Category: oxazolidine

SDS of cas: 7789-45-9. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Cupric bromide, is researched, Molecular Br2Cu, CAS is 7789-45-9, about Geometrical Confinement Modulates the Thermoresponse of a Poly(N-isopropylacrylamide) Brush. Author is Gresham, Isaac J.; Humphreys, Ben A.; Willott, Joshua D.; Johnson, Edwin C.; Murdoch, Timothy J.; Webber, Grant B.; Wanless, Erica J.; Nelson, Andrew R. J.; Prescott, Stuart W..

The structure of grafted-from poly(N-isopropylacrylamide) (PNIPAM) brushes is investigated as a function of confining stress and system temperature using neutron reflectometry (NR), numerical SCF theory, and the reanal. of colloid probe at. force microscopy (AFM) data from the literature. For NR experiments, confinement is achieved using a custom-made sample environment, and the corresponding reflectometry data are analyzed using a novel “”distribution model.”” The NR and AFM experiments probe similar temperature-stress combinations and generally find qual. agreement, with some variations highlighting path-dependent (isostress vs. isothermal, resp.) behavior. All techniques indicate that confinement removes the critical transition point in the thermoresponse of PNIPAM and results in the brush assuming a block-like volume fraction profile with a uniform internal structure. The PNIPAM brushes recover from such treatment, regaining their thermoresponse upon resolvation. Understanding the structure of responsive polymer brushes under confinement is essential, as brush applications are often accompanied by a surface-normal force (i.e., lubrication) and brush properties are dependent on their structure.

Although many compounds look similar to this compound(7789-45-9)SDS of cas: 7789-45-9, numerous studies have shown that this compound(SMILES:[Cu+2].[Br-].[Br-]), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Green synthesis of pyrido[2,1-a]isoquinolines and pyrido[1,2-a]quinolines using Fe3O4-MNPs as efficient nanocatalyst: Study of antioxidant activity, published in 2020, which mentions a compound: 70-23-5, Name is Ethyl 3-bromo-2-oxopropanoate, Molecular C5H7BrO3, Category: oxazolidine.

In this work, synthesis of pyrido[2,1-a]isoquinolines I (R = COOEt, 4-MeOC6H4, 4-MeC6H4, 4-BrC6H4, 4-O2NC6H4) and pyrido[1,2-a]quinolines II (R1 = COOEt, 4-MeOC6H4, 4-MeC6H4) in excellent yields using multicomponent reaction of phthalaldehyde, Me amine, Me malonyl chloride, alkyl bromides, and triphenylphosphine in the presence of catalytic amount of Fe3O4-MNPs and aqueous sodium hydroxide at 80° was investigated. The reduction of ferric chloride solution with Clover Leaf water extract was used for the synthesis of magnetic iron oxide nanoparticles (Fe3O4-MNPs) as a green method. As well, antioxidant activity was studied for the some newly synthesized compounds such as I (R = COOEt, 4-MeC6H4), II (R1 = 4-MeOC6H4, 4-MeC6H4) using the DPPH radical trapping, reducing of ferric ion experiments and comparing results with synthetic antioxidants (TBHQ and BHT). From the results, the above compounds showed good DPPH radical trapping and excellent reducing strength of ferric ion.

Although many compounds look similar to this compound(70-23-5)Category: oxazolidine, numerous studies have shown that this compound(SMILES:O=C(OCC)C(CBr)=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, RSC Advances called The design, synthesis, and in vitro trypanocidal and leishmanicidal activities of 1,3-thiazole and 4-thiazolidinone ester derivatives, Author is Haroon, Muhammad; de Barros Dias, Mabilly Cox Holanda; Santos, Aline Caroline da Silva; Pereira, Valeria Rego Alves; Barros Freitas, Luiz Alberto; Balbinot, Rodolfo Bento; Kaplum, Vanessa; Nakamura, Celso Vataru; Alves, Luiz Carlos; Brayner, Fabio Andre; Leite, Ana Cristina Lima; Akhtar, Tashfeen, which mentions a compound: 70-23-5, SMILESS is O=C(OCC)C(CBr)=O, Molecular C5H7BrO3, Recommanded Product: Ethyl 3-bromo-2-oxopropanoate.

Given this, novel 1,3-thiazoles I (Ar = Ph, 3-chlorophenyl, furan-2-yl, etc.; R = H, Me) and 4-thiazolidinones II (R1 = (phenylmethylidene)aminyl, [(4-hydroxy-3-methoxyphenyl)methylidene]aminyl, 1,2,3,4-tetrahydronaphthalen-1-iminyl, etc.; R2 = Me, Et) using bioisosteric and esterification strategies to develop improved and safer drug candidates were synthesized. Then, in vitro assays were performed, against Leishmania infantum and Leishmania amazonensis promastigotes, Trypanosoma cruzi trypomastigotes and amastigotes, for selected compounds I and II to determine IC50 and SI, with cytotoxicity on LLC-MK2 cell lines. Overall, 1,3-thiazoles I exhibited better trypanocidal activity than 4-thiazolidinones II. The compound I[Ar = 2-bromophenyl, R = H] (III), an ortho-bromobenzylidene-substituted 1,3-thiazole (IC50 = 0.83μM), is the most potent of them all. In addition, compounds I and II had negligible cytotoxicity in mammalian cells (CC50 values > 50μM). Also noteworthy is the examination of the cell death mechanism of T. cruzi, which showed that compound III induced necrosis and apoptosis in the parasite. SEM anal. demonstrated that the treatment of Trypanosoma cruzi trypomastigote cells with the compound III at different IC50 concentrations promoted alterations in the shape, flagella and body surface, inducing parasite death. Together, the data revealed a novel series of 1,3-thiazole structure-based compounds I with promising activity against Trypanosoma cruzi and Leishmania spp., broadening ways for scaffold optimization.

Although many compounds look similar to this compound(70-23-5)Recommanded Product: Ethyl 3-bromo-2-oxopropanoate, numerous studies have shown that this compound(SMILES:O=C(OCC)C(CBr)=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Palladium-Catalyzed Germylation of Aryl Bromides and Aryl Triflates Using Hexamethyldigermane, published in 2018-05-31, which mentions a compound: 67914-60-7, mainly applied to palladium catalyst aryl bromide triflate germylation hexamethyldigermane aryltrimethylgermane preparation, Quality Control of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone.

Pd-catalyzed germylation of aryl bromides and aryl triflates using com. available hexamethyldigermane is described. Optimized reaction conditions afforded various functionalized aryltrimethylgermanes, including drug-like mols., in moderate to good yields, demonstrating the versatility of the presented protocols.

Although many compounds look similar to this compound(67914-60-7)Quality Control of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, numerous studies have shown that this compound(SMILES:CC(N1CCN(C2=CC=C(O)C=C2)CC1)=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Synthetic Route of C5H6N2O2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Effect of 4,6-dihydroxypyrimidine and 2-methyl-4,6-dihydroxypyrimidine on the development of pulmonary adenomas in mice. Author is Labkovskii, B. M..

4,6-Dihydroxypyrimidine (50 mg./kg.) administered s.c. into mice simultaneously or daily for 1 week following injection of urethane (1 g./kg.) stimulated the formation of adenomas on the lung surfaces. These morphological changes were first observed 1-1.5 months after administration of the carcinogen. 2-Methyl-4,6-dihydroxypyrimidine did not have the ability to stimulate urethane-induced blastomogenesis under similar conditions.

Although many compounds look similar to this compound(1194-22-5)Synthetic Route of C5H6N2O2, numerous studies have shown that this compound(SMILES:CC1=NC(=CC(N1)=O)O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 5451-40-1, is researched, Molecular C5H2Cl2N4, about Promising 2,6,9-trisubstituted purine derivatives for anticancer compounds: synthesis, 3D-QSAR, and preliminary biological assays, the main research direction is trisubstituted purine regioselective preparation SAR QSAR antitumor apoptosis human; 3D-QSAR; apoptosis; cancer; cell cycle; cytotoxicity; purine derivatives.Reference of 2,6-Dichloropurine.

Two series of 2,6,9-trisubstituted purine derivatives I [R1 = Et, n-Bu, n-hexyl, etc.; R2 = cyclopentyl, cyclohexyl, cycloheptanyl, etc.] and II [R3 = 4-CF3OC6H4, 4-phenyl-piperidin-1-yl, 4-phenyl-piperazin-1-yl, 4-(4-chlorophenyl)piperazin-1-yl, etc.; R4 = Cl, 5-(nitropyridin-2-yl)piperazin-1-yl, 4-(pyrazin-2-yl)piperazin-1-yl, etc.; R5 = n-pentyl, n-hexyl, cyclopentyl] were synthesized and evaluated for their prospective role as antitumor compounds Compounds I and II were tested for their in vitro cell toxicity on seven cancer cells lines and one non-neoplastic cell line. Structural requirements for antitumor activity on two different cancer cell lines were analyzed with SAR and 3D-QSAR. The 3D-QSAR models showed that steric properties could better explain the cytotoxicity of compounds than electronic properties (70% and 30% of contribution, resp.). From this anal., conclusion was that arylpiperazinyl system connected at position 6 of the purine ring was beneficial for cytotoxic activity, while the use of bulky systems at position C-2 of the purine was not favorable. Compound II [R3 = 4-(4-nitrophenyl)piperazin-1-yl; R4 = Cl; R5 = cyclopentyl] was found to be an effective potential agent when compared with a currently marketed drug, cisplatin, in four out of the seven cancer cell lines tested. Compound II [R3 = 4-(4-nitrophenyl)piperazin-1-yl; R4 = Cl; R5 = cyclopentyl] showed the highest potency, unprecedented selectivity and complied with all the Lipinski rules. Finally, it was demonstrated that compound II [R3 = 4-(4-nitrophenyl)piperazin-1-yl; R4 = Cl; R5 = cyclopentyl] induced apoptosis and caused cell cycle arrest at the S-phase on HL-60 cells.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Soleimani-Amiri, Somayeh; Shafaei, Faezeh; Varasteh Moradi, Ali; Gholami-Orimi, Fathali; Rostami, Zohreh published the article 《A Novel Synthesis and Antioxidant Evaluation of Functionalized [1,3]-Oxazoles Using Fe3O4-Magnetic Nanoparticles》. Keywords: cyclopenta oxazole thione green preparation radical trapping ferric reduction; oxazole thione preparation bromo ketone isothiocyanate cyclization; magnetic iron oxide nanoparticle catalyst preparation.They researched the compound: Ethyl 3-bromo-2-oxopropanoate( cas:70-23-5 ).Synthetic Route of C5H7BrO3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:70-23-5) here.

In this research, green procedure was employed for biosynthesis of magnetic nanoparticles of iron oxide (Fe3O4-MNPs) by reduction of ferric chloride solution with Orange peel water extract Also, dihydro-2H-cyclopenta[d][1,3]oxazoles I (R = CO2Et, 4-MeOC6H4, 4-MeC6H4, 4-BrC6H4; R1 = t-Bu, 4-MeOC6H4, 4-O2NC6H4; R2 = Me, Et; R3 = CO2Et, 4-MeOC6H4, 4-MeC6H4) were generated through multi-component reaction of 1,3-oxazole-2(3H)-thione, dialkyl acetylenedicarboxylates, α-haloketones, and Fe3O4-MNPs as catalyst at ambient temperature in good yield. Initially, 1,3-oxazole-2(3H)-thione derivatives as one of the precursors are produced through the reaction of alkyl bromides, isothiocyanate, sodium hydride, and Fe3O4-MNPs as catalyst water at ambient temperature in 83-95% yields. Also, diphenyl-picrylhydrazine radical trapping and ferric reduction activity potential assays are used for evaluation of antioxidant activity of some synthesized compounds Among investigated compounds, I (R = CO2Et; R1 = 4-O2NC6H4; R2 = Me; R3 = 4-MeOC6H4) has good power for radical trapping activity and I (R = 4-MeOC6H4; R1 = t-Bu; R2 = Me; R3 = 4-MeC6H4) has good reduction power to butylated hydroxytoluene and 2-tert-butylhydroquinone.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Organic Process Research & Development called The development of a commercial manufacturing route to 2-fluoroadenine, the key unnatural nucleobase of islatravir, Author is Hong, Cynthia M.; Xu, Yingju; Chung, John Y. L.; Schultz, Danielle M.; Weisel, Mark; Varsolona, Richard J.; Zhong, Yong-Li; Purohit, Akasha K.; He, Cyndi Q.; Gauthier, Donald R. Jr.; Humphrey, Guy R.; Maloney, Kevin M.; Levesque, Francois; Wang, Zhixun; Whittaker, Aaron M.; Sirota, Eric; McMullen, Jonathan P., which mentions a compound: 5451-40-1, SMILESS is C2=NC1=C(C(=NC(=N1)Cl)Cl)[NH]2, Molecular C5H2Cl2N4, Application In Synthesis of 2,6-Dichloropurine.

Synthesis of a key fragment of islatravir (MK-8591), a novel nucleoside reverse transcriptase translocation inhibitor (NRTTI) currently under investigation for treatment and pre-exposure prophylaxis (PrEP) against HIV infection was discussed. The fragment, the unnatural nucleobase 2-fluoroadenine, was incorporated into MK-8591 via a biocatalytic aldol-glycosylation cascade, which imposed stringent requirements for its synthesis and isolation. Presented herein was the development work leading to a practical, scalable route from guanine, featuring a dual fluorination approach to a novel 9-THP-2,6-difluoropurine intermediate that enables a mild, highly selective, direct amination. This one-pot fluorination/amination sequence utilized a direct isolation to deliver high purity 9-THP-2-fluoroadenine, which features ideal properties with respect to reactivity, solubility, and crystallinity. An acid-catalyzed liberation of 2-fluoroadenine in aqueous buffer delivers the appropriate purity profile to facilitate the enzymic cascade to access MK-8591.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Recommanded Product: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, is researched, Molecular C12H16N2O2, CAS is 67914-60-7, about Efficient factors on the hydrolysis reaction rate of some para-aminophenol derivatives in acidic pHs. Author is Beiginejad, Hadi; Nematollahi, Davood; Varmaghani, Fahimeh; Bayat, Mehdi.

Electrochem. oxidation of some p-aminophenol derivatives (1-5) in acidic solutions was studied both exptl. and theor. to provide insight into the influence of some factors on the hydrolysis reaction rate. The result of this work shows that the electrogenerated p-quinoneimines participate in the hydrolysis reaction and are converted to the p-benzoquinone. The hydrolysis reaction rate strongly depends on the structure of the p-aminophenols and solution’s pH. The observed homogeneous rate constants of hydrolysis (kobshyd) of p-quinoneimines were determined using digital simulation technique. The effect of different parameters such as: change of Gibbs free energy (ΔG) of the electrochem. oxidation of para-aminophenol derivatives (1-5), charge of reaction site, N-C4 bond order (Wiberg Bond Indexes, WBIs) and the nature of substituted group, on the hydrolysis rate constant were also studied. All calculations were performed using D. Functional Theory (DFT) both BP86 and B3LYP levels of theory and 6-311G (p,d) basis set. The N-C4 bond order and charge on the reaction site play significant roles in hydrolysis reaction’s rate.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 70-23-5, is researched, Molecular C5H7BrO3, about Green production and antioxidant activity study of new pyrrolo[2,1-a]isoquinolines, the main research direction is phthaldehyde primary amine bromoalkane acetylene carboxylate four component reaction; pyrroloisoquinoline preparation antioxidant green chem; chromenoindolizine preparation; pyranopyrroloisoquinoline preparation.Category: oxazolidine.

In current research, pyrrolo[2,1-a]isoquinolines, compounds I [R1 = CN; R2 = CO2Et, 4-BrC6H4, etc.; R3 = H, CO2Me, CO2Et; R4 = Me, Et; X1 = H, Me, MeO; X2 = H, Me] were synthesized via a new process of four-component reaction of phthalaldehyde or its derivatives, primary amines, alkyl bromides, activated acetylenic compounds and potassium fluoride/Clinoptilolite nanoparticles (KF/CP NPs) under solvent-free conditions at room temperature Also, Diels-Alder reactions took place in the reaction of synthesized pyrrolo[2,1-a]isoquinoline derivatives, activated acetylenic compounds and triphenylphosphine in the presence of KF/CP NPs under solvent-free conditions at room temperature As well, antioxidation property of some prepared pyrrolo[2,1-a]isoquinolines were investigated by employing trapping of diphenyl-picrylhydrazine (DPPH) radical and ability of ferric reduction experiment Among investigated compounds, compounds I [R1 = CN, R2 = 4-MeC6H4, R3 = CO2Me, R4 = Me, X1 = H, X2 = Me] have good results relative to BHT and TBHQ as standard antioxidant. Reported method has good rate of reaction, product with high efficiency and simple removal of catalyst from mixture of reaction. In these reactions, KF/Clinoptilolite nanoparticles show a satisfactory recyclable activity.

Compounds in my other articles are similar to this one(Ethyl 3-bromo-2-oxopropanoate)Category: oxazolidine, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem