Category: oxazolidine

SDS of cas: 70-23-5. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Synthesis of tubuvaline (Tuv) fragment of tubulysin via diastereoselective dihydroxylation of homoallylamine.

Tubulysins are natural anticancer mols. that directly bind and inhibit tubulin polymerization in actively dividing cells leading to apoptosis and cell death. Structurally, tubulysins are linear tetrapeptides, constituted by a natural amino acid (Ile) and three non-canonical amino acids (Mep, Tuv, and Tup). Herein, we report a convenient strategy for the practical synthesis of tubuvaline fragment of tubulysin natural products. In this approach, we describe the regioselective ring opening of a chiral aziridine with vinyl Grignard reagent to obtain (R)-tert-butyl(2-methylhex-5-en-3-yl)(tosyl)carbamate which was further subjected to Sharpless asym. dihydroxylation with AD-mix-β resulting in the formation of (2 R,4R)-4-((tert-butoxycarbonyl)amino)-2-(methoxymethoxy)-5-methylhexanoic acid that was finally transformed to tubuvaline by heterocyclization.

This compound(Ethyl 3-bromo-2-oxopropanoate)SDS of cas: 70-23-5 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Zeng, Hongyun; Zhang, Jun-gan; Hong, Wei published an article about the compound: Ethyl 3-bromo-2-oxopropanoate( cas:70-23-5,SMILESS:O=C(OCC)C(CBr)=O ).HPLC of Formula: 70-23-5. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:70-23-5) through the article.

Thiazole ring is an important five-membered aromatic heterocyclic ring, and its derivatives have various biol. activities and are widely used in medicine. The synthesis of 2,5-diarylthiazole derivatives by acylation, thiolation, cyclization and Heck reaction using inexpensive and readily available substituted benzoic acid as raw materials was developed. The key point was to optimize the Heck reaction conditions and explore the possible reaction mechanism. The method has mild reaction conditions, simple operation, and good substrate universality, which provides a new direction for the synthesis of 2,5-diaryl substituted thiazoles.

This compound(Ethyl 3-bromo-2-oxopropanoate)HPLC of Formula: 70-23-5 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Experimental therapy of stomach ulcers in rats》. Authors are Akimov, A. A.; Pazarev, N. V..The article about the compound:6-Hydroxy-2-methylpyrimidin-4(3H)-onecas:1194-22-5,SMILESS:CC1=NC(=CC(N1)=O)O).Safety of 6-Hydroxy-2-methylpyrimidin-4(3H)-one. Through the article, more information about this compound (cas:1194-22-5) is conveyed.

Gastric ulcers were induced in rats by repeated administration of caffeine by a gastric sonde. Animals were then treated with 4-methyluracil (I), dihydrouracil, dihydro-4-methyluracil, 5-hydroxy-4-methyluracil, thymine, 4,6-dihydroxypyrimidine (II), 2-methyl-4,6-dihydroxypyrimidine (III), cytosine (IV), 4-amino-6-hydroxypyrimidine, or 2-amino-6-oxy-4-methylpyrimidine (all compounds given by gastric sonde, 50 mg./kg.). A 42-72% reduction of ulcers followed the treatment of animals with I, II, III, and IV; with all other compounds the effect was not significant. Combined treatment of rats with I and III, or I and IV was most effective. Higher doses of all compounds tested had a smaller therapeutic effect. Pyrimidines apparently stimulate regenerative processes and thus complement the effect of other therapeutics in the treatment of gastric ulcers.

This compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one)Safety of 6-Hydroxy-2-methylpyrimidin-4(3H)-one was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Jiang, Jie; Seel, Catharina Julia; Temirak, Ahmed; Namasivayam, Vigneshwaran; Arridu, Antonella; Schabikowski, Jakub; Baqi, Younis; Hinz, Sonja; Hockemeyer, Joerg; Mueller, Christa E. published the article 《A2B Adenosine Receptor Antagonists with Picomolar Potency》. Keywords: A2B adenosine receptor antagonist benzenesulfonamide.They researched the compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone( cas:67914-60-7 ).Computed Properties of C12H16N2O2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:67914-60-7) here.

The A2B adenosine receptor (A2BAR) was proposed as a novel target for the (immuno)therapy of cancer since A2BAR blockade results in antiproliferative, anti-angiogenic, anti-metastatic, and immuno-stimulatory effects. In this study, we explored the structure-activity relationships of xanthin-8-yl-benzenesulfonamides mainly by introducing a variety of linkers and substituents attached to the sulfonamide residue. A new, convergent strategy was established which facilitated the synthesis of the target compounds Many of the new compounds exhibited subnanomolar affinity for the A2BAR combined with high selectivity. Functional groups were introduced which will allow the attachment of dyes and other reporter groups. 8-(4-((4-(4-Bromophenyl)piperazin-1-yl)sulfonyl)phenyl)-1-propylxanthine (34, PSB-1901) was the most potent A2B-antagonist (Ki 0.0835 nM, KB 0.0598 nM, human A2BAR) with >10,000-fold selectivity vs. all other AR subtypes. It was similarly potent and selective at the mouse A2BAR, making it a promising tool for preclin. studies. Computational studies predicted halogen bonding to contribute to the outstanding potency of 34.

This compound(1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone)Computed Properties of C12H16N2O2 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2,6-Dichloropurine(SMILESS: C2=NC1=C(C(=NC(=N1)Cl)Cl)[NH]2,cas:5451-40-1) is researched.Related Products of 1194-22-5. The article 《System-oriented optimization of multi-target 2,6-diaminopurine derivatives: Easily accessible broad-spectrum antivirals active against flaviviruses, influenza virus and SARS-CoV-2》 in relation to this compound, is published in European Journal of Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:5451-40-1).

The worldwide circulation of different viruses coupled with the increased frequency and diversity of new outbreaks, strongly highlight the need for new antiviral drugs to quickly react against potential pandemic pathogens. Broad-spectrum antiviral agents (BSAAs) represent the ideal option for a prompt response against multiple viruses, new and re-emerging. Starting from previously identified anti-flavivirus hits, we report herein the identification of promising BSAAs by submitting the multi-target 2,6-diaminopurine chemotype to a system-oriented optimization based on phenotypic screening on cell cultures infected with different viruses. Among the synthesized compounds, 6i showed low micromolar potency against Dengue, Zika, West Nile and Influenza A viruses (IC50 = 0.5-5.3μM) with high selectivity index. Interestingly, 6i also inhibited SARS-CoV-2 replication in different cell lines, with higher potency on Calu-3 cells that better mimic the SARS-CoV-2 infection in vivo (IC50 = 0.5μM, SI = 240). The multi-target effect of 6i on flavivirus replication was also analyzed in whole cell studies (in vitro selection and immunofluorescence) and against isolated host/viral targets.

Different reactions of this compound(2,6-Dichloropurine)Reference of 2,6-Dichloropurine require different conditions, so the reaction conditions are very important.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Reference of Ethyl 3-bromo-2-oxopropanoate. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Comparative evaluation of the inhibitory potential of synthetic N-heterocycles, Cu/Fe3O4@SiO2 nanocomposites and some natural products against non-resistant and antibiotic-resistant Acinetobacter baumannii. Author is Mardaneh, Jalal; Beyzaei, Hamid; Hashemi, Seyed Hadi; Ghasemi, Behzad; Rahdar, Abbas.

Acinetobacter baumannii is a common infectious agent in hospitals. New antimicrobial agents are identified and prepared to combat these bacterial pathogens. In this context, the blocking potentials of a series of synthesized N-heterocyclic compounds, Cu/Fe3O4@SiO2 nanocomposites, glycine, poly-L-lysine, nisin and hydroalcoholic extracts of Trachyspermum ammi, Curcuma longa and green tea catechins were evaluated against non-resistant and multidrug-resistant strains of A. baumannii. Solutions of heterocyclic derivatives and hydroalcoholic extracts of Trachyspermum ammi, Curcuma longa and green tea catechins were prepared at initial concentration of 10240μg ml-1 in 10% DMSO. Other compounds were dissolved in water at the same concentrations Their in vitro inhibitory activity was assessed by determination of IZD, MIC and MBC values. Glycine, poly-L-lysine, nisin, Curcuma longa and green tea catechins extracts, and thiazoles 3a, 3d and 3f were ineffective at their initial concentrations Heterocyclic derivatives 7a-f, 3c, 3e and 3h, Cu/Fe3O4@SiO2 nanocomposites and Trachyspermum ammi extract could block the growth of bacterial strains with IZDs (7.40-15.51 mm), MICs (32-1024μg ml-1) and MBCs (128-2048μg ml-1). Among synthetic chems. and natural products, the best antimicrobial effects were recorded with (E)-2-(5-acetyl-4-methylthiazol-2-yl)-2-(thiazolidin-2-ylidene)acetonitrile (7b) and the extract of Trachyspermum ammi. It is imperative that their toxic and histopathol. effects were assessed in future researches. It is predicted that the essential oil of Trachyspermum ammi will improve its antibacterial activities.

Different reactions of this compound(Ethyl 3-bromo-2-oxopropanoate)Reference of Ethyl 3-bromo-2-oxopropanoate require different conditions, so the reaction conditions are very important.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Computed Properties of C5H7BClNO2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Pyridin-3-ylboronic acid hydrochloride, is researched, Molecular C5H7BClNO2, CAS is 265664-63-9, about Pyridinium boronic acid salts in crystal synthesis. Author is Kara, Hulya; Adams, Christopher J.; Orpen, A. Guy; Podesta, Thomas J..

Salts of pyridinioboronic acids, [HNC5H4B(OH)2-4]2[M(S2C2O2)2]·2H2O (M = Cu 1, Ni 2, Pd 3, Pt 4), [HNC5H4B(OH)2-4]2[Pt(O2C2O2)2] (5); [HNC5H4B(OH)2-3]2 [M(S2C2O2)2] (M = Cu 6, Ni 7, Pd 8, Pt 9) and [HNC5H4B(OH)2-3]2[Pt(O2C2O2)2] (10) were prepared and characterized by x-ray diffraction methods. Salts 2, 3 and 4 are isostructural and isomorphous and contain H-bonded supermols. [pyridinium]2[M(S2C2O2)2] linked by BOH···OB and B(OH)-H2O H bonds into a three-dimensional network. Anhydrous salt 5 has a different structure in which the ions are linked by R(2,2)8 B(OH)2···carboxylate and pyridinium···carboxylate interactions to form a planar H-bonded ribbon. Salts 6, 7, 8 and 10 are all isostructural and isomorphous and contain H-bonded supermols. [pyridinium]2[M(S2C2O2)2] linked by B(OH)2···carboxylate synthons to form a stepped chain. These chains pack in layers superimposed so as to afford short metal···metal contacts of length 3.6-4 Å between layers. The structure of 5 is isomorphous with that of salts 6-8 and 10 but with a different pattern of NH H bonding as a result of the different isomer of pyridinioboronic acid present.

《Pyridinium boronic acid salts in crystal synthesis》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Pyridin-3-ylboronic acid hydrochloride)Computed Properties of C5H7BClNO2.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Recommanded Product: 6-Hydroxy-2-methylpyrimidin-4(3H)-one. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Methods for improvement of the process of synthesis of 1,1-diamino-2,2-dinitro-ethylene from 6-hydroxy-2-methyl-pyrimidin-4(3H)-one and 2-methyl-2-methoxyimidazolidin-4,5-dione. Author is Kushtaev, Aleksandr A.; Yudin, Nikolai V.; Zbarskii, Vitol’d L.; Zhilin, Viktor F..

The nitration kinetics of 6-hydroxy-2-methyl-pyrimidin-4(3H)-one and 2-methoxy-2-methyl-imidazolidone-4,5-dione was investigated. The hydrolysis kinetics of 2-(dinitro-methylene)-5,5- dinitro-pyrimidine-4,6(1 H,3H,5H)-dione and 2-(dinitro-methylene)-imidazolidone-4,5-dione has been studied. These results can be used for 1,1-diamino-2,2-dinitro-ethene technol. creation.

《Methods for improvement of the process of synthesis of 1,1-diamino-2,2-dinitro-ethylene from 6-hydroxy-2-methyl-pyrimidin-4(3H)-one and 2-methyl-2-methoxyimidazolidin-4,5-dione》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(6-Hydroxy-2-methylpyrimidin-4(3H)-one)Recommanded Product: 6-Hydroxy-2-methylpyrimidin-4(3H)-one.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Oxazole( cas:288-42-6 ) is researched.COA of Formula: C3H3NO.Cao, Zhu; Zhang, Huihui; Wu, Xinxin; Li, Yahong; Zhu, Chen published the article 《Radical heteroarylation of unactivated remote C(sp3)-H bonds via intramolecular heteroaryl migration》 about this compound( cas:288-42-6 ) in Organic Chemistry Frontiers. Keywords: heteroarenyl alkanol regioselective radical heteroarylation; heteroaryl alkanone preparation. Let’s learn more about this compound (cas:288-42-6).

The radical-mediated heteroarylation of unactivated remote C(sp3)-H bonds via intramol. heteroaryl migration is achieved, leading to a variety of heteroaryl-substituted aliphatic ketones. A library of O-/S-/N-containing heteroaryls such as benzofuryl, benzothiazolyl, benzothienyl, benzoxazolyl, oxazolyl and thiazolyl are amenable to the migration approach. The heteroaryl migration was triggered by an azido radical-mediated hydrogen atom abstraction from unactivated aliphatic C(sp3)-H bonds. The transformation features mild C-C bond cleavage, good selectivity for tertiary C(sp3)-H bonds and broad functional group compatibility.

《Radical heteroarylation of unactivated remote C(sp3)-H bonds via intramolecular heteroaryl migration》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Oxazole)COA of Formula: C3H3NO.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Computed Properties of C5H7BrO3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Addition of malonic esters to azoalkenes generated in situ from α-bromo- and α-chlorohydrazones. Author is Kokuev, Aleksandr O.; Ioffe, Sema L.; Sukhorukov, Alexey Yu..

Michael addition of malonic esters to azoalkenes, generated in situ from α-bromo- and α-chlorohydrazones, has been accomplished. Both aliphatic and aromatic substrates bearing different functional groups were tolerated. The use of a strong base (sodium hydride) for generation of azoalkenes and deprotonation of malonate was found to be essential for a successful coupling. Synthetic potential of the obtained β-hydrazonoalkylmalonates RNHN:C(R1)CH2CH(CO2R2)2 [R = Ac, Boc, Cbz, 2,4-(O2N)2C6H3; R1 = t-Bu, EtO2C, Ph, 2-naphthyl, 2-thienyl, etc.; R2 = Me, PhCH2] was demonstrated by their smooth conversion into five- and six-membered N-heterocycles, functionalized hydrazides, 2-(2-oxo-2-arylethyl)malonates and 2-arylethylmalonates.

《Addition of malonic esters to azoalkenes generated in situ from α-bromo- and α-chlorohydrazones》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Ethyl 3-bromo-2-oxopropanoate)Computed Properties of C5H7BrO3.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem