Category: oxazolidines

Chemistry is an experimental science, Product Details of 99395-88-7, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 99395-88-7, Name is (S)-4-Phenyloxazolidin-2-one, molecular formula is C9H9NO2, belongs to oxazolidines compound. In a document, author is Lubin, Hodney.

Crystallization-Induced Dynamic Resolution of Fox Chiral Auxiliary and Application to the Diastereoselective Electrophilic Fluorination of Amide Enolates

A highly efficient crystallization-induced dynamic resolution (CIDR) of trans-Fox (fluorinated oxazolidine) chiral auxiliary is reported. This chiral auxiliary was used for highly diastereoselective (>98% de) electrophilic fluorination of amide enolates. After removal of the chiral auxiliary, highly valuable enantiopure alpha-fluorocarboxylic acids and beta-fluoroalcohols are obtained.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 99395-88-7, in my other articles. Product Details of 99395-88-7.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Let¡¯s face it, organic chemistry can seem difficult to learn, Formula: C10H11NO2, Especially from a beginner¡¯s point of view. Like 16251-45-9, Name is (4S,5R)-4-Methyl-5-phenyloxazolidin-2-one, molecular formula is C11H18N2O, belongs to ethers-buliding-blocks compound. In a document, author is Goncalves, Raoni S. B., introducing its new discovery.

Mefloquine-oxazolidine derivatives, derived from mefloquine and arenecarbaldehydes: In vitro activity including against the multidrug-resistant tuberculosis strain T113

Ten new mefloquine-oxazolidine derivatives, 4-[(1S,8aR)-3-(aryl)hexahydro[1,3]oxazolo[3,4-a]pyridin-1-yl]-2,8-bis(trifluoromethyl)quinoline (1: aryl = substituted phenyl) and 4-[(1S, 8aR)-3-(heteroaryl) hexahydro[1,3] oxazolo[3,4-a] pyridin-1-yl]-2,8-bis(trifluoromethyl) quinoline [2: heteroaryl = 5-nitrothien-2-yl (2a); 5-nitrofuran-2-yl (2b) and 4H-imidazol-2-yl) (2c)], have been synthesized and evaluated against Mycobacterium tuberculosis. Compounds 1f (aryl = 3-ethoxyphenyl), 1g (Ar = 3,4,5-(MeO)(3)-C6H2) and 2c were slightly more active than mefloquine (MIC = 33 mu M) with MICs = 24.5, 22.5 and 27.4, respectively, whereas compounds 1e (aryl = 3,4-(MeO)(2)-C6H3) and 2a (MICs = 11.9 and 12.1 mu M, respectively) were ca. 2.7 times more active than mefloquine, with a better tuberculostatic activity than the first line tuberculostatic agent ethambutol (MIC = 15.9). The compounds were also assayed against the MDR strain T113 and the same MICs were observed. Thus the new derivatives have advantages over such anti-TB drugs as isoniazid, rifampicin, ethambutol and ofloxacin, for which this strain is resistant. The most active compounds were not cytotoxic to Murine Macrophages Cells in a concentration near their MIC values. (C) 2011 Elsevier Ltd. All rights reserved.

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Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Related Products of 90319-52-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 90319-52-1, Name is (R)-4-Phenyloxazolidin-2-one, SMILES is O=C1OC[C@@H](C2=CC=CC=C2)N1, belongs to oxazolidines compound. In a article, author is Noguera, Martin E., introduce new discover of the category.

High-resolution structure of intramolecularly proteolyzed human mucin-1 SEA domain

SEA domains are ubiquitous in large proteins associated with highly glycosylated environments. Certain SEA domains undergo intramolecular proteolysis involving a nucleophilic attack of a serine hydroxyl group on the preceding glycine carbonyl. The mucin-1 (MUC1) SEA domain has been extensively investigated as a model of intramolecular proteolysis. Since neither a general base, a general acid, nor an oxyanion hole could be identified in MUC1 SEA, it has been suggested that proteolysis is accelerated by a non-planarity of the scissile peptide bond imposed by protein folding. A reactant distorted peptide bond has been also invoked to explain the autoproteolysis of several unrelated proteins. However, the only evidence of peptide distortion in MUC1 SEA stems from molecular dynamic simulations of the reactant modeled upon a single NMR structure of the cleaved product. We report the first high-resolution X-ray structure of cleaved MUC1 SEA. Structural comparison with uncleaved SEA domains suggests that the number of residues evolutionarily inserted in the cleaved loop of MUC1 SEA precludes the formation of a properly hydrogen-bonded beta turn. By sequence analysis, we show that this conformational frustration is shared by all known cleaved SEA domains. In addition, alternative conformations of the uncleaved precursor could be modeled in which the scissile peptide bond is planar. The implications of these structures for autoproteolysis are discussed in the light of the previous research on autoproteolysis.

Related Products of 90319-52-1, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 90319-52-1 is helpful to your research.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Application of 6704-31-0, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 6704-31-0, Name is Oxetan-3-one, SMILES is O1CC(C1)=O, belongs to oxazolidines compound. In a article, author is Mardani, Zahra, introduce new discover of the category.

Structural conversion of an oxazolidine ligand upon treatment with copper(I) and (II) halides; structural, spectral, theoretical and docking studies

In this work, the 2-(2-(pyridin-2-yl)oxazolidin-3-yl)ethanol (AEPC) ligand was prepared under solvent free conditions using ultrasonic irradiation, before reaction with a Cu(NO3)(2)/KSCN mixture, CuCl2 and CuI, the products of which were characterized by elemental analysis, UV-Vis, FT-IR spectroscopy and single-crystal X-ray diffraction. The X-ray analyses results revealed that AEPC, after reactions with the three copper(I/II) halides, gave structures ([Cu(DEA)Cl-2] (2), DEA = diethanolamine, [Cu(BHEG)(2)] (3), BHEG = bis(2-hydroxyethyl)glycinato); however, it retains its structure on treatment with Cu(NO3)(2)/KSCN mixture ([Cu(AEPC)(NCS)(2)] (1)). The geometrical parameters for the complexes were compared with the Cambridge Structural Database (CSD) and coordination modes for thiocyanate ion were extracted. In the crystal structure of 1, the copper ion has a distorted square-pyramidal geometry and a (CuNN2NOalc)-N-py-N-NCS-O-tert environment in which the AEPC acts as NN’O-donor in a facial coordination mode. In the crystal structure of 2, the copper ion has a Cu(N-sec)(O-alc)(2)Cl-2 environment and distorted square-pyramidal geometry in which the DEA ligand is coordinated as a mer-NO2-donor. The copper ion in 3 has a CuN2O4 environment and distorted octahedral geometry. The ability of these compounds to interact with the nine biomacromolecules (BRAF kinase, CatB, DNA gyrase, HDAC7, rHA, RNR, TrxR, TS and Top II) was investigated by Docking calculations and compared with that of doxorubicin. The thermodynamic stability of 1 and its isomer and also charge distribution patterns were studied by DFT and NBO analysis, respectively.

Application of 6704-31-0, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 6704-31-0 is helpful to your research.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Synthetic Route of 90319-52-1, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 90319-52-1, Name is (R)-4-Phenyloxazolidin-2-one, SMILES is O=C1OC[C@@H](C2=CC=CC=C2)N1, belongs to oxazolidines compound. In a article, author is Zuriaga-Agusti, E., introduce new discover of the category.

Pollution reduction in an eco-friendly chrome-free tanning and evaluation of the biodegradation by composting of the tanned leather wastes

Chromium is one of the most important environmental concerns related to tanneries. The most often used process for hide tanning is chrome tanning. This implies the presence of chromium both in wastewaters and in leather wastes. Leather wastes have to be disposed in landfills what entails a considerable environmental impact and high cost. In this work, a study about the effect of a chrome-free tanning process using titanium salts instead, on the wastewater and on the solid wastes has been performed. In this way, a study of biodegradation of leather waste samples tanned with different tanned agents by composting together with food wastes is carried out in a laboratory composter. Results indicated that leather tanned with titanium salts met the required quality standards. Besides, the concentration of organic matter and salts in the tannery process wastewater was lower comparing with the chromium tanning agent. In the biodegradation study by composting, leather samples tanned with titanium were degraded, reducing around 10% the carbon content with the subsequent diminution of the C/N ratio. In addition, the size was reduced 41% in 45 days. However, leather sample tanned with oxazolidine was partially degraded in the composter; meanwhile chrome and vegetable tanned leather kept inalterable. (C) 2014 Elsevier Ltd. All rights reserved.

Synthetic Route of 90319-52-1, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 90319-52-1.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 16251-45-9, Name is (4S,5R)-4-Methyl-5-phenyloxazolidin-2-one, molecular formula is , belongs to oxazolidines compound. In a document, author is Luo Jianxun, Quality Control of (4S,5R)-4-Methyl-5-phenyloxazolidin-2-one.

Wet-White Leather Processing: A New Complex Combination Tannage

A new complex combination tannage based on combination tannages of veg-Al and veg-Oxa has been developed as a chrome-free tannage. The veg-Al-Oxa tannage was applied to hide powder and pickled goatskin. The shrinkage temperature of the finished leather obtained by veg-Al-Oxa complex combination tanning is 112 degrees C, which is much higher than that of binary combination tannages. The fibre weave is better separated in ternary combination tannage than in a single tannage or binary combination tannage as judged from SEM images. Based on Ts, length contraction rate, tensile strength and tear strength of the leather on heat-ageing, a good ternary combination tannage sequence is confirmed to be vegetable tannins, aluminium tanning agent and oxazolidine. The optimized offers of vegetable tannins, aluminium tanning agent and oxazolidine are 10%, 3% and 3% based on pickled goatskin pelt.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 16251-45-9, in my other articles. Quality Control of (4S,5R)-4-Methyl-5-phenyloxazolidin-2-one.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Category: oxazolidines, 6704-31-0, Name is Oxetan-3-one, SMILES is O1CC(C1)=O, belongs to oxazolidines compound. In a document, author is Schmid, Markus B., introduce the new discover.

Formation and Stability of Prolinol and Prolinol Ether Enamines by NMR: Delicate Selectivity and Reactivity Balances and Parasitic Equilibria

Enamine key intermediates in organocatalysis, derived from aldehydes and prolinol or Jorgensen-Hayashitype prolinol ether catalysts, were generated in different solvents and investigated by NMR spectroscopy. Depending on the catalyst structure, trends for their formation and amounts are elucidated. For prolinol catalysts, the first enamine detection in situ is presented and the rapid cyclization of the enamine to the oxazolidine (parasitic equilibrium) is monitored. In the case of diphenylprolinol, this equilibrium is fully shifted to the endo-oxazolidine (dead end) by the two geminal phenyl rings, most probably because of the Thorpe-Ingold effect. With bulkier and electron-withdrawing aryl rings, however, the enamine is stabilized relative to the oxazolidine, allowing for the parallel detection of the enamine and the oxazolidine. In the case of prolinol ethers, the enamine amounts decrease with increasing sizes of the aryl meta-substituents and the O-protecting group. In addition, for small aldehyde alkyl chains, Z-configured enamines are observed for the first time in solution. Prolinol silyl ether enamines are evidenced to undergo slow desilylation and subsequent rapid oxazolidine formation in DMSO. For unfortunate combinations of aldehydes, catalysts, solvents, and additives, the enamine formation is drastically decelerated but can be screened for by a rapid and facile NMR approach. Altogether, especially by clarifying the delicate balances of catalyst selectivity and reactivity, our NMR spectroscopic findings can be expected to substantially aid synthetically working organic chemists in the optimization of organocatalytic reaction conditions and of prolinol (ether) substitution patterns for enamine catalysis.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 6704-31-0. Category: oxazolidines.

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Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Application In Synthesis of (S)-4-Phenyloxazolidin-2-one, 99395-88-7, Name is (S)-4-Phenyloxazolidin-2-one, molecular formula is C9H9NO2, belongs to oxazolidines compound. In a document, author is Zhao, Li-Xia, introduce the new discover.

3-Dichloroacetyl oxazolidine protect maize from imazethapyr herbicide injury

Safeners are an important tool used to ensure the safe using of herbicide. The objective of this paper was to investigate the protective effect of four 3-dichloroacetyl oxazolidine safeners (3-dichloroacetyl-2,2-dimethyl-1,3-oxazolidine [R-28725], racemate of 3-dichloroacetyl-2,2-dimethyl-4-ethyl- 1,3-oxazolidine, and its two chiral stereoisomers) in reducing the injury caused by imazethapyr. Physiological and biochemical tests were conducted under laboratory condition, by using seed treatment with safeners and soil treatment with imazethapyr, respectively. The interaction of two safeners (R-28725 and R-stereoisomer) and imazethapyr reduced the injury of maize significantly, and also increased glutathione content, activity of glutathione S-transferases, and activity of acetolactate synthase in maize. When induced by R-stereoisomer, the GSH content in root and in shoot increased 100.7% and 73.6%, respectively. When induced by R-28725, the GST activity in vivo increased threefold and the GST activity in vitro more than doubled. The kinetic parameter V-max of GST in the maize treated with R-28725 and R-stereoisomer increased by 102.2% and 81.9%, respectively, compared with the control. The results also showed that R-28725 and R-stereoisomer induced glutathione S-transferases affinity for the substrate of conjugation reaction significantly.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 99395-88-7. Application In Synthesis of (S)-4-Phenyloxazolidin-2-one.

Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

In an article, author is Wang, Wengui, once mentioned the application of 90319-52-1, Name is (R)-4-Phenyloxazolidin-2-one, molecular formula is C9H9NO2, molecular weight is 163.1733, MDL number is MFCD00192393, category is oxazolidines. Now introduce a scientific discovery about this category, Application In Synthesis of (R)-4-Phenyloxazolidin-2-one.

Palladium-catalyzed allylation of trifluoromethylated ketene aminoacetals

A new development in the palladium-catalyzed allylation reaction of trifluoromethylated ketene aminoacetals was reported. These nucleophilic reagents were prepared by adding aminoalcohols to methyl 3,3,3-trifluoro-2-trifluoromethylpropanoate. The asymmetric version of the allylation reaction was investigated using chiral oxazolidine-based starting materials or chiral palladium catalysts. Asymmetric allylic alkylation was carried out with up to 74% ee using a chiral catalyst. However, no improvement was observed using double stereodifferentiation. These results provided a novel access for trifluoromethylated all-carbon quaternary carbon centers. (C) 2014 Elsevier B.V. All rights reserved.

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Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 34052-90-9, Name is 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene, formurla is C12H12N2O2. In a document, author is Yuan, Liemei, introducing its new discovery. Computed Properties of C12H12N2O2.

Synthesis of oxazolidines as latent curing agents for single-component polyurethane adhesive and its properties study

Four oxazolidine compounds OX1-OX4 were prepared. Their structures were characterized using Fourier transform infrared spectra, H-1-NMR, C-13-NMR, and ESI-MS. The hydrolysis kinetics research of oxazolidines suggested that the hydrolysis of oxazolidine followed the first-order reaction. The gap of the ground energies between the open- and closed-ring was calculated using Gaussian software, which indicated that the stability of the open-ring system of OX1 was the best. Then, the obtained oxazolidines were applied to single-component polyurethane (SPU) and filler CaCO3 was added to investigate the effect of the two above on the properties of SPU. The results show that the pore size and the number of bubbles produced in the SPU decreased with the increase of the rate of hydrolysis of the added oxazolidine, and the bondability of the polyurethane was better. With the increase of CaCO3 content, the polyurethane surface became smoother and the bond strength was stronger. (c) 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45722.

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Reference:
Oxazolidine – Wikipedia,
,Oxazolidine | C3H7NO – PubChem