Discovery of (R)-4-Benzyl-2-oxazolidinone

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Chemistry is traditionally divided into organic and inorganic chemistry. HPLC of Formula: C10H11NO2, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent,Which mentioned a new discovery about 102029-44-7

Incubation of [2-2H]-(2S,3R)-2-methyl-3-hydroxypentanoyl-SACP ([2-2H]-1a) with the epimerizing ketoreductase domain EryKR1 in the presence of a catalytic amount NADP+ (0.05 equiv) resulted in time- and cofactor-dependent washout of deuterium from 1a, as a result of equilibrium isotope exchange of transiently generated [2-2H]-2-methyl-3- ketopentanoyl-ACP. Incubations of [2-2H]-(2S,3S)-2-methyl-3-hydroxy- pentanoyl-SACP with RifKR7 and with NysKR1 also resulted in time-dependent loss of deuterium. By contrast, incubations of [2-2H]-(2R,3S)-2-methyl-3- hydroxypentanoyl-SACP and [2-2H]-(2R,3R)-2-methyl-3-hydroxypentanoyl- SACP with the non-epimerizing ketoreductase domains EryKR6 and TylKR1, respectively, did not result in any significant washout of deuterium. The isotope exchange assay directly establishes that specific polyketide synthase ketoreductase domains also have an intrinsic epimerase activity, thus enabling mechanistic analysis of a key determinant of polyketide stereocomplexity.

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Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H1828NO – PubChem