Category: oxazolidine

On November 30, 1985, Hamaguchi, Shigeki; Yamamura, Hiroshi; Hasegawa, Junzo; Watanabe, Kyoshi published a patent.Computed Properties of 97859-49-9 The title of the patent was Enzymic separation of optical isomers of 2-oxazolidinones. And the patent contained the following:

(R,S)-5-Acyloxymethyloxazolidin-2-ones I (R1 = H, (un)substituted aryl; R2 = (un)substituted alkyl) are treated with stereoselective esterases or microorganisms containing these enzymes to yield optically active 5-hydroxymethyloxazolidin-2-ones (II) and optically active but unreacted I (III). II and III are precursors for antibiotics. Thus, Pseudomonas aeruginosa lipoprotein lipase (L.P.L. Amano 3) 0.5 g and (R,S)-5-butanoyloxymethyloxazolidin-2-one 18.7 g were dissolved in 100 mL 0.1M phosphate buffer, pH 7.0. The mixture was stirred at 30° for 12 h. EtOAc extraction and fractionation by silica gel column chromatog. of the mixture yielded (R)-5-hydroxymethyloxazolidin-2-one and (S)-5-butanoyloxymethyloxazolidin-2-one (IV). The hydrolysis of IV (4 g) with NaOH yielded (S)-5-hydroxymethyloxazolidin-2-one (1.8 g). The experimental process involved the reaction of (R)-5-(Hydroxymethyl)oxazolidin-2-one(cas: 97859-49-9).Computed Properties of 97859-49-9

The Article related to acyloxymethyloxazolidinone optical isomer separation esterase, oxazolidinone isomer separation esterase, Fermentation and Bioindustrial Chemistry: Industrial Chemicals and other aspects.Computed Properties of 97859-49-9

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On June 23, 2016, Musicki, Branislav published a patent.Safety of (R)-5-(Hydroxymethyl)oxazolidin-2-one The title of the patent was Preparation of benzenesulfonamide derivatives as inverse agonists of retinoid-related orphan receptor gamma. And the patent contained the following:

The invention relates to the preparation of benzenesulfonamide derivatives I, wherein q is an integer 0-3; L is a bond, CH2; R1 is alkyl, cycloalkyl, alkenyl, alkyl-cycloalkyl, alkyl-heterocycloalkyl; R2 is H, halogen, alkyl, alkenyl, alkoxy, CN; R3 is H, alkyl, NH2; R4 is H, alkyl, alkoxy, ether, alkyl-amino-alkyl; A1 is substituted amine, O, S, SO, SO2, SO(=NH), CH2, C=C, alkylidene; A2 is bond, S, SO, SO2, sulfonimide, CH(OH), C(=O)O; Q1-Q5 are independently N, alkylidene, and the pharmaceutically acceptable addition salts thereof, the hydrates and/or solvates thereof, and the use of same as inverse agonists of retinoid-related orphan receptor gamma (RORγt). Thus, benzenesulfonamide II was prepared and tested in vitro as inverse agonist of retinoid-related orphan receptor gamma (IC50 = 100 nM – 1 μM). The invention also relates to pharmaceutical compositions comprising such compounds, as well as to the use thereof for the topical and/or oral treatment of RORγt receptor-mediated inflammatory diseases, in particular acne, psoriasis and/or atopic dermatitis. The experimental process involved the reaction of (R)-5-(Hydroxymethyl)oxazolidin-2-one(cas: 97859-49-9).Safety of (R)-5-(Hydroxymethyl)oxazolidin-2-one

The Article related to human interleukin acne benzenesulfonamide preparation, cosmetic atopic dermatitis psoriasis antiinflammatory receptor acne benzenesulfonamide preparation, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.Safety of (R)-5-(Hydroxymethyl)oxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On June 24, 2016, Musicki, Branislav published a patent.SDS of cas: 97859-49-9 The title of the patent was Preparation of benzenesulfonamide derivatives as inverse agonists of retinoid-related orphan receptor gamma. And the patent contained the following:

The invention relates to the preparation of benzenesulfonamide derivatives I, wherein m is an integer 0-3; L is a bond, CH2; R1 is alkyl, cycloalkyl, alkenyl, alkyl-cycloalkyl, alkyl-heterocycloalkyl; R2 is H, halogen, alkyl, alkenyl, alkoxy, CN; R3 is H, alkyl, NH2; R4 is H, alkyl, alkoxy, ether, alkyl-amino-alkyl; A1 is substituted amine, O, S, SO, SO2, SO(=NH), CH2, C=C, alkylidene; A2 is bond, S, SO, SO2, sulfonimide, CH(OH), C(=O)O; Q1-Q5 are independently N, alkylidene, and the pharmaceutically acceptable addition salts thereof, the hydrates and/or solvates thereof, and the use of same as inverse agonists of retinoid-related orphan receptor gamma (RORγt). Thus, benzenesulfonamide II was prepared and tested in vitro as inverse agonist of retinoid-related orphan receptor gamma (IC50 = 100 nM – 1 μM). The invention is also relative to a composition pharmaceutical including such compounds like its use for the treatment by way topics and/or oral of the inflammatory diseases in particular the acne, the psoriasis and/or the atopic dermatitis. The experimental process involved the reaction of (R)-5-(Hydroxymethyl)oxazolidin-2-one(cas: 97859-49-9).SDS of cas: 97859-49-9

The Article related to cosmetic atopic dermatitis psoriasis antiinflammatory receptor acne benzenesulfonamide preparation, human interleukin acne benzenesulfonamide preparation, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.SDS of cas: 97859-49-9

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On June 30, 2016, Shiers, Jason John; Watts, John Paul; Onions, Stuart Thomas; Abdul Quddus, Mohammed; Wrigglesworth, Joseph William; Sambrook-Smith, Colin Peter; Naylor, Alan; Londesbrough, Derek published a patent.Synthetic Route of 168297-86-7 The title of the patent was Preparation of pyridine, pyridazine and triazine derivatives for the treatment of cancer and/or other diseases. And the patent contained the following:

Title compounds I [one of Q1 and Q2 = N and the other = CH, or both Q1 and Q2 = N, and Q3 = CH; or Q1 , Q2 and Q3 = N; A = (un)substituted five- or six-membered aromatic ring; R1 = aliphatic carbocyclic or heterocyclic ring; R2 = H, alkyl or halo; R3 = aryl or heteroaryl; R5 and R6 independently = H or alkyl] and their pharmaceutically acceptable salts, are prepared and disclosed for the treatment of cancer. Thus, II was prepared in a multi-step synthesis starting from Et 2-(trans-4-aminocyclohexyl)acetate hydrochloride with CbzCl. Compounds of the invention were tested for their inhibitory activity in Akt activation assay, e.g., compound II showed IC50 value of 780 nM, 110 nM and 15 nM against Akt1 and Akt2 and Akt3. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Synthetic Route of 168297-86-7

The Article related to pyridine pyridazine triazine preparation cancer, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.Synthetic Route of 168297-86-7

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On January 31, 2008, Wang, Guijun published an article.Application of 97859-49-9 The title of the article was Synthesis and antibacterial properties of oxazolidinones and oxazinanones. And the article contained the following:

A review. Oxazolidinones are important synthetic antibacterial agents useful for the treatment of multi-antibiotic resistant Gram-pos. bacterial infections. Since the launch of Linezolid, the first member of the oxazolidinone antibacterial family, there have been many studies directed towards structural optimization and the development of second generation oxazolidinones. The N-aryl 5-acetamido Me oxazolidinone is the core structure for this class of antibacterial agents and the oxazolidinone component is essential for antibacterial activities. The chiral cyclic carbamates, 5-hydroxymethyl-oxazolidin-2-one and 6-hydroxymethyl-[1,3]oxazinan-2-one, are also important building blocks for synthesizing other biol. active compounds Because of the importance of these compounds, many methods have been developed for their facile syntheses. In the first part of this paper, the synthesis of linezolid and its analogs, as well as the preparation of the oxazolidinone core structures, will be reviewed. Secondly, recent developments in the area of oxazolidinone antibacterial agents including structure-activity relationships (SAR) will be reviewed. The experimental process involved the reaction of (R)-5-(Hydroxymethyl)oxazolidin-2-one(cas: 97859-49-9).Application of 97859-49-9

The Article related to review oxazolidinone oxazinanone substituted preparation linezolid analog antibacterial agent, Heterocyclic Compounds (More Than One Hetero Atom): Reviews and other aspects.Application of 97859-49-9

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On February 3, 2003, Ortiz, Aurelio; Quintero, Leticia; Hernandez, Hector; Maldonado, Sotero; Mendoza, Guadalupe; Bernes, Sylvain published an article.Recommanded Product: 168297-86-7 The title of the article was (S)-4-Isopropyl-5,5-dimethyl-1,3-oxazolidinethione as chiral auxiliary for the intramolecular sulfur transfer in α,β-unsaturated N-acylimides, promoted by NbCl5. And the article contained the following:

The 1,3-oxazolidinethione was synthesized from (S)-valine and used in the intramol. S transfer in its N-enoyl derivatives in the presence of NbCl5 as catalyst, which, also, works as an indicator of the reaction. The adducts have subsequently been transformed into the corresponding β-mercapto esters by action of Sm(OTf)3 in MeOH. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).Recommanded Product: 168297-86-7

The Article related to oxazolidinethione preparation reactivity, crystal structure oxazolidinethione derivative, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Recommanded Product: 168297-86-7

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On August 19, 2002, Sciotti, Richard J.; Pliushchev, Marina; Wiedeman, Paul E.; Balli, Darlene; Flamm, Robert; Nilius, Angela M.; Marsh, Kennan; Stolarik, DeAnne; Jolly, Robert; Ulrich, Roger; Djuric, Stevan W. published an article.Reference of (R)-5-(Hydroxymethyl)oxazolidin-2-one The title of the article was The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class. And the article contained the following:

A novel series of antimicrobials of the oxazolidinone class is disclosed. These compounds are characterized relative to previously described analogs by a ‘halostilbene-derived’ pharmacophore and demonstrate enhanced antimicrobial activity against key Gram-pos. pathogens when compared to Linezolid. The experimental process involved the reaction of (R)-5-(Hydroxymethyl)oxazolidin-2-one(cas: 97859-49-9).Reference of (R)-5-(Hydroxymethyl)oxazolidin-2-one

The Article related to antimicrobial oxazolidinone compound preparation biol evaluation, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Reference of (R)-5-(Hydroxymethyl)oxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On June 30, 2000, Bew, Sean P.; Davies, Stephen G.; Fukuzawa, Shin-Ichi published an article.COA of Formula: C8H15NO2 The title of the article was Kinetic resolution of α-acetoxy carboxylic acids with homochiral SuperQuats. And the article contained the following:

Preliminary investigations focused on the kinetic resolution of (±)-O-acetyl mandelic acid chloride with iso-Pr SuperQuat and iso-Pr Evans’ homochiral auxiliaries. The addition of 2 equiv of the acid chloride to the lithium salts of the auxiliaries (SuperQuat and Evans’) at -100° in THF afforded the N-acyl auxiliaries in high chem. yields (95 and 89%) and d.e.’s of 66 and 40%, resp. Using the same mandelic acid chloride but incorporating SuperQuat auxiliaries derived from (S)-phenylglycine and (S)-phenylalanine gave the N-acyl SuperQuats in 86 and 90% yield and d.e.’s of 66 and 30%, resp. Replacing the Ph group in the O-acetyl mandelic acid chloride with a Bu, tert-Bu, or cyclohexyl group changed the d.e. significantly when kinetically resolved with iso-Pr SuperQuat. The yields were all similar, i.e., ∼90%, but the d.e.’s varied considerably, with values of 20, 50, and 82%, resp. Attempted kinetic resolution of α-methoxy-phenylacetyl chloride using the lithium salt of iso-Pr SuperQuat revealed a diastereoselectivity of 45%, significantly lower than that obtained with the corresponding α-acetoxy carboxylic acid chlorides. The experimental process involved the reaction of (S)-4-Isopropyl-5,5-dimethyloxazolidin-2-one(cas: 168297-86-7).COA of Formula: C8H15NO2

The Article related to acetoxy acid chloride kinetic resolution superquat, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.COA of Formula: C8H15NO2

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On May 31, 1995, Danielmeier, Karsten; Steckhan, Eberhard published an article.Quality Control of (R)-5-(Hydroxymethyl)oxazolidin-2-one The title of the article was Efficient pathways to (R)- and (S)-5-hydroxymethyl-2-oxazolidinone and some derivatives. And the article contained the following:

Two new syntheses of enantiomerically pure (R)- and (S)-5-hydroxymethyl-2-oxazolidinone have been developed starting with D-mannitol, L-ascorbic acid and (R)- or (S)-malic acid. (R)- and (S)-5-hydroxymethyl-2-oxazolidinone have been used to synthesize some new homochiral 2-oxazolidinone derivatives The experimental process involved the reaction of (R)-5-(Hydroxymethyl)oxazolidin-2-one(cas: 97859-49-9).Quality Control of (R)-5-(Hydroxymethyl)oxazolidin-2-one

The Article related to oxazolidinone derivative enantiomerically pure, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Quality Control of (R)-5-(Hydroxymethyl)oxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

On March 24, 2005, Hagen, Susan Elizabeth; Josyula, Vara Prasad Venkata Nagendra published a patent.Recommanded Product: (R)-5-(Hydroxymethyl)oxazolidin-2-one The title of the patent was Preparation of substituted quinolones and derivatives thereof as antibacterial agents. And the patent contained the following:

Title compounds I [Z2 = aminocarbonyl, carbonylamino, CN; either D = N, E = C, F = CH or D = CH, E = N, F = CH2 if — is absent; J, K, Q = (un)substituted alkyl, N with provisions; n = 0-2; at least one of W, X, Y = NP; P = substituted quinolone] are prepared For instance, II is prepared from 8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid boron difluoride chelate and N-[2-oxo-3-(2,3,4,5-tetrahydro-1H-benzo[c]azepin-7-yl)oxazolidin-5-ylmethyl]acetamide to give an intermediate borate ester which is converted to the final product upon treatment with Et3N, water at reflux for 18 h. II has MIC 1 μg/mL against E. Faecalis and 0.06 μg/mL against S. aureus. I are useful for the treatment of bacterial infections. The experimental process involved the reaction of (R)-5-(Hydroxymethyl)oxazolidin-2-one(cas: 97859-49-9).Recommanded Product: (R)-5-(Hydroxymethyl)oxazolidin-2-one

The Article related to antibacterial agent quinolone preparation, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Recommanded Product: (R)-5-(Hydroxymethyl)oxazolidin-2-one

Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem