Category: oxazolidine

Recommanded Product: 7789-45-9. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Cupric bromide, is researched, Molecular Br2Cu, CAS is 7789-45-9, about Effect of Dispersity on the Conformation of Spherical Polymer Brushes. Author is Li, Tzu-Han; Yadav, Vivek; Conrad, Jacinta C.; Robertson, Megan L..

We show that dispersity (D) markedly alters the conformation of spherical polymer brushes. The average lengths (lb) of poly(tert-Bu acrylate) (PtBA) brushes of varying D grafted to nanoparticles were measured using dynamic light scattering. In the semidilute polymer brush (SDPB) regime, the lb of PtBA and polymers from earlier studies of various D could be cleanly collapsed onto a master curve as a function of the scaling variable Nwσ1/3, where Nw is the weight-average d.p. and σ is the grafting d. In the concentrated polymer brush (CPB) regime, however, lb collapsed onto a bifurcated curve as a function of the scaling variable Nwσ1/2, indicating D more strongly affects the average length of brushes with low Nwσ1/2. We propose that the stretching of the stem near the particle surface due to interchain interactions in the CPB regime leads to greater lb in broad dispersity brushes of low but not high Nwσ1/2.

As far as I know, this compound(7789-45-9)Recommanded Product: 7789-45-9 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Bagli, Jehan; Bogri, T.; Palameta, B.; Rakhit, S.; Peseckis, S.; McQuillan, J.; Lee, D. K. H. published the article 《Chemistry and positive inotropic effect of pelrinone and related derivatives. A novel class of 2-methylpyrimidones as inotropic agents》. Keywords: inotropic activity aminomethylpyrimidinone preparation; chronotropic activity aminomethylpyridinone; cardiotonic activity aminomethylpyrimidinone; mol structure cardiotonic activity; crystal structure cyanomethylpyridylmethylaminopyrimidinone salt.They researched the compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one( cas:1194-22-5 ).Synthetic Route of C5H6N2O2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1194-22-5) here.

Novel pyrimidine derivatives (e.g., I; R = cyano, R1 = 3-pyridylmethyl) were synthesized and evaluated for pos. inotropic activity. Thus, (MeS)2C:C(CN)CO2Me cyclocondensed with MeC(:NH)NH2·HCl to give cyano methyl(methythio)dihydropyrimidinone II, which was treated with 3-(aminomethyl)pyridine to give 48% I (R = cyano, R1 = 3-pyridylmethyl). Inotropic and chronotropic effects were determined in vitro in cat papillary muscle and right atrium, resp. Selected compounds were then evaluated in vivo in a dog heart failure model. Changes in ventricular dP/dt, heart rate, and blood pressure were monitored. Several of these agents produced relatively minor changes in heart rate. This class of agents demonstrated a varying degree of vasodilator effects concomitant with increases in ventricular contractility. The most potent analogs, I (R = cyano, R1 = 3-pyridylmethyl; R = Br, R1 = Et, 3-pyridylmethyl), were evaluated orally in conscious dogs with implanted Konisberg pressure transducers, and their effect on left ventricular dP/dt was compared with that of milrinone. Mechanistically, the agents of this novel class appear not to mediate their effect either via β-receptors or inhibition of Na+/K+-ATPase. A major component of their inotropic effect is mediated by the inhibition of cardiac phosphodiesterase (PDE)-Fr. III. This was clearly demonstrated by I. Compound I (R = Br, R1 = 3-pyridylmethyl) was found to be the most potent inhibitor of PDE-Fr. III from among the compounds tested in this assay. The crystal structure of I (R = cyano, 3-pyridylmethyl)·HBF4 is also reported.

As far as I know, this compound(1194-22-5)Synthetic Route of C5H6N2O2 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Yoneyama, Hiroshi; Kobayashi, Satoshi; Okachi, Ryo researched the compound: 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone( cas:67914-60-7 ).Recommanded Product: 67914-60-7.They published the article 《Studies on antimicrobial activity of ketoconazole (KW-1414). VI. In vitro antifungal and antibacterial activity of ketoconazole (KW-1414) and its analogs》 about this compound( cas:67914-60-7 ) in Shinkin to Shinkinsho. Keywords: ketoconazole analog microbicide; bactericide ketoconazole derivative; fungicide ketoconazole derivative. We’ll tell you more about this compound (cas:67914-60-7).

Antifungal activities of structural analogs and metabolites of the synthetic antifungal agent ketoconazole (KCZ; KW-1414) (I) were investigated. R-39519 (desacetyl derivative) and R-44319 (trans isomer) had less antifungal activity against Candida species and dermatophytes than did I. HLI-151 (oxidized derivative) had no antifungal activity against any of the yeasts or fungi. Two known physiol. metabolites of I, R-43568 and T-1141, also showed no antifungal activity. I, R-39519, R-43568, and T-1141 showed no antibacterial activity against 12 strains of Lactobacillus species which are normal flora of the vagina. In blood of human volunteers administered orally 200 mg of I, no antifungal activity was detected except for I by bioautog. seeded with Kluyveromyces fragilis. In human urine of the same volunteers, no antifungal activity was detected by the bioautog.

As far as I know, this compound(67914-60-7)Recommanded Product: 67914-60-7 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis and biological evaluation of 2-chloro-3-[(thiazol-2-yl)amino]-1,4-naphthoquinones, published in 2019-07-01, which mentions a compound: 70-23-5, Name is Ethyl 3-bromo-2-oxopropanoate, Molecular C5H7BrO3, Synthetic Route of C5H7BrO3.

A series of novel, substituted 2-chloro-3-[(thiazol-2-yl)amino]-1,4-naphthoquinones have been prepared and shown to exhibit promising concentration-dependent activity against human SH-SY5Y cells, Plasmodium falciparum, Mycobacterium tuberculosis and P. aeruginosa. Substituent effects on observed bioactivity have been explored; the para-fluorophenyl derivative I exhibited activity across the range of the bioassays employed, indicating the potential of the 2-chloro-3-[(4-arylthiazol-2-yl)amino]-1,4-naphthoquinone scaffold in the development of novel, broad spectrum therapeutics.

As far as I know, this compound(70-23-5)Synthetic Route of C5H7BrO3 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2,6-Dichloropurine, is researched, Molecular C5H2Cl2N4, CAS is 5451-40-1, about Identification of a potent and selective phosphatidylinositol 3-kinase δ inhibitor for the treatment of non-Hodgkin′s lymphoma, the main research direction is non hodgkins lymphoma PIP3 delta antiproliferative apoptosis; Antiproliferative; Apoptosis; Non Hodgkin’s lymphoma; PI3Kδ inhibitor; Piperazinone; Purine.Related Products of 5451-40-1.

PI3Kδ has proved to be an effective target for anti-lymphoma drugs. However, the application of current approved PI3Kδ inhibitors has been greatly limited due to their specific immune-mediated toxicity and increased risk of infection, it is necessary to develop more PI3Kδ inhibitors with new scaffold. In this study, SAR study with respect to piperazinone-containing purine derivatives led to the discovery of a potent and selective PI3Kδ inhibitor, 4-(cyclobutanecarbonyl)-1-((2-(2-ethyl-1H-benzo[d]imidazol-1-yl)-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperazin-2-one (WNY1613). WNY1613 exhibits good antiproliferative activity against a panel of non-Hodgkin′s lymphoma (NHL) cell lines by inducing cancer cell apoptosis and inhibiting the phosphorylation of PI3K and MAPK downstream components. In addition, it can also prevent the tumor growth in both SU-DHL-6 and JEKO-1 xenograft models without observable toxicity. WNY1613 thus could be developed as a promising candidate for the treatment of NHL after subsequent extensive pharmacodynamics and pharmacokinetics investigation.

As far as I know, this compound(5451-40-1)Related Products of 5451-40-1 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Reaction of 4,6-dihydroxypyrimidines with bisulfite ion. III. Reactions of 2- and 5-substituted 4,6-dihydroxypyrimidines with the participation of bisulfite ion.Quality Control of 6-Hydroxy-2-methylpyrimidin-4(3H)-one.

Bisulfite catalyzed the hydrolysis of I (R = H, R1 = MeS) to barbituric acid and the debromination of I (R = Br, R1 = H). The debromination occurred via the bisulfite adduct. UV and 13C NMR data were given.

As far as I know, this compound(1194-22-5)Quality Control of 6-Hydroxy-2-methylpyrimidin-4(3H)-one can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Hazardous Materials called Bromination of carbon and formation of PBDD/Fs by copper bromide in oxidative thermal process, Author is Kojima, Yusuke; Fujimori, Takashi; Goto, Akitoshi; Shiota, Kenji; Kunisue, Tatsuya; Takaoka, Masaki, which mentions a compound: 7789-45-9, SMILESS is [Cu+2].[Br-].[Br-], Molecular Br2Cu, Related Products of 7789-45-9.

Brominated aromatic compounds are unintentionally generated during various thermal processes, including municipal solid waste incineration, elec.-waste open burning, and secondary copper smelting. Copper (Cu) plays an important role in the formation of brominated aromatic compounds In the present study, the thermochem. behaviors of Cu and Br in model samples, including copper bromide (CuBr2) and activated carbon, were studied using in situ X-ray absorption near-edge structure (XANES) and thermogravimetry. Quantification of polybrominated dibenzo-p-dioxins/furans (PBDD/Fs) was also conducted by gas chromatograph-high resolution mass spectrometer. Three key reactions were identified: (i) the reduction of CuBr2 to CuBr (room temperature to 300°C), (ii) the generation of Br bonded with aromatic carbon (150-350°C), and (iii) the oxidation of copper (>350°C). Maximum amounts of PBDD/Fs were found in residual solid phase after heating at 300°C. The anal. results indicated the direct bromination of aromatic carbon by the debromination of copper bromides (I, II) and that CuBr and CuO acted as catalysts in the oxidation of the carbon matrix. The bromination mechanisms revealed in this study are essential to the de novo formation of PBDD/Fs and other brominated aromatic compounds

As far as I know, this compound(7789-45-9)Related Products of 7789-45-9 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Priyadharsini, R.; Dharuman, A.; Nithya, P.; Shalini, P.; Sumithra, G. published an article about the compound: Oxazole( cas:288-42-6,SMILESS:O1C=NC=C1 ).Product Details of 288-42-6. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:288-42-6) through the article.

Epilepsy is a chronic disorder that causes unprovoked, recurrent seizures like a sudden rush of elec. activity in the brain. Neuronal hyperexcitability in epilepsy is due to an imbalance between glutamate-mediated excitation and GABA-mediated inhibition. This prompted us to design newer CSF1R inhibitors as efficient therapeutic drugs for the treatment of epilepsy. Based on the common pharmacophoric features for the inhibition of CSF1R inhibitors, a series of leads were designed using computational methods. A virtual library consisting of newly designed 60 mols. as CSF1R inhibitors were constructed .Based on these facts, a virtual library has been generated with 60 newly designed ligands containing imidazole, benzo pyrrole, quinoline, oaxzole, quinoxaline, benzimidazole, heterocyclic nucleus as CSF1R inhibitors (60). The binding mechanism of newly designed ligands with target enzymes CSF1R inhibitors was studied using Auto dock tools 1.5.6. The designed compounds were subjected and filtered by applying ADMET properties. In comparison with docking scores of standard antiepileptic drugs vigabatrin (GABA-2.14, CSF1R-1, 31) and sodium valproate (GABA-3.19, CSF1R-3.6) and the newly designed ligands, CS1 (-6.61), CS3 (-6.22), CS14 (-6.04) were found to be highly active hits than that of standards

From this literature《Virtual screening of newer potential colony stimulating factor 1 inhibitors as potent antiepileptic agents》,we know some information about this compound(288-42-6)Product Details of 288-42-6, but this is not all information, there are many literatures related to this compound(288-42-6).

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Hamedani, Naghmeh Faal; Azad, Leila; Shafiee, Shahin; Noushin, Annataj published an article about the compound: Ethyl 3-bromo-2-oxopropanoate( cas:70-23-5,SMILESS:O=C(OCC)C(CBr)=O ).Name: Ethyl 3-bromo-2-oxopropanoate. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:70-23-5) through the article.

The multicomponent reaction of aldehydes, benzoylisothiocyanate and alkyl bromides in the presence of ammonium acetate, sodium cyanide and a catalytic amount of KF/Clinoptilolite nanoparticles (KF/CP NPs) in the water at 100°C was investigated. In these reactions, thiazole I [R= H, Me, i-Pr; R1 = ethoxycarbonyl, 4-methoxyphenyl, 4-bromophenyl] were produced in good to excellent yields and short time. Also, the antioxidant activity was studied for some newly synthesized compounds using the DPPH radical trapping and reducing of ferric ion experiments and compared the results with synthetic antioxidants (TBHQ and BHT). As a result, the compounds I [R= i-Pr; R1 = ethoxycarbonyl] showed excellent DPPH radical trapping and reducing the strength of ferric ion. These compounds I [R= H, Me, i-Pr; R1 = ethoxycarbonyl, 4-methoxyphenyl, 4-bromophenyl] have biol. potential because of the thiazole core. For this reason, the antimicrobial activity of some synthesized compounds I [R= H, Me, i-Pr; R1 = ethoxycarbonyl, 4-methoxyphenyl, 4-bromophenyl] was studied by employing the disk diffusion test on Gram-pos. bacteria and Gram-neg. bacteria. The results of the disk diffusion test showed that these compounds I [R= H, Me, i-Pr; R1 = ethoxycarbonyl, 4-methoxyphenyl, 4-bromophenyl] prevented bacterial growth.

From this literature《Green Synthesis of Thiazole Derivatives using Multi-component Reaction of Aldehydes, Isothiocyanate and Alkyl Bromides: Investigation of Antioxidant and Antimicrobial Activity》,we know some information about this compound(70-23-5)Name: Ethyl 3-bromo-2-oxopropanoate, but this is not all information, there are many literatures related to this compound(70-23-5).

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem

Related Products of 1194-22-5. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Novel dinitromethyl-featured polynitro energetic salts. Author is Li, Ying; Huang, Haifeng; Lin, Xiangyang; Pan, Renming; Yang, Jun.

A unique and facile method was developed to synthesize a new class of energetic salts based on 2-amino-1,1,5,5-tetranitro-4-oxo-3-aza-pentene. All the salts were fully characterized by NMR (1H and 13C), IR spectroscopy and elemental anal. Furthermore, the crystal structure of the guanidinium salt was determined by single-crystal X-ray diffraction. The differential scanning calorimetry (DSC) results showed that the decomposition temperatures of these salts were between 126.2 °C and 148.8 °C. The densities of these salts lie in the range of 1.745 to 1.880 g cm-3. Their impact sensitivities and friction sensitivities were measured to be in the range of 1-16 J and 48-84 N, resp. All the salts exhibited promising detonation performances (detonation pressure: 28.6 to 34.3 GPa; detonation velocity: 8037 to 8674 m s-1), and the detonation performances of one of the salts were comparable to those of RDX.

From this literature《Novel dinitromethyl-featured polynitro energetic salts》,we know some information about this compound(1194-22-5)Related Products of 1194-22-5, but this is not all information, there are many literatures related to this compound(1194-22-5).

Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem