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A process for producing thermoplastic polyoxazolidinone comprising copolymerization of a diisocyanate compound (A) with a bisepoxide compound (B) in the presence of a catalyst (C) and a compound (D) in a solvent (E), wherein the catalyst (C) is selected from the group consisting of alkali halogenides and earth alkali halogenides, and transition metal halogenides, compound (D) is selected from the group consisting of monofunctional isocyanate, monofunctional epoxide, and wherein the process comprises step (alpha) of placing the solvent (E) and the catalyst (C) in a reactor to provide a mixture, and adding the diisocyanate compound (A), the bisepoxide compound (B) and the compound (D) in step (P) to the mixture resulting from the step (alpha). The invention is also related to the resulting thermoplastic polyoxazolidinone.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H236NO – PubChem

 

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A process is described for the stereochemically controlled synthesis of intermediates useful in producing 1-betamethylcarbapenem antibiotics.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H215NO – PubChem

 

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The electrochemical hydroxylation of 1,3-oxazolidin-2-one to 4-hydroxy-1,3-oxazolidin-2-one is reported; a substantial size product is the symmetrical ether derived from the hydroxycompound.An improved synthesis of 3H-1,3-oxazol-2-one has been developed; nothing more is involved than boiling the readily available 4-methoxy-1,3-oxazolidin-2-one with an excess of acetic acid and one equivalent of acetic anhydride, evaporation of the solvents and recrystallization of the residue.The mechanism of the reaction is discussed.In a reinvestigation of the known conversion, by acetic anhydride, of 4-methoxy-1,3-oxazolidin-2-one to N-acetyl-1,3-oxazol-2-one, we have uncovered the formation of two 3,4′-bioxazole side products <3-(2-oxo-1,3-oxazolidin-4-yl) 1,3-oxazol-2-one and its N-acetyl derivative>, especially in the presence of added acids.We have found that N-formyl-1,3-oxazol-2-one can be made in good yield by treatment of 3H-1,3-oxazol-2-one with a mixture of formic acid and acetic anhydride (“acetic formic anhydride”) in the presence of 4-(N,N-dimethylamino)pyridine; the formation of an intermediate phosphonate derived from 3H-1,3-oxazol-2-one, as described in the literature synthesis of N-formyl-1,3-oxazolone, is superfluous.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1049NO – PubChem

 

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The present invention is directed to compounds which inhibit prenyl-protein transferases, farnesyl-protein transferase and geranylgeranyl-protein transferase type I, and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and geranylgeranyl-protein transferase type I and the prenylation of the oncogene protein RAS.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H66NO – PubChem

 

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497-25-6, Name is Oxazolidin-2-one, belongs to oxazolidine compound, is a common compound. Quality Control of Oxazolidin-2-oneIn an article, once mentioned the new application about 497-25-6.

Previous structure-activity relationship studies involving a series of lactone-based muscarinic ligands identified a lead compound containing a diphenylmethylpiperazine moiety (4; IC50 = 340 nM). The purpose of the present work is to investigate 1,3-benzodioxoles, 4,4-diethyl substituted tetrahydrofurans, 5-substituted oxazolidinones and chromones as bioisosteric replacements for the lactone ring in a novel series of muscarinic ligands. The approach provided compounds with improved % inhibition values and identified a non-selective muscarinic ligand with an IC50 value of 280 nM. The structure-activity relationship for this new series will be discussed. Selected compounds were evaluated in preliminary assays for subtype selectivity and were found to be non-selective.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H349NO – PubChem

 

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A novel method for metal-free oxothiolation of ynamides to construct oxazolidine-2,4-diones bearing sulfur-substituted quaternary carbon atoms has been developed. It represents a rare C-O bond cleavage of ynamides, as well as a facile and tandem approach for the formation of C-O, C-S, and C-Cl bonds. This redox-neutral protocol can be applied to the synthesis of multisubstituted oxazolidine-2,4-diones with good chemoselectivity and good yields of isolated products under mild conditions.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H623NO – PubChem

 

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The synthesis and structure-activity relationship analysis of a novel class of amide-based biaryl NR2B-selective NMDA receptor antagonists are presented. Some of the studied compounds are potent, selective, non-competitive, and voltage-independent antagonists of NR2B-containing NMDA receptors. Like the founding member of this class of antagonists (ifenprodil), several interesting compounds of the series bind to the amino terminal domain of the NR2B subunit to inhibit function. Analogue potency is modulated by linker length, flexibility, and hydrogen bonding opportunities. However, unlike previously described classes of NR2B-selective NMDA antagonists that exhibit off-target activity at a variety of monoamine receptors, the compounds described herein show much diminished effects against the hERG channel and alpha1-adrenergic receptors. Selections of the compounds discussed have acceptable half-lives in vivo and are predicted to permeate the blood-brain barrier. These data together suggest that masking charged atoms on the linker region of NR2B-selective antagonists can decrease undesirable side effects while still maintaining on-target potency.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H840NO – PubChem

 

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Practical syntheses of a series of novel ynamides and allenamides are described here. While a base-induced isomerization protocol of propargyl amides leads to an array of chiral and achiral allenamides, ynamides are prepared from enamides via bromination followed by base-induced elimination of the Z-bromoenamides. These ynamides and allenamides possess improved thermal stability compared to ynamines and allenamines. They can be isolated, purified, and handled with ease, and thus, should be synthetically more useful than traditional ynamines and allenamines.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1124NO – PubChem

 

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The chemical shifts of amino acid N-carboxyanhydrides (NCAs) and cyclic or linear urethanes are less sensitive to solvent effects than those of amides and lactams.The values of the one-bond 15N-1H coupling constants depend on the solvent and are 5-8 Hz larger than those of ureas and amides.The 15N-13C coupling constant of the N-CO group is also unusually high, while that of the N-CH group lies within the range known for N-acetylated aliphatic amines.The one-bond 15N-13C coupling constant was found to be insensitive to conformational changes.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H706NO – PubChem

 

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An efficient process based on the gold-catalyzed redox reaction has been developed to oxidize 1,2-diarylacetylene or ynamide to 1,2-diaryldiketone or alpha-keto imide respectively. This process can tolerate a variety of functional groups and affords 1,2-dicarbonyl compounds in excellent yields under mild reaction conditions.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1147NO – PubChem