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The present invention relates to 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives having the general Formula Ito pharmaceutical compositions comprising the same as well as to the use of these derivatives for the preparation of a medicament for the treatment of cathepsin S related diseases such as atherosclerosis, obesity, inflammation and immune disorders, such as rheumatoid arthritis, psoriasis, cancer, and chronic pain, such as neuropathic pain.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H133NO – PubChem

 

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Fly ash contains varying amounts of transition metals depending on the fuel, combustion and also downstream emission control process. As certain transition metal ions are known to catalyze solvent degradation, the impact of fly ash is an important consideration for a post-combustion CO2 capture process. Here, five different fly ashes were screened with a representative carbon dioxide loaded aqueous monoethanolamine solution. The addition of fly ash has been found to impact oxidative degradation and product distribution significantly. Eight products have been identified and quantified by LC-TOF method. Some of the new products identified here contain a secondary amine group that could potentially nitrosate further. The rates of formation of these products were determined and found much higher with fly ash compared to MEA alone.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H414NO – PubChem

 

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The acid catalyzed condensation of lactams and aldehydes is a facile and highly stereoselective preparative route to a wide variety of N-alkenyl lactams of various ring sizes, and it is compatible with a useful range of aldehydes.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1193NO – PubChem

 

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The calorimetric data on dimethylenecyclourethan, trimethylenecyclourethan, 2-methyltrimethylenecyclourethan, 2,2-dimethyltrimethylenecyclourethan, and tetramethylenecyclourethan in the temperature range 5-340 K were used to determine the dependences of heat capacity Cp (T), entropy S(T), enthalpy H(T) – H(0), Gibbs function G(T) – H(0), standard enthalpy of combustion DeltacH, and the thermodynamic parameters of formation (DeltafH, DeltafG, and AfG) of cyclourethanson the number of ring carbon atoms at various temperatures in the range 50-300 K. The dependences at given temperatures were straight lines, which could be used to estimate the same thermodynamic properties of still unstudied cyclourethans. The thermodynamic properties of cyclourethans with 7-13 carbon atoms were estimated in the specified temperature range with errors not exceeding 3%.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1086NO – PubChem

 

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A series of new chiral N,N?-sulfonyl bisoxazolidin-2-ones were synthesized starting from 2-aminoalcohols, sulfuryl chloride, and diethyl carbonate. This method utilizes natural amino acids as a source of chirality for the preparation of oxazolidinones.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H347NO – PubChem

 

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Thermal rearrangement of N-acyl-2-oxazolidones in the presence of calcium oxide has been shown to provide a new entry into 2-substituted oxazolines.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H848NO – PubChem

 

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 497-25-6, name is Oxazolidin-2-one, introducing its new discovery. category: oxazolidine

What a catch! Basic ionic liquids (ILs) based on a phosphonium hydroxide derivative can be tuned for CO2 capture by varying the weak proton donors, which have different pKa values. The stability, absorption capacity, and absorption enthalpy of the ILs could be easily tuned: the best IL for CO2 capture has good stability (>300 C), energy saving (ca. 56kJ mol-1), and equimolar absorption capability. Copyright

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1107NO – PubChem

 

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ConspectusThe construction of libraries of acyclic polyketides remains a challenging topic, mostly due to the difficulties associated with finding the right balance between diversity and brevity for the synthetic routes leading to polyketides. Recently, relatively short methods have been developed and applied to the synthesis of natural products. However, these short routes often suffer from limited diversity with respect to the arrangement of functional groups and stereochemistry, as these usually require reactions that direct multiple functional groups simultaneously in one step. Therefore, methods that combine a small number of reaction steps with structural diversity remain an attractive research target for the construction of acyclic polyketide libraries.In 2004, we reported a remote asymmetric induction reaction using chiral vinylketene silyl N,O-acetal 1, which is commensurate to an anti-selective vinylogous Mukaiyama aldol reaction. Ever since, this reaction has been applied to the synthesis of numerous natural products, as this synthetic route is short and efficient on account of the simultaneous introduction of both asymmetric centers and the multiply functionalized carbon chain. Recently, we have developed a variety of this remote asymmetric induction reaction based on the E,E-vinylketene N,O-acetal 1, which includes syn-selective vinylogous Mukaiyama aldol reactions, as well as alkylation, acylation, and bromination reaction. These reactions provide polypropionates in a highly stereoselective manner. The proposed transition states of these reactions are discussed in this Account. Additionally, we have developed a new short synthesis of polypropionates by combining reactions for the remote asymmetric induction and the functionalization of double bonds (wide-range stereocontrol, WRS). The remote asymmetric induction reaction simultaneously constructs the stereogenic centers at the central part of the products and introduces the alpha,beta-unsaturated imide, while the new strategy is based on the initial construction of the central part of the molecule and a subsequent functionalization of the surroundings (WRS). This strategy successfully furnished stereoisomers in a few steps, and the stereodivergent synthesis of 2,4,6-trimethyloctanoic acid derivatives was accomplished. This strategy should also be feasible to construct an acyclic polyketide library. Moreover, we applied this method to the concise synthesis of natural products. In this Account, the development of remote asymmetric induction reactions and the new WRS strategy are described. Applications of the WRS strategy as well as reactions for the stereodivergent synthesis of polypropionates and natural products are also described. The aforementioned acyclic polyketide library should be constructed in the future with the help of the WRS strategy and become a powerful tool in drug discovery.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H617NO – PubChem

 

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Intramolecular nucleophilic acyl substitution reactions involving a broad range of halo substituted carboxylic acid derivatives have been accomplished in excellent yield employing samarium(II) iodide as the reductive coupling agent.Although particular substrates cyclized most effectively in THF in the presence of tripiperidinophosphine oxide, carboxylic acid esters, the focus of this report, cyclize equally well without such an additive in the presence of a catalytic quantity of iron(III) complexes.Thus a comprehensive series of halo substituted esters were cyclized in excellent yield to the corresponding 4-, 5-, and 6 -membered carbocycles.The reaction is extremely mild and selective as demonstrated by experiments wherein alkyl chlorides, acetals, and olefins remain completely intact under the reaction conditions.In addition to introducing a convenient procedure for preparing stereodefined spirocyclic systems, a new ring expansion sequence has been developed that appears extremely general for the preparation of various ring systems.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H828NO – PubChem

 

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A protocol for the palladium(0)-catalyzed amidation of heteroaromatic tosylates was successfully developed. The methodology proved to be effective for a variety of heteroaryl tosylates including the pyridine, pyrimidine, quinoline and quinoxaline ring systems. Successful carbon-nitrogen bond formation with these heteroaryl tosylates could be performed with a wide range of primary amides, oxazolidinones, lactams, anilines and indoles, including one cyclic urea. Moreover, this C-N bond forming reaction provided products with high structural diversity. The coupling reaction was also amenable to scale up applications.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H791NO – PubChem