Category: oxazolidine

St. Angelo, A. J. published the artcileChemical and instrumental analyses of warmed-over flavor in beef, Application of 4,5-Dimethyloxazole, the publication is Journal of Food Science (1987), 52(5), 1163-8, database is CAplus.

Raw, freshly cooked, stored, and recooked beef muscle samples were assessed by chem., instrumental, and sensory methods of analyses for flavor quality, with particular emphasis on warmed-over flavor (WOF). The character notes used by a trained sensory panel to describe WOF were cardboardy, rancid, stale, and metallic. Samples analyzed by direct gas chromatog. utilizing either packed of fused silica capillary columns showed that compounds usually associated with lipid oxidation reactions could be used as marker compounds to follow the development of WOF. Of the many compounds that appeared to be markers, hexanal and 2,3-octanedione as well as total volatiles showed a highly significant degree of correlation when compared to sensory scores and 2-thiobarbituric acid (TBA) numbers Many of the volatile compounds that were identified in WOF meat samples were also found in the distillates prepared for the TBA reaction.

Journal of Food Science published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C8H5F3N4, Application of 4,5-Dimethyloxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Kulyk-Sindler, Marija published the artcileFormylation of 2,5-unsubstituted oxazoles: preparation and characterization of 2- and 5-formyl-4-methyloxazoles, SDS of cas: 20662-83-3, the publication is Heterocycles (1994), 38(8), 1791-6, database is CAplus.

Vilsmeier formylation of 4-methyloxazole gave a mixture of 4-methyl-5-oxazolecarboxaldehyde (2) and 4-methyl-2-oxazolecarboxaldehyde (3) in a 1:1 ratio. Both aldehydes were prepared unambiguously: aldehyde 2 by oxidation of 5-hydroxymethyl-4-methyloxazole and reduction of the chloride of 4-methyl-5-oxazolecarboxylic acid and aldehyde 3 by BuLi/DMF procedure. Aldehyde 2 sublimes in a refrigerator while aldehyde 3 forms hydrate, 5-dihydroxymethyl-4-methyloxazole.

Heterocycles published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, SDS of cas: 20662-83-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Wu, Yongqi published the artcileIdentification of Novel Tricyclic Benzo[1,3]oxazinyloxazolidinones as Potent Antibacterial Agents with Excellent Pharmacokinetic Profiles against Drug-Resistant Pathogens, SDS of cas: 1219707-39-7, the publication is Journal of Medicinal Chemistry (2021), 64(6), 3234-3248, database is CAplus and MEDLINE.

A series of conformationally constrained novel benzo[1,3]oxazinyloxazolidinones were designed, synthesized, and evaluated on their activities against Mycobacterium tuberculosis, Gram-pos. bacteria, and Gram-neg. bacteria. The studies identified a new compound 20aa that displayed good to excellent antibacterial and antitubercular profiles against drug-resistant TB strains (MIC = 0.48-0.82μg/mL), MRSA (MIC = 0.25-0.5μg/mL), MRSE (MIC = 1μg/mL), VISA (MIC = 0.25μg/mL), and VRE (MIC = 0.25μg/mL) and some linezolid-resistant strains (MIC 1-2μg/mL). Compound 20aa was demonstrated as a promising candidate through ADME/T evaluation including microsomal stability, cytotoxicity, and inhibition of hERG and monoamine oxidase. Notably, 20aa showed excellent mouse PK profile with high plasma exposure (AUC_{0-âˆ?/sub> = 78 669 h·ng/mL), high peak plasma concentration (Cmax = 10 253 ng/mL), appropriate half-life of 3.76 h, and superior oral bioavailability (128%). The present study not only successfully provides a novel benzo[1,3]oxazinyloxazolidinone scaffold with superior druggability but also lays a good foundation for new antibacterial drug development.}

Journal of Medicinal Chemistry published new progress about 1219707-39-7. 1219707-39-7 belongs to oxazolidine, auxiliary class Other Aliphatic Heterocyclic,Oxazolidine,Chiral,Fluoride,Benzene,Amide,Alcohol,Anti-infection, name is (R)-3-(3-Fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one, and the molecular formula is C8H14O4, SDS of cas: 1219707-39-7.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Xi, Yang published the artcilePalladium-Catalyzed Regio-, Diastereo-, and Enantioselective 1,2-Arylfluorination of Internal Enamides, Name: (4S,4’S)-4,4′-Diisobutyl-4,4′,5,5′-tetrahydro-2,2′-bioxazole, the publication is Angewandte Chemie, International Edition (2021), 60(5), 2699-2703, database is CAplus and MEDLINE.

We herein describe a palladium-catalyzed three-component coupling of internal enamides, arylboronic acids, and Selectfluor to access the chiral β-fluoroaminated moiety with up to 99% ee. The prefunctionalized oxazolidinone substituted alkene enables the expedient construction of two vicinal stereocenters with excellent regio-, diastereo-, and enantioselectivities. The synthetic application is exhibited by selective transformation of the product into various vicinal benzylic fluoride derivatives

Angewandte Chemie, International Edition published new progress about 138429-17-1. 138429-17-1 belongs to oxazolidine, auxiliary class BOX Ligands, name is (4S,4’S)-4,4′-Diisobutyl-4,4′,5,5′-tetrahydro-2,2′-bioxazole, and the molecular formula is C4H6O3, Name: (4S,4’S)-4,4′-Diisobutyl-4,4′,5,5′-tetrahydro-2,2′-bioxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Onimura, Kenjiro published the artcileAsymmetric coupling polymerizations of 2,3-dihalido-N-substituted maleimide derivatives in the presence of chiral bisoxazolines, Computed Properties of 138429-17-1, the publication is Chemistry Letters (2013), 42(4), 366-368, database is CAplus.

Yamamoto coupling polymerizations of 2,3-dihalido-N-substituted maleimides (DXRMI) were carried out using nickel catalysts. In addition, coupling reactions of 2,3-dihalido-N-cyclohexylmaleimide (DXCHMI) were performed with nickel complexes in the presence of directly coupled chiral bisoxazolines (R’box) to give optically active poly(N-substituted maleimide-2,3-diyl)s [poly(RMI)s] (sp. rotation [α]₄₃₅ = +6.0 to -34.6°). Polymers with number-average mol. weights (M_n) ranging from 270 to 36200 were obtained in 17% to quant. yields. Poly(N-cyclohexylmaleimide-2,3-diyl) [poly(CHMI)] formed with [Ni(cod)₂]R’box exhibited the largest absolute value, [α]₄₃₅ = -34.6°.

Chemistry Letters published new progress about 138429-17-1. 138429-17-1 belongs to oxazolidine, auxiliary class BOX Ligands, name is (4S,4’S)-4,4′-Diisobutyl-4,4′,5,5′-tetrahydro-2,2′-bioxazole, and the molecular formula is C14H24N2O2, Computed Properties of 138429-17-1.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Khan, Anwar Arfien Md. published the artcilePositive and negative modulation of Bombyx mori adenylate cyclase by 5-phenyloxazoles: identification of Octopamine and tyramine receptor agonists, Name: 5-(4-Bromophenyl)oxazole, the publication is Archives of Insect Biochemistry and Physiology (2003), 52(1), 7-16, database is CAplus and MEDLINE.

Nineteen 5-phenyloxazoles (5POs) were examined for their ability to modulate adenylate cyclase by measuring cAMP produced in head membrane homogenates of fifth instar larvae of the silkworm Bombyx mori. Among the compounds tested, 5-(4-methoxyphenyl)oxazole and the 2,6-dichlorophenyl congener showed the highest activation of adenylate cyclase; both compounds produced approx. half the level of cAMP produced by the action of octopamine (OCT). The OCT receptor antagonists chlorpromazine, mianserin, and metoclopramide attenuated 9-stimulated cAMP production In contrast, 5-(4-hydroxyphenyl)oxazole and the 4-cyanophenyl congener attenuated both OCT-stimulated and basal cAMP production The tyramine (TYR) receptor antagonist yohimbine inhibited the neg. effect of 8. These findings indicate that the 5PO class of compounds includes both pos. and neg. modulators of adenylate cyclase in the heads of B. mori larvae, and that 9 and 8 are OCT and TYR receptor agonists, resp. These compounds might prove useful for a pharmacol. dissection of biogenic amine receptors.

Archives of Insect Biochemistry and Physiology published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Name: 5-(4-Bromophenyl)oxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Li, Minyong published the artcileStructure-based discovery and experimental verification of novel Al-2 quorum sensing inhibitors against Vibrio harveyi, Product Details of C9H6BrNO, the publication is ChemMedChem (2008), 3(8), 1242-1249, database is CAplus and MEDLINE.

Quorum sensing has been implicated in the control of pathol. relevant bacterial behavior such as secretion of virulence factors, biofilm formation, sporulation, and swarming motility. The Al-2 quorum sensing pathway is found in both Gram-pos. and Gram-neg. bacteria. Therefore, antagonizing Al-2 quorum sensing is a possible approach to modifying bacterial behavior. However, efforts in developing inhibitors of Al-2-mediated quorum sensing are especially lacking. High-throughput virtual screening using the V. harveyi LuxP crystal structure identified two compounds that were found to antagonize Al-2-mediated quorum sensing in V. harveyi without cytotoxicity. The sulfone functionality of these inhibitors was identified as critical to their ability to mimic the natural ligand in their interactions with Arg215 and Arg310 of the active site.

ChemMedChem published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Product Details of C9H6BrNO.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Jouquand, Celine published the artcileEffect of added nitrogen fertilizer on pyrazines of roasted chicory, Recommanded Product: 4,5-Dimethyloxazole, the publication is Journal of the Science of Food and Agriculture (2017), 97(4), 1172-1177, database is CAplus and MEDLINE.

BACKGROUND : Coffee substitutes made of roasted chicory are affected by the formation of acrylamide whose main precursor is asparagine. One strategy for limiting the formation of acrylamide is to reduce free asparagine in the chicory roots by lessening the supply of nitrogen in the field. However, decreasing nitrogen fertilizer could affect the formation of the volatile compounds and, consequently, the sensory characteristics of the roasted chicory. The present study aimed to investigate the impact of the nitrogen supply in five com. varieties on their aroma profile. RESULTS : The addition of 120 kg ha^-1 of nitrogen fertilizer in the field resulted in a greater amount of pyrazines in the roasted chicory. Triangle tests were performed to determine the effect of the nitrogen level on the sensory quality of the five varieties. The results revealed that the chicory aroma was modified in two out of five varieties. CONCLUSION : The results of the present study suggest that a strategy aiming to limit the amount of acrylamide could affect the sensory quality of some varieties of chicory. Further acceptance tests need to be conducted to assess the effect (whether favorable or otherwise) on the sensory quality of the coffee substitutes. © 2016 Society of Chem. Industry.

Journal of the Science of Food and Agriculture published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Recommanded Product: 4,5-Dimethyloxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Nakamura, Shuichi published the artcileIdentification of volatile flavor components of the oil from roasted sesame seeds, Synthetic Route of 20662-83-3, the publication is Agricultural and Biological Chemistry (1989), 53(7), 1891-9, database is CAplus.

The volatile extract obtained by steam distillation of the oil from roasted sesame seeds was separated into its neutral, weakly acidic, acidic, and basic fractions. The neutral fraction was further separated by preparative TLC. All fractions were analyzed by a gas chromatograph (GC) equipped with FID and FPD, and by gas chromatog./mass spectrometry (GC/MS) and/or gas chromatog./Fourier transform-IR (GC/FT-IR) spectrometry. Two-hundred-and-twenty-one constituents were identified. One-hundred-and-forty-six of these compounds are being reported for the 1st time in the aroma of roasted sesame seeds, 7 of which were newly identified as naturally occurring flavor components. Two dithioketones, 1-methyldithio-2-propanone, and 1-methyldithio-2-butanone, are new compounds

Agricultural and Biological Chemistry published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Synthetic Route of 20662-83-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Dart, S. K. published the artcileThe changes in the volatile components of instant coffee with storage, Related Products of oxazolidine, the publication is Developments in Food Science (1985), 239-52, database is CAplus.

The headspace volatiles of fresh instant coffee were identified by capillary gas chromatog.-mass spectrometry, after enrichment on activated charcoal. The changes occurring to the volatiles during storage for â‰?2 mo at -18° and at ambient temperature were followed by direct headspace anal. Several components were highly susceptible to change, even at -18°. Overall, changes (increases as well as decreases) took place in about half the peaks, and these were interpreted in terms of the identifications made.

Developments in Food Science published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Related Products of oxazolidine.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem