Category: oxazolidine

Application In Synthesis of 2,6-Dichloropurine. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2,6-Dichloropurine, is researched, Molecular C5H2Cl2N4, CAS is 5451-40-1, about Study of the N7 Regioselective Glycosylation of 6-Chloropurine and 2,6-Dichloropurine with Tin and Titanium Tetrachloride.

6-Chloropurine and 2,6-dichloropurine were regioselectively glycosylated at position 7 to give the corresponding peracetylated N7-nucleosides, which can be suitable for other purine transformations. In this work, we study the distribution of N7/N9-isomers produced via the Vorbruggen method under different conditions, using an N-trimethylsilylated purine derivative and SnCl4 or TiCl4 as a catalyst. The main effort is devoted to reversing the disadvantageous predominant selectivity of most glycosylation reactions at the N9 position and thus to determining conditions that maximize the regioselectivity of glycosylation toward the desired N7-isomer.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one( cas:1194-22-5 ) is researched.Recommanded Product: 6-Hydroxy-2-methylpyrimidin-4(3H)-one.Chen, Lei-xiang; Deng, Sheng-song; Guan, Qiu-xiang; Gu, Lei-ming published the article 《Synthesis and process research of 4,6-dichloro-2-methylpyrimidine》 about this compound( cas:1194-22-5 ) in Anhui Huagong. Keywords: acetamidine hydrochloride dimethyl malonate synthesis. Let’s learn more about this compound (cas:1194-22-5).

4,6-Dichloro-2-methylpyrimidine is an important intermediate of synthetic anticancer drug dasatinib. 4,6-Dichloro-2-methylpyrimidine was synthesized from acetamidine hydrochloride and di-Me malonate via the cyclization and chlorination with phosphorus oxychloride. The optimal conditions of synthesis of 4,6-dihydroxy-2-methyipyrimidine were investigated by orthogonal test. They were: n(acetamidine hydrochloride)/n (sodium methoxide)=1:3.4, in methanol at 20°C for 4h, the yield of 4, 6-dihydroxy-2-methylpyrimidine was 85.76%. The optimal conditions of chlorination with phosphorus oxychloride were investigated by orthogonal test. They were: n (N,N-diethyl-Benzenamine)/n (4,6-dihydroxy-2-methylpyrimidine)=2:1, in phosphorus oxychloride at 105°C for 4 h, the yield of 4,6-dichloro-2-methylpyrimidine was 69.55%, the yield of two-steps was 59.65%.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Formula: C5H2Cl2N4. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2,6-Dichloropurine, is researched, Molecular C5H2Cl2N4, CAS is 5451-40-1, about NMR studies of new heterocycles tethered to purine moieties with anticancer activity. Author is Fernandez-Saez, Nerea; Campos, Joaquin M.; Camacho, Maria Encarnacion; Carrion, Maria Dora.

The synthesis and biol. evaluation of a novel family of purine derivatives linked to six-membered heterocyclic moieties, which were designed and evaluated as anticancer agents, are described. The structures of these new compounds have been determined by 1H and 13C NMR and mass spectrometry. Some of them have been studied more in detail in order to corroborate their skeleton by using two-dimensional techniques.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Application of 7789-45-9. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Cupric bromide, is researched, Molecular Br2Cu, CAS is 7789-45-9, about In silico mechanically mediated atom transfer radical polymerization: A detailed kinetic study. Author is Liu, Jie; Wang, Tian-Tian; Luo, Zheng-Hong; Zhou, Yin-Ning.

Mech. mediated atom transfer radical polymerization (mechanoATRP) utilizing ultrasound to generate activators and improve the diffusivity of macromol. chains is introduced as an innovative externally controlled ATRP. Herein, a comprehensive kinetic model with free volume theory based “”series”” encounter pair model accounting for diffusional limitations on termination, activation, and deactivation is developed for the mechanoATRP of Me acrylate. Comparative study by using different diffusion models, for example, wp model and reduced composite kt model, as well as constant apparent kjapp model confirms the goodness of the as-developed model. Critically, mechanochem. induced reduction rate coefficient kr,s as a key kinetic parameter is associated with exptl. conditions excluding the sonication effect by a fitting equation for the first time. In silico tracking of polymer dispersity with the help of kinetic model shows a better result compared with that by the classical dispersity equation. By defining an ultrasonic factor γj, a qual. anal. for the effect of ultrasound conditions on the diffusional limitation in mechanoATRP is presented.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 7789-45-9, is researched, SMILESS is [Cu+2].[Br-].[Br-], Molecular Br2CuJournal, Article, Journal of the American Chemical Society called Wavelength-Resolved PhotoATRP, Author is Nardi, Martina; Blasco, Eva; Barner-Kowollik, Christopher, the main research direction is wavelength resolved photochem atom transfer radical polymerization.Electric Literature of Br2Cu.

The careful mapping of photoinduced reversible-deactivation radical polymerizations (RDRP) is a prerequisite for their applications in soft matter materials design. Here, we probe the wavelength-dependent behavior of photochem. induced atom transfer radical polymerization (ATRP) using nanosecond pulsed-laser polymerization (PLP). The photochem. reactivities at identical photon fluxes of Me acrylate in terms of conversion, number-average mol. weight, and dispersity of the resulting polymers are mapped against the absorption spectrum of the copper(II) catalyst in the range of 305-550 nm. We observe a red shift of the action spectrum relative to the absorption spectrum of the copper(II) catalyst. Both the number-average mol. weight and the dispersity show a wavelength dependence, while the mol. weight and conversion remain linearly correlated. The reported data allow the judicious selection of optimum wavelengths for photoATRP.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Computed Properties of C12H16N2O2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, is researched, Molecular C12H16N2O2, CAS is 67914-60-7, about Electrochemical synthesis of a new phosphonium betaine. Kinetic evaluation and antibacterial susceptibility. Author is Daneshyar, Anahita; Nematollahi, Davood; Varmaghani, Fahimeh; Goljani, Hamed; Alizadeh, Hojjat.

Cyclic voltammetry, controlled-potential coulometry, chronoamperometry, chronocoulometry and chronopotentiometry methods were used for the electrochem. study of 1-acetyl-4-(4-hydroxyphenyl)piperazine (APIP) in the presence of PPh3 (TPP) as a nucleophile. Electrochem. generated APIPox can serve as a Michael acceptor for nucleophilic attack by TPP to yield a new phosphonium betaine (APTP). The authors prepared a new product in good yield and purity by reaction of TPP with APIPox in an undivided cell equipped with C anode. Based on an EC mechanism, the observed homogeneous rate constant (kobs) of the Michael addition reaction of APIPox with TPP were estimated by comparing the exptl. cyclic voltammograms with the digital simulated results. Also, electrochem. oxidation of APIP was studied both exptl. and theor. to provide insight into the influence of natural charge and thermodn. stability parameters on the type of chem. reaction which follows APIPox. The synthesized compound was evaluated for in vitro antibacterial.

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Oxazolidine – Wikipedia,
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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 288-42-6, is researched, Molecular C3H3NO, about Current Scenario of 1,3-oxazole Derivatives for Anticancer Activity, the main research direction is review oxazole anticancer agent neoplasm; 1; 3-oxazole; Anticancer; Drug-resistant; Drug-susceptible; Heterocycles; Mechanisms of action.Synthetic Route of C3H3NO.

A review. Cancer, which has been cursed for human beings for long time is considered as one of the leading causes of morbidity and mortality across the world. In spite of different types of treatments available, chemotherapy is still deemed as a favored treatment for the cancer. Unfortunately, many currently accessible anticancer agents have developed multidrug resistance along with fatal adverse effects. Therefore, intensive efforts have been made to seek for new active drugs with improved anticancer efficacy and reduced adverse effects. In recent years, the emergence of heterocyclic ring-containing anticancer agents has gained a great deal of attention among medicinal chemists. 1,3- oxazole is a versatile heterocyclic compound, and its derivatives possess broad-spectrum pharmacol. properties, including anticancer activity against both drug-susceptible, drug-resistant and even multidrug-resistant cancer cell lines through multiple mechanisms. Thus, the 1,3-oxazole moiety is a useful template for the development of novel anticancer agents. This review will provide a comprehensive overview of the recent advances on 1,3-oxazole derivatives with potential therapeutic applications as anticancer agents, focus on the chem. structures, anticancer activity, and mechanisms of action.

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Oxazolidine – Wikipedia,
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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, is researched, Molecular C12H16N2O2, CAS is 67914-60-7, about Rapid screening of protein-protein interaction inhibitors using the protease exclusion assay.Reference of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone.

We have previously developed a sensitive and modular homogenous biosensor system using peptides to detect target ligands. By transposing the basic mechanistic principle of the nuclease protection assay into this biosensor framework, we have developed the protease exclusion (PE) assay which can discern antagonists of protein-protein interactions in a rapid, single-step format. We demonstrate the concept with multiple protein-peptide pairs and validate the method by successfully screening a small mol. library for compounds capable of inhibiting the therapeutically relevant p53-Mdm2 interaction. The Protease Exclusion method adds to the compendium of assays available for rapid analyte detection and is particularly suited for drug screening applications.

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Oxazolidine – Wikipedia,
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Safety of 2,6-Dichloropurine. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2,6-Dichloropurine, is researched, Molecular C5H2Cl2N4, CAS is 5451-40-1, about Synthesis and fluorescent properties of N(9)-alkylated 2-amino-6-triazolylpurines and 7-deazapurines. Author is Sisulins, Andrejs; Bucevieius, Jonas; Tseng, Yu-Ting; Novosjolova, Irina; Traskovskis, Kaspars; Bizdena, Erika; Chang, Huan-Tsung; Tumkevieius, Sigitas; Turks, Maris.

The synthesis of novel fluorescent N(9)-alkylated 2-amino-6-triazolylpurine and 7-deazapurine derivatives is described. A new C(2)-regioselectivity in the nucleophilic aromatic substitution reactions of 9-alkylated-2,6-diazidopurines and 7-deazapurines with secondary amines has been disclosed. The obtained intermediates, 9-alkylated-2-amino-6-azido-(7-deaza)purines, were transformed into the title compounds by CuAAC reaction. The designed compounds belong to the push-pull systems and possess promising fluorescence properties with quantum yields in the range from 28% to 60% in acetonitrile solution Due to electron-withdrawing properties of purine and 7-deazapurine heterocycles, which were addnl. extended by triazole moieties, the compounds with electron-donating groups showed intramol. charge transfer character (ICT/TICT) of the excited states which was proved by solvatochromic dynamics and supported by DFT calculations In the 7-deazapurine series this led to increased fluorescence quantum yield (74%) in THF solution The compounds exhibit low cytotoxicity and as such are useful for the cell labeling studies in the future.

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Recommanded Product: Cupric bromide. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Cupric bromide, is researched, Molecular Br2Cu, CAS is 7789-45-9, about Study of the Cu[I]/Cu[II] catalytic system in 2,6-dimethylphenol polymerization to poly(phenylene oxide). Author is Firlik, Sebastian; Alichniewicz-Kalinowska, Dorota; Skupinski, Wincenty.

The study of Allan S. Hay catalytic systems containing copper[I] and copper[II] complexes, ie. CuBr/dbeda (where dbeda = N, N’-di-(t-butyl)ethylenediamine), Cu2O/Br2/dbeda CuBr2/dbeda and CuCO3/Br2/dbeda in the polymerization of 2,6-dimethylphenol(2,6-DMP) to poly(phenylene oxide) (PPO) was presented. In the presence of bromine in the amount of 4.5 Br2/Cu, the copper[II] catalysts formed the greater number of polymerization centers. The values of the molar mass as well as its distribution depended on the 2,6-DMP/Cu molar ratio and the reaction time. Polymer with the higher molar mass was obtained at the molar ratio 2,6-DMP/Cu = 1000 and with the use of the copper[I] catalyst. By increasing the 2,6-DMP/Cu ratio to 1800, polymer with the lower molar mass was prepared The reverse effect was observed for the copper[II] catalyst. The mechanism of 2,6-DMP polymerization to PPO was proposed in presence of the used catalysts. Also, the role of the bromine excess in the process was explained. In this mechanism the copper system Cu[I]⇌Cu[II] is responsible for the formation of oxygen and para-carbon radicals which are the starting mols. to launch the polymer synthesis. The “”bromine”” system reversibly provides the Br2 mol. to brominate 2,6-DMP. The resulting 4-bromo-2,6-dimethylphenol forms a carbon radical in the reaction with copper[I] complex.

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Oxazolidine – Wikipedia,
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