Heterocyclic Building Blocks-Oxazolidine

Shibamoto, Takayuki published the artcileFlavor in the cysteine-glucose model system prepared in microwave and conventional ovens, Recommanded Product: 4,5-Dimethyloxazole, the publication is ACS Symposium Series (1994), 457-65, database is CAplus.

Flavors created by cooking in a microwave oven and a conventional oven are significantly different. The difference is due to the formation, both in quality and quantity, of heterocyclic compounds The volatile heterocyclic compounds generated from an aqueous D-glucose/L-cysteine Maillard system upon microwave irradiation or conventional heating were isolated and identified by gas chromatog. and mass spectrometry. Heterocyclic compounds were formed in considerably higher amounts in the microwave-irradiated samples. They included thiazole, 2,5-dimethylthiazole, 4,5-dimethyloxazole, 2-methylpyridine, and 2,3-dihydro-3,5-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one. Compounds formed in significantly higher amounts in the conventionally heated samples were 2-methylpyrazine, 2,6-dimethylpyrazine, 2-furanmethanol, and 4-hydroxy-2,5-dimethyl-3(2H)-furanone. The lack of desirables cooked flavors in microwaved foods may be due to the absence of or decreased formation of pyrazines and furans. The flavor profiles of microwaved and conventionally heated foods suggest that the formation mechanisms of compounds, especially of pyrazines, are different. Various factors such as electrolytes, pH, and moisture content have been shown to alter the generation of volatiles and degree of browning in microwaved systems.

ACS Symposium Series published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C18H28B2O4, Recommanded Product: 4,5-Dimethyloxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Yang, Ji published the artcileStudy on nonaqueous phase Maillard reaction of glucose/L-lysine model system, Safety of 4,5-Dimethyloxazole, the publication is Yancao Keji (2011), 55-61, 83, database is CAplus.

The thermogravimetric characteristics of glucose, L-lysine and their mixture were determined by thermogravimetry. The pyrolytic products of glucose and L-lysine mixture at 5 temperature ranges were analyzed by the combination of thermogravimetry, solid phase microextraction and gas chromatog.-mass spectrometry (TG-SPME-GC-MS). The effects of the proportion of glucose to L-lysine, and air flow on the yields of 2-ethyl-3,5-dimethylpyrazine and 3,5-diethyl-2-methylpyrazine were investigated as well. The results showed that : (1) the activation energy of reaction of glucose/L-lysine model system was far lower than that of degradation on their own. There was an endothermic process at the early reaction stage. In the temperature range of 135 to 245°C weight loss started, the mixture lost about 40% of its weight (2) 39 Compounds were identified in pyrolytic products of the model system. Ketones and furfurals were the main products at 100 to 250°C. From 250 to 350°C, pyrazine, pyridine, pyrrole, oxazole, imidazole and other nitrogenous heterocyclic compounds were detected. And the important flavor compounds were produced started from 150°C. (3) The yields of 2-ethyl-3,5-dimethylpyrazine and 3,5-diethyl-2-methylpyrazine culminated at air velocity of 200 mL/min and the mass ratio of glucose to L-lysine of 1:1.

Yancao Keji published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C18H34N4O5S, Safety of 4,5-Dimethyloxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Wang, Shuai published the artcileFormal Carbene C-H Bond Insertion in the Cu(I)-Catalyzed Reaction of Bis(trimethylsilyl)diazomethane with Benzoxazoles and Oxazoles, SDS of cas: 72571-06-3, the publication is Organic Letters (2019), 21(6), 1809-1812, database is CAplus and MEDLINE.

A Cu(I)-catalyzed cross-coupling reaction of bis(trimethylsilyl)diazomethane and benzoxazoles/oxazoles is reported. A wide range of functional groups can be tolerated in this transformation. This reaction provides a new method to directly introduce a 1,1-bis(trimethylsilyl)methyl group into heteroaromatic C-H bonds. Subsequent transformations of 1,1-bis(trimethylsilyl)-methylated heteroaromatic compounds are also presented.

Organic Letters published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C12H21NO3, SDS of cas: 72571-06-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Wang, Shuai published the artcileFormal Carbene C-H Bond Insertion in the Cu(I)-Catalyzed Reaction of Bis(trimethylsilyl)diazomethane with Benzoxazoles and Oxazoles, Application In Synthesis of 20662-83-3, the publication is Organic Letters (2019), 21(6), 1809-1812, database is CAplus and MEDLINE.

A Cu(I)-catalyzed cross-coupling reaction of bis(trimethylsilyl)diazomethane and benzoxazoles/oxazoles is reported. A wide range of functional groups can be tolerated in this transformation. This reaction provides a new method to directly introduce a 1,1-bis(trimethylsilyl)methyl group into heteroaromatic C-H bonds. Subsequent transformations of 1,1-bis(trimethylsilyl)-methylated heteroaromatic compounds are also presented.

Organic Letters published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C15H14O3, Application In Synthesis of 20662-83-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Zhang, Ling-Juan published the artcileTandem cycloaddition-decarboxylation of α-keto acid and isocyanide under oxidant-free conditions towards monosubstituted oxazoles, Related Products of oxazolidine, the publication is RSC Advances (2016), 6(77), 73450-73453, database is CAplus.

An efficient method, tandem [3+2] cycloaddition-decarboxylation of α-keto acid and isocyanide promoted by copper salt was developed. Under oxidant-free conditions, a series monosubstituted oxazoles was constructed. Different from the traditional application of α-oxo acids as acyl surrogates, the elegant approach ingeniously avoided consuming excess oxidants.

RSC Advances published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C25H29N9O3, Related Products of oxazolidine.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

He, Zhen published the artcileMicrobiota in mesenteric adipose tissue from Crohns disease promote colitis in mice, Name: 4,5-Dimethyloxazole, the publication is Microbiome (2021), 9(1), 228, database is CAplus and MEDLINE.

Mesenteric adipose tissue (mAT) hyperplasia, known as creeping fat is a pathol. characteristic of Crohns disease (CD). The reserve of creeping fat in surgery is associated with poor prognosis of CD patients, but the mechanism remains unknown. Mesenteric microbiome, metabolome, and host transcriptome were characterized using a cohort of 48 patients with CD and 16 non-CD controls. Multidimensional data including 16S rRNA gene sequencing (16S rRNA), host RNA sequencing, and metabolome were integrated to reveal network interaction. Mesenteric resident bacteria were isolated from mAT and functionally investigated both in the dextran sulfate sodium (DSS) model and in the Il10 gene-deficient (Il10-/-) mouse colitis model to validate their pro-inflammatory roles. Mesenteric microbiota contributed to aberrant metabolites production and transcripts in mATs from patients with CD. The presence of mAT resident microbiota was associated with the development of CD. Achromobacter pulmonis (A. pulmonis) isolated from CD mAT could translocate to mAT and exacerbate both DSS-induced and Il10 gene-deficient (Il10-/-) spontaneous colitis in mice. The levels of A. pulmonis in both mAT and mucous layer from CD patients were higher compared to those from the non-CD group. This study suggests that the mesenteric microbiota from patients with CD sculpt a detrimental microenvironment and promote intestinal inflammation.

Microbiome published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Name: 4,5-Dimethyloxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Vitzthum, O. G. published the artcileOxazoles and thiazoles in coffee aroma, Product Details of C5H7NO, the publication is Journal of Food Science (1974), 39(6), 1210-15, database is CAplus.

Twenty oxazoles and 23 thiazoles not previously reported as constituents of roasted coffee were identified by a combination of glass capillary gas chromatog. and mass spectrometry. Roasted coffee volatiles were isolated using atm. steam distillation The enrichment of steam volatiles was carried out on Porapak Q by organic solvent extraction and separation of the organic phase into basic and neutral fractions.

Journal of Food Science published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C9H10O4, Product Details of C5H7NO.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Vitzthum, O. G. published the artcileVolatile components of roasted cocoa. Basic fraction, Recommanded Product: 4,5-Dimethyloxazole, the publication is Journal of Food Science (1975), 40(5), 911-16, database is CAplus.

Roasted cocoa volatiles were isolated using the following technique:extraction with supercritical CO2 under pressure followed by atm. steam distillation; adsorption on Porapak Q and subsequent extraction with purified diethylether; separation of the organic phase into basic and neutral fractions. Identification of basic cocoa aroma constituents was accomplished by mass spectrometry in combination with a 200m × 0.31 mm i.d. glass capillary column. For the 1st time 59 compounds are reported in roasted cocoa including alkyl-, alkenyl, acyl-, furyl- and alicyclic pyrazines, pyridines, quinoxalines, oxazoles, quinoline [91-22-5] and methyl o-aminobenzoate [134-20-3]. The CO2-extraction process described is generally applicable to studies on volatile aroma constituents in food odor research.

Journal of Food Science published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C9H8BClN2O2, Recommanded Product: 4,5-Dimethyloxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Wang, Zhen-Hua published the artcileNickel-catalyzed decarboxylative cross-coupling of indole-3-acetic acids with aryl bromides by convergent paired electrolysis, Application In Synthesis of 72571-06-3, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(59), 8202-8205, database is CAplus and MEDLINE.

Herein, nickel-catalyzed decarboxylative cross-coupling of indole-3-acetic acids with aryl bromides by convergent paired electrolysis was developed in an undivided cell. This protocol features good functional group tolerance, and is chem. redox agent- and sacrificial electrode-free. Mechanistic studies indicated that the base was crucial for the decarboxylation step and a Ni^I/Ni^III catalytic cycle was involved in this transformation.

Chemical Communications (Cambridge, United Kingdom) published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C12H10FeO4, Application In Synthesis of 72571-06-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Hamilton, Jacqueline F. published the artcileQuantifying small molecules in secondary organic aerosol formed during the photo-oxidation of toluene with hydroxyl radicals, Computed Properties of 20662-83-3, the publication is Atmospheric Environment (2005), 39(38), 7263-7275, database is CAplus.

The composition of secondary organic aerosol (SOA) formed during the photooxidation of toluene in a large-volume smog chamber was determined using direct thermal desorption coupled to comprehensive gas chromatog.-time of flight mass spectrometry (TD-GC×GC-TOF/MS). TD-GC×GC eliminated offline sample preparation and resulted in a single shot inventory of GC-amenable organic species within the aerosol. Seventy-four species were identified and quantified from chromatog. retention behavior and mass spectral fragmentation. Functional groups resolved included organic acids, aromatics, dicarbonyls, furans, furanones, furandiones and pyranones. Concentrations of individual species were derived either directly from standards or from chem. surrogates. The major small organic mol. components by mass were formed via the peroxy-bicyclic reaction mechanism (e.g., 5-methyl-2(3H)-furanone = 2972 ng m^-3 or 0.861% of aerosol mass), although only around 10% of the total aerosol mass could be quantified. A large number of lower concentration species were observed with ambiguous chem. characteristics. Interpretation of their mass spectra suggests these species may be fragments of larger mols. broken down during the thermal desorption and separation stages.

Atmospheric Environment published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Computed Properties of 20662-83-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem