Brief introduction of Oxazolidin-2-one

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Total synthesis and absolute stereochemical assignment of (+)- and (-)-galbulimima alkaloid 13

We describe the total synthesis of (+)- and (-)-galbulimima alkaloid 13. The absolute stereochemistry of natural (-)-galbulimima alkaloid 13 is revised to 2S. Sequential use of catalytic cross-coupling and cross-metathesis reactions followed by an intramolecular Diels-Alder reaction provided the required trans-decalin AB-ring system and masked the C16 carbonyl as an N-vinyl carbamate for late-stage unveiling in the form of the necessary C16 enone. A vinyl radical cyclization secured the C-ring, while successful execution of our strategy for introduction of the CDE-ring system in complex galbulimima alkaloids provided the target pentacycle with complete diastereoselection. Copyright

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H843NO – PubChem

 

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Palladium-catalyzed intermolecular aminocarbonylation of alkenes: Efficient access of beta-amino acid derivatives

A novel palladium-catalyzed intermolecular aminocarbonylation of alkenes has been developed in which the employment of hypervalent iodine reagent can accelerate the intermolecular aminopalladation, which thus provides the successful catalytic transformation. The current transformation presents one of the most convenient methods to generate beta-amino acid derivatives from simple alkenes.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H434NO – PubChem

 

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Aqueous ZnCl2 Complex Catalyzed Prins Reaction of Silyl Glyoxylates: Access to Functionalized Tertiary alpha-Silyl Alcohols

An efficient Prins reaction of silyl glyoxylates in the presence of an aqueous ZnCl2 complex as a catalyst was developed, providing functionalized tertiary alpha-silyl alcohols in high yields under mild conditions. A preliminary investigation indicated that the aqueous ZnCl2 complex acted as a dual functional catalyst of Br°nsted and Lewis acid to activate the carbonyl groups of silyl glyoxylates via a dual-activation model.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H587NO – PubChem

 

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Catalytic Radical Process for Enantioselective Amination of C(sp3)?H Bonds

A new catalytic radical system involving CoII-based metalloradical catalysis is effective in activating sulfamoyl azides for enantioselective radical 1,6-amination of C(sp3)?H bonds, affording six-membered chiral heterocyclic sulfamides in high yields with excellent enantioselectivities. The CoII-catalyzed C?H amination features an unusual degree of functional-group tolerance and chemoselectivity. The unique reactivity and stereoselectivity is attributed to the underlying stepwise radical pathway. The resulting optically active cyclic sulfamides can be readily converted into synthetically useful chiral 1,3-diamine derivatives without loss in enantiopurity.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H731NO – PubChem

 

Extracurricular laboratory:new discovery of Oxazolidin-2-one

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Phenoxypropylamine compounds

The present invention relates to a phenoxypropylamine compound of the formula (I) 1wherein each symbol is as defined in the specification, an optically active compound thereof or a pharmaceutically acceptable salt thereof and hydrates thereof, which simultaneously show selective affinity for and antagonistic activity against 5-HT1A receptor, as well as 5-HT reuptake inhibitory activity, and can be used as antidepressants quick in expressing an anti-depressive effect.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

 

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Electrochemical degradation of nitrofurans furazolidone by cathode: Characterization, pathway and antibacterial activity analysis

Antibiotics existing in wastewaters must be degraded to eliminate its antibacterial activity before discharging into the environment. Electrochemical reduction by continuous electrons supply can degrade various refractory pollutants, however, the information about the feasibility and characterization of the cathodic degradation of nitrofurans antibiotic furazolidone (FZD) is scarce. Here, we investigated the degradation of FZD using a poised cathode electrochemical reactor. The cyclic voltammetry (CV) preliminarily proved the feasibility of FZD degradation on cathode. In contrast to the different buffer solutions concentrations, buffer types, and initial FZD concentrations which only had obvious impact on the FZD degradation efficiency, different cathode potentials had significant effects both on the FZD degradation efficiency and degradation products composition. Catholyte PBS could be replaced by Na2CO3-NaHCO3 and NaCl buffer solution for the FZD degradation. The cathodic degradation pathway of FZD was proposed based on intermediate products analysis. When the cathode potential was lower than -0.75V, both the furan ring and oxazole ring of FZD were destroyed to generate linear chain products after N-N bond disconnection, suggesting that the high toxic biological metabolite of FZD, 3-amino-2-oxazolidinone (AOZ) could be detoxified by cathodic degradation. This study suggests that the electrochemical reduction could serve as a potential strategy for the treatment of FZD and AOZ containing wastewater.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H701NO – PubChem

 

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Intermolecular oxidative C-N bond formation under metal-free conditions: Control of chemoselectivity between aryl sp2 and benzylic sp 3 C-H bond imidation

A new synthetic approach toward intermolecular oxidative C-N bond formation of arenes has been developed under transition-metal-free conditions. Complete control of chemoselectivity between aryl sp2 and benzylic sp 3 C-H bond imidation was achieved by the choice of nitrogen sources, representatively being phthalimide and dibenzenesulfonimide, respectively.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H691NO – PubChem

 

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Copper-catalyzed N-arylation of aryl iodides with benzamides or nitrogen heterocycles in the presence of ethylenediamine

The copper-catalyzed N-arylation of benzamides or nitrogen heterocycles was carried out with catalytic CuI (10 mol%) in the presence of ethylenediamine (10 mol%) as a ligand and K3PO4 or Cs2CO3 as a base under mild conditions.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H677NO – PubChem

 

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NOVEL COMPOUNDS OF AMINO SULFONYL DERIVATIVES

The present invention relates to compounds with formula (I) or a pharmaceutically acceptable salt thereof: (I);wherein; T is a (4 to 10)-membered heterocyclyl and wherein R1, R2 and R3 are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a condition that is mediated by the modulation of the 11-beta-hsd-1 enzyme.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H61NO – PubChem

 

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Formaldehyde-free high performance tris(alkoxycarbonylamino) triazine coatings

Tris(alkoxycarbonylamino) triazine (TACT) has been successfully formulated with acrylic and polyester backbone resins in coating applications. Yet, the film properties can be greatly enhanced by the addition of epoxy functionality onto the backbone resin, or by the incorporation of an epoxy modifier into the formulation. The advantages of these new systems are formaldehyde-free characteristics and excellent film properties. Examples and their performances, catalysis, and reaction mechanisms are described and discussed.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1139NO – PubChem