with 3-(aminomethyl)pyridine to give 48% I (R = cyano, R1 = 3-pyridylmethyl). Inotropic and chronotropic effects were determined in vitro in cat papillary muscle and right atrium, resp. Selected compounds were then evaluated in vivo in a dog heart failure model. Changes in ventricular dP/dt, heart rate, and blood pressure were monitored. Several of these agents produced relatively minor changes in heart rate. This class of agents demonstrated a varying degree of vasodilator effects concomitant with increases in ventricular contractility. The most potent analogs, I (R = cyano, R1 = 3-pyridylmethyl; R = Br, R1 = Et, 3-pyridylmethyl), were evaluated orally in conscious dogs with implanted Konisberg pressure transducers, and their effect on left ventricular dP/dt was compared with that of milrinone. Mechanistically, the agents of this novel class appear not to mediate their effect either via β-receptors or inhibition of Na+/K+-ATPase. A major component of their inotropic effect is mediated by the inhibition of cardiac phosphodiesterase (PDE)-Fr. III. This was clearly demonstrated by I. Compound I (R = Br, R1 = 3-pyridylmethyl) was found to be the most potent inhibitor of PDE-Fr. III from among the compounds tested in this assay. The crystal structure of I (R = cyano, 3-pyridylmethyl)·HBF4 is also reported.

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Oxazolidine – Wikipedia,
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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Anomalous high reactivity of formyl and acetone ketyl radicals with uracil and its derivatives, published in 1998-05-08, which mentions a compound: 1194-22-5, Name is 6-Hydroxy-2-methylpyrimidin-4(3H)-one, Molecular C5H6N2O2, Related Products of 1194-22-5.

CO2·- and (CH3)2·COH radicals apparently react with uracil and its derivatives, containing two carbonyl groups, with high rate constants (k=1010 dm3 mol-1 s-1). Various mechanistic aspects of such reactions have been probed. The effect of pH and buffer concentration on the initial formation of absorbance points to some keto-enol tautomerism-type fast-reaction between OH- and the substrate, followed by a slower relaxation to the original equilibrium The radical anions of these compounds react with Me viologen mainly via an electron transfer reaction with a high rate constant value (4-9)×109 dm3 mol-1 s-1.

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