Category: oxazolidine

COA of Formula: C5H7BrO3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about A selective “”turn-on”” sensor for recognizing In3+ and Zn2+ in respective systems based on imidazo[2,1-b]thiazole. Author is Xu, Yuankang; Zhao, Songfang; Zhang, Yanxia; Wang, Hanyu; Yang, Xiaofeng; Pei, Meishan; Zhang, Guangyou.

A new simple and easily synthesized multitarget sensor, (E)-N′-(4-(diethylamino)-2-hydroxybenzylidene)imidazo[2,1-b]thiazole-6-carbohydrazide (X), was designed and synthesized using imidazo[2,1-b]thiazole-6-carboxylic acid and 4-(diethylamino)-2-hydroxybenzaldehyde. X could be used as a sensor to detect In3+ in DMF-H2O buffer solution and detect Zn2+ in EtOH-H2O buffer solution through fluorescence enhancement with detection limits of 1.02 × 10-9 M and 5.5 × 10-9 M, resp. X exhibited an efficient “”off-on-off”” fluorescence behavior by cyclic addition of metal ions (In3+ and Zn2+) and EDTA. The stoichiometry between X and metal ions (In3+ and Zn2+) was 1 : 1. The binding mode and sensing mechanism of X with metal ions (In3+ and Zn2+) was verified by theor. calculations using Gaussian 09 based on B3LYP/6-31G(d) and B3LYP/LANL2DZ basis, resp. Moreover, X could be applied as a potential sensor for the quant. detection of In3+ and Zn2+ with a satisfactory recovery and relative standard deviation (RSD) in real water samples.

Here is just a brief introduction to this compound(70-23-5)COA of Formula: C5H7BrO3, more information about the compound(Ethyl 3-bromo-2-oxopropanoate) is in the article, you can click the link below.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Category: oxazolidine. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Oxazole, is researched, Molecular C3H3NO, CAS is 288-42-6, about Nickel-catalyzed cross-electrophile coupling of aryl bromides and cyclic secondary alkyl bromides with spiro-bidentate-pyox ligands. Author is Gao, Nanxing; Li, Yanshun; Cao, Guorui; Teng, Dawei.

The cross-electrophile coupling of aryl bromides RBr [R = Ph, 4-(ethoxycarbonyl)phenyl, 1-(1H-indol-1-yl)ethan-1-one, etc.] and cyclic secondary alkyl bromides I [R1 = ethoxycarbonyl, (benzyloxy)carbonyl, (4-methylbenzene)sulfonyl, etc., X = (CH2)n, n = 1, 2] catalyzed by nickel/spiro-bidentate-pyox ligands, e.g., II, with lithium chloride as the additive for the Csp2-Csp3 bond formation is reported. The reaction could tolerate functional groups such as sulfonamide, ester, aldehyde, ketone, protected indolyl, tert-butoxycarbonyl, aryl nitriles and aryl chloride. Various aryl-cyclic secondary alkyl Csp2-Csp3 bond products, e.g., III, were synthesized under optimal reaction conditions (19 examples).

Here is just a brief introduction to this compound(288-42-6)Category: oxazolidine, more information about the compound(Oxazole) is in the article, you can click the link below.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2,6-Dichloropurine(SMILESS: C2=NC1=C(C(=NC(=N1)Cl)Cl)[NH]2,cas:5451-40-1) is researched.Category: oxazolidine. The article 《Multifunctional lipophilic purines: a coping strategy for anti-counterfeiting, lipid droplet imaging and latent fingerprint development》 in relation to this compound, is published in Materials Chemistry Frontiers. Let’s take a look at the latest research on this compound (cas:5451-40-1).

Nowadays, multifunctional materials based on fluorescent small mols. have bright prospects for the development of materials science. However, those materials, based on purine derivatives in particular, still face challenges and need to be further explored. In this study, a new multifunctional small mol. (CDP) based on the purine skeleton was readily synthesized, and its lipophilicity and fluorescence properties were improved by introducing dodecyl groups and carbazole groups. CDP could not only be assembled as anti-counterfeiting inks with waterproofing, ideal light stability and good fluorescence contrast, but also be applied in lipid droplet imaging of living cells. More importantly, CDP provided a simple, efficient, and widely applicable visualization method of latent fingerprints and achieved information extraction down to a minutiae level of latent fingerprints on multiple substrates. Overall, the present work supplied a new strategy for the development of multifunctional fluorescent mol. materials in mol. design and practical applications.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Structure-Activity Relationships of a Series of Pyrrolo[3,2-d]pyrimidine Derivatives and Related Compounds as Neuropeptide Y5 Receptor Antagonists.Reference of 6-Hydroxy-2-methylpyrimidin-4(3H)-one.

Neuropeptide Y (NPY) has been shown to play an important role in the regulation of food intake and energy balance. Pharmacol. data suggests that the Y5 receptor subtype contributes to the effects of NPY on appetite, and therefore a Y5 antagonist might be a useful therapeutic agent for the treatment of obesity. In attempts to identify potential Y5 antagonists, a series of pyrrolo[3,2-d]pyrimidine derivatives was prepared and evaluated for their ability to bind to Y5 receptors in vitro. The authors report here the synthesis and initial structure-activity relation investigations for this class of compounds The target compounds were prepared by a variety of synthetic routes designed to modify both the substitution and the heterocyclic core of the pyrrolo[3,2-d]pyrimidine lead compound (I). In addition to identifying several potent Y5 antagonists for evaluation as potential antiobesity agents, a pharmacophore model for the human Y5 receptor is presented.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Orientation effects on C2(5)-C2′(5′) linked bioxazole isomers synthesized via regioselective and sequential C-H arylation, published in 2021-01-31, which mentions a compound: 288-42-6, Name is Oxazole, Molecular C3H3NO, SDS of cas: 288-42-6.

Bis(4-fluorophenyl) substituted oxazole (2,5-Oxz) and C2(5)-C2′(5′) linked bioxazole isomers (C2-C2’_BOxz, C2-C5’_BOxz and C5-C5’_BOxz) (I – IV, resp.) were concisely synthesized via palladium-catalyzed regioselective and sequential C-H arylation in 1-3 reaction steps along with 20%-83% of total yields from oxazole and 4-bromofluorobenzene. The linking orientation plays a key role in the packing geometry and photophys. properties of C2-C2’_BOxz, C2-C5’_BOxz and C5-C5’_BOxz. These bioxazole isomers in solid state showed significant differences in photoluminescence quantum yields (PLQY) (0.33, 0.25 and 0.04, resp.), delayed fluorescence properties and powder X-ray diffraction (PXRD) patterns, suggesting the divergence in intermol. interactions. The theor. calculated gradient isosurfaces and complexation energies indicate the existence of intense π-π interactions between mol. layers, which are in good agreement with the variation trend of optical properties.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Electrophotocatalytic C-H Functionalization of Ethers with High Regioselectivity, published in 2020-01-29, which mentions a compound: 5451-40-1, mainly applied to electrophotocatalytic regioselective functionalization ether, Recommanded Product: 5451-40-1.

The highly regioselective electrophotocatalytic C-H functionalization of ethers is described. These reactions are catalyzed by a trisaminocyclopropenium (TAC) ion at mild electrochem. potential with visible light irradiation Ethers undergo oxidant-free coupling with isoquinolines, alkenes, alkynes, pyrazoles, and purines with typically high regioselectivity for the less-hindered α-position. The reaction is proposed to operate via hydrogen atom transfer (HAT) from the substrate to the photoexcited TAC radical dication, thus demonstrating a new reactivity mode for this electrophotocatalyst.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis, characterization, crystal structures, and the biological evaluation of 2-phenylthiazole derivatives as cholinesterase inhibitors, published in 2021-05-31, which mentions a compound: 70-23-5, Name is Ethyl 3-bromo-2-oxopropanoate, Molecular C5H7BrO3, Application of 70-23-5.

Four 2-phenylthiazole derivatives I [R = 4-methylpiperazin-1-yl, 2-morpholin-4-yl-Et, 3,5-dimethylpiperidin-1-yl, etc.] were synthesized, characterized and evaluated as cholinesterase inhibitors. The structures of the 2-phenylthiazole derivatives were confirmed by 1H and 13C NMR spectroscopy, single-crystal X-ray diffraction studies, and Hirshfeld surfaces anal. Hirshfeld surface anal. of the prepared compounds showed C-H···O intermol. interactions. The cholinesterase inhibition activities of the synthesized compounds were tested by Ellman’s method. Compound I [R = 3,5-dimethylpiperidin-1-yl] showed the best acetylcholinesterase inhibition activity with an IC50 value of 8.86μM and the best butyrylcholinesterase inhibition activity with an IC50 value of 1.03μM. A docking study demonstrated that the same compound interacted with the catalytic anionic site and peripheral anionic site of acetylcholinesterase and the catalytic anionic site of butyrylcholinesterase.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, is researched, Molecular C12H16N2O2, CAS is 67914-60-7, about Regioselective Green Electrochemical Approach to the Synthesis of Nitroacetaminophen Derivatives, the main research direction is nitroacetaminophen derivative regioselective synthesis green chem; acetaminophen hydroxyphenylacetamide hydroxyphenylpiperazinylethanone electrochem oxidation nitrite ion.Product Details of 67914-60-7.

A regioselective green synthesis of nitroacetaminophen derivatives e. g., I, was carried out by electrochem. oxidation of acetaminophen, N-(2-hydroxyphenyl)acetamide, and 1-(4-(4-hydroxyphenyl)piperazin-1-yl)ethanone in the presence of nitrite ion as a nucleophile. The present work has led to the development of a reagentless green and facile electrochem. method for the synthesis of some nitroacetaminophen derivatives

There is still a lot of research devoted to this compound(SMILES：CC(N1CCN(C2=CC=C(O)C=C2)CC1)=O)Product Details of 67914-60-7, and with the development of science, more effects of this compound(67914-60-7) can be discovered.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Reaction of oxide radical ion (O·-) with substituted pyrimidines, published in 2002-06-30, which mentions a compound: 1194-22-5, mainly applied to reaction oxide radical substituted pyrimidine oxidizing radical electron transfer; pulse radiolysis reaction oxide radical substituted pyrimidine, Formula: C5H6N2O2.

Pulse radiolysis technique has been used to investigate the reaction of oxide radical ion (O·-) with 4,6-dihydroxy-2-Me pyrimidine (DHMP), 2,4-dimethyl-6-hydroxy pyrimidine (DMHP), 5,6-di-Me uracil (DMU) and 6-Me uracil (MU) in strongly alk. medium. The second-order rate constants for the reaction of O·- with these compounds are in the range 2-5 × 108 dm3 mol-1 s-1. The transient absorption spectra obtained with DHMP have two maxima at 290 and 370 nm and with DMHP have maxima at 310 and 470 nm. The transient spectrum from DMU is characterized by its absorption maxima at 310 and 520 nm and that of MU by its single maximum at 425 nm. The intermediate species were found to react with N,N,N’,N’-tetramethyl-p-phenylenediamine (TMPD) with high G(TMPD·+) values ranged between 3.9 × 10-7 mol J-1 and 4.8 × 10-7 mol J-1. These radicals undergo decay by second-order kinetics (2k/ε = 1.0-1.7 × 106 s-1). The reaction of O·- with the selected pyrimidines is proposed to proceed through a hydrogen abstraction from the Me group forming allyl type radicals. These are mainly oxidizing radicals and hence readily undergo electron transfer reactions with TMPD.

There is still a lot of research devoted to this compound(SMILES：CC1=NC(=CC(N1)=O)O)Formula: C5H6N2O2, and with the development of science, more effects of this compound(1194-22-5) can be discovered.

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Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Infrared spectra of derivatives of pyrimidine》. Authors are Short, L. N.; Thompson, H. W..The article about the compound:6-Hydroxy-2-methylpyrimidin-4(3H)-onecas:1194-22-5,SMILESS:CC1=NC(=CC(N1)=O)O).Name: 6-Hydroxy-2-methylpyrimidin-4(3H)-one. Through the article, more information about this compound (cas:1194-22-5) is conveyed.

Graphs of the vibrational spectra between 2 and 25 μ are given for the following compounds suspended as solids in paraffin or perfluorokerosine, and for the deuterio derivatives of the starred compounds (deuteriated by treatment with D2O): pyrimidine, monosubstituted pyrimidines: 2-Cl-, 2-NH*2-, 5-NH2-2-OH-*, 4-OH-*, 2-SH-*; 2,4-disubstituted pyrimidines: Cl2-, (OEt)2, (OPh)2, 2-Cl-4-NH2-*, (OH)2-*, 2-OH-4-NH2-*, (NH2)2-(SH)2-*, 2-SH-4-NH2-, 2(-)SH-4-OH-*; 4,6-disubstituted pyrimidines: 4-NH2-6-Cl-*, 4-OH-6-Me-, (OH)2-, 4-OH-6NH2-*, (NH2)2-*, 2,4,6-trisubstituted pyrimidines: Cl3-, 2-Me-4,6-Cl2-, 2-NH2-4,6-Me*2-2-NH2-4,6-(OMe)2-, 2-NH2-4,6-Cl2-, 2-NH2-4-Me-6-OEt-*, 2-NH2-4-Me-6-Cl-*, 2,6-Cl2-4-NH2-, 2-Cl-4-NH2-6-Me-, 2,6-Me2-4-NH2-*, 2-Me-4-NH2-6-Cl-, 2-NHMe-4-Me-6-Cl-, 2,6-Me2-4-OH-, 2,4-(OH)2-6-Me-, 2-Me-4,6-(OH)2-, (OH)3-, 2-NH2-4-OH-6-Me-*, 2-NMe2-4-OH-6-Me-*, 2-NH2-4-OH-6-Cl-, 2-SMe-4-OH-6-NH2-, 2-Me-4-OH-6-NH2-*, (NH2)3-, 2,4-(OH)2-6-NH2-, 2-NH2-4,6-(OH)2-, 2,4-(NH2)2-6-OH, 2-OH-4,6-(NH2)2-, 2-SH-4-OH-6-Me-, 2-SH-4-OH-6-NH2-, 2-NH2-4-Me-6-CONH2-, 2-NH2-4-Me-6-CN-; also the 4-NH2-5-Ph-*, 2,4-(OH)2-5-NO2-, 4,6-(NH2)2-5-Br-, 2-Me-4,6-(OMe)2-5-NO2-, 2-Me-4,6-(OMe)2-5-NH2-, 2-SEt-4-OH-5-Et-6-Me-, 1,4-Me2-2-SMe-6-O-, 1,3-Me2-2,4-O2-, 2-NH2-3-Et-4-Me-6-O-, and 1-Et-2-NH2-4-Me-6-O- pyrimidine derivatives In the OH and NH2 pyrimidines with or without other substituents around the ring, the main regions connected with the possibility of tautomerism are at 6 μ and 3 μ. Since ambiguities occur in both these regions, exact frequency assignments are difficult to make. The spectra are highly characteristic with sharp bands and might be used for analysis and identification. The spectral evidence suggests a ketonic structure for simple 2-OH and 4-OH derivatives and probably a diketonic form for 2,4-(OH)2 derivatives In 4,6-dihydroxypyrimidine one CO and one OH group may be present. NH2-substituents are probably not tautomerized and have the character of an amido group. The electronic effects of different substituents may influence the tautomerism and the amount of H-bonding. These conclusions do not agree in some respects with those of Brownlie (C.A. 45, 2778d).

There is still a lot of research devoted to this compound(SMILES：CC1=NC(=CC(N1)=O)O)Name: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, and with the development of science, more effects of this compound(1194-22-5) can be discovered.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem