Heterocyclic Building Blocks-Oxazolidine

Yoshizumi, Tomoki published the artcileSynthesis of 2,5-diaryloxazoles through van Leusen reaction and copper-mediated direct arylation, Related Products of oxazolidine, the publication is Tetrahedron Letters (2009), 50(26), 3273-3276, database is CAplus.

The direct arylation of 5-aryloxazoles, prepared by the van Leusen reaction, with various aryl iodides is effectively promoted by a system of CuI combined with PPh₃ and Na₂CO₃ as a ligand and a base, resp., in DMF to produce the corresponding 2,5-diaryloxazoles in good yields.

Tetrahedron Letters published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C8H10O2, Related Products of oxazolidine.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Ok, H. O. published the artcileSubstituted oxazole benzenesulfonamides as potent human β₃ adrenergic receptor agonists, Application In Synthesis of 72571-06-3, the publication is Bioorganic & Medicinal Chemistry Letters (2000), 10(14), 1531-1534, database is CAplus and MEDLINE.

As a part of our investigation into the development of orally bioavailable β₃ adrenergic receptor agonists, we have identified a series of substituted oxazole derivatives that are potent β₃ agonists with excellent selectivity against other β receptors. Several of these compounds showed excellent oral bioavailability in dogs. The cyclopentylethyloxazole (I) is a potent β₃ agonist (EC₅₀=14 nM, 84% activation) with 340-fold and 160-fold selectivity over β₁ and β₂ receptors, resp., and has 38% oral bioavailability in dogs.

Bioorganic & Medicinal Chemistry Letters published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Application In Synthesis of 72571-06-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Motamen, Sara published the artcileAnalysis of Approaches to Anti-tuberculosis Compounds, Formula: C14H17FN4O3, the publication is ACS Omega (2020), 5(44), 28529-28540, database is CAplus and MEDLINE.

Mycobacterium tuberculosis (Mtb) remains a deadly pathogen two decades after the announcement of tuberculosis (TB) as a global health emergency by the World Health Organization. Medicinal chem. efforts to synthesize potential drugs to shorten TB treatments have not always been successful. Here, we analyze physiochem. properties of 39 TB drugs and 1271 synthetic compounds reported in 40 publications from 2006 to early 2020. We also propose a new TB space of physiochem. properties that may provide more appropriate guidelines for design of anti-TB drugs.

ACS Omega published new progress about 1219707-39-7. 1219707-39-7 belongs to oxazolidine, auxiliary class Other Aliphatic Heterocyclic,Oxazolidine,Chiral,Fluoride,Benzene,Amide,Alcohol,Anti-infection, name is (R)-3-(3-Fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one, and the molecular formula is C14H17FN4O3, Formula: C14H17FN4O3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Vechorkin, Oleg published the artcileThe Nickel/Copper-Catalyzed Direct Alkylation of Heterocyclic C-H Bonds, Category: oxazolidine, the publication is Angewandte Chemie, International Edition (2010), 49(17), 3061-3064, S3061/1-S3061/94, database is CAplus and MEDLINE.

A combination of the Ni complex I and CuI gave efficient coupling of aromatic heterocycles with nonactivated alkyl halides containing a β-hydrogen atom. The chemo- and regioselectivities were excellent. E.g., alkylation of benzoxazole by octyl bromide gave 72% 2-octylbenzoxazole.

Angewandte Chemie, International Edition published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C4Br2N2O4S, Category: oxazolidine.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Foti, Claudia published the artcileOxazolidinone Antibiotics: Chemical, Biological and Analytical Aspects, Recommanded Product: (R)-3-(3-Fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one, the publication is Molecules (2021), 26(14), 4280, database is CAplus and MEDLINE.

A review. This review covers the main aspects concerning the chem., the biol. activity and the anal. determination of oxazolidinones, the only new class of synthetic antibiotics advanced in clin. use over the past 50 years. They are characterized by a chem. structure including the oxazolidone ring with the S configuration of substituent at C5, the acylaminomethyl group linked to C5 and the N-aryl substituent. The synthesis of oxazolidinones has gained increasing interest due to their unique mechanism of action that assures high antibiotic efficiency and low susceptibility to resistance mechanisms. Here, the main features of oxazolidinone antibiotics licensed or under development, such as Linezolid, Sutezolid, Eperezolid, Radezolid, Contezolid, Posizolid, Tedizolid, Delpazolid and TBI-223, are discussed. As they are protein synthesis inhibitors active against a wide spectrum of multidrug-resistant Gram-pos. bacteria, their biol. activity is carefully analyzed, together with the drug delivery systems recently developed to overcome the poor oxazolidinone water solubility Finally, the most employed anal. techniques for oxazolidinone determination in different matrixes, such as biol. fluids, tissues, drugs and natural waters, are reviewed. Most are based on HPLC (High Performance Liquid Chromatog.) coupled with UV-Vis or mass spectrometer detectors, but, to a lesser extent are also based on spectrofluorimetry or voltammetry.

Molecules published new progress about 1219707-39-7. 1219707-39-7 belongs to oxazolidine, auxiliary class Other Aliphatic Heterocyclic,Oxazolidine,Chiral,Fluoride,Benzene,Amide,Alcohol,Anti-infection, name is (R)-3-(3-Fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one, and the molecular formula is C14H17FN4O3, Recommanded Product: (R)-3-(3-Fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Hsu, Chen Ming published the artcileCharacterization of new volatile compounds in the neutral fraction of roasted beef flavor, Quality Control of 20662-83-3, the publication is Journal of Food Science (1982), 47(6), 2068-9, 2071, database is CAplus.

Volatile flavor compounds were isolated from 190 lb of roasted eye round beef. The neutral fraction of the flavor isolate was subjected to extensive gas-chromatog. (GC) fractionation and the pure fractions obtained were identified by GC-mass spectrometry. A total of 67 compounds were reported to be new constituents in beef flavor.

Journal of Food Science published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Quality Control of 20662-83-3.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Mortensen, Deborah S. published the artcileDiscovery and SAR exploration of a novel series of imidazo[4,5-b]pyrazin-2-ones as potent and selective mTOR kinase inhibitors, Recommanded Product: 5-(4-Bromophenyl)oxazole, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(22), 6793-6799, database is CAplus and MEDLINE.

We report here the discovery of a novel series of selective mTOR kinase inhibitors. A series of imidazo[4,5-b]pyrazin-2-ones, represented by screening hit 1, was developed into lead compounds with excellent mTOR potency and exquisite kinase selectivity. Potent compounds from this series show >1000-fold selectivity over the related PI3Kα lipid kinase. Further, compounds such as 2 achieve mTOR pathway inhibition, blocking both mTORC1 and mTORC2 signaling, in PC3 cancer cells as measured by inhibition of pS6 and pAkt (S473).

Bioorganic & Medicinal Chemistry Letters published new progress about 72571-06-3. 72571-06-3 belongs to oxazolidine, auxiliary class Oxazole,Bromide,Benzene, name is 5-(4-Bromophenyl)oxazole, and the molecular formula is C9H6BrNO, Recommanded Product: 5-(4-Bromophenyl)oxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Lu, Chih-Ying published the artcileMaillard volatile generation from reaction of glucose with dipeptides, Gly-Ser, and Ser-Gly, Name: 4,5-Dimethyloxazole, the publication is ACS Symposium Series (2008), 147-157, database is CAplus.

Peptides abundant in food and protein hydrolyzates are known to be important to both unprocessed and processed flavors. The effect of peptide bond hydrolysis on the formation of Maillard volatile compounds was studied. The Gly-Ser dipeptide bond was the most labile among all the Gly-X dipeptides (X = Ala, Cys, Gln, Glu, Gly, His, Leu, Lys, Phe, Pro, Ser, Thr, Tyr and Val). However, Ser-Gly was 2 to 3 times more stable than Gly-Ser. Volatiles formation was investigated using Gly-Ser and Ser-Gly as precursors in the reaction with glucose. Gly-Ser generated more volatiles than Ser-Gly which confirmed the pos. correlation between peptide bond susceptibility and volatiles generation.

ACS Symposium Series published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Name: 4,5-Dimethyloxazole.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Trifonov, R. E. published the artcileBasicity of phenyl-substituted 1,3-oxazoles, Category: oxazolidine, the publication is Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) (2001), 37(3), 416-420, database is CAplus.

Ph substituents in positions 2, 4, and 5 of the oxazole ring exert different effects on the electronic structure of the hetero ring, which are reflected in the basicity constants of isomeric phenyl-substituted oxazoles and in changes of the spectral patterns on protonation. The calculated (AM1) gas-phase proton affinities and energies of ionization of isomeric methyl-, phenyl-, and methylphenyloxazoles were correlated with the exptl. pK_BH⁺ values. In acid medium specific solvation of phenyloxazoles is possible with participation of the heterocyclic fragment.

Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C8H19NO, Category: oxazolidine.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem

Dart, S. K. published the artcileThe changes in the volatile components of instant coffee with storage, Related Products of oxazolidine, the publication is Developments in Food Science (1985), 239-52, database is CAplus.

The headspace volatiles of fresh instant coffee were identified by capillary gas chromatog.-mass spectrometry, after enrichment on activated charcoal. The changes occurring to the volatiles during storage for â‰?2 mo at -18° and at ambient temperature were followed by direct headspace anal. Several components were highly susceptible to change, even at -18°. Overall, changes (increases as well as decreases) took place in about half the peaks, and these were interpreted in terms of the identifications made.

Developments in Food Science published new progress about 20662-83-3. 20662-83-3 belongs to oxazolidine, auxiliary class Oxazole, name is 4,5-Dimethyloxazole, and the molecular formula is C5H7NO, Related Products of oxazolidine.

Referemce:
https://en.wikipedia.org/wiki/Oxazolidine,
Oxazolidine | C3H7NO – PubChem