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Synthesis of 2-oxazolidinones/2-imidazolidinones from CO2, different epoxides and amino alcohols/alkylene diamines using Br-Ph3+P-PEG600- P+Ph3Br- as homogenous recyclable catalyst

Syntheses of various 2-oxazolidinones/2-imidazolidinones were carried out using polyethylene glycol functionalized phosphonium salt as an efficient homogenous recyclable catalyst via sequential addition of CO2, different epoxides and amino alcohols/alkylene diamines. The effects of various reaction parameters such as temperature, reaction time and catalyst concentration were investigated in detail. The catalyst was readily separated and reused. Excellent yields of 2-oxazolidinones/2-imidazolidinones and higher conversion of cyclic carbonates were observed.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H885NO – PubChem

 

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An overview on ultraviolet persulfate based advances oxidation process for removal of antibiotics from aqueous solutions: A systematic review

Pollution of water resources with pharmaceuticals along with the failure of conventional water treatment methods to remove resistant pollutants increased the attention to advanced water treatment techniques. The present study reviewed the literature of ultraviolet persulfate based advanced oxidation process (AOP) for the removal of antibiotics. Results showed that the removal of antibiotics in UV/ PS systems was pH dependent and the sulfate radicals were dominant in the neutral situation. Also, complete degradation of Ciprofloxacin (CIP) occurred at pH 7 in 60-min reaction time at the peroxymonosulfate [PMS]/[CIP] molar ratio of 20 in wastewater medium. Analyzing the antibiotic degradation pathway in UV/PS system suggested that regions with the highest electron density values were most susceptible to react with reactive oxygen species from which decomposition began. Finally, based on the literature review, the removal of antibiotics needs to be considered by UV/PS processes in the real aqueous medium. It is also necessary to study the scavenging effect of mineral scavengers, as well as the study of organic scavengers can provide significant information in this area. Both toxicity test and determining the bacterial resistance of new degradation compounds can be useful to clarify the degradation pathway.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H902NO – PubChem

 

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PYRAZOLINES AS PAR-1 ANTAGONISTS FOR TREATMENT OF CARDIOVASCULAR DISEASES

The invention relates to pyrazolines of formula (I), where E = methylene, NH, O or S and R2 = a group of formula (II), methods for the production and use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular, cardiovascular diseases, such as thromboembolitic diseases.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H12NO – PubChem

 

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Chapter 3: Solvent-based absorption

Solvent-based CO2 absorption processes are the oldest and most mature technology, having been deployed at what is considered full-scale for post-combustion CO2 capture. There are many commercial 1st and 2nd generation technologies such as Econamine FG+, CANSOLV, Oase Blue, KS-1, with dozens if not hundreds of 3rd generation solvents that are been studied at various stages of testing. While there are many solvents that are under development, nearly all solvents function on the same physical and chemical principles and it is not surprising that they all have similar configurations with comparable levels of performance. The enhancements in energy efficiency for solvents have come primarily from the engineering advancements that have been achieved over many decades of refinement, whereas little has changed with respect to the molecular structure of solvents over the same period of time. In this chapter, we explain the tenets of solvent-based processes and provide a chronological timeline of solvents throughout their nearly 90-year history with discussions as to why and how the advancements in solvent efficiency have been achieved and we conclude with an outlook on the future of solvents and their place in carbon capture and storage.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H606NO – PubChem

 

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N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. STR1 The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H153NO – PubChem

 

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Oculoselective beta-blockers

Hydroxyalkyl-phenoxy-propan-2-ol-3-amines are oculoselective beta-blockers useful in the treatment of elevated intraocular pressure with little or no effect on the pulmonary or cardiovascular system.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H24NO – PubChem

 

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Rational design of highly effective asymmetric Diels-Alder catalysts bearing 4,4-sulfonamidomethyl groups

(Chemical Equation Presented) The rational design of bis(oxazoline)- copper(II) catalysts based on postulated intramolecular secondary n-cation interaction for the highly enantioselective Diels-Alder reaction is presented. A theoretical calculation suggested that the n electrons of the 4,4-sulfonamidomethyl groups successfully interact with the Cu(II) cation and that the counteranions with protons of sulfonamido groups. These secondary interactions might be essential for the high catalytic activity, the broad range of substrates, and the high level of induction of the enantioselectivity.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H949NO – PubChem

 

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Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 1. Michael acceptor structre-activity studies

The structure-based design, chemical synthesis, and biological evaluation of peptide-derived human rhinovirus (HRV) 3C protease (3CP) inhibitors are described. These compounds incorporate various Michael acceptor moieties and are shown to irreversibly bind to HRV serotype 14 3CP with inhibition activities (k(obs)/[I]) ranging from 100 to 600 000 M-1 s- 1. These inhibitors are also shown to exhibit antiviral activity when tested against HRV-14-infected H1-HeLa cells with EC50’s approaching 0.50 muM. Extensive structure-activity relationships developed by Michael acceptor alteration are reported along with the evaluation of several compounds against HRV serotypes other than 14. A 2.0 A crystal structure of a peptide- derived inhibitor complexed with HRV-2 3CP is also detailed.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H501NO – PubChem

 

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Enantioselective Construction of Acyclic Quaternary Carbon Stereocenters: Palladium-Catalyzed Decarboxylative Allylic Alkylation of Fully Substituted Amide Enolates

We report a divergent and modular protocol for the preparation of acyclic molecular frameworks containing newly created quaternary carbon stereocenters. Central to this approach is a sequence composed of a (1) regioselective and -retentive preparation of allyloxycarbonyl-trapped fully substituted stereodefined amide enolates and of a (2) enantioselective palladium-catalyzed decarboxylative allylic alkylation reaction using a novel bisphosphine ligand.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H1021NO – PubChem

 

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METHOD FOR THE PRODUCTION OF THERMOPLASTIC POLYOXAZOLIDINONE POLYMERS

A process for producing thermoplastic polyoxazolidinone, comprising the following steps: (i) Reaction of a diisocyanate compound (A) with a bisepoxide compound (B) in the presence of a catalyst (C) and a compound (D) in a solvent (E) forming an intermediate compound (F) and (ii) Reaction of a compound (G) with the intermediate (F) formed in step (i), wherein compound (D) is one or more compounds selected from the group consisting of monofunctional isocyanate and monofunctional epoxide, and wherein compound (G) is an alkylene oxide. The invention is also related to the resulting thermoplastic polyoxazolidinone.

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Reference£º
Oxazolidine – Wikipedia,
Oxazolidine | C3H237NO – PubChem