Category: oxazolidines

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 90319-52-1, Name is (R)-4-Phenyloxazolidin-2-one, formurla is C9H9NO2. In a document, author is Angelov, Plamen, introducing its new discovery. Application In Synthesis of (R)-4-Phenyloxazolidin-2-one.

Biomimetic synthesis, antibacterial activity and structure-activity properties of the pyroglutamate core of oxazolomycin

Biomimetic intramolecular aldol reactions on oxazolidine templates derived from serine may be used to generate densely functionalised pyroglutamates, which are simpler mimics of the right hand side of oxazolomycin. Some of the compounds from this sequence exhibit in vivo activity against S. aureus and E. coli, suggesting that pyroglutamate scaffolds may be useful templates for the development of novel antibacterials, and cheminformatic analysis has been used to provide some structure-activity data.

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Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 34052-90-9, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, molecular formula is C12H12N2O2. In an article, author is Hajra, Saumen,once mentioned of 34052-90-9, Application In Synthesis of 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene.

Catalyst-Free Stereocontrolled Formal [3+2]-Cycloaddition of CO2 for the Synthesis of Enantiopure Spiro[indoline-3,5 ‘-oxazolidine]-2,2 ‘-diones under Aqueous and Ambient Conditions

A highly efficient regio- and stereoselective spontaneous formal [3 + 2]-cycloaddition of CO2 in aqueous medium is developed for the one-pot synthesis of spiro[indoline-3,5′-oxazolidine]-2,2’-diones with excellent enantiopuirity (ee up to 99%) under catalyst-free and ambient conditions. The detailed study reveals NH-spiroaziridine- and 3-(aminomethyl)-3-chloro-oxindoles, two in situ generated reactive intermediate compounds for the spontaneous cycloaddition with CO2, and the latter is responsible for the stereoselectivity. An unprecedented mechanism of desulfinylation is also disclosed herewith.

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Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 99395-88-7, Name is (S)-4-Phenyloxazolidin-2-one, molecular formula is C9H9NO2, belongs to oxazolidines compound, is a common compound. In a patnet, author is Ding, Caixia, once mentioned the new application about 99395-88-7, HPLC of Formula: C9H9NO2.

Polynuclear Complexes of Ligands Containing in Situ Formed Oxazinane and Oxazolidine Rings with Appended Alkoxyl and Phenol Groups

In situ formation of ligands is an efficient approach to synthesizing novel complexes with unique coordinating moieties. Oxazolidines and oxazinanes are 1,3-N,O-containing five-membered and six-membered heterocycles, respectively. Metal complexes of Ligands derived from these two heterocycles are rather rare. In this work, we designed and synthesized a novel multihydoxy ligand, 2((2,3-dihydroxypropylamino)methyl)phenol (H3L1). It contains both aminoethanol and aminopropanol units, which may be employed to react with aldehydes to afford oxazolidines and oxazinanes, respectively. Thus, H3L1 was reacted with metal salts in the absence cr presence of aldehydes to afford complexes [Cu(HL1)](2) (1), [CuL2](4)center dot 4CH(3)OH (2) [Zn5Na2(L-3)(4)(DMSO)(2.65)(DMF)(1.35)]-DMF (3), and [Ni(HL4)](2) (4). Complex 1 is a dialkoxo-bridged binuclear Cu(II) complex. The coordination moieties are linked by intermolecular C-H center dot center dot center dot O hydrogen bonds to afford a 1D double-chain supramolecular structure. Interestingly, in complexes 2-4, H3L1 has been reacted with formaldehyde, salicylaldehyde, and 2,6-diformyl-4-cresol to afford novel ligands H2L2, H3L3, and H3L4, respectively. The combination of in situ formed oxazinane or oxazolidine rings with appended alkoxyl and phenol functionalities in these ligands has been demonstrated to form a rich diversity of coordination structures. Thus, 2 is a tetranuclear Cu(II) complex with a face-sharing double defective cubane core structure. In this complex, (L-2)(2-) ligands coordinate in two different bridging modes with the Harris notations of 3.1(1)2(12)2(13)1(1) and 3.1(1)3(123)1(1)1(1), respectively. Complex 3 has an interesting heptanuclear Zn5Na2 core structure. A central Zn(II) is coordinated with four alkoxo O atoms from four (L-3)(3-) ligands. Each of the O atom further bridges another Zn(II) atom, resulting in a Zn-5 moiety, which is then connected to two Na+ by phenoxo O bridges, finally affording the Zn5Na2 core. The bridging mode of (L-3)(3-) can be designated as 4.2(12)2(13)1(1)3(124)1(1). And Complex 4 is a binuclear Ni(II) complex containing di-mu(2)-phenoxo bridges. The coordination moieties are linked by intermolecular C-H center dot center dot center dot pi, C-H center dot center dot center dot O, and pi center dot center dot center dot pi interactions to afford a two-dimensional supramolecular network. These results indicate that the combination of in situ formed oxazinane and oxazolidine rings with appended phenol and alkoxyl functionalities is an efficient approach to developing novel ligands and complexes with a rich structural diversity. Variable temperature magnetic data measurements revealed that medium antiferromagnetic interaction exists between the Cu(II) centers in complex 1 with a -2J value of 278 cm(-1). And in complex 4, weak antiferromagnetic coupling occurs between the Ni(II) centers, with a -2J value of 9.36 cm(-1).

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Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Chemistry is an experimental science, Application In Synthesis of (R)-4-Phenyloxazolidin-2-one, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 90319-52-1, Name is (R)-4-Phenyloxazolidin-2-one, molecular formula is C9H9NO2, belongs to oxazolidines compound. In a document, author is Perfetti, Mauro.

Lanthanide Complexes with a Tripodal Nitroxyl Radical Showing Strong Magnetic Coupling

A series of isomorphous mononuclear complexes of Ln(III) ions comprising one stable tripodal oxazolidine nitroxyl radical were obtained in acetonitrile media starting from nitrates. The compounds, [LnRad(NO3)(3)] (Ln = Gd, Tb, Dy, Tm, Y; Rad = 4,4-dimethyl-2,2-bis(pyridin-2-yl)-1,3-oxazolidine-3-oxyl), have a molecular structure. Their coordination polyhedron, LnO(7)N(2), can be described as a tricapped trigonal prism with symmetry not far from D-3h. The extracted value of 23 cm(-1) for the antiferromagnetic coupling of Gd-Rad established from the DC magnetic and EPR data is a record strength for the complexes of 4f elements with nitroxyl radicals. The terbium derivative displays frequency-dependent out-of-phase signals in zero field, indicating single-molecule magnetic behavior. With an applied field of 0.1 T, an effective barrier of 57 cm(-1) is found.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 90319-52-1, in my other articles. Application In Synthesis of (R)-4-Phenyloxazolidin-2-one.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Arai, Takayoshi, once mentioned the application of 6704-31-0, Name is Oxetan-3-one, molecular formula is C3H4O2, molecular weight is 72.0627, MDL number is MFCD09263255, category is oxazolidines. Now introduce a scientific discovery about this category, Recommanded Product: Oxetan-3-one.

Development of a tailor-made bis(oxazolidine)pyridine-metal catalyst for the [3+2] cycloaddition of azomethine imines with propiolates

A series of bis(oxazolidine)pyridine ligands (the PyBodines) were newly designed and synthesized for the development of a highly efficient, tailor-made catalyst for the [3+2] cycloaddition of azomethine imines with propiolates. The PyBodine(L-Ala)-Cu(OAc)(2) catalyst was selected on the basis of solid-phase catalysis/CD-HTS and exhibited high efficiency, producing the (R)-adducts with excellent enantioselectivity.

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Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Electric Literature of 16251-45-9, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 16251-45-9, Name is (4S,5R)-4-Methyl-5-phenyloxazolidin-2-one, SMILES is O=C1O[C@H](C2=CC=CC=C2)[C@H](C)N1, belongs to oxazolidines compound. In a article, author is Soni, Vijay, introduce new discover of the category.

Depletion of M. tuberculosis GlmU from Infected Murine Lungs Effects the Clearance of the Pathogen

M. tuberculosis N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU(Mtb)) is a bifunctional enzyme engaged in the synthesis of two metabolic intermediates N-acetylglucosamine-1-phosphate (GlcNAc-1-P) and UDP-GlcNAc, catalyzed by the C- and N-terminal domains respectively. UDP-GlcNAc is a key metabolite essential for the synthesis of peptidoglycan, disaccharide linker, arabinogalactan and mycothiols. While glmU(Mtb) was predicted to be an essential gene, till date the role of GlmU(Mtb) in modulating the in vitro growth of Mtb or its role in survival of pathogen ex vivo / in vivo have not been deciphered. Here we present the results of a comprehensive study dissecting the role of GlmU(Mtb) in arbitrating the survival of the pathogen both in vitro and in vivo. We find that absence of GlmU(Mtb) leads to extensive perturbation of bacterial morphology and substantial reduction in cell wall thickness under normoxic as well as hypoxic conditions. Complementation studies show that the acetyl-and uridyl-transferase activities of GlmU(Mtb) are independently essential for bacterial survival in vitro, and GlmU(Mtb) is also found to be essential for mycobacterial survival in THP-1 cells as well as in guinea pigs. Depletion of GlmU(Mtb) from infected murine lungs, four weeks post infection, led to significant reduction in the bacillary load. The administration of Oxa33, a novel oxazolidine derivative that specifically inhibits GlmU(Mtb), to infected mice resulted in significant decrease in the bacillary load. Thus our study establishes GlmU(Mtb) as a strong candidate for intervention measures against established tuberculosis infections.

Electric Literature of 16251-45-9, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 16251-45-9 is helpful to your research.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 34052-90-9, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, molecular formula is C12H12N2O2. In an article, author is Minor-Villar, Leticia,once mentioned of 34052-90-9, Quality Control of 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene.

Desulfurization-Oxygenation of Chiral 1,3-Thiazolidine-2-thiones and 1,3-Oxazolidine-2-thiones Using Propylene Oxide and Microwave Irradiation

An efficient method for the desulfurization-oxygenation of 1,3-thiazolidine-2-thiones and 1,3-oxazolidine-2-thiones using propylene oxide and employing microwave irradiation is described. This strategy of oxygenation of the thiocarbonyl group provides an attractive methodology to prepare chiral 1,3-thiazolidin-2-ones and 1,3-oxazolidin-2-ones from the corresponding precursors in good yields.

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Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 6704-31-0, Name is Oxetan-3-one. In a document, author is Haynes, Craig S., introducing its new discovery. Product Details of 6704-31-0.

syn-Diastereoselective glycolate aldol addition reactions of an N(3)-(p-methoxyphenoxy)acetyloxazolidine-2-thione

An N-3-(p-methoxyphenoxy)acetyloxazolidine-2-thione has been synthesized and employed in glycolate asymmetric aldol addition reactions with aromatic and aliphatic aldehydes. It was determined that the titanium tetrachloride medicated aldol reaction afforded diastereoselectivities that ranged from 75:25 to 94:6 when the reaction was conducted at -78 degrees C. The absolute stereochemistry of the aldol adducts was determined by H-1 NMR spectroscopy and X-ray crystallography. The H-1 NMR spectra of the aldol adducts contained a signal (the a-proton of the glycolate position of the aldol side chain) that was highly deshielded due to conformational restriction about the N(3)-(p-methoxyphenoxy)acetyl side chain and the oxazolidine-2-thione auxiliary. (C) 2016 Elsevier Ltd. All rights reserved.

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Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Related Products of 99395-88-7, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 99395-88-7, Name is (S)-4-Phenyloxazolidin-2-one, SMILES is [C@H]1(NC(OC1)=O)C2=CC=CC=C2, belongs to oxazolidines compound. In a article, author is Tewary, Subrata, introduce new discover of the category.

Theoretical Perspectives on Redox Non-Innocent Oxazolidine N-Oxide Iron Nitroxide Complexes

One-electron redox processes in ligands that exhibit non-innocent behaviour invariably leads to the generation of radical species, which, when coupled with redox-active metal centres, can lead to strong magnetic exchange, ambiguous electronic structures and even spin crossover (SCO). We have chosen two iron complexes [Fe-II(L-center dot)(2)](BF4)(2) (1) and [Fe-III(L-)(2)](BPh4) (2) [with L-center dot = 4-dimethyl-2,2-di(2-pyridyl)oxazolidine N-oxide] as the basis for an extensive theoretical study to determine the influence and interplay of the strong magnetic exchange, the redox non-innocent behaviour and any possible spin transitions. A series of calculations established the low-spin character of the Fe in both the complexes and gave us valuable insight into the electronic structure of 1 and 2 along with their one- and two-electron reduced species. An attempt has been made to relate the bonding features to the energy difference between different spin states and to the influence of the exchange coupling on any possible SCO properties.

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Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Synthetic Route of 6704-31-0, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 6704-31-0, Name is Oxetan-3-one, SMILES is O1CC(C1)=O, belongs to oxazolidines compound. In a article, author is Tonnele, Claire, introduce new discover of the category.

Nonlinear optical responses of self-assembled monolayers functionalized with indolino-oxazolidine photoswitches

A computational approach combining molecular dynamic simulations and density functional theory (DFT) calculations is implemented to evaluate the second-order nonlinear optical (NLO) responses of photoresponsive self-assembled monolayers (SAMs) based on indolino-oxazolidine molecular switches. These numerical simulations provide a complete atomistic picture of the morphology of the SAMs, revealing a high degree of positional disorder and an almost isotropic orientation of the chromophores. Subsequent DFT calculations, carried out to evaluate the average first hyperpolarizability of indolino-oxazolidine switches within the SAM, predict that the structural disorder does not significantly reduce the NLO contrast compared to that of the isolated molecules. Chromophores in the SAM can assume a limited number of specific conformations, due to the high rotational barrier that characterize the conjugated bonds along the indolino/oxazolidine-dyene-thiophene sequence. A notable exception is the rotation about the thiophene-thioalkyl bond, which is not only almost free, but also strongly correlated with the magnitude of the first hyperpolarizability. Controlling this rotation by chemical design could thus be a viable strategy to optimize the SAMs NLO response and the performance of photoresponsive devices based on indolino/oxazolidine switches.

Synthetic Route of 6704-31-0, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 6704-31-0.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem