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A general, mild and efficient procedure with which to access hydroxamic acids, in good yields and purity, is reported. Esters are used as substrates and reacted with hydroxylamine, in the presence of a base, under microwave activation. The method has been successfully applied to enantiomerically pure esters without loss of stereochemical integrity. Georg Thieme Verlag Stuttgart.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H2535NO – PubChem

 

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The present invention relates to a novel manufacturing method of N-Boc-(S)-4-formyl-2,2-dimethyl-3-oxazolidine carboxylate denoted by chemical formula 1, which does not go through a supercooling process whose temperature is 78 degree Celsius below zero by chemical formula 3 as a starting material, comprising a step of manufacturing N-[(1,1-dimethylethoxy)carbonyl]-2,2-dimethyloxazolidine methanol of a chemical formula 2 compound by reducing 3-(1,1-dimethylethyl)-4-methyl-(S)-2,2-dimethyloxazolidine-3,4-dicarboxylate of a chemical formula 3 compound under a reducing agent, an inorganic acid, or an acid catalyst of Lewis acid at room temperature.COPYRIGHT KIPO 2015

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Oxazolidine – Wikipedia,
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Provided is a novel compound having bromodomain and extra terminal domain (BET) protein inhibiting activities, and a pharmaceutical composition comprising the same which can be useful for prevention or treatment of precancerous transformation or cancer.

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Oxazolidine – Wikipedia,
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The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H2478NO – PubChem

 

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The “Garner” aldehyde has been used as a common intermediate for the preparation of the corresponding alkyne 7 and the alkenylboronic esters 12-16 (24-80%). Diastereoselective cyclopropanation afforded cyclopropylboronic esters 17-20 (60-84%, dr 22:78 to 92:8), the configurations of which were determined by chemical correlation (cyclopropanols 22), X-ray structural analysis (of 21a), and characteristic NMR spectroscopic data. The protected amino alcohols 23-26 and amino acids 27 have been synthesised from the cyclopropylboronic esters 19 by oxidation, Matteson homologation or Suzuki coupling. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H2548NO – PubChem

 

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1H-Tetrazole-1-alkanenitrile SR-9g exhibits a >10-fold in vivo potency enhancement over the lead nitrile 1 and has acceptable oral bioavailability in rats and dogs. An enantiospecific synthesis of 1H-tetrazole-1-alkanenitrile nitriles 9 has been developed.

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Oxazolidine – Wikipedia,
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A convenient synthesis of delta,gamma-unsaturated valine (L-3,4- didehydrovaline), an important constituent of an antibiotic phomopsin A, was achieved from H-D-Ser-OH through a seven-step conversion in 31% overall yield.

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Oxazolidine – Wikipedia,
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Four configurational isomers of 3-benzylglutamic acid, acyclic analogues of kainoids were synthesized to examine their structure-activity relationship.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H2561NO – PubChem

 

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The introduction of a cyclic amino acid in a peptide is one of the best methods to rigidify a strand. A general approach towards a new class of seven-membered ring amino acids is described starting from (S)-tribenzyl glutamic acid gamma-aldehyde, which reacts with beta-keto phosphonates to generate the Horner-Wadsworth-Emmons product. In the presence of H2 and a Pd catalyst, a four-step process occurs involving double-bond hydrogenation, hydrogenolysis of three benzyl protecting groups, imine formation, and reductive amination to produce the 7-substituted azepane carboxylic acid in good overall yield and with good to excellent diastereomeric ratios. An amino function can be introduced in the 7-position as an additional orthogonal chemical handle for readily generating diversity on the cyclic amino acid scaffold by using a beta-keto phosphonate derived from amino acids. A cyclic RGD (Arg-Gly-Asp) pentapeptide analogue containing this new class of noncoded amino acids was also prepared by microwave-assisted cyclization, showing a promising activity as alphavbeta3 integrin inhibitor.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H2501NO – PubChem

 

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N-tert-Butoxycarbonyl serinate acetonide methyl ester, an important intermediate in organic synthesis, can be obtained in large quantity according to the procedure described herein.

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Oxazolidine – Wikipedia,
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