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The present invention relates to compounds of formula (I): in which Y, Y, R, R2, R3 and R4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H98NO – PubChem

 

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The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular Itk activity

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H9NO – PubChem

 

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The effect of tethering a thioether to a rhodium(II) paddlewheel complex are evaluated in Si?H insertion reactions. This study provides further evidence for the benefits of incorporating thioethers into the rhodium paddlewheel motif. When using a tethered complex, the in situ carbenoid formation and subsequent Si?H insertion are not impeded, yields are improved by up to 12 % at elevated temperatures, and selectivity for diazo compounds is greater when compared to non-tethered catalysts. Computational modelling of the complexes is also presented in order to rationalize the results.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H976NO – PubChem

 

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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Recommanded Product: Oxazolidin-2-one, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 497-25-6, name is Oxazolidin-2-one. In an article,Which mentioned a new discovery about 497-25-6

Amine-based CO2 capture (ACC) has become one cost-effective method for reducing carbon emissions in order to mitigate climate changes. The amine-rich wastewater (ARWW) generated from ACC may contain a series of degradation products of amine-based solvents (ABSs). These products are harmful for ecological environment and human health. Effective and reliable ARWW treatment methods are highly required for mitigating the harmfulness. However, there is a lack of a comprehensive review of the existing limited methods that can guide ARWW-related technological advancements and treatment practices. To fill this gap, the review is achieved in this study. All available technologies for treating the ARWW from washwater, condenser, and reclaimer units in ACC are examined based on clarification of degradation mechanisms and ARWW compounds. A series of significant findings and recommendations are revealed through this review. For instance, ARWW treatment methods should be selected according to degradation conditions and pollution concentrations. UV light can be only used for treating wastewater from washwater and condenser units in ACC. Biological activated carbon is feasible for removing nitrosamines from washwater and condenser units. Sequence batch reactors, microbial fuel cells, and the other techniques for removing amines and similar degradation products are applicable for treating ARWW. This review provides scientific support for the selection and improvement of ARWW treatment techniques, the mitigation of ACC’s consequences in environment, health and other aspects, and the extensive development and applications of ACC systems.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H498NO – PubChem

 

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One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Product Details of 497-25-6, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 497-25-6, Name is Oxazolidin-2-one, molecular formula is C3H5NO2

3-[(4-Substituted) (2-oxo-1,3-oxazolidin-3-yl)-phosphoryl]-1,3-oxazolidin- 2-ones (4a-j) were synthesized through a two-step process. Bis-(2-oxo-1,3- oxazolidin-3-yl)-phosphonic chloride (2) prepared by the reaction of two moles of oxazolidin-2-one (1) with phosphorus oxychloride in dry tetrahydrofuran in the presence of triethylamine and treatment with various heterocyclic aromatic and aliphatic amines under the same experimental conditions afforded the title compounds (4a-j). They were characterized by elemental analysis, IR, NMR ( 1H, 13C and 31P) and mass spectroscopy. Their antimicrobial activities were also evaluated.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H928NO – PubChem

 

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The conjugate addition nitro-Mannich reactions of ethyl-beta-nitroacrylate (1) and beta-nitrostyrene (2) with electron rich aromatic nucleophiles, stabilized carbanions, alcohols, amines, thiols, and diphenyl phosphine oxide were investigated. The one pot conjugate addition nitro-Mannich reaction was unsuccessful except for the addition of alkoxides to 2 in alcohol as solvent. Isolation of the conjugate addition products followed by deprotonation with nBuLi and treatment with a simple imine in the presence of TFA led to beta-nitroamine derived products. Products derived from 1 spontaneously cyclised in only a few examples and on the whole led to inherently unstable products. Products derived from 2 were isolated as their trifluoroacetamides, gave good yields of single diastereoisomers for aromatic and alkoxide nucleophiles and the structures were verified by single crystal X-ray crystallography. Products derived from amine nucleophiles were isolated in low yields while sulfur nucleophiles gave poor diastereoselectivities.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H299NO – PubChem

 

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497-25-6, Name is Oxazolidin-2-one, belongs to oxazolidine compound, is a common compound. Safety of Oxazolidin-2-oneIn an article, once mentioned the new application about 497-25-6.

The present invention relates to 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives having the general Formula (I), to pharmaceutical compositions comprising the same as well as to the use of these derivatives for the preparation of a medicament for the treatment of cathepsin S related diseases such asatherosclerosis,obesity, inflammation and immune disorders, such as rheumatoid arthritis, psoriasis, cancer,and chronic pain, such as neuropathic pain.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H45NO – PubChem

 

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497-25-6, Name is Oxazolidin-2-one, belongs to oxazolidine compound, is a common compound. Product Details of 497-25-6In an article, once mentioned the new application about 497-25-6.

The combined use of a copper halide, a silver salt and a phosphane ligand was applied for the catalysis of inter- and intramolecular hydroamination of alkenes. The reactions of unactivated olefins with nitrogen substrates were investigated. Mechanistic investigations demonstrated that the catalytic system generated a Bronsted acid which appeared to be the prominent catalytic species. Copyright

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Oxazolidine – Wikipedia,
Oxazolidine | C3H815NO – PubChem

 

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497-25-6, Name is Oxazolidin-2-one, belongs to oxazolidine compound, is a common compound. COA of Formula: C3H5NO2In an article, once mentioned the new application about 497-25-6.

Atom economic: A commercially available palladium catalyst system is applied for an environmentally benign allylation of electron-deficient N-heterocycles using allylic alcohols (see scheme). The system is also applied for the N-allylation of biologically important uridine and thymidine derivatives. Copyright

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Oxazolidine – Wikipedia,
Oxazolidine | C3H333NO – PubChem

 

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A new synthesis of N-enoyloxazolidin-2-ones has been performed by electrochemical reduction of alpha,alpha?-di- and trichloroketones in aprotic solvent in the presence of Evans’ chiral auxiliaries (oxazolidin-2-ones). The electrochemical reduction of trichloroketones via a chlorocyclopropanone as intermediate allows a Favorskii rearrangement involving trichloroketones and oxazolidin-2-ones. N-Enoyloxazolidin-2-ones have been obtained this way under mild reaction conditions and in good to high yields.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H520NO – PubChem