Category: oxazolidine

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, is researched, Molecular C12H16N2O2, CAS is 67914-60-7, about Electrochemical Synthesis of a New Derivative of 1,4-Dihydroxybenzene: Embedded Nucleophile in the Structure of Electrophile.Application of 67914-60-7.

The electrochem. oxidation of 4-(Piperazin-1-yl)phenols (1a,b) was studied in the H2O, MeCN and nitromethan by cyclic voltammetry and controlled-potential coulometry. P-quinone-imines generated of oxidation 4-(Piperazin-1-yl)phenols after the hydrolysis reaction participate in Michael-addition reactions with released piperazine of hydrolysis reaction of p-quinone imines. The present work led to the development of a facile and environmentally friendly electrochem. method for the synthesis of a new derivative of 1,4-dihydroxybenzene under green conditions. The effect of H2O as a solute on the electrochem. response of 4-(Piperazin-1-yl)phenols (1a,b) was examined in the MeCN (AN) and nitromethane (NM) solvent.

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Synthetic Route of C3H3NO. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Oxazole, is researched, Molecular C3H3NO, CAS is 288-42-6, about Prediction of 15N NMR chemical shifts for nitrogenated aromatic compounds. Author is de Oliveira, Marcelo T.; Alves, Julia M. A.; de A. Morais, Sara F.; Braga, Ataualpa A. C..

Building on recent developments, we compare performance of two distinct protocols, namely SMD-mPW1PW91/6-311+G(2d,p) and CPCM-OLYP/pcSseg-2, for the computation of 15N chem. shifts of nitrogenated aromatic compounds The latter shows best overall performance (MAD 5.3 ppm) albeit results in chloroform favors the former.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1194-22-5, is researched, SMILESS is CC1=NC(=CC(N1)=O)O, Molecular C5H6N2O2Conference, New Trends in Research of Energetic Materials, Proceedings of the Seminar, 10th, Pardubice, Czech Republic, Apr. 25-27, 2007 called On the synthesis of 1,1-diamino-2,2-dinitroethene (FOX-7) by nitration of 4,6-dihydroxy-2-methylpyrimidine, Author is Johansson, Martin; Latypov, Nikolaj V.; Holmgren, Erik; Sizova, Ekaterina V.; Sizov, Vladimir; Bellamny, Anthony J., the main research direction is dihydroxy methylpyrimidine nitration diamino dinitroethene explosive.Category: oxazolidine.

The synthesis of 1,1-diamino-2,2-dinitroethene (FOX-7) by nitration of 4, 6-dihydroxy-2-methylpyrimidine and hydrolysis of the resulting intermediate 2-dinitromethylene-5,5-dinitropyrimidine-4, 6-dione has been studied. By varying the reactions parameters the optimal conditions for the synthesis of FOX-7 have been identified and gave a >90% yield of the pure product. The optimized process allowed the spent acid to be recycled without loss of yield, with almost stoichiometric consumption of nitric acid. The purity of the FOX-7 has been determined using a newly developed HPLC method.

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Perego, Michele; Kuschlan, Stefano; Seguini, Gabriele; Chiarcos, Riccardo; Gianotti, Valentina; Antonioli, Diego; Sparnacci, Katia; Laus, Michele published an article about the compound: Cupric bromide( cas:7789-45-9,SMILESS:[Cu+2].[Br-].[Br-] ).Reference of Cupric bromide. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:7789-45-9) through the article.

Phosphorus δ-layers in SiO2 were prepared by means of poly(Me methacrylate) (PMMA) terminated with a phosphorus-containing moiety acting as an anchoring group. In particular, grafting of two P-terminated PMMA samples with Mn = 7.5 kg/mol (D = 1.14) and Mn = 17.8 kg/mol (D = 1.23) onto 10 nm thick SiO2 films deposited on Si substrates was investigated, focusing on the thickness evolution of the brush layer as a function of the processing parameters, i.e., annealing temperature and time. Upon removal of the polymer chains and subsequent encapsulation into a SiO2 matrix, the concentration of phosphorus atoms into the P δ-layers has been monitored by time-of-flight secondary ion mass spectrometry. The effective P dose in the P δ-layer is mainly dictated by the mol. weight of the P-terminated PMMA, and the doping process results are highly reproducible, provided that tight control over the exptl. protocol is granted. However, although the grafting d. is expected to progressively increase as a function of annealing time with a linear correlation between grafting d. and thickness, the measured P dose in the δ-layers is observed to follow the opposite trend. This effect was accounted for by considering a distortion of the mol. weight distribution of the grafted species with respect to the initial mol. weight distribution of the polymer. The overall picture reveals important information about the mechanism and dynamics governing the “”grafting to”” process of P-terminated PMMA polymers onto nondeglazed Si substrates.

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Jing, Benxin; Wang, Xiaofeng; Shi, Yi; Zhu, Yingxi; Gao, Haifeng; Fullerton-Shirey, Susan K. published an article about the compound: Cupric bromide( cas:7789-45-9,SMILESS:[Cu+2].[Br-].[Br-] ).Recommanded Product: 7789-45-9. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:7789-45-9) through the article.

Polyethylene oxide (PEO)-based polymers are commonly studied for use as a solid polymer electrolyte for rechargeable Li-ion batteries; however, simultaneously achieving sufficient mech. integrity and ionic conductivity has been a challenge. To address this problem, a customized polymer architecture is demonstrated wherein PEO bottle-brush arms are hyperbranched into a star architecture and then functionalized with end-grafted, linear PEO chains. The hierarchical architecture is designed to minimize crystallinity and therefore enhance ion transport via hyperbranching, while simultaneously addressing the need for mech. integrity via the grafting of long, PEO chains (Mn = 10,000). The polymers are doped with lithium bis(trifluoromethane) sulfonimide (LiTFSI), creating hierarchically hyperbranched (HB) solid polymer electrolytes. Compared to electrolytes prepared with linear PEO of equivalent mol. weight, the HB PEO electrolytes increase the room temperature ionic conductivity from ∼ 2.5 x 10-6 to 2.5 x 10-5 S/cm. The conductivity increases by an addnl. 50% by increasing the block length of the linear PEO in the bottle brush arms from Mn = 1,000 to 2,000. The mech. properties are improved by end-grafting linear PEO (Mn = 10,000) onto the terminal groups of the HB PEO bottle-brush. Specifically, the Young’s modulus increases by two orders of magnitude to a level comparable to com. PEO films, while only reducing the conductivity by 50% below the HB electrolyte without grafted PEO. This study addresses the trade-off between ion conductivity and mech. properties, and shows that while significant improvements can be made to the mech. properties with hierarchical grafting of long, linear chains, only modest gains are made in the room temperature conductivity

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called The effect of some derivatives of pyrimidine on metastasis of the transplantable rat sarcoma SSK, published in 1963, which mentions a compound: 1194-22-5, mainly applied to , Reference of 6-Hydroxy-2-methylpyrimidin-4(3H)-one.

Sarcoma SSK was transferred to normal rats by injection of a tumor cell suspension in physiol. saline containing penicillin into the middle third of the tail. Treatment by intraperitoneal injection of metacil (I), 2-methyl-4,6-dioxypyrimidine (II), thymine (III), dihydrothymine (IV), cytosine (V), isocytosine (VI), 4,6-dioxy-5-nitropyrimidine (VII), 2,6-mercapto-5-amino-4-methylpyrimidine (VIII), and pentoxyl (IX) in solution or suspension in physiol. saline in doses of 100 mg./kg./day was begun within 24 hrs., and continued for 19 days. Control animals received physiol. saline. In one group, the tails were amputated after 5 days; in the second, after 9 days. In the 1st group, animals which received VII all died in the postoperative period, while those which received I, II, V, VI, or IX developed fewer metastases than the controls. No such inhibitory effect of metastasis was observed in the 2nd group. In both groups, animals which received III, IV, or VIII developed more metastases than the controls.

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Srinivasarao, Talasila; Mohanty, Sandeep; Venkata, Suryanarayana C. H.; Reddy, G. Sandeep; Jaydeepkumar; Rao, B. Venkateswara published the article 《An efficient and novel process for the synthesis of nizatidine》. Keywords: dimethylamino ethanethioamide ethyl bromopyruvate green cyclocondensation reduction amination; nizatidine preparation.They researched the compound: Ethyl 3-bromo-2-oxopropanoate( cas:70-23-5 ).SDS of cas: 70-23-5. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:70-23-5) here.

A facile eco-friendly, cost effective and robust process for the synthesis of Nizatidine via the cyclocondensation of 2-(dimethylamino)ethanethioamide with Et bromopyruvate followed by reduction then coupled with cysteamine hydrochloride. The later formed product was coupled with N-methyl-1-(methylthio)-2-nitroethenamine in water resulted Nizatidine. The synthesized product met European pharmacopeia (EP) monograph.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 5451-40-1, is researched, Molecular C5H2Cl2N4, about 1,2,3-Triazoles as leaving groups in SNAr-arbuzov reactions: synthesis of C6-phosphonated purine derivatives, the main research direction is heptyl bisphenyltriazolyl purine regioselective nucleophilic aromatic substitution Arbuzov reaction; diethoxyphosphoryl heptyl triazolyl purine preparation; 2,6-bistriazolylpurines; Arbuzov reaction; nucleophilic aromatic substitution; purinylphosphonates.Formula: C5H2Cl2N4.

A new method for C-N bond transformations into C-P bonds was developed using 1,2,3-triazoles as leaving groups in SNAr-Arbuzov reactions. A series of C6-phosphonated 2-triazolylpurine derivatives I [R = methoxycarbnonyl, Bu, 2-pyridyl, etc.] was synthesized for the first time, with the isolated yields reaching up to 82% in the C-P-bond-forming event. The SNAr-Arbuzov reaction of 2,6-bistriazolylpurines follows the general regioselectivity pattern of the C6-position being more reactive towards substitution, which was unambiguously proved by X-ray anal. of I [R = phenyl].

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Name: 2,6-Dichloropurine. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2,6-Dichloropurine, is researched, Molecular C5H2Cl2N4, CAS is 5451-40-1, about Design, synthesis and biological evaluation of novel histone deacetylase1/2 (HDAC1/2) and cyclin-dependent Kinase2 (CDK2) dual inhibitors against malignant cancer. Author is Yun, Fan; Cheng, Chunhui; Ullah, Sadeeq; Yuan, Qipeng.

Designe and synthesis of series of novel histone deacetylase1/2 (HDAC1/2) and cyclin-dependent kinase2 (CDK2) dual inhibitors by integrating purine-based pharmacophore into the recognition cap group of CS055. The representative compound e.g., I [R1 = 4-MeC6H4] with excellent antiproliferative activities towards five solid cancer cells, showed potent inhibitory activities against HDAC1, HDAC2 and CDK2 with IC50 values of 70.7 nM, 23.1 nM and 0.80μM, resp. Besides, compound I could effectively block the cell cycle in the G2/M phase and induce apoptosis, which might be related to increasing intracellular ROS levels. Importantly, compound I exhibited desirable pharmacokinetic (PK) properties with the i.p. bioavailability of 50.8% in ICR mice, and potent in vivo antitumor activity in the HCT116 xenograft model. Therefore, compound I could be considered as a promising lead compound for the development of multitargeting anticancer agents.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 288-42-6, is researched, Molecular C3H3NO, about 14N Nuclear quadrupole coupling and methyl internal rotation in the microwave spectrum of 2-methylpyrrole, the main research direction is methylpyrrole nitrogen nuclear quadrupole coupling microwave spectrum.COA of Formula: C3H3NO.

Using two mol. jet Fourier transform microwave spectrometers, the rotational spectrum of 2-methylpyrrole was recorded in the frequency range from 2 to 40 GHz. From the torsional splittings due to the internal rotation of the Me group a barrier height of 279.7183(26) cm-1 was deduced. Because of the 14N nucleus, all lines show a quadrupole hyperfine structure. The microwave spectra were analyzed using the XIAM and BELGI-Cs-hyperfine codes. The XIAM code enabled us to reproduce the whole data set with a root-mean-square deviation of 5.6 kHz while the BELGI-Cs-hyperfine code could provide a better root-mean-square almost by a factor of 2 compared to that of XIAM. The exptl. results were complemented by quantum chem. calculations The values of the Me torsional barrier and the 14N nuclear quadrupole coupling constants are discussed and compared with other Me substituted pyrroles as well as other aromatic five-membered rings.

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