SDS of cas: 5451-40-1. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2,6-Dichloropurine, is researched, Molecular C5H2Cl2N4, CAS is 5451-40-1, about Adamantane-Substituted Purines and Their β-Cyclodextrin Complexes: Synthesis and Biological Activity. Author is Rouchal, Michal; Rudolfova, Jana; Krystof, Vladimir; Vojackova, Veronika; Cmelik, Richard; Vicha, Robert.
Cyclin-dependent kinases (CDKs) play an important role in the cell-division cycle. Synthetic inhibitors of CDKs are based on 2,6,9-trisubstituted purines and are developed as potential anticancer drugs; however, they have low solubility in water. In this study, authors proved that the pharmaco-chem. properties of purine-based inhibitors can be improved by appropriate substitution with the adamantane moiety. Authors prepared ten new purine derivatives with adamantane skeletons that were linked at position 6 using phenylene spacers of variable geometry and polarity. Authors demonstrated that the adamantane skeleton does not compromise the biol. activity, and some of the new purines displayed even higher inhibition activity towards CDK2/cyclin E than the parental compounds These findings were supported by a docking study, which showed an adamantane scaffold inside the binding pocket participating in the complex stabilization with non-polar interactions. In addition, authors demonstrated that β-cyclodextrin (CD) increases the drug’s solubility in water, although this is at the cost of reducing the biochem. and cellular effect. Most likely, the drug concentration, which is necessary for target engagement, was decreased by competitive drug binding within the complex with β-CD.
Compound(5451-40-1)SDS of cas: 5451-40-1 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(2,6-Dichloropurine), if you are interested, you can check out my other related articles.
Reference:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem