A new method development and validation of dual wavelength UV spectro- photometric method for simultaneous estimation of Metaxolone and Diclofenac potassium in combined dosage form was written by Mallela, Vijaya Jyothi;Kovvuru, Praneeth Kumar Reddy;Amulya, B.;Latha, Sree P.. And the article was included in Indo American Journal of Pharmaceutical Research in 2016.Safety of 5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one This article mentions the following:
A simple, accurate, and precise dual wavelength UV spectrophotometric method was developed for simultaneous determination of Metaxolone and Diclofenac potassium in combined pharmaceutical dosage forms. The literature review reveals that there is no dual wavelength method development for this combination of drugs, hence this method was developed. The wavelengths selected for determination of Metaxolone were 270 nm and 280 nm, whereas, the wavelengths selected for determination of Diclofenac potassium were 265 nm and 278 nm. Methanol and distilled water were used as solvents. Regression anal. of Beer’s plots showed good correlation in concentration range of 15-90 μg/mL for Metaxolone and 2-12 μg/mL for Diclofenac potassium. Accuracy of method was found between 98.0-102.0%. The intra-day and inter-day precision studies of the method were found to be within limits. Limit of Detection was found to be 0.780μg and 0.0456 μg for Metaxolone and Diclofenac potassium resp. and Limit of Quantitation was found to be 2.36μg and 0.1382 μg for Metaxolone and Diclofenac potassium resp. The developed method is validated as per ICH guidelines and the results were found to be within the results. Hence, the proposed method can be successfully applied for determination of these drugs in com. tablets. In the experiment, the researchers used many compounds, for example, 5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one (cas: 1665-48-1Safety of 5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one).
5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one (cas: 1665-48-1) belongs to oxazolidine derivatives. Oxazolidine-based compounds have started to attract attention also in the medicinal and materials chemistry fields. Oxazolidines are cyclic condensation products of β-amino alcohols and aldehydes or ketone, and they undergo a facile and complete hydrolysis in aqueous solution. Alterations in carbonyl moiety control the rate of formation of a given β-amino alcohol.Safety of 5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one
Referemce:
Oxazolidine – Wikipedia,
Oxazolidine | C3H7NO – PubChem