Category: oxazolidine

Mukku, Narasimharao published the artcileA Facile Microwave-Assisted Synthesis of Oxazoles and Diastereoselective Oxazolines Using Aryl-Aldehydes, p-Toluenesulfonylmethyl Isocyanide under Controlled Basic Conditions, SDS of cas: 72571-06-3, the publication is ACS Omega (2020), 5(43), 28239-28248, database is CAplus and MEDLINE.

In this study, a highly efficient two-component [3+2] cycloaddition reaction of substituted aryl aldehydes with 4-toluenesulfonylmethyl isocyanide (TosMIC) in the presence of 2 equiv of potassium phosphate as a base to 5-substituted oxazoles were established in a isopropanol medium under microwave irradiation However, using 1 equiv of K₃PO₄ as a base resulted in the diastereoselective synthesis of 4,5-disubstituted oxazolines under identical reaction conditions. The foremost benefits of these protocols are the moderate-to-excellent yields with good functional group compatibility, simple exptl. procedure, inexpensive readily available starting materials, nonchromatog. purification, and high bond-forming efficiency. The synthetic manipulation reported herein represents a cleaner route to the sustainable preparation of 5-substituted oxazoles and diastereoselective 4,5-disubstituted oxazolines derivatives

ACS Omega published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, SDS of cas: 72571-06-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Sanz, Cristina published the artcileProfiles of volatile compounds and sensory analysis of three blends of coffee: influence of different proportions of Arabica and Robusta and influence of roasting coffee with sugar, SDS of cas: 20662-83-3, the publication is Journal of the Science of Food and Agriculture (2002), 82(8), 840-847, database is CAplus.

One hundred and forty-six volatile compounds were identified and quantified using a static headspace sampler in 3 blends of coffee: Arabica/Robusta 80:20 (A80:R20) natural roasted coffee, Arabica/Robusta 20:80 (A20:R80) natural roasted coffee and Arabica/Robusta 20:80 with 50% of Robusta coffee roasted with sugar (A20:R80 50% Torrefacto). The different proportion of Arabica and Robusta coffee in the blend A80:R20 vs. A20:R80 influenced the amounts of 20 chem. families of volatile compounds Aldehydes, ketones, alcs., pyrroles, pyrazines, furans, thiazoles, thiophenes, esters, oxazoles, lactones, sulfur compounds, pyridines, alkanes, alkenes, phenolic compounds, benzenic compounds, acids, pyranones and terpenes were present in higher quantities in the sample containing 80% of Arabica coffee, whereas sulfur compounds were more abundant in the coffee with 80% of Robusta. Sensory differences were also found between the 2 blends of coffee in the burnt, caramel, nutty, earthy and roasty notes. Torrefacto coffee, widely consumed in Spain, is obtained by roasting coffee with sugar. Higher quantities of ketones, alcs., pyrazines, furans, pyridines, alkanes, phenolic compounds, pyranones and terpenes were found in the blend A20:R80 50% Torrefacto coffee vs. A20:R80 natural roasted coffee. These differences in the volatile fraction were perceived by our panelists in the intensities of the nutty, roasty, earthy, burnt and caramel notes.

Journal of the Science of Food and Agriculture published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, SDS of cas: 20662-83-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Medvedskaya, L. B. published the artcileStructural orientation of heterodiene synthesis during the reaction of oxazoles with acetylenic dienophiles, Name: 4,5-Dimethyloxazole, the publication is Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya (1973), 1311-15, database is CAplus.

The Hueckel approximation of MO calculation gave the energy level values and electron densities in oxazoles with H, Me, Ac, CO2R and OR in the 5-position and Me in the 4-position. The stabilization energies of probable transition states in reactions of these compounds with acetylenic dienophiles (Et propiolate or Et phenylpropiolate) were computed. The results of these calculations agreed with the general results of Diels-Alder reactions of these substances. The π-electron density in the reactants was not a satisfactory criterion for deducing the orientation of such reactions since dynamic features were important. Hence, stabilization energy or some index of reactivity that describes reactant polarizability was the more useful parameter.

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Name: 4,5-Dimethyloxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Nishimura, O. published the artcileIdentification of volatile flavor components of the oil from roasted sesame seeds, Application of 4,5-Dimethyloxazole, the publication is Koryo (1990), 91-101, database is CAplus.

Two hundred and twenty-one constituents were identified from the volatile extract obtained by steam distillation of the oil from roasted sesame seeds. One hundred and forty-six of these compounds are reported for the first time in the aroma of roasted sesame seed, 7 of which were newly identified as naturally occurring flavor components. Two dithioketones, 1-methyl-2-propanone and 1-methyldithio-2-butanone, are new compounds

Koryo published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Application of 4,5-Dimethyloxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Han, Wei published the artcilePalladium-Catalyzed Dehydrogenative Cross-Couplings of Benzazoles with Azoles, Category: oxazolidine, the publication is Angewandte Chemie, International Edition (2011), 50(9), 2178-2182, S2178/1-S2178/58, database is CAplus and MEDLINE.

Unsym. 2,2′-bisheteroaryls are prepared by regioselective C-C coupling between the nonfunctionalized C2 positions of azoles through the cleavage of two C-H bonds. E.g., in the presence of Pd(OAc)₂, Cu(OAc)₂.H₂O, KF, and AgNO₃ under a normal air atm., coupling of benzothiazole and 1-methylimidazole gave 91% 2-(1-methyl-1H-imidazol-2-yl)benzothiazole (I). Formation of homocoupling products was suppressed by the presence of Ag⁺ ions.

Angewandte Chemie, International Edition published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Category: oxazolidine.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Belaidi, Salah published the artcileElectronic structure and effect of methyl substitution in oxazole and thiazole by quantum chemical calculations, Related Products of oxazolidine, the publication is Research Journal of Pharmaceutical, Biological and Chemical Sciences (2014), 5(3), 811-818, database is CAplus.

Geometric and electronic structure of oxazole and thiazole and the effect of Me group substitution in thiazole and oxazole have been studied by PM3, ab initio method and d. functional Theory. In the present work, the calculated values, namely net charges, bond length, dipole moments, ionization potentials, electron-affinities and heats of formation are reported and discussed in terms of the reactivity of oxazole and thiazole systems.

Research Journal of Pharmaceutical, Biological and Chemical Sciences published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Related Products of oxazolidine.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Kondrat’eva, G. Ya. published the artcileReaction of oxazoles with dienophiles of methylenemalonic ester type, Safety of 4,5-Dimethyloxazole, the publication is Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya (1972), 2125-6, database is CAplus.

Oxazoles (I) reacted with dienophiles e.g. CH:C-(CO2Et)2 (II) by 1,4-cycloaddition to give 25-40 adduct (III, R1 = PrO, BuO, Me; R2 = H, Me; R3 = CO2Et, Ac). All the dienophiles tried reacted with I (R1 = alkoxy), but I (R1 = Me) reacted with II only. I (R = PrO) and piperidinylcyclo-pentene reacted similarly to give 26 1:1 adduct. II were stable in storage or when heated to 200°.

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Safety of 4,5-Dimethyloxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Belaidi, Salah published the artcileElectronic structure and physical-chemistry property relationship for oxazole derivatives by ab initio and DFT methods, Category: oxazolidine, the publication is Organic Chemistry International (2011), 254064, 7 pp., database is CAplus.

The geometric, electronic structure, effect of the substitution, and structure phys.-chem. relationship for oxazoles derivatives have been studied by ab initio and DFT theory. In the present work, the calculated values, namely, net charges, bond lengths, dipole moments, electron affinities, heats of formation, and QSPR properties are reported and discussed in terms of the reactivity of oxazole derivatives

Organic Chemistry International published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Category: oxazolidine.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Narziss, L. published the artcileVolatile substances formed during malt and beer production, especially those formed by heating the product. Part 1. Analysis, identification and effects on aroma, Application of 4,5-Dimethyloxazole, the publication is Monatsschrift fuer Brauwissenschaft (1988), 41(9), 344-52, database is CAplus.

The N-containing heterocyclic compounds in malt and beer were extracted and determined by gas chromatog. They were analyzed at a sniffing port as they came off the gas chromatograph, and the aroma of many of the substances was described.

Monatsschrift fuer Brauwissenschaft published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Application of 4,5-Dimethyloxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Ukaji, Yutaka published the artcileAsymmetric bis(alkoxycarbonylation) reaction of homoallylic alcohols catalyzed by palladium in the presence of Cu(I) triflate using the chiral bioxazoline ligand, HPLC of Formula: 138429-17-1, the publication is Bulletin of the Chemical Society of Japan (1996), 69(3), 735-42, database is CAplus.

Palladium-catalyzed asym. intra- and intermol. bis(alkoxycarbonylation) reactions of homoallylic alcs. in the presence of copper(I) triflate were achieved by using the chiral bioxazoline ligand, (S,S)-4,4′-bis(phenylmethyl)-4,4′,5,5′-tetrahydro-2,2′-bioxazole, under normal pressure of carbon monoxide and oxygen at 25 °C to give the corresponding optically active γ-butyrolactones in 19-65% ee. For example, the allyl palladiumchloride dimer-catalyzed alkoxycarbonylation of 1-(2-propenyl)cyclohexanol (I) in the presence of trifluoromethanesulfonic acid copper(1+) salt (benzene solvate) and [S-(R*,R*)]-4,4′,5,5′-tetrahydro-4,4′-bis(phenylmethyl)-2,2-bioxazole in THF gave (S)-2-oxo-1-oxaspiro[4.5]decane-3-acetic acid Me ester (II) in 57% yield and in 65% enantiomeric excess.

Bulletin of the Chemical Society of Japan published new progress about 138429-17-1. 138429-17-1 belongs to oxazolidine, auxiliary class BOX Ligands, name is (4S,4’S)-4,4′-Diisobutyl-4,4′,5,5′-tetrahydro-2,2′-bioxazole, and the molecular formula is C4H6BrFO2, HPLC of Formula: 138429-17-1.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem