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N-Tributylstannyl-2-oxazolidone is formed from the reaction of (Bu3Sn)2O and 2-chloroethyl isocyanate in the presence of hexamethylphosphoric triamide, and reacts with electrophiles to give N-substituted 2-oxazolidones in good yields.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H984NO – PubChem

 

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Conversion of a wide range of N-Boc amides to aryl ketones was achieved with Grignard reagents via chemoselective C(O)-N bond cleavage. The reactions proceeded under catalyst-free conditions with different aryl, alkyl, and alkynyl Grignard reagents. alpha-Ketoamide was successfully converted to aryl diketones, while alpha,beta-unsaturated amide underwent 1,4-addition followed by C(O)-N bond cleavage to provide diaryl propiophenones. N-Boc amides displayed higher reactivity than Weinreb amides with Grignard reagents. A broad substrate scope, excellent yields, and quick conversion are important features of this methodology.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1034NO – PubChem

 

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The addition of the N-pronucleophiles to 2- or 3-nitro-2-alkenoates in the presence of base provided Michael addition products. In the case of 3-nitro compounds, reaction occurred via the formation of alpha-adducts and the subsequent elimination of nitrous acid to produce olefins with high Z stereoselectivity. 3-Phthalimido-2-nitrocinnamate adduct 8a was converted into 2,3-diamino ester 11a.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H728NO – PubChem

 

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Methods for preventing the penetration of toxic chemicals through the stratum corneum of the skin of a mammal are disclosed which employ, as a penetration prevention agent, at least one compound selected from the group consisting of compounds represented by the formula: STR1 wherein W1 is a divalent oxygen, sulfur or nitrogen radical, W2 and W3 are independently a divalent oxygen or sulfur radical, R’ is an alkyl radical comprising from 1 to 4 carbon atoms, y is 0 or 1, R1 and R2 are alkyl radicals comprising from 1 to 10 carbon atoms and R and R3 are individually a hydrocarbyl radical containing from 1 to 20 carbon atoms or a heteroatom-substituted derivative thereof wherein at least one but not two adjacent carbon atoms may be replaced by a divalent oxygen or sulfur radical or by NR”, wherein R” is hydrogen or R’, n is an integer from 2 to 5 and compounds represented by the above formula in which the ring and/or R includes one to three carbon carbon double bonds.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H196NO – PubChem

 

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We describe the synthesis and radical polymerization of series of styrenes with 2-oxazolidone moieties inherited from alpha-amino acids on the side chain. The 2-oxazolidone 2 was readily synthesized through the reaction of diphenyl carbonate with amino alcohols 1 that were prepared through the reduction of the corresponding alpha-amino acids (glycine, l-alanine, l-phenylalanine, l-valine, and l-methionine), in the presence of 1,8-diazabicyclo[5.4.0]-7-undecene as a base catalyst. The subsequent N-substitution reaction of 2-oxazolidone with 4-(chloromethyl) styrene in the presence of sodium hydride produced high yield of the corresponding styrenic compounds 3. Free radical polymerization of these monomers 3 smoothly proceeded in the quantitative monomer-conversion using benzoyl peroxide as a radical initiator to give the corresponding polymers (P3). The thermal properties of the resulting polymers were evaluated by differential scanning calorimetry and thermogravimetric analysis. These oxazolidone-containing polymers effectively adsorbed phenols from aqueous solution, and were also miscible with poly(4-vinylphenol) in the equimolar ratio mixture, because of the effective hydrogen bond interaction involving a carboxyl group of oxazolidone moieties and a hydroxyl group of the phenol.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1163NO – PubChem

 

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The present invention relates to: a compound as a ligand in a variety of catalytic organic synthetic reactions; a method for producing the compound; a synthetic intermediate of the compound; and a transition metal complex which has the compound as a ligand. The compound includes a compound represented by the following general formula (1A):

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H177NO – PubChem

 

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Endowing rigid polyurethane foam (PUF) with a good fire-retardancy is essential for improving fire safety. Chemical improvement in fire-retardancy by using reactive-type flame retardants is better because of the disadvantages of traditional additive-type flame retardants. A reactive flame retardant tri-glycidyl phosphate (POG), which was synthesized by using phosphorus oxychloride and glycidol, was bound to the cross-linked network structure of PUF. The effects of POG on the physical-mechanical properties, morphology, thermal stability and fire-retardancy of PUF system were systematically investigated. Research results showed that POG resulted in an improvement in the thermal insulation ability and a slight decrease in the compressive strength of PUF. Furthermore, thermogravimetric analysis certified that the thermal stability and the char yield at 700 C of PUF were significantly enhanced by incorporating POG. The limiting oxygen index increased to 22.3% with rising loading of POG. Moreover, a 30.2% decline in total heat release was achieved, the time to flameout was significantly shortened. Additionally, the vertical burning test illustrated that POG effectively limited the spread of flame and eliminated melt dripping. Further study confirmed that the fire-retardancy of PUF was significantly improved by inhibiting flame in the gas phase and charring in condensed phase.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H662NO – PubChem

 

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Three illustrative examples are presented from our own approaches to development of drug candidates based on structure-activity relationship analyses. Starting from a lead, 3-(S)-n-butyl-phthalide, an anticonvulsive principle, isolated from Chinese celery seeds, a number of congeners were synthesized and tested. Quantitative structure-activity relationship (QSAR) analyses revealed that the potency depends upon the configuration of substituents around the chiral center at the 3-position, in addition to the hydrophobicity and electronic structure of compounds, and the polarity of substituents in the aromatic moiety. RS-3-n-Butyl-6-amino-phthalide was selected as a candidate for antiepileptic drug. A series of modifications of an antipeptic-ulcer prototype, furazolidone, led to deduction of a lead skeleton. A series of related (hetero) aromatic aldehyde (thio) semicarbazones were synthesized and tested. The QSAR analyses showed that the activity is significantly dependent on the electron density of the (thio) carbonyl group, which is enhanced by the introduction of electrons-donating substituents. Hepatoprotective biphenyl compounds with structures simplified from that of an active principle of a Chinese traditional medicine, were investigated by the analysis of structural parameters obtained from their X-ray crystallography and UV spectrum. The structural requirements for activity were suggested from their configuration and conformation.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H578NO – PubChem

 

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The palladium-catalyzed reaction of alpha-bromomethyl sulfoxides, carbon monoxide, and N-nucleophiles follows different reaction pathways according to the catalytic system and the reaction conditions. The Pd-xantphos catalyst affords high yields of alpha-sulfinyl amides by an aminocarbonylation process and is the first example of this type of transformation for a nonbenzylic sp3-hybridized carbon. On the other hand, the oxidative carbonylation of amines occurs with alpha-bromomethyl sulfoxides, carbon monoxide, and catalytic Pd(PPh3)4 under aerobic conditions, yielding ureas and oxalamides from either primary or secondary amines. The reaction with ambident nucleophiles such as amino alcohols was highly selective and took place exclusively at the amino group despite the presence of the alcohol functionality. In parallel to the reaction paths for simple amines, amino alcohols were converted into hydroxy sulfinyl amides when the reaction was catalyzed by Pd-xantphos, while Pd(PPh3)4 catalyst afforded cyclic carbamates. The alkoxycarbonylation reaction of bromomethyl sulfoxides with simple alcohols and CO leading to the corresponding sulfinyl esters is also described.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H829NO – PubChem

 

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Two of the main challenges in post-combustion CO2 capture with ethanolamine are solvent degradation and material corrosion. It has been shown that there is a correlation between degradation and corrosion. The present paper examines this correlation by studying the effect of 10 MEA degradation products on corrosion. Thermal degradation experiments were conducted under stripper conditions for 5 weeks. 30wt% MEA solution with 1wt% of the various degradation products was placed in 316 SS cylinders and stored in a thermostat chamber at 135C. ICP-MS was used for the metal concentration analyses for all the solutions, while ion chromatography was used for the quantitative determination of heat stable salts anions and MEA concentrations. The solutions were also analysed for degradation products in order to study the formation and thermal stability of these compounds. For corrosion monitoring, in addition to ICP-MS analyses, SEM-EDS was used for examining the cylinders’ surface morphology and elemental composition while XRD was used for corrosion product identification. In the present paper, the influence of the secondary degradation products on corrosion is studied. Results show that some specific degradation products, such as Bicine, HeGly and HEEDA, enhance corrosion while others do not seem to have a significant effect on corrosion of stainless steel.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H539NO – PubChem