Category: oxazolidine

Jeong, Ji-Woong published the artcileIn vitro and in vivo activities of LCB01-0371, a new oxazolidinone, Quality Control of 1219707-39-7, the publication is Antimicrobial Agents and Chemotherapy (2010), 54(12), 5359-5362, database is CAplus and MEDLINE.

LCB01-0371 is a new oxazolidinone with cyclic amidrazone. In vitro activity of LCB01-0371 against 624 clin. isolates was evaluated and compared with those of linezolid, vancomycin, and other antibiotics. LCB01-0371 showed good activity against Gram-pos. pathogens. In vivo activity of LCB01-0371 against systemic infections in mice was also evaluated. LCB01-0371 was more active than linezolid against these systemic infections. LCB01-0371 showed bacteriostatic activity against Staphylococcus aureus.

Antimicrobial Agents and Chemotherapy published new progress about 1219707-39-7. 1219707-39-7 belongs to oxazolidine, auxiliary class Other Aliphatic Heterocyclic,Oxazolidine,Chiral,Fluoride,Benzene,Amide,Alcohol,Anti-infection, name is (R)-3-(3-Fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one, and the molecular formula is C14H17FN4O3, Quality Control of 1219707-39-7.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Savanur, Hemantkumar M. published the artcileLibraries of C-5 Substituted Imidazoles and Oxazoles by Sequential Van Leusen (VL)-Suzuki, VL-Heck and VL-Sonogashira in Imidazolium-ILs with Piperidine-Appended-IL as Base, Safety of 5-(4-Bromophenyl)oxazole, the publication is European Journal of Organic Chemistry (2018), 2018(38), 5285-5288, database is CAplus.

Facile access to diverse C5-substituted imidazoles and oxazoles via sequential Van Leusen-Suzuki, Van Leusen-Heck, and Van Leusen-Sonogashira protocols, employing imidazolium-ILs as solvents along with piperidine-appended imidazolium [PAIM][NTf₂] as task-specific basic IL has been demonstrated, in a high-yielding one-pot method, starting with readily available aldimines (for imidazole) or aldehydes (for oxazole) and tosylmethyl isocyanide (TOSMIC), under mild conditions with potential for recycling and reuse of the IL solvent. The scope of the method is supported 49 examples.

European Journal of Organic Chemistry published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Safety of 5-(4-Bromophenyl)oxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Joshi, Poorvashree published the artcileUnlocking the concealed targets using system biology mapping for Alzheimer′s disease, COA of Formula: C14H17FN4O3, the publication is Pharmacological Reports (2019), 71(6), 1104-1107, database is CAplus and MEDLINE.

Alzheimer′s disease (AD) constitutes a neural loss in histol. of brain with involvement of complex genomic and environmental factors. Accumulation of amyloid beta (Aβ) peptide and phosphorylated tau are indicative of progression and cognitive decline. Hence an understanding of the underlying biol. pathways and targets along with associated mechanisms would be useful for the development of improved therapeutics for treating AD. In the present work, we aim to identify concealed targets for developing first line therapeutics and repositioning of validated targets as well as FDA- approved drugs using a system biol. approach. We have collated information pertaining to the biol. targets as well as the approved drugs, from scientific literature and patents. In all, the imbalance in the functioning of around 79 proteins and genes were identified to be involved in Alzheimer′s cascade. Amongst them, around 21 targets were found to be under therapeutic consideration for AD. Of the remaining, around 17 targets were reported as potential targets for AD, although they are under researcher′s attention for other physio-pathol. conditions. The anal. further revealed that âˆ?1 therapeutic targets are pharmacol. concealed but structurally validated targets and may constitute as potential therapeutic candidate for future drug discovery for AD.The biol. pathway vs. drug mapping provides a complete overview about underlying biol. pathways, therapeutic targets (explored and concealed), associated mechanisms, existing therapeutics and the information pertaining to mols. currently under active drug development for further drug discovery and drug re-positioning/repurposing approaches for AD management.

Pharmacological Reports published new progress about 1219707-39-7. 1219707-39-7 belongs to oxazolidine, auxiliary class Other Aliphatic Heterocyclic,Oxazolidine,Chiral,Fluoride,Benzene,Amide,Alcohol,Anti-infection, name is (R)-3-(3-Fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one, and the molecular formula is C14H17FN4O3, COA of Formula: C14H17FN4O3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Duppeti, Haritha published the artcileInfluence of processing conditions on the aroma profile of Litopenaeus vannamei by SPME-GC-MS, Formula: C5H7NO, the publication is Flavour and Fragrance Journal, database is CAplus.

This study reports the aroma profile of Litopenaeus vannamei under different processing conditions such as raw, boiled, hot air dried, microwave dried and roasted using SPME-GC-MS. A total of 86 volatile compounds were identified, among which 38 compounds reported as aroma-active compounds (AAC) having the odor activity value (OAV) greater than one. The microwave-dried shrimp meat (MSM) exhibited the highest summation of odor activity value, and roasted shrimp meat (RSM) showed the highest concentration of aroma-active compounds (3448.78 μg/g). The partial least square regression (PLSR) anal. and cluster anal. (CA) showed that MSM and RSM are related to each other in their aroma characteristics while boiled shrimp meat (BSM) is different than these samples. The results of this study illustrate the typical volatile markers and the impact of processing methods on flavor generation in L. vannamei, which should be examined for the assessment of its freshness and product development based on shrimp flavor.

Flavour and Fragrance Journal published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Formula: C5H7NO.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Oliveira, Alcilucia published the artcileIdentification and recovery of volatiles organic compounds (VOCs) in the coffee-producing wastewater, Name: 4,5-Dimethyloxazole, the publication is Journal of Water Resource and Protection (2014), 6(4), 375-380, 6 pp., database is CAplus.

The objectives of the present study were to recover and identify volatiles organic compounds (VOCs) in the wastewater (WW) coming from a soluble coffee industrial plant. For VOCs recover, the WW was concentrated by pervaporation using a polydimethylsiloxane (PDMS) membrane. Furthermore, the solid phase micro extraction (SPME) and gas chromatog.-mass spectrometry (GC-MS) were used for VOCs identification. The multivariate method of principal component anal. (PCA) was performed to evaluate differences amongst the feed and concentrate streams. Regarding the number of VOCs identified in the wastewater (33) and permeate (72), a significant statistical difference at p < 0.05 was observed Clusters discriminating were clearly observed, as the feed and permeate streams are compared. Thus, we can conclude that pervaporation process using a PDMS membrane was effective to recover different class of VOCs present in the aqueous effluent and can be recommended for industrial wastewater treatment.

Journal of Water Resource and Protection published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Name: 4,5-Dimethyloxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Xiang, Zhangmin published the artcileAnalysis of nitrogenous organic compounds from mainstream cigarette smoke using low-temperature solvent extraction followed by comprehensive two-dimensional gas chromatography with high-resolution time-of-flight mass spectrometry, Name: 4,5-Dimethyloxazole, the publication is Journal of Separation Science (2015), 38(15), 2655-2663, database is CAplus and MEDLINE.

A method involving comprehensive two-dimensional gas chromatog. coupled to high-resolution time-of-flight mass spectrometry was developed and applied to the anal. of nitrogenous organic compounds present in mainstream cigarette smoke trapped on self-designed equipment. The samples were prepared using low-temperature solvent extraction under liquid nitrogen and analyzed by comprehensive two-dimensional gas chromatog. with high-resolution time-of-flight mass spectrometry. Important exptl. parameters, such as the type and volume of the extraction solvent and flow rate of smoking, were optimized to improve the anal. parameter. The results indicated that 180 mL of di-Et ether in the low-temperature solvent extraction apparatus system with a 4 mL/min smoke flow rate were the optimal conditions. Then, 85 nitrogenous organic compounds were identified and quantified using a mass spectral library search, accurate mass ion and N-rules of a mol. formula for nitrogen compounds Finally, a comparison of the low temperature solvent extraction and Cambridge filter pad method indicated that more peaks, a higher peak volume and better repeatability were obtained using the low-temperature solvent extraction method.

Journal of Separation Science published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C6H8N2, Name: 4,5-Dimethyloxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Gu, Bo published the artcileCatalytic Fast Pyrolysis of Sewage Sludge over HZSM-5: A Study of Light Aromatics, Coke, and Nitrogen Migration under Different Atmospheres, Application of 4,5-Dimethyloxazole, the publication is Industrial & Engineering Chemistry Research (2020), 59(39), 17537-17545, database is CAplus.

catalytic fast pyrolysis of wastewater sludge was conducted to assess pyrolysis temperature and atm., and catalysts effect on C and N distribution in a fixed-bed reactor. a H₂ atmosphere had the lowest C selectivity of solid products and the highest gaseous product yield over HZSM-5 (HZ) at the same temperature vs. Ar and steam atmospheres. higher temperature led to increased C selectivity of gaseous products and decreased C selectivity of solids. H₂ increased the C yield of light aromatics (LA); steam reduced generation of LA. over 0.5 Ni-HZ, H₂ had the highest LA C yield (11.4%) vs. 1.6% from non-catalytic fast pyrolysis of sludge. higher temperatures, H₂ and steam atmospheres, and metal-loaded HZ promoted N transfer to gaseous products. the highest N yield (i.e., NH₃) of 55.6% was obtained from sludge pyrolysis over HZ at 700° in a H₂ atmosphere.

Industrial & Engineering Chemistry Research published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Application of 4,5-Dimethyloxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Bianchi, Federica published the artcileComparison of comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry and gas chromatography-mass spectrometry for the qualitative characterisation of roasted barley by solid-phase microextraction, Name: 4,5-Dimethyloxazole, the publication is Journal of Separation Science (2007), 30(4), 527-533, database is CAplus and MEDLINE.

Volatile compounds of roasted barley used in the production of barley coffee, the most common coffee substitute, were analyzed by using solid-phase microextraction (SPME) followed by GC-MS and comprehensive GC × GC-TOF-MS, resp. The optimized SPME extraction conditions in terms of selection of the fiber coating, extraction time and extraction temperature allowed to obtain the highest GC response, thus enhancing the identification capabilities of the developed method. As for the SPME-GC × GC-TOF-MS anal., 64 compounds with similarity, reverse and probability values above 800, 900 and 6000, resp., were identified, by using a polar × apolar column set combination; in contrast, GC-MS was able to identify a lower number of compounds, i.e. 40 volatiles.

Journal of Separation Science published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Name: 4,5-Dimethyloxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Puvipirom, J. published the artcileContribution of roasted grains and seeds in aroma of oleang (Thai coffee drink), Application In Synthesis of 20662-83-3, the publication is International Food Research Journal (2012), 19(2), 583-588, database is CAplus.

Oleang, a Thai coffee drink, contained roasted robusta coffee and several roasted grains and seeds. In this research the typical ingredients of oleang that were robusta coffee, corn, soybean, rice, sesame and brown sugar, were roasted and studied for their volatile compounds Coffee, corn, sesame, and brown sugar were roasted at 220°C for 20 min and soybean and rice were roasted at 240°C for 20 min. Major aroma compounds from roasted com were 2-furfurylthiol, furfural, 2-methoxyphenol, hexanal, and alkylpyrazines. Soybean contributed mostly pyrazines and phenols similar to those of coffee. The roasted rice had strong sulfurous and burnt characteristics but was low in concentrations of the volatile compounds The roasted sesame was most abundant in the numbers of aroma compounds provided di-Me trisulfide, di-Me disulfide, 2-furfurylthiol, 3-ethyl-2,5-dimethylpyrazine, and 2-methoxyphenol to oleang. Sixteen oleang formulations were evaluated for their sensory preference. The samples were composed of 5% brown sugar, coffee (50, 60, 70, and 80%) with various corn: soybean: rice: sesame ratios (2:3:0:0, 3:2:0:0, 3:1:1:0, and 3:1:0:1). The most preferred formulation for oleang was 50% coffee, 5% brown sugar, and 45% grain mixture that had the corn: soybean: rice: sesame ratio of 3:1:1:0.

International Food Research Journal published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Application In Synthesis of 20662-83-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Yang, Ke published the artcileCobalt-Catalyzed Decarboxylative 2-Benzoylation of Oxazoles and Thiazoles with α-Oxocarboxylic Acids, Recommanded Product: 5-(4-Bromophenyl)oxazole, the publication is Journal of Organic Chemistry (2015), 80(21), 11065-11072, database is CAplus and MEDLINE.

Cobalt-catalyzed decarboxylative cross-coupling of oxazoles and thiazoles with α-oxocarboxylic acids was developed through an sp² C-H bond functionalization process. This work represents the first example of cobalt-catalyzed decarboxylative C-H bond functionalization and provides an efficient means of building some important bioactive heteroaryl ketone derivatives

Journal of Organic Chemistry published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C16H20N2, Recommanded Product: 5-(4-Bromophenyl)oxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem