145589-03-3, (R)-4-Benzyl-3-(3-methylbutanoyl)oxazolidin-2-one is a oxazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a stirred solution of (S)-4-benzyl-3-(3-methylbutyryl)-2-oxazolidinone (13.0 g, 50 mmol), which is prepared according to Rueger et a/ Tetrahedron Letters (2000), 41 (51), 10085-10089, in dry THF at -78 0C is added LiHMDS (55 mL, 1.0 M in toluene, 55 mmol) and the solution is stirred at 0 0C for 30 minutes before cooling down to -78 0C. AIIyI bromide (4.0 mL, 55 mmol) is then added and the mixture is stirred at room temperature for 2 hours. The products are extracted with EtOAc, washed with saturated aqueous NH4CI, water and saturated aqueous NaCI, dried (MgSO4) and evaporated to give a yellow oil which is purified by flash chromatography on silica gel eluting with 10% EtOAc/hexane to give IVA as a colourless oil. 1H NMR (400.13 MHz, CDCI3) delta 0.91 (d, 6H, J = 6.8 Hz), 1.8-2.0 (m, 1 H), 2.2-2.5 (m, 2H), 2.57 (dd, 1 H1 J = 13.3, 10.1 Hz), 3.25 (dd, 1 H, J = 13.3, 3.2 Hz), 3.7-3.9 (m, 1 H), 4.0-4.1 (m, 2H), 4.5-4.7 (m, 1H), 4.95 (d, 1 H, J = 10.2 Hz), 5.02 (dq, 1 H, J = 17.1 , 1.5 Hz), 5.7-5.8 (m, 1 H), 7.1-7.3 (m, 5H) ppm., 145589-03-3
As the paragraph descriping shows that 145589-03-3 is playing an increasingly important role.
Reference£º
Patent; NOVARTIS AG; WO2008/155338; (2008); A2;,
Oxazolidine – Wikipedia
Oxazolidine | C3H7NO – PubChem