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Matrix presented. The Cul-catalyzed coupling reaction of vinyl halides with amides or carbamates proceeds well at room temperature to 80C in dioxane to give enamides using N,N-dimethylglycine as the promoter and Cs 2CO3 as the base. The geometry of the C-C double bond is retained during the reaction course.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H882NO – PubChem

 

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An efficient synthesis of selectively N-substituted xanthine derivatives is described. Cyclocondensation of a suitably protected aminoimidazole with methyl-2-phenylthioethyl carbamate, followed by oxidation of sulfur to the sulfone, provides access to an orthogonally 1,7-protected xanthine, which may then be regioselectively alkylated and deprotected under mild conditions.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H290NO – PubChem

 

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Non-nucleoside inhibitors of HIV-1 reverse transcriptase (NNRTIs) are part of the combination therapy currently used to treat HIV infection. Based on analogy with known HIV-1 NNRT inhibitors, 18 novel alkenyldiarylmethanes (ADAMs) containing 5-chloro-2-methoxyphenyl, 3-cyanophenyl, or 3-fluoro-5- trifluoromethylphenyl groups were synthesized and evaluated as HIV inhibitors. Their stabilities in rat plasma have also been investigated. Although introducing 5-chloro-2-methoxyphenyl or 3-fluoro-5-trifluoromethylphenyl groups into alkenyldiarylmethanes does not maintain the antiviral potency, the structural modification of alkenyldiarylmethanes with a 3-cyanophenyl substituent can be made without a large decrease in activity. The oxazolidinonyl group was introduced into the alkenyldiarylmethane framework and found to confer enhanced metabolic stability in rat plasma.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H482NO – PubChem

 

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The invention encompasses a series cyclic bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H20NO – PubChem

 

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Di(2-ethylhexyl) phthalate (DEHP) is the most common phthalate ester, which has been used as a plasticizer for the production of numerous polymers, particularly polyvinyl chloride (PVC). Many other groups have synthesized meso-DEHP indicating interest in this molecule, but we are the first to synthesize enantiomerically pure di[(R)-2-ethylhexyl] phthalate. We report herein, for the first time, the isolation-from the cultures of Bacillus thuringiensis, B. subtilis, and B. velezensis strains-of di[(R)-2-ethylhexyl] phthalate, enantiomerically pure and in good yields: its biological activity against bacteria and fungi was probed and for the first time its synthesis was done.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H407NO – PubChem

 

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1,6-Bis(2-oxooxazolidin-3-ylcarbonylamino)hexane (1) was prepared from 2-oxazolidinone and hexamethylenediisocyanurate using triethylenediamine as a catalyst in benzene.A TG effluent gas is collected in a cold trap and then directly injected into a GC for separation, the MS for unequivocal identification.The 13 effluent compounds from the thermal degradation of 1 were identified.

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Oxazolidine – Wikipedia,
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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 497-25-6, name is Oxazolidin-2-one, introducing its new discovery. Formula: C3H5NO2

4-Aminopyridines are valuable scaffolds for the chemical industry in general, from life sciences to catalysis. We report herein a collection of structurally diverse polycyclic fused and spiro-4-aminopyridines that are prepared in only three steps from commercially available pyrimidines. The key step of this short sequence is a [4 + 2]/retro-[4 + 2] cycloaddition between a pyrimidine and an ynamide, which constitutes the first examples of ynamides behaving as electron-rich dienophiles in [4 + 2] cycloaddition reactions. In addition, running the ihDA/rDA reaction in continuous mode in superheated toluene, to overcome the limited scalability of MW reactions, results in a notable production increase compared to batch mode. Finally, density functional theory investigations shed light on the energetic and geometric requirements of the different steps of the ihDA/rDA sequence.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H508NO – PubChem

 

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A convergent synthesis of trifluoromethyl ketones and alpha,beta-unsaturated trifluoromethyl ketones is described, starting with aliphatic iodides and dithiocarbonates (xanthates) and exploiting both the alpha- and beta-fragmentations of a sulfonyl radical. The transformation initially furnishes the ketones in a masked enol carbonate form, from which they can be easily regenerated.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H308NO – PubChem

 

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Anodic oxidation in THF of aminyl anions (lithium amides and aminomagnesium bromides) together with free aliphatic amines efficiently afforded 2-aminotetrahydrofurans.A similar reaction took place in the anodic oxidation of N-lithiolactams.These reactions are the first examples of anodic amination of an aliphatic saturated ether.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H533NO – PubChem

 

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The present application relates to positive allosteric modulators of the muscarinic M2 receptor, especially to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of cardiovascular disorders and/or renal disorders.

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Oxazolidine – Wikipedia,
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