Category: oxazolidines

Chemistry is an experimental science, Computed Properties of C12H12N2O2, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 34052-90-9, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, molecular formula is C12H12N2O2, belongs to oxazolidines compound. In a document, author is Cruz-Hurtado, Marycarmen.

In vitro phase I metabolism of vinclozolin by human liver microsomes

1. Vinclozolin (Vin) is a fungicide used in agricultural settings and is classified as an endocrine disruptor. Vin is non-enzymatically hydrolyzed to 2-[[(3,5-dichlorophenyl)-carbamoyl]oxy]-2-methyl-3-butenoic acid (M1) and 3′,5′-dichloro-2-hydroxy-2-methylbut-3-enanilide (M2) metabolites. There is no information about Vin biotransformation in humans, therefore, the aim of this study was to characterize its in vitro metabolism using human liver microsomes. 2. Vin was metabolized to the [3-(3,5-dichlorophenyl)-5-methyl-5-(1,2-dihydroxyethyl)-1,3-oxazolidine-2,4-dione] (M4) and N-(2,3,4-trihydroxy-2-methyl-1-oxo)-3,5-dichlorophenyl-1-carbamic acid (M7) metabolites, which are unstable and gradually converted to 3 ‘,5 ‘-dichloro-2,3,4-trihydroxy-2-methylbutyranilide (DTMBA, formerly denoted as M5). M4 and DTMBA metabolites co-eluted in the same HPLC peak; this co-elute peak exhibited a Michaelis-Menten kinetic, whereas M7 showed a substrate inhibition kinetics. The K-M app for co-eluted M4/DTMBA and M7 was 24.2 +/- 5.6 and 116.0 +/- 52.6 mu M, the V-Max app was 0.280 +/- 0.015 and 0.180 +/- 0.060 nmoles/min/mg protein, and the CLint app was 11.5 and 1.5 mL/min/g protein, respectively. The K-i for M7 was 133.2 +/- 63.9 mu M. Cytochrome P450 (CYP) chemical inhibitors furafylline (CYP1A2), ketoconazole (CYP3A4), pilocarpine (CYP2A6) and sulfaphenazole (CYP2C9) inhibited M4/DTMBA and M7 formation, suggesting that Vin is metabolized in humans by CYP. 3. DTMBA is a stable metabolite and specific of Vin, therefore, it could be used as a biomarker of Vin exposure in humans to perform epidemiological studies.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 34052-90-9, in my other articles. Computed Properties of C12H12N2O2.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 90319-52-1, Name is (R)-4-Phenyloxazolidin-2-one, SMILES is O=C1OC[C@@H](C2=CC=CC=C2)N1, in an article , author is Jin, Zhichao, once mentioned of 90319-52-1, HPLC of Formula: C9H9NO2.

Enantioselective Organocatalytic Synthesis of Oxazolidine Derivatives through a One-Pot Cascade Reaction

An asymmetric organocatalytic cascade reaction which can afford a series of oxazolidine derivatives has been developed. The one-pot reaction reported here can produce an oxazolidine derivative in a highly enantioselective manner and good yield with good to excellent diastereomeric ratio.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 90319-52-1, you can contact me at any time and look forward to more communication. HPLC of Formula: C9H9NO2.

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Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 34052-90-9, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, molecular formula is C12H12N2O2. In an article, author is Hariono, Maywan,once mentioned of 34052-90-9, Name: 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene.

2-Bromo-4-(3,4-dimethyl-5-phenyl-1,3-oxazolidin-2-yl)-6-methoxyphenol

In the title compound, C18H20BrNO3, the oxazolidine ring adopts an envelope conformation with the N atom at the flap position. The mean plane of oxazolidine ring makes dihedral angles of 82.96 (13) and 70.97 (12)degrees, respectively, with the phenyl and benzene rings. In the crystal, adjacent molecules are connected via O-H center dot center dot center dot O and C-H center dot center dot center dot O hydrogen bonds and C-H center dot center dot center dot pi interactions into a zigzag chain along the b axis.

Interested yet? Keep reading other articles of 34052-90-9, you can contact me at any time and look forward to more communication. Name: 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Safety of (R)-4-Phenyloxazolidin-2-one, 90319-52-1, Name is (R)-4-Phenyloxazolidin-2-one, SMILES is O=C1OC[C@@H](C2=CC=CC=C2)N1, belongs to oxazolidines compound. In a document, author is Zhang, Yu, introduce the new discover.

Taburnaemines A-I, Cytotoxic Vobasinyl-Iboga-Type Bisindole Alkaloids from Tabernaemontana corymbosa

Nineteen vobasinyl-ibogan-type bisindole alkaloids, including nine new compounds, taburnaemines A-I (1-9), were isolated from the twigs and leaves of Tabernaemontana corymbosa. The structures and absolute configurations of the new alkaloids were determined by a combination of MS, NMR, and ECD analyses. Alkaloids 1-5 contain a rare 1,3-oxazinane moiety in the vobasinyl unit, while 6 has an uncommon 1,3-oxazolidine moiety in the iboga unit. The absolute configurations of alkaloid 1 and the known alkaloid tabernaecorymbosine A (10) were confirmed by single-crystal X-ray diffraction analysis. All of the bisindole alkaloids, except 2 and 16′-decarbomethoxytabernaecoryrnbosine A (14), showed antiproliferative activity (IC50 2.6-9.8 mu M) against several human cancer cell lines, including A-549, MDA-MB-231, MCF-7, KB, and P-glycoprotein-overexpressing multidrug-resistant KB cells. The preliminary structure-activity relationship correlations are also discussed.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 90319-52-1. Safety of (R)-4-Phenyloxazolidin-2-one.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

90319-52-1, Name is (R)-4-Phenyloxazolidin-2-one, molecular formula is C9H9NO2, belongs to oxazolidines compound, is a common compound. In a patnet, author is Li, Hai-Hua, once mentioned the new application about 90319-52-1, Application In Synthesis of (R)-4-Phenyloxazolidin-2-one.

Zinc and thiocyanate-mediated oxazolidine ring formation in a trinuclear zinc(II) complex: Synthesis, structure, and properties

A novel trinuclear zinc(II) complex, [Zn3L2(NCS)(2)], where L is the deprotonated form of 2-(3-(2-(2-hydroxy-3-methoxybenzylideneamino)ethyl)oxazolidin-2-yl)-6-methoxyphenol (H2L), has been unexpectedly prepared from the reaction of Schiff base ligand 2-((2-(2-hydroxyethylamino)ethylimino)methyl)-6-methoxyphenol (HL’) with 3-methoxysalicylaldehyde, ammonium thiocyanate, and zinc nitrate in methanol. The complex has been characterized by elemental analysis, IR spectroscopy and single-crystal X-ray diffraction studies. It is interesting that the Schiff base ligand HL’ used to prepare the complex was transferred to a novel ligand H2L, bearing newly formed oxazolidine ring. Zinc ion and thiocyanate anion may be the essential factors for the cyclorization. Thermal stability and fluorescent property of the complex were also studied. (c) 2013 Elsevier B.V. All rights reserved.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 90319-52-1. The above is the message from the blog manager. Application In Synthesis of (R)-4-Phenyloxazolidin-2-one.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

In an article, author is Tarighat, Maryam Abbasi, once mentioned the application of 6704-31-0, Application In Synthesis of Oxetan-3-one, Name is Oxetan-3-one, molecular formula is C3H4O2, molecular weight is 72.0627, MDL number is MFCD09263255, category is oxazolidines. Now introduce a scientific discovery about this category.

Chemometrics-assisted spectrophotometric method for simultaneous determination of Pb2+ and Cu2+ ions in different foodstuffs, soil and water samples using 2-benzylspiro [isoindoline-1,5 ‘-oxazolidine]-2 ‘,3,4 ‘-trione using continuous wavelet transformation and partial least squares – Calculation of pK(f) of complexes with rank annihilation factor analysis

A new multi-component analysis method based on zero-crossing point-continuous wavelet transformation (CWT) was developed for simultaneous spectrophotometric determination of Cu2+ and Pb2+ ions based on the complex formation with 2-benzyl espiro[isoindoline-1,5oxasolidine]-2,3,4 trione (BSIIOT). The absorption spectra were evaluated with respect to synthetic ligand concentration, time of complexation and pH. Therefore according the absorbance values, 0.015 mmol L-1 BSIIOT, 10 min after mixing and pH 8.0 were used as optimum values. The complex formation between BSIIOT ligand and the cations Cu2+ and Pb2+ by application of rank annihilation factor analysis (RAFA) were investigated. Daubechies-4 (db4), discrete Meyer (dmey), Monet (morl) and Symlet-8 (sym8) continuous wavelet transforms for signal treatments were found to be suitable among the wavelet families. The applicability of new synthetic ligand and selected mother wavelets were used for the simultaneous determination of strongly overlapped spectra of species without using any pre-chemical treatment. Therefore, CWT signals together with zero crossing technique were directly applied to the overlapping absorption spectra of Cu2+ and Pb2+. The calibration graphs for estimation of Pb2+ and Cu2+ were obtained by measuring the CWT amplitudes at zero crossing points for Cu2+ and Pb2+ at the wavelet domain, respectively. The proposed method was validated by simultaneous determination of Cu2+ and Pb2+ ions in red beans, walnut, rice, tea and soil samples. The obtained results of samples with proposed method have been compared with those predicted by partial least squares (PLS) and flame atomic absorption spectrophotometiy (FAAS). (C) 2015 Elsevier B.V. All rights reserved.

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Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Electric Literature of 34052-90-9, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 34052-90-9, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, SMILES is C1(C2=NCCO2)=CC=CC(C3=NCCO3)=C1, belongs to oxazolidines compound. In a article, author is Silva, Sandrina, introduce new discover of the category.

N-Thiocarbonyl Iminosugars: Synthesis and Evaluation of Castanospermine Analogues Bearing Oxazole-2(3H)-thione Moieties

A straightforward and efficient synthetic route to a new class of glycosidase inhibitors containing an oxazole-2(3H)-thione moiety has been devised. The approach involves the formation of -hydroxy ketones, which, after condensation with thiocyanic acid, leads to the formation of the heterocycle. By exploiting the ability of the nitrogen atom of oxazoline-2-thione precursors to act as nucleophiles in intramolecular addition, castanospermine analogues could be readily prepared in good overall yields. Glycosidase inhibitory activity compared to oxazolidinethione analogues showed a strong influence of the double bond, for example with pseudoiminosugar 19, by suppressing -glucosidase inhibition and introducing, to a moderate level, -glucosidase inhibitory activity. Reactivities showed the propensity of oxazole-2(3H)-thiones – especially when fused on carbohydrate frames – to convert into 1,3-oxazolidine-2-thione aminals through nucleophilic addition to the double bond, leading to unexpected tricyclic structure 21.

Electric Literature of 34052-90-9, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 34052-90-9.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 84793-24-8, Name is Ethyl (S)-2-[(S)-4-Methyl-2,5-dioxo-3-oxazolidinyl]-4-phenylbutanoate, formurla is C16H19NO5. In a document, author is Hong, Xiao-Wei, introducing its new discovery. Category: oxazolidines.

Asymmetric Synthesis of 1,3-Oxazolidine Derivatives with Multi-Component Reaction and Research of Kinetic Resolution

An efficient multi-component reaction to synthesize multi-substituted 1,3-oxazolidine compounds of high optical purity was described. All the products were well-characterized and the absolute configuration of one chiral center was determined. The plausible mechanism was proposed and a kinetic resolution of epoxides process was confirmed.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 84793-24-8 help many people in the next few years. Category: oxazolidines.

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Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 84793-24-8, Name is Ethyl (S)-2-[(S)-4-Methyl-2,5-dioxo-3-oxazolidinyl]-4-phenylbutanoate, molecular formula is C16H19NO5, belongs to oxazolidines compound. In a document, author is Sardela, V. F., introduce the new discover, Formula: C16H19NO5.

Consequences of the formation of 3,4-dimethyl-5-phenyl-1,3-oxazolidine on the analysis of ephedrines in urine by gas chromatography and a new method for confirmation as N-trifluoroacetyl-O-t-butyldimethylsilyl ether derivatives

The compound 3,4-dimethyl-5-phenyl-1,3-oxazolidine can appear as an artifact during the gas chromatographic analysis of ephedrines. Its presence is a risk for doping control and forensic analyses. An evaluation about the consequences of its formation showed the possibility of a false positive for ephedrine, a false negative for pseudophedrine and increased uncertainty in the quantitative approach. Misinterpretations can be avoided with the observation of fragments m/z 56 and 71 in the ephedrine mass spectrum during GC-MS analysis and also by the formation of N-TFA-O-TBDMS derivatives prior to GC analysis. These N-TFA-O-TBDMS derivatives lead to an increase in the number and mass of diagnostic ions, meet the identification criteria, and provide an improvement in chromatographic resolution, allowing the separation of the ephedrines. (C) 2011 Elsevier B.V. All rights reserved.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 84793-24-8. Formula: C16H19NO5.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Related Products of 90319-52-1, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 90319-52-1, Name is (R)-4-Phenyloxazolidin-2-one, SMILES is O=C1OC[C@@H](C2=CC=CC=C2)N1, belongs to oxazolidines compound. In a article, author is Savarimuthu, S. Antony, introduce new discover of the category.

Highly Z-selective synthesis of 1,3-oxathiol-2-ylidenes and 4-methylene-oxazolidine-2-thiones via atom-specific 5-exo-dig cyclization of propargyl alcohol with isothiocyanate

DBU mediated 5-exo-dig cyclization of isothiocyanate and propargyl alcohol leading to valuable heterocyclic compounds has been accomplished. The different modes of nucleophilicity (either S-selective or N-selective) of isothiocyanates were found to depend on the substitution pattern of propargyl alcohol. The terminal propargyl alcohol and isothiocyanate underwent an N-nucleophilic attack to afford 3-substituted 4-methylene oxazolidine-2-thiones. In contrast, exclusive S-nucleophilic cyclization was observed with internal propargyl alcohol to produce (Z)-1,3-oxathiol-2-ylidenes and (Z)-N-(Z)-4-ethylidene-1,3-oxathiolan-2-ylidenes from secondary and primary propargyl alcohols, respectively. The formation of high Z-selectivity in the imine motif and alkene is the highlight of this new method as multiple selectivities over C = N and C = C in a single system are synthetically highly challenging. The Z-selectivity in imine and alkene may be attributed to electronic and steric factors respectively.

Related Products of 90319-52-1, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 90319-52-1.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem