Category: oxazolidine

Yang, Ruiyang published the artcileSynthesis and application of chiral bidentate N-donor ligands, 2,2′-bis(oxazolines), Category: oxazolidine, the publication is Huaxue Xuebao (1991), 49(10), 1038-40, database is CAplus.

The chiral bidentate ligands I (R = Me₂CH, PhCH₂, CH₂CHMe₂) were prepared from RCH(NH₂)CH₂OH by condensation with di-Et oxalate, chlorination with SOCL₂, and cyclization of the resulting chlorides II with MeONa. The use of I in asym. hydroxylation of PhCH:CHPh, PhCH:CH₂, and 1-phenlcyclohexene with OsO₄ was reported.

Huaxue Xuebao published new progress about 138429-17-1. 138429-17-1 belongs to oxazolidine, auxiliary class BOX Ligands, name is (4S,4’S)-4,4′-Diisobutyl-4,4′,5,5′-tetrahydro-2,2′-bioxazole, and the molecular formula is C10H10O6, Category: oxazolidine.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Kim, Tae Sung published the artcileActivity of LCB01-0371, a novel oxazolidinone, against Mycobacterium abscessus, HPLC of Formula: 1219707-39-7, the publication is Antimicrobial Agents and Chemotherapy (2017), 61(9), e02752-16/1-e02752-16/12, database is CAplus and MEDLINE.

Mycobacterium abscessus is a highly pathogenic drug-resistant rapidly growing mycobacterium. In this study, we evaluated the in vitro, intracellular, and in vivo activities of LCB01-0371, a novel and safe oxazolidinone derivative, for the treatment of M. abscessus infection and compared its resistance to that of other oxazolidinone drugs. LCB01-0371 was effective against several M. abscessus strains in vitro and in a macrophage model of infection. In the murine model, a similar efficacy to linezolid was achieved, especially in the lungs. We induced laboratory-generated resistance to LCB01-0371; sequencing anal. revealed mutations in rplC of T424C and G419A and a nucleotide insertion at the 503 position. Furthermore, LCB01-0371 inhibited the growth of amikacin-, cefoxitin-, and clarithromycin-resistant strains. Collectively, our data indicate that LCB01-0371 might represent a promising new class of oxazolidinones with improved safety, which may replace linezolid for the treatment of M. abscessus.

Antimicrobial Agents and Chemotherapy published new progress about 1219707-39-7. 1219707-39-7 belongs to oxazolidine, auxiliary class Other Aliphatic Heterocyclic,Oxazolidine,Chiral,Fluoride,Benzene,Amide,Alcohol,Anti-infection, name is (R)-3-(3-Fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one, and the molecular formula is C14H17FN4O3, HPLC of Formula: 1219707-39-7.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Liu, Wei published the artcileA Strategy for the Synthesis of Sulfonamides on DNA, Name: 5-(4-Bromophenyl)oxazole, the publication is Organic Letters (2019), 21(24), 9909-9913, database is CAplus and MEDLINE.

An efficient method is reported to synthesize sulfonamides on DNA from sulfinic acids or sodium sulfinates and amines in the presence of iodine under mild conditions. This method demonstrates a major expansion of scope of sulfonamide formation on DNA through the utilization of a novel sodium carbonate-sodium sulfinate bifunctional reagent class.

Organic Letters published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Name: 5-(4-Bromophenyl)oxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Bowie, J. H. published the artcileElectron impact studies. XXIII. Mass spectra of some alkyl and aryl oxazoles, Formula: C5H7NO, the publication is Organic Mass Spectrometry (1968), 1(1), 13-29, database is CAplus.

The mass spectra of a variety of alkyl and aryl oxazoles have been determined and the spectra analyzed with the aid of D labeling and high resolution mass spectrometry. In contrast to the corresponding benzenoid compounds, the mass spectra of isomeric alkyl oxazoles are distinctive and in this respect are akin to those of the corresponding pyridines. Further analogy to the pyridines is suggested by the unfavorable nature of a carbonium ion adjacent to the 2-position and this effect may be used to locate alkyl substituents attached to the oxazole nucleus. The loss of CO from the mol. ions of 2,5-disubstituted oxazoles probably occurs with ring opening and migration of the C-5 substituent (e.g., Br) to the C-4 position. 22 references.

Organic Mass Spectrometry published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Formula: C5H7NO.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Beatty, Joel W. published the artcileA scalable and operationally simple radical trifluoromethylation, Product Details of C9H6BrNO, the publication is Nature Communications (2015), 7919pp., database is CAplus and MEDLINE.

The large number of reagents that was developed for the synthesis of trifluoromethylated compounds was a testament to the importance of the CF₃ group as well as the associated synthetic challenge. Current state-of-the-art reagents for appending the CF₃ functionality directly were highly effective; however, their use on preparative scale had minimal precedent because they required multistep synthesis for their preparation, and/or were prohibitively expensive for large-scale application. For a scalable trifluoromethylation methodol., trifluoroacetic acid and its anhydride represented an attractive solution in terms of cost and availability; however, because of the exceedingly high oxidation potential of trifluoroacetate, previous endeavours to use this material as a CF₃ source was required the use of highly forcing conditions. A strategy for the use of trifluoroacetic anhydride for a scalable and operationally simple trifluoromethylation reaction using pyridine N-oxide and photoredox catalysis to affect a facile decarboxylation to the CF₃ radical was reported.

Nature Communications published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Product Details of C9H6BrNO.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Bento-Silva, Andreia published the artcileComprehensive two-dimensional gas chromatography as a powerful strategy for the exploration of Broas volatile composition, SDS of cas: 20662-83-3, the publication is Molecules (2022), 27(9), 2728, database is CAplus and MEDLINE.

Broa is a Portuguese maize bread with characteristic sensory attributes that can only be achieved using traditional maize varieties. This study intends to disclose the volatile compounds that are mainly associated with the baking process of broas, which can be important contributors to their aroma. Twelve broas were prepared from twelve maize flours (eleven traditional maize varieties and one com. hybrid). Their volatile compounds were analyzed by GCxGC-ToFMS (two-dimensional gas chromatog. coupled with time-of-flight mass spectrometry) for an untargeted screening of the chem. compounds mainly formed during baking. It was possible to identify 128 volatiles that belonged to the main chem. families formed during this stage. Among these, only 16 had been previously detected in broas. The most abundant were furans, furanones, and pyranones, but the most relevant for the aroma of broas were ascribed to sulfur-containing compounds, in particular di-Me trisulfide and methanethiol. Pyrazines might contribute neg. to the aroma of broas since they were present in higher amounts in the com. broa. This work constitutes the most detailed study of the characterization of broas volatile compounds, particularly those formed during the Maillard reaction. These findings may contribute to the characterization of other maize-based foodstuffs, ultimately improving the production of foods with better sensory features.

Molecules published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, SDS of cas: 20662-83-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Mahadevan, Kritika published the artcileKey Odor Impact Compounds in Three Yeast Extract Pastes, Application In Synthesis of 20662-83-3, the publication is Journal of Agricultural and Food Chemistry (2006), 54(19), 7242-7250, database is CAplus and MEDLINE.

Three types of yeast extract pastes from 2 different suppliers were compared. Compounds responsible for the key odors include 2-methyl-3-furanthiol, 2-methyl-3-methyldithiofuran, methional, 1-octen-3-one, di-Me trisulfide together with a number of pyrazines, thiophenes, and aliphatic compounds The 3 types of yeast extract paste differed in the intensity of their main odors and, in particular, those caused by furans, furanthiols, and heterocyclic sulfur compounds Not only do pastes from different suppliers differ in terms of odor volatiles, but so do different treatments and batches of yeast extract from one supplier. The results suggest that normal variations in the concentrations of precursors and processing conditions may cause variations in the flavor of the end product.

Journal of Agricultural and Food Chemistry published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Application In Synthesis of 20662-83-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Qin, Xurong published the artcileCopper(II)-catalyzed dehydrogenative cross-coupling between two azoles, COA of Formula: C9H6BrNO, the publication is Journal of Organic Chemistry (2012), 77(17), 7677-7683, database is CAplus and MEDLINE.

The copper(II)-catalyzed dehydrogenative coupling between two different azoles for the preparation of unsym. biazoles e. g., I has been developed. The current catalytic system can effectively control the chemoselectivity for heterocoupling over homocoupling.

Journal of Organic Chemistry published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, COA of Formula: C9H6BrNO.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Yonezawa, Yasushi published the artcileDesymmetrization of meso-methylenecyclopropanes by a palladium-catalyzed asymmetric ring-opening bis(alkoxycarbonylation) reaction, Name: (4S,4’S)-4,4′-Diisobutyl-4,4′,5,5′-tetrahydro-2,2′-bioxazole, the publication is Tetrahedron: Asymmetry (2014), 25(12), 936-943, database is CAplus.

Desymmetrization of various meso-(methylene)cyclopropane derivatives was accomplished by a palladium-catalyzed asym. ring-opening bis(alkoxycarbonylation) reaction using a chiral bis[oxazole] ligand. The reaction proceeded smoothly in the presence of copper(I) triflate under carbon monoxide and oxygen at ambient pressure to give the corresponding optically active α-(methylene)glutarate derivatives with up to 60% ee. Desymmetrization of protected meso-(3-methylenecyclopropane-1,2-diyl)dimethanol derivatives was also carried out to give enantioenriched highly oxygen-functionalized α-(methylene)glutaric acid esters. Under optimized conditions the synthesis of the target compounds was achieved using palladium chloride (PdCl₂) and , (4S,4′S)-4,4′,5,5′-tetrahydro-4,4′-bis(phenylmethyl)-2,2′-bioxazole as catalyst and ligand combination. Starting materials included 7-(methylene)bicyclo[4.1.0]heptane, (1R,8S)-rel-9-(methylene)bicyclo[6.1.0]nonane, rel-1,1′-[[(1R,2S)-3-methylene-1,2-cyclopropanediyl]bis(methyleneoxymethylene)]bis[benzene].

Tetrahedron: Asymmetry published new progress about 138429-17-1. 138429-17-1 belongs to oxazolidine, auxiliary class BOX Ligands, name is (4S,4’S)-4,4′-Diisobutyl-4,4′,5,5′-tetrahydro-2,2′-bioxazole, and the molecular formula is C14H10O4S2, Name: (4S,4’S)-4,4′-Diisobutyl-4,4′,5,5′-tetrahydro-2,2′-bioxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Wen, Shu′an published the artcileComparison of the in vitro activity of linezolid, tedizolid, sutezolid, and delpazolid against rapidly growing mycobacteria isolated in Beijing, China, Computed Properties of 1219707-39-7, the publication is International Journal of Infectious Diseases (2021), 253-260, database is CAplus and MEDLINE.

The natural resistance of rapidly growing mycobacteria (RGM) to multiple antibiotics renders the treatment of the infections caused less successful. The objective of this study was to evaluate the in vitro susceptibilities of four oxazolidinones against different RGM species. The microplate alamarBlue assay was performed to identify the min. inhibitory concentrations (MICs) of four oxazolidinones as delpazolid, sutezolid, tedizolid, and linezolid for 32 reference strains and 115 clin. strains of different RGM species. The MIC breakpoint concentration was defined as 16 μg/mL for linezolid. Next, the gene fragments associated with oxazolidinone resistance were amplified and sequenced, and mutations were defined in contrast with the sequences of the reference strains. Tedizolid showed the strongest inhibitory activity against the Mycobacterium abscessus isolates. Delpazolid exhibited better antimicrobial activity against the Mycobacterium fortuitum isolates when compared to linezolid, with 4-fold lower MIC values. The protein alignment and structure-based anal. showed that there might be no correlation between oxazolidinone resistance and mutations in the rplC, rplD, and 23S rRNA genes in the tested RGM. Tedizolid had the strongest inhibitory activity against M. abscessus in vitro, while delpazolid presented the best inhibitory activity against M. fortuitum. This provides important insights into the potential clin. application of oxazolidinones to treat RGM infections.

International Journal of Infectious Diseases published new progress about 1219707-39-7. 1219707-39-7 belongs to oxazolidine, auxiliary class Other Aliphatic Heterocyclic,Oxazolidine,Chiral,Fluoride,Benzene,Amide,Alcohol,Anti-infection, name is (R)-3-(3-Fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one, and the molecular formula is C8H14O4, Computed Properties of 1219707-39-7.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem