Category: 184346-45-0

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Product Details of 184346-45-0. Introducing a new discovery about 184346-45-0, Name is (S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one

The heterocyclic compound specified in the title (and readily prepared from commercial precursors) has a sterically protected C=O group, so that direct lithiation by BuLi at the exocyclic CH2 group is possible (3 ? Li-3). The lithiated N,S-acetal derivative (Li-3) adds diastereoselectively to aldehydes (Table 2), unsymmetrical ketones (Table 3), chalcone (1,4-addition, Scheme 2), and N-phosphinoyl-and N-sulfonylimines (Table 4). Protection of the newly formed OH groups (Scheme 3) and/or MeS/OH displacement by Hg(O2CCF3)2 in aqueous THF/acetonitrile converts the N,S-acetals into hemiaminals (? 20) which, in turn, are readily cleaved to aldehydes, with recovery of the chiral auxiliary (1, Scheme 4). The aldehydes (especially those lacking alpha-carbonyl hydrogens) may be isolated, or they are trapped in situ by reduction to (selectively protected) diols or amino alcohols, by addition of Grignard or Li reagents, which provides diols with two stereogenic centers, by oxidation to give 2-hydroxy esters, or by olefination to provide 4-hydroxy-2-alkenoates (Scheme 5). The scope and limitations of the new, overall enantioselective transformation are determined, and the readily recovered chiral auxiliary used is compared with oxazolidinones of other substitution patterns (Scheme 7). The configuration of a number of products has been assigned by single-crystal X-ray diffraction (cf. Figure 5). These structures and similarities of NMR data led to configurational assignment of the other products (see formulas in the schemes and tables) by analogy. A simple mechanistic model for the stereochemical course of the addition of Li-3 to aldehydes and ketones is presented (Figure 6).

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Product Details of 184346-45-0, you can also check out more blogs about184346-45-0

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2634NO – PubChem

 

Electric Literature of 184346-45-0, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 184346-45-0, molcular formula is C18H19NO2, introducing its new discovery.

Subtype-selective agonists of the neurotensin receptor NTS2 represent a promising option for the treatment of neuropathic pain, as NTS2 is involved in the mediation of m-opioid-independent anti-nociceptive effects. Based on the crystal structure of the subtype NTS1 and previous structure-activity relationships (SARs) indicating a potential role for the sub-pocket around Tyr11 of NT(8-13) in subtype-specific ligand recognition, we have developed new NTS2-selective ligands. Starting from NT(8-13), we replaced the tyrosine unit by beta2-amino acids (type 1), by heterocyclic tyrosine bioisosteres (type 2) and peptoid analogues (type 3). We were able to evolve an asymmetric synthesis of a 5-substituted azaindolylalanine and its application as a bioisostere of tyrosine capable of enhancing NTS2 selectivity. The S-configured test compound 2a, [(S)-3-(pyrazolo[1,5-alpha]pyridine-5-yl)-propionyl11]NT(8-13), exhibits substantial NTS2 affinity (4.8 nm) and has a nearly 30-fold NTS2 selectivity over NTS1. The (R)-epimer 2b showed lower NTS2 affinity but more than 600-fold selectivity over NTS1.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 184346-45-0 is helpful to your research. Electric Literature of 184346-45-0

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2646NO – PubChem

 

Application of 184346-45-0, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 184346-45-0, (S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one, introducing its new discovery.

A series of three 5,5-diaryl substituted oxazolidin-2-ones (diphenyl, dinaphthyl and ditolyl) have been prepared and shown to be particularly effective chiral auxiliaries to afford high yields and diastereoselectivities for alkylation and azidations of their N-acyl derivatives. The 5,5-ditolyl oxazolidin-2-one proved to be particularly efficacious in terms of diastereoselectivity, yield and solubility.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 184346-45-0. In my other articles, you can also check out more blogs about 184346-45-0

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2636NO – PubChem

 

Synthetic Route of 184346-45-0, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 184346-45-0, molcular formula is C18H19NO2, introducing its new discovery.

A range of chiral ester and chiral imide derivatives of 2-oxocyclohexanecarboxylic acid were utilised in double-Mannich reactions with bis(aminol)ethers to develop an asymmetric synthesis of azabicyclo[3.3.1]nonanes. An improved method for the double-Mannich reaction of beta-ketoesters and bis(aminol)ethers using sub-stoichiometric quantities of a Lewis acid was developed. Additionally, a sequential, double-Mannich approach was investigated incorporating chiral auxiliaries into N,O-acetals. The use of oxazolidinone auxiliaries afforded the best yields and diastereoselectivities enabling separation of the resulting diastereomers of the azabicyclo[3.3.1]nonanes.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 184346-45-0 is helpful to your research. Synthetic Route of 184346-45-0

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2651NO – PubChem

 

Related Products of 184346-45-0, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 184346-45-0, molcular formula is C18H19NO2, introducing its new discovery.

What I Have Learned from Jack Dunitz

The lessons taught me by Jack Dunitz about the use of X-ray crystal structure analysis, far beyond just for determining the structure of an isolated product, are described. The direct and indirect influence Jack had on the way various topics of my synthetic group developed at ETH is demonstrated with selected examples from our various research areas: Li-enolates, the gem-diaryl effect and TADDOLs, self-regeneration of stereocenters, poly(hydroxybutanoates) (PHB), beta-peptides, and mechanistic investigations of organocatalytic reactions. Furthermore, the role Jack plays in the Laboratorium of Organic Chemistry at ETH Zuerich is described and appreciated.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 184346-45-0 is helpful to your research. Related Products of 184346-45-0

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2650NO – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. name: (S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 184346-45-0

A short synthesis of (S)-alpha-(diphenylmethyl)alkyl amines from amino acids

A range of (S)-alpha-(diphenylmethyl)alkyl amines were prepared from the corresponding (S)-alpha-amino acid ester hydrochlorides. These amines were derived by direct hydrogenation of their precursor oxazolidinones.

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Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2643NO – PubChem

 

Electric Literature of 184346-45-0, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.184346-45-0, Name is (S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one, molecular formula is C18H19NO2. In a article，once mentioned of 184346-45-0

Structure-Based Evolution of Subtype-Selective Neurotensin Receptor Ligands

Subtype-selective agonists of the neurotensin receptor NTS2 represent a promising option for the treatment of neuropathic pain, as NTS2 is involved in the mediation of mu-opioid-independent anti-nociceptive effects. Based on the crystal structure of the subtype NTS1 and previous structure-activity relationships (SARs) indicating a potential role for the sub-pocket around Tyr11 of NT(8-13) in subtype-specific ligand recognition, we have developed new NTS2-selective ligands. Starting from NT(8-13), we replaced the tyrosine unit by beta2-amino acids (type 1), by heterocyclic tyrosine bioisosteres (type 2) and peptoid analogues (type 3). We were able to evolve an asymmetric synthesis of a 5-substituted azaindolylalanine and its application as a bioisostere of tyrosine capable of enhancing NTS2 selectivity. The S-configured test compound 2a, [(S)-3-(pyrazolo[1,5-a]pyridine-5-yl)-propionyl11]NT(8-13), exhibits substantial NTS2 affinity (4.8 nm) and has a nearly 30-fold NTS2 selectivity over NTS1. The (R)-epimer 2b showed lower NTS2 affinity but more than 600-fold selectivity over NTS1. Tyrosine surrogates: Peptides 2a,b showed that the 5-substituted azaindolylalanine is an appropriate bioisostere of tyrosine capable of enhancing NTS2 selectivity. Compound 2a exhibits single-digit nanomolar affinity (4.8 nm) and a nearly 30-fold NTS2 selectivity over NTS1.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 184346-45-0

Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2647NO – PubChem

 

Related Products of 184346-45-0, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.184346-45-0, Name is (S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one, molecular formula is C18H19NO2. In a article，once mentioned of 184346-45-0

A concise asymmetric synthesis of (-)-virolin, (-)-surinamensin,(-)- raphidecursinol B and (-)-polysphorin

Highly concise and general asymmetric syntheses of biologically important natural (-)-8,4-oxyneolignans [(-)-virolin, (-)-surinamensin, (-)-raphidecursinol B, and (-)-polysphorin] are reported. The key step in the synthesis is the Evan’s syn-aldol reaction to achieve the adducts with the desired stereochemistry. The four biologically important plant metabolites were synthesized using two common intermediates. Georg Thieme Verlag Stuttgart · New York.

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Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2641NO – PubChem

 

Synthetic Route of 184346-45-0, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 184346-45-0, Name is (S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one,introducing its new discovery.

New chiral propargylic silanes and the first examples of asymmetric intramolecular Sakurai reactions

The syntheses of four new chiral propargylic silanes are reported. The syntheses of these cyclization precursors offer the possibility of studying the asymmetry of the first examples of the intramolecular version of the Sakurai reaction.

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Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2627NO – PubChem

 

Reference of 184346-45-0, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 184346-45-0, Name is (S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one, molecular formula is C18H19NO2. In a Patent，once mentioned of 184346-45-0

HETEROCYCLIC COMPOUNDS

The present invention provides a compound represented by the following formula [1′] or a salt there of: where in ring A, R2, R3, R4 and X are as defined in the description, and an agent for the treatment or prophylaxis of a pathology involving glucocorticoid, or a 11beta HSD1 inhibitor, containing the compound or a salt thereof.

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Reference：
Oxazolidine – Wikipedia,
Oxazolidine | C3H2621NO – PubChem