Category: oxazolidine

Patil, R. S.; Jadhav, P. M.; Radhakrishnan, S.; Soman, T. published the article 《Process chemistry of 4, 6-dihydroxy-2-methylpyrimidine-A potential precursor in pharmaceutical and explosive industries》. Keywords: dihydroxy methylpyrimidine A pharmaceutical explosive industry.They researched the compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one( cas:1194-22-5 ).Related Products of 1194-22-5. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1194-22-5) here.

4,6-Dihydroxy-2-methylpyrimidine is an important precursor, finding widespread applications in the preparation of high explosives and medicinal products. The synthesis of 4,6-dihydroxy-2-methylpyrimidine has been carried out by the condensation of acetamidinium chloride and di-Et malonate in absolute methanol and further acidified by hydrochloric acid. Process chem. has been studied by using various alcs., alkoxides and effect of reaction period. The role of process variables and parameters has been understood thoroughly and developed an economic process. Modified process yielded the product without compromising on its quality, which was confirmed by spectroscopic techniques and elemental anal. Hence, the study finds its usefulness in the development of an economic process for the production of 4,6-dihydroxy-2-methylpyrimidine.

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Oxazolidine – Wikipedia,
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Application In Synthesis of Ethyl 3-bromo-2-oxopropanoate. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Syntheses of Novel Tetrasubstituted Thiophenes from Benzene-1,2-Diamines, Ethyl Bromopyruvate, Malononitrile, and Aryl Isothiocyanates. Author is Piltan, Mohammad.

Synthesis of amino(oxo-dihydroquinoxalinyl)(phenylamino)thiophene-carbonitrile derivatives I [R = H, Me, Cl; R1 = 2-MeOC6H4, 4-NO2C6H4, Et, Ph] was reported via sequential base mediated condensation of malononitrile with aryl isothiocyanates followed by S-alkylation with 3-(bromomethyl)quinoxalin-2(1H)-one compounds and concurrent intramol. enamine type condensation of S-alkylated compounds in excellent yields.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthetic modification and scale-up process for 1,1-diamino-2,2-dinitroethene (FOX-7)》. Authors are Chung, Kyoo-Hyun; Goh, Eun Mee; Cho, Jin Rai.The article about the compound:6-Hydroxy-2-methylpyrimidin-4(3H)-onecas:1194-22-5,SMILESS:CC1=NC(=CC(N1)=O)O).Recommanded Product: 1194-22-5. Through the article, more information about this compound (cas:1194-22-5) is conveyed.

Many different synthetic routes to FOX-7 were developed until now. Each starting material such as 2-methylimidazole, 2-methoxy-2-methylimidazolidine-4,5-dione, or 2-methylpyrimidine-4,6-dione (4,6-dihydroxy-2-methylpyrimidine), was nitrated and then hydrolyzed to FOX-7 by somewhat different process, but the yields were more or less low and the processes were felt a little boring. In the modified process from 4,6-dihydroxy-2-methylpyrimidine, FOX-7 was synthesized in about 90% yield within several hours. The reaction temperature was well controlled in the preparation of 4,6-dihydroxy-2-methylpyrimidine, while some heat was evolved at the beginning of nitration, judging from a reaction calorimeter.

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Oxazolidine – Wikipedia,
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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about Properties of the OH Adducts of Hydroxy-, Methyl-, Methoxy-, and Amino-Substituted Pyrimidines: Their Dehydration Reactions and End-Product Analysis.Recommanded Product: 1194-22-5.

Reactions of hydroxyl radicals (•OH) with 2-amino-4-methylpyrimidine (AMP), 2-amino-4,6-dimethylpyrimidine (ADMP), 2-amino-4-methoxy-6-methylpyrimidine (AMMP), 2-amino-4-hydroxy-6-methylpyrimidine (AHMP), 4,6-dihydroxy-2-methylpyrimidine (DHMP), 2,4-dimethyl-6-hydroxypyrimidine (DMHP), 6-methyluracil (MU), and 5,6-dimethyluracil (DMU) have been studied by pulse radiolysis and steady-state radiolysis techniques at different pH values. The second-order rate constants of the reaction of •OH with these systems are of the order of (2-9) × 109 dm3 mol-1 s-1 at near neutral pH. The difference in the spectral features of the intermediates at near neutral pH and at higher pH (10.4) obtained with these pyrimidines are attributed to the deprotonation of the OH adducts. The G(TMPD•+) obtained at pH ∼ 6, from the electron-transfer reactions of the oxidizing intermediates with the reductant, N,N,N’,N’-tetramethyl-p-phenylenediamine (TMPD), are in the range (0.2-0.9) × 10-7 mol J-1 which constituted about 3-16% oxidizing radicals. These yields were highly enhanced at pH 10.5 in the case of AHMP, DHMP, DMU, and MU [G(TMPD•+) = 3.8-5.5 equivalent 66-95% oxidizing radical]. On the basis of these results, it is proposed that a nonoxidizing C(6)-ylC(5)OH radical adduct is initially formed at pH 6 which is responsible for the observed transient spectra. The high yield of TMPD•+ at higher pH is explained in terms of a base-catalyzed conversion (via a dehydration reaction) of the initially formed C(6)-ylC(5)OH adduct (nonoxidizing) to C(5)-ylC(6)OH adduct which is oxidizing in nature. Among the selected pyrimidines, such a dehydration reaction was observed only with those having a keto (or hydroxy) group at the C(4) position of the pyrimidine ring. Qual. analyses of the products resulting from the OH adducts of DHMP (at pH 4.5) and DMHP (at pH 6) were carried out using HPLC-ES-MS and a variety of products have been identified. Glycolic and dimeric products were observed as the major end-products. The product profiles of both DHMP and DMHP have shown that the precursors of the products are mainly the C(6)-ylC(5)OH and the H adduct radicals. The identified products are formed mainly by disproportionation and dimerization reactions of these radicals. The mechanistic aspects are discussed.

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Oxazolidine – Wikipedia,
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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Metelytsia, Larysa O.; Trush, Maria M.; Kovalishyn, Vasyl V.; Hodyna, Diana M.; Kachaeva, Maryna V.; Brovaret, Volodymyr S.; Pilyo, Stepan G.; Sukhoveev, Volodymyr V.; Tsyhankov, Serhii A.; Blagodatnyi, Volodymyr M.; Semenyuta, Ivan V. researched the compound: Oxazole( cas:288-42-6 ).HPLC of Formula: 288-42-6.They published the article 《1,3-Oxazole derivatives of cytisine as potential inhibitors of glutathione reductase of Candida spp.: QSAR modeling, docking analysis and experimental study of new anti-Candida agents》 about this compound( cas:288-42-6 ) in Computational Biology and Chemistry. Keywords: Candida cytisine oxazole derivative glutathione reductase mol docking; 1,3-oxazole; Candida spp.; Cytisine; Glutathione reductase; Molecular docking; QSAR. We’ll tell you more about this compound (cas:288-42-6).

Natural products as well as their derivatives play a significant role in the discovery of new biol. active compounds in the different areas of our life especially in the field of medicine. The synthesis of compounds produced from natural products including cytisine is one approach for the wider use of natural substances in the development of new drugs. QSAR modeling was used to predict and select of biol. active cytisine-containing 1,3-oxazoles. The eleven most promising compounds were identified, synthesized and tested. The activity of the synthesized compounds was evaluated using the disk diffusion method against C. albicans M 885 (ATCC 10,231) strain and clin. fluconazole-resistant Candida krusei strain. Mol. docking of the most active compounds as potential inhibitors of the Candida spp. glutathione reductase was performed using the AutoDock Vina. The built classification models demonstrated good stability, robustness and predictive power. The eleven cytisine-containing 1,3-oxazoles were synthesized and their activity against Candida spp. was evaluated. Compounds 10, 11 as potential inhibitors of the Candida spp. glutathione reductase demonstrated the high activity against C. albicans M 885 (ATCC 10,231) strain and clin. fluconazole-resistant Candida krusei strain. The studied compounds 10, 11 present the interesting scaffold for further investigation as potential inhibitors of the Candida spp. glutathione reductase with the promising antifungal properties. The developed models are publicly available online at http://ochem.eu/article/120720 and could be used by scientists for design of new more effective drugs.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 288-42-6, is researched, Molecular C3H3NO, about Fragment-Based Ligand Discovery Using Protein-Observed 19F NMR: A Second Semester Organic Chemistry CURE Project, the main research direction is chem laboratory research fluorine 19 NMR spectroscopy ligand discovery.Synthetic Route of C3H3NO.

Curriculum-based undergraduate research experiences (CUREs) have been shown to increase student retention in STEM fields and are starting to become more widely adopted in chem. curricula. Here we describe a 10-wk CURE that is suitable for a second-semester organic chem. laboratory course. Students synthesize small mols. and use protein-observed 19F (PrOF) NMR to assess the small mol.’s binding affinity to a target protein. The research project introduced students to multistep organic synthesis, structure-activity relationship studies, quant. biophys. measurements (measuring Kd from PrOF NMR experiments), and scientific literacy. Docking experiments could be added to help students understand how changes in a ligand structure may affect binding to a protein. Assessment using the CURE survey indicates self-perceived skill gains from the course that exceed gains measured in a traditional and an inquiry-based laboratory experience. Given the speed of the binding experiment and the alignment of the synthetic methods with a second-semester organic chem. laboratory course, a PrOF NMR fragment-based ligand discovery lab can be readily implemented in the undergraduate chem. curriculum.

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Oxazolidine – Wikipedia,
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Application In Synthesis of 6-Hydroxy-2-methylpyrimidin-4(3H)-one. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 6-Hydroxy-2-methylpyrimidin-4(3H)-one, is researched, Molecular C5H6N2O2, CAS is 1194-22-5, about The nitration peculiarity of 6-hydroxy-2-methylpyrimidine-4(3H)-one to 6-hydroxy-2-methyl-5-nitropyrimidine-4(3H)-one. Author is Kushtaev, A. A.; Yudin, N. V.; Zbarsky, V. L..

The nitration kinetic of 6-hydroxy-2-methylpyrimidine-4(3H)-one to 6-hydroxy-2-methyl-5-nitropyrimidine-4(3H)-one was studied in sulfuric-nitric acid mixtures The dependences of rate constants from medium acidity and nitric acid concentration were obtained. The nitrogen oxides influence was discovered on this process. The basicity constant of 6-hydroxy-2-methylpyrimidine-4(3H)-one was calculated.

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Oxazolidine – Wikipedia,
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Reference of Oxazole. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Oxazole, is researched, Molecular C3H3NO, CAS is 288-42-6, about Exploring Bioactive Compounds in Anaerobically Digested Slurry: Extraction, Characterization, and Assessment of Antifungal Activity. Author is Lu, Jiaxin; Muhmood, Atif; Liu, Hongtao; Dong, Renjie; Pang, Sen; Wu, Shubiao.

Anaerobically digested slurry is well known for its use as a bio-fertilizer because of its high macro-nutrient content (e.g. N, P, K), which is essential for plant growth. Ultrasound-assisted extraction using three solvents, Et acetate (EA), dichloromethane (DM), and n-butanol (NB), was employed for extraction of bioactive compounds After extraction and characterization, antifungal activity against Fusarium oxysporum was assessed. EA was found to be a more efficient extractant with less evaporating time (4 min), irresp. of temperature DM was found to be efficient in the extraction of O-heterocycles, while N-heterocycles were enriched in EA extracts Furthermore, the bioactive compounds, 1,2-benzenedicarboxylic acid, Bu 2-methylpropyl ester (54.9%), and 9-octadecenamide, (Z)-(2.51%) were detected in the EA extract, while tetrahydro-2-furanmethanamine (1.32%), cyclic octat. sulfur (1.17%), squalene (4.06%), and cholestan-3-ol (9.06%) were detected in the DM extract The EA extract achieved approx. 84% inhibition of F. oxysporum, while only 63% inhibition was observed with the DM extract Collectively, these findings indicate that in addition to its role as a fertilizer, digested slurry may also contribute to the control of phytopathogens upon land application because of the presence of various bioactive compounds However, further work is needed to explore the diversity of bioactive compounds in digested manures and evaluate their antimicrobial potential.

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Reference of Ethyl 3-bromo-2-oxopropanoate. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Ethyl 3-bromo-2-oxopropanoate, is researched, Molecular C5H7BrO3, CAS is 70-23-5, about Four-component green synthesis of benzochromene derivatives using nano-KF/clinoptilolite as basic catalyst: study of antioxidant activity. Author is Ezzatzadeh, Elham; Hossaini, Zinatossadat.

An efficient procedure for the synthesis of benzochromene derivatives I (R = Me, Et, Ph, 4-MeC6H4, 4-MeOC6H4; R1 = COOEt, 4-MeC6H4, 4-MeOC6H4; R2 = Me, Et) employing 1-(6-hydroxy-2-isopropenyl-1-benzofuran-yl)-1-ethanone (euparin), aldehydes, alkyl bromides, dialkyl acetylenedicarboxylate and triphenylphosphine in the presence of KF/CP NPs as a heterogeneous base nano-catalyst in water at 80° is investigated. Also, the antioxidant activity of some synthesized compounds was studied. The workup of mixture of reaction is simple, and the products can be separated easily by filtration. KF/CP NPs showed a good improvement in the yield of the product and displayed significant reusable activity.

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Oxazolidine – Wikipedia,
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Reference of 2,6-Dichloropurine. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2,6-Dichloropurine, is researched, Molecular C5H2Cl2N4, CAS is 5451-40-1, about Hydrogen-Bonding Interactions of Methylated Adenine Derivatives. Author is Osifova, Zuzana; Socha, Ondrej; Muzikova Cechova, Lucie; Sala, Michal; Janeba, Zlatko; Dracinsky, Martin.

Hydrogen bonding between nucleobases is a crucial noncovalent interaction for the life on Earth. Apart from Watson-Crick binding, Hoogsteen pairing has been found in many structures of nucleic acids. Methylation of nucleic acids (NAs) is a post-replication or post-transcription mechanism that can modulate the structure and function of a NA without changing its sequence. Methylation of adenine at the N6 position to form N6-methyladenine (m6A) is one of the most important and common epigenetic markers. This paper describes an investigation of intermol. H-bonding interactions of methylated derivatives of adenine with its complementary partner, thymine. Adenine derivatives with (di)methylamino groups in positions 2 or 6, I (R1 = NHMe, R2 = H; R1 = H, R2 = Me; R1 = NMe2, R2 = H; R1 = R2 = H), have been prepared and their interactions with thymine derivative II have been studied by NMR spectroscopy and DFT calculations It has been found that Hoogsteen pairing is preferred for adenine derivatives, which offers two hydrogen-bond sites on both Watson-Crick and Hoogsteen sides of the mol. Methylation of the N6 position leads to further stabilization of the Hoogsteen pair.

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