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The present invention provides a 1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one compound having an inhibitory effect on Wee 1, and includes an application of the compound in treating various types of tumors.

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A new series of glycine-derived ligands of the alpha2delta subunit of voltage gated calcium channels is described. Several novel compounds (7) based on (6) were prepared that possessed a potency <100 nM in the alpha2delta binding assay. Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Related Products of 497-25-6. In my other articles, you can also check out more blogs about 497-25-6

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Amine degradation is an important and current focus in the development of chemical absorption technology based on the use of aqueous amines for post-combustion capture (PCC) of CO2. The oxidative degradation and carbamate polymerisation of monoethanolamine (the current industry standard amine for PCC) has been studied extensively at the laboratory scale. However, methods for monitoring long-term amine degradation during pilot, demonstration and commercial scale PCC are needed to enable researchers and operators to optimise amine management (e.g. minimising degradation and optimising reclamation strategies), improve PCC plant operation and avoid operational instabilities. The current industry standard method, based on the measurement of heat-stable salts (HSS) is not suitable for continuous monitoring of amine degradation. This study discusses the organic structural changes of severely degraded 30% (w/w) aqueous monoethanolamine samples obtained from a PCC pilot plant operating at a brown coal-fired power station in Australia. It demonstrates that absorbance measurement at 313nm by UV-vis, change in infra-red absorbance and the organic carbon content of degradation products correlate strongly with HSS concentrations. These parameters are easily measured using well established technology and are suitable for monitoring the degradation of aqueous monoethanolamine during PCC.

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Pd-catalyzed hydroarylation reactions of ynamides were studied in pure water in the presence of the water-soluble industrial TPPTS ligand in comparison with the use of PCy3 or P(o-Tol)3. Pd(OAc)2/TPPTS (3,3?,3?-phosphanetriyltris(benzenesulfonic acid) trisodium salt) system exhibited high activity for the conversion of various aryl- and alkyl-ynamides in the presence of arylboronic acids bearing either electron-donating and electron-withdrawing groups. The hydroarylation reactions allowed the formation of (Z)-alpha,beta-disubstituted enamides as major compounds in the case of arylynamides and as unique isomer in the case of alkylynamides. The reaction conditions were optimized and the presence of a base was necessary for the efficient preparation of enamides at room temperature. Conversely, alpha,beta-disubstituted or beta,beta?-disubstituted enamides were isolated as major single stereoisomers and at room temperature in water in the absence of any additive by using PCy3 or P(o-Tol)3, respectively. The best activity was observed for oxazolidin-2-one, whereas other a tosylynamide was non-reactive.

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On treatment with LDA, the acylated oxazolidinones 3 and 10 gave the N-vinylamides 6, 7 and 11 in low yields.The esters 13, on treatment with an excess of LDA at 0 degC, gave a low yield of the beta-aminovinyl ketones 15 in addition to the enolates.Methyl benzoate similarly gave the beta-aminovinyl ketone 17.Neither the formation of the N-vinylamides nor of the beta-aminovinyl ketones was easily made high yielding.

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Compounds of formula (I), pharmaceutically acceptable salts thereof, and uses of the compounds of formula (I) for treating bacterial infections are disclosed.

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Reaction between secondary amines and vinyl triflates of alpha-keto esters and imides under solvent-free condition provides a ready access to alpha,beta-diamino carboxylates.

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The intramolecular Diels-Alder adduct 12 was converted via dimesylate 20 into dienone 7, which represents the unusual, and apparently quite stable, core of the antitumor agent ottelione B (1).

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Chemical modification of cellulose fibers with a trialkoxysilane has been performed and modified cellulose-castor oil polyurethane composites have been successfully studied. The modified cellulose and all composites was characterized by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetry (TGA) and water uptake test (WU). Compared with the crude cellulose fibers, the organosilane treatment reduces the hydrophilicity of the natural fibers and increases the fiber/matrix compatibility. In addition, the better dispersion of treated cellulose fibers was characterized by scanning electron microscopy (SEM). Cellulose fiber modification effect on mechanical properties was investigated by uniaxial traction test. Results show an improvement of Young modulus and tensile strength. Composites thermal properties of are also improved after the organosilane treatment of fibers. These results are due to the interfacial adhesion improvement by the formation of chemical bonding between prepolymer isocyanate extremities and the glycidol grafted on cellulose surface.

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(Chemical Equation Presented) Intramolecular anodic olefin coupling reactions utilizing N,O-ketene acetals have been studied. Coupling reactions with both enol ether and allylsilane terminating groups were examined. The reactions involving the coupling of the N,O-ketene acetals with allylsilane groups were found to be much more efficient than corresponding reactions utilizing dithioketene acetal groups and allylsilanes. The reactions were also more efficient than the intramolecular coupling reactions between enol ethers and allylsilanes studied earlier.

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